Jeff P. Sharman, MD¹, Luca Laurenti, MD^2*, Emmanuelle Ferrant^3*, Luis Felipe Casado Montero^4*, Stephen P Mulligan^5*, Rosemary Harrup^6*, Stephen Opat^7*, Adalberto Ibatici^8*, Roberto Marasca⁹, Paolo Sportoletti^10*, Marcus Lefebure^11*, Michelle Boyer^12*, Yanwen Jiang^12*, Simona Barlera^13*, Oscar Cazares^12* and Franck Morschhauser, MD, PhD¹⁴

¹Willamette Valley Cancer Institute, Sarah Cannon Research, Eugene, OR
²Department of Diagnostic Imaging, Oncological Radiotherapy and Hematology, Agostino Gemelli University Hospital Foundation IRCCS, Rome, Italy
³Department of Hematology, Lyon Sud Hospital, Pierre Benite, France
⁴Hematology, Hospital General Universitario de Toledo, Toledo, Spain
⁵Royal North Shore Hospital, Sydney, AUS
⁶Royal Hobart Hospital and University of Tasmania, Tasmania, Australia
⁷Monash Health, Melbourne, VIC, Australia
⁸Division of Hematology and Bone Marrow Transplant, IRCCS Ospedale Policlinico San Martino, Genoa, Italy
⁹University of Modena and Reggio Emilia, Modena, Italy
¹⁰Department of Medicine and Surgery, Institute of Hematology, Centro di Ricerca Emato-Oncologica, University of Perugia, Perugia, Italy
¹¹Roche Products Ltd, Welwyn Garden City, United Kingdom
¹²Genentech, Inc., South San Francisco, CA
¹³Parexel International, Milan, Italy
¹⁴Centre Hospitalier Régional Universitaire de Lille, Lille, France

Moritz Fürstenau, MD^1*, Emelie Curovic Rotbain, MD, PhD^2*, Laura Eurelings, MD, PhD^3*, Sandra Robrecht, PhD^4*, Julia Von Tresckow, MD^5*, Adam Giza^6*, Michael Gregor, MD^7*, Patrick Thornton^8*, Philipp Bernhard Staber, MD, PhD⁹, Tamar Tadmor, MD^10*, Vesa Lindström^11*, Gunnar Juliusson, MD, PhD¹², Ann Janssens, MD^13*, Christof Schneider, MD^14*, Thomas Noesslinger, MD¹⁵, Martin Andres^16*, Adrian Schmidt^17*, Elisabeth Vandenberghe, MD¹⁸, Lev Shvidel, MD^19*, Christian Bjørn Poulsen, MD, PhD^20*, Henrik Frederiksen, MD, PhD²¹, Caspar Da Cunha-Bang, MD, PhD^2*, Kourosh Lotfi^22*, Rogier Mous, MD PhD^23*, Martine E.D. Chamuleau, MD PhD²⁴, Ka Lung Wu²⁵, Margriet Oosterveld, MD^26*, Jesus Duque-Afonso, MD^27*, Christian Bogner^28*, Thomas Wolff, MD^29*, Johannes Schetelig, MD, MSc³⁰, Ursula Vehling-Kaiser, MD^31*, Christoph van Roye^32*, Nadine Kutsch, MD^6*, Anna Maria Fink, MD^33*, Kirsten Fischer, MD^33*, Emily Holmes^34*, Matthias Ritgen^35*, Eugen Tausch, MD^14*, Stephan Stilgenbauer, MD¹⁴, Michael J. Hallek, MD³⁶, Arnon P. Kater, MD, PhD³⁷, Carsten Utoft Niemann, MD, PhD^2*, Mark-David Levin³⁸ and Barbara F. Eichhorst, MD³⁹

¹Department I of Internal Medicine, Faculty of Medicine and Cologne University Hospital, Koeln, Germany
²Department of Hematology, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark
³Albert Schweitzer Ziekenhuis, Dordrecht, Netherlands
⁴German CLL Study Group, University of Cologne, Cologne, Germany
⁵Clinic for Hematology and Stem Cell Transplantation, West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, Essen, Germany
⁶Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf; German CLL Study Group, University of Cologne, Cologne, Germany
⁷Division of Hematology, Cantonal Hospital of Lucerne, Lucerne, Switzerland, Lucerne, Switzerland
⁸Department of Haematology, Beaumont Hospital, RCSI, Cancer Trials Ireland, Dublin, Dublin, IRL
⁹Department of Medicine I, Division of Hematology & Hemostaseology, Medical University of Vienna, Vienna, Austria
¹⁰Bnai Zion, Haifa, Israel
¹¹Comprehensive Cancer Center, Department of Hematology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland
¹²Department of Hematology, Lund University Cancer Center, Lund, Sweden
¹³University Hospitals Leuven, Leuven, Belgium
¹⁴Department of Internal Medicine III, Division of CLL, University Hospital Ulm, Ulm, Germany
¹⁵Hanusch Hospital, Vienna, AUT
¹⁶Department of Hematology and Central Hematology Laboratory, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland
¹⁷Stadtspital Zürich Triemli, Zürich, Switzerland
¹⁸St. James's Hospital, Dublin, IRL
¹⁹Kaplan Medical Center, Rehovot, Israel, ISR
²⁰Department of Hematology, Zealand University Hospital, Roskilde, Denmark
²¹Department of Hematology, Odense University Hospital, Odense, DNK
²²University Hospital/Linkoping University, Linkoping, SWE
²³Department of Hematology, University Medical Center Utrecht, Amsterdam, Netherlands
²⁴Department of Hematology, Amsterdam UMC location Vrije Universiteit Amsterdam, Amsterdam, Netherlands
²⁵ZNA Stuivenberg, Antwerp, Belgium
²⁶Canisius-Wilhelmina Hospital, Nijmegen, NLD
²⁷Univ. of Freiburg, Freiburg, DEU
²⁸Klinikum Landshut, Landshut, DEU
²⁹Onkologie-Lerchenfeld, Hamburg, DEU
³⁰Department of Internal Medicine I, University Hospital Carl Gustav Carus, Technical University Dresden, Dresden, Saxony, Germany
³¹Outpatient Clinic, Landshut, Germany
³²Onkologie Koblenz, Koblenz, Germany
³³Department I of Internal Medicine, Faculty of Medicine and Cologne University Hospital, Cologne, Germany
³⁴German CLL Study Group, University of Cologne, Cologne, Cologne, Germany
³⁵Department of Internal Medicine II (Hematology/Oncology), University Hospital Schleswig-Holstein Campus Kiel, Kiel, Germany
³⁶University of Cologne, Cologne, DEU
³⁷Amsterdam University Medical Center, Amsterdam, on behalf of HOVON, Netherlands
³⁸Albert Schweitzer Hospital, Dordrecht, Netherlands
³⁹University Hospital Cologne, Cologne, Germany

Tamar Tadmor, MD^1,2*, Guy Melamed^3*, Hilel Alapi^4*, Sivan Gazit^5*, Tal Patalon^6* and Lior Rokach, Prof^7*

¹Technion, Ruth and Bruce Rappaport Faculty of Medicine,, Haifa,, Israel
²Hematology Unit, Bnai Zion Medical Center, Haifa, Israel
³Kahn Sagol Maccabi Research & Innovation Center, Maccabi Healthcare Services, T, Tel-Aviv, Israel
⁴Kahn Sagol Maccabi Research & Innovation Center, Maccabi Healthcare Services,, Tel Aviv, Israel
⁵Kahn Sagol Maccabi Research & Innovation Center, Maccabi Healthcare Services, Tel Aviv, Israel
⁶Kahn Sagol Maccabi Research & Innovation Center, Maccabi Healthcare Services, Tel-Aviv, Israel, Tel Aviv, Israel
⁷Ben-Gurion University of the Negev,, Department of Software and Information Systems Engineering,, Beer-sheva, Israel

Linlin Cao^1*, Song Hao^2*, Cuicui Wang^2*, Qiang Xu^2*, Chenyang Zhou^2*, Maogui Hu^2*, Jing Ming^2*, Guolin Wu^2*, Dandan Fan^2*, Yuanyuan Feng^2*, Xinchen Wang^2*, Hailiang Chu^3* and Kaiyang Ding^2*

¹Department of Hematological Oncology, Anhui Province Cancer Hospital, Anhui, China
²Department of Hematological Oncology, Anhui Province Cancer Hospital, Hefei, China
³Department of hematology ,Bozhou People's Hospital, Bozhou, China

Merieme Bensalah, PharmD^1*, Amal Messaoudi^1*, Carole Fleury^1*, Giulia Tueur^1*, Rémi Letestu, MD, PhD^1,2*, Marine Armand, PhD^3*, Sabine Brechignac, MD^4,5*, Sarah Ivanoff, MD^4,6*, Valérie Vidal, MD^4,6*, Ramy Rahmé, MD, MSc^4,6*, Chadi Al Nawakil, MD^7*, Thorsten Braun, MD, PhD^4,6, Catherine Thieblemont, MD⁸, Cymbalista Florence, MD, PhD^1,2*, Vincent Levy, MD, PhD^7*, Fanny Baran-Marszak, MD, PhD^2,9* and Grégory Lazarian, PharmD, PhD^1,2*

¹Hematology Laboratory, Avicenne University Hospital, Assistance Publique – Hôpitaux de Paris, Bobigny, France
²INSERM U978, Université Sorbonne Paris Nord, Bobigny, France
³Department of Biological Hematology, Hôpital Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris (AP-HP), Sorbonne Université, PARIS, France
⁴UFR SMBH, Sorbonne Paris Nord University, Bobigny, France
⁵Clinical Hematology, Avicenne Hospital, Greater Paris University Hospitals (AP-HP), Bobigny, France
⁶Clinical Hematology, Avicenne University Hospital, Assistance Publique – Hôpitaux de Paris, Bobigny, France
⁷Département de Recherche Clinique, Hôpitaux Universitaire Paris Seine Saint Denis (HUPSSD), Hôpital Avicenne, Université Sorbonne Paris Nord, Bobigny, France
⁸Hospital Saint-Louis, Paris, France
⁹INSERM U978, University of Paris 13, Bobigny, France

Krzysztof Jamroziak, MD, PhD^1*, Elzbieta Iskierka-Jazdzewska, MD, PhD^2*, Sebastian Giebel, MD, PhD^3*, Kamil Wisniewski, MD, PhD^4*, Joanna Drozd-Sokolowska, MD, PhD^1*, Tadeusz Robak^5,6*, Justyna Rybka, MD, PhD^7*, Weronika Piszczek, MD^8*, Monika Joks, MD, PhD^9*, Anna Paulina Dabrowska-Iwanicka, MD, PhD¹⁰, Andrzej Mital, MD, PhD^11*, Paweł Steckiewicz, MD^12*, Ewa Lech-Maranda, MD, PhD^13*, Marcin Jasinski, MD^1*, Marcin Rymko, MD, PhD^14*, Dawid Marciniak, MD^15*, Tomasz Wrobel, MD, PhD^16*, Lidia Gil, MD, PhD⁹, Joanna Romejko-Jarosinska, MD, PhD^17*, Dorota Kruk-Kwapisz, MSc^18*, Agnieszka Chudy, PhD^19*, Krzysztof Giannopoulos, MD, PhD^20*, Tomasz Stoklosa, MD, PhD²¹ and Bartosz Michal Pula, MD, PhD^22*

¹Department of Hematology, Transplantation and Internal Medicine, Medical University of Warsaw, Warsaw, Poland
²Copernicus Memorial Hospital, Medical University of Łódź, Lodz, Poland
³Department of Bone Marrow Transplantation and Onco-Hematology, Maria Sklodowska-Curie National Research Institute of Oncology, Gliwice Branch, Gliwice, Poland
⁴Department of Hematology, Instutute of Hematology and Trasnfusion Medicine, Warsaw, POL
⁵Department of Hematology, Medical University of Lodz, Lodz, Poland
⁶Copernicus Memorial Hospital, Lodz, Poland
⁷Department of Hematology, Blood Neoplasms and Bone Marrow Transplantation, Wroclaw Medical University, Wroclaw, Poland
⁸Hematology Department, Rydygier Provincial Polyclinical Hospital in Toruń, Torun, Poland
⁹Department of Hematology and Bone Marrow Transplantation, Poznan University of Medical Sciences, Poznan, Poland
¹⁰Department of Lymphoid Malignancies, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland
¹¹Department of Hematology and Transplantology, Medical University of Gdansk, Gdańsk, Poland
¹²Department of Hematology, Holy Cross Cancer Center, Kielce, Poland
¹³Department of Hematology, Institute of Hematology and Transfusion Medicine, Warsaw, Poland
¹⁴Hematology Department, Rydygier Provincial Polyclinical Hospital in Torun, Torun, POL
¹⁵Department of Bone Marrow Transplantation and Hematology-Oncology, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland
¹⁶Department of Hematology, Blood Neoplasms and Bone Marrow Transplantation, Medical University of Wroclaw, Wroclaw, Poland
¹⁷Department of Lymphoid Malignancies, Marie Sklowdoska-Curie National Research Institute of Oncology, Warszawa, Poland
¹⁸Medical University of Warsaw, Warsaw, Poland
¹⁹Department of Tumor Biology and Genetics, University Clinical Center, Medical University of Warsaw, Warsaw, Poland
²⁰Department of Experimental Hematooncology, Medical University of Lublin, Lublin, Poland
²¹Department of Tumor Biology and Genetics, Medical University of Warsaw, Warsaw, Poland
²²Department of Hematology, Institute of Hematology and Transfusion Medicine, Warsaw, Masovian Voivodeship, Poland

Emelie Curovic Rotbain, MD, PhD^1,2*, Mikkel Werling, MSc^1*, Casper Møller Frederiksen, PhD^1*, Christian Bjørn Poulsen, MD, PhD^3*, Martin Hutchings, MD, PhD^1,4, Caspar Da Cunha-Bang, MD, PhD^1* and Carsten Utoft Niemann, MD, PhD^1,4*

¹Department of Hematology, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark
²Hematology Group, Danish Cancer Institute, Copenhagen, Denmark
³Department of Hematology, Zealand University Hospital, Roskilde, Denmark
⁴Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark

Huayuan Zhu^1*, Yi Miao, MD^2*, Shuchao Qin, MD PHD^2*, Ming Liu^2*, Yi Xia^2*, Luomengjia Dai^2*, Tonglu Qiu, MD^2*, Chong-Yang Ding^3*, Hairong Qiu^2*, Chun Qiao^2*, Yujie Wu^2*, Fei Li⁴, Xiao Lu, MD^2*, Wei Xu^2*, Lei Fan^2* and Jianyong Li, MD⁵

¹Pukou CLL Center, Pukou Division of Jiangsu Province Hospital, Nanjing, Jiangsu, China
²Lymphoma Center, Department of Hematology, Jiangsu Province Hospital, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
³Department of Nuclear Medicine, Jiangsu Province Hospital, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
⁴Department of Hematology, The First Affiliated Hospital of Nanchang University, Nanchang, China
⁵First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, China

Cecelia Miller, PhD¹, Ying Huang, MS, MA², John N. Allan, MD³, Seema A. Bhat, MD^4*, David A. Bond, MD, BS⁵, Danielle M. Brander, MD⁶, John C. Byrd, MD⁷, Julio C. Chavez, MD⁸, Elise A. Chong, MD⁹, Alexey Danilov, MD, PhD¹⁰, Mark R Dowling, MBBS, PhD¹¹, Kaitlyn M. Dvorak-Kornaus, PhD^5*, Paul J. Hampel, MD¹², Carrie I Ho, MD¹³, Prioty Islam, MD^14*, Nikita Malakhov, MD¹⁵, Matthew Matasar, MD, MS¹⁶, Sarah Miller, BS^17*, Sameer A. Parikh, MBBS¹², Kari G. Rabe, MS^18*, Joanna M. Rhodes, MD, MSCE^19*, Lindsey Roeker, MD²⁰, Kerry A. Rogers, MD⁵, Aditi Saha, MBBS⁸, Alan P Skarbnik, MD²¹, Hamish W Scott, MD^22*, Jake Schade, BA^23*, Mazyar Shadman, MD, MPH^24*, Geoffrey Shouse, PhD, DO²⁵, Deborah M. Stephens, DO²⁶, Meghan C. Thompson, MD¹⁴, Philip A. Thompson, MBBS, FRACP, FRCPA²⁷, Yucai Wang, MD, PhD¹², Jennifer A. Woyach, MD²⁸, Max Yano, MD, PhD^29*, Zulfa Omer, MD³⁰ and Adam S Kittai, MD³¹

¹Department of Pathology, The Ohio State University Comprehensive Cancer Center, Columbus, OH
²Division of Hematology, Department of Statistics, The Ohio State University Wexner Medical Center, Columbus, OH
³Division of Hematology & Medical Oncology, Weill Cornell Medicine, New York, NY
⁴Division of Hematolopgy, The Ohio State University, Columbus, OH
⁵Division of Hematology, The Ohio State University, Columbus, OH
⁶Duke University, Durham, NC
⁷Department of Internal Medicine, University of Cincinnati, Cincinnati, OH
⁸Department of Malignant Hematology, Moffitt Cancer Center, Tampa, FL
⁹Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA
¹⁰City of Hope National Medical Center, Duarte, CA
¹¹Peter MacCallum Cancer Centre, Department of Clinical Haematology, Royal Melbourne Hospital, Melbourne, VIC, Australia
¹²Division of Hematology, Mayo Clinic, Rochester, MN
¹³Division of Hematology and Oncology, University of Washington, Seattle, WA
¹⁴Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY
¹⁵Division of Hematology and Oncology, Weill Cornell Medicine, New York, NY
¹⁶Division of Blood Disorders, Rutgers Cancer Institute, New Brunswick, NJ
¹⁷Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, OH
¹⁸Division of Clinical Trials and Biostatistics, Mayo Clinic, Rochester, MN
¹⁹Rutgers Cancer Institute of New Jersey, New Brunswick, NJ
²⁰Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY
²¹Lymphoma and CLL Program, Novant Health Cancer Institute, Charlotte, NC
²²Department of Clinical Haematology, Peter MacCallum Cancer Centre and Royal Melbourne Hospital, Melbourne, VIC, Australia
²³Rutgers Cancer Institute, New Brunswick, NJ
²⁴Fred Hutch Cancer Center, University of Washington, Seattle, WA
²⁵City of Hope Cancer Center, Duarte, CA
²⁶University of North Carolina Chapel Hill, Chapel Hill, NC
²⁷Department of Clinical Haematology, Royal Melbourne Hospital and Peter MacCallum Cancer Centre, Melbourne, VIC, Australia
²⁸Division of Hematology, Ohio State University Comprehensive Cancer Center, Columbus, OH
²⁹College of Medicine, The Ohio State University, Columbus, OH
³⁰Division of Hematology, University of Cincinnati, Cincinnati, OH
³¹Icahn School of Medicine at Mount Sinai, New York, NY

Anjali Lankford, MD^1*, Mahesh Swaminathan, MD², Amrit S. Gonugunta, MD^3*, Himachandana Atluri, MD², Hannah Goulart, MD⁴, Koji Sasaki, MD², Guilin Tang, MD, PhD^5*, Rashmi Kanagal-Shamanna, MD⁶, Jan A. Burger, MD, PhD ⁴, Alessandra Ferrajoli, MD², Hagop Kantarjian, MD², William G. Wierda⁷ and Nitin Jain, MD⁸

¹Department of Internal Medicine, The University of Texas Health Science Center McGovern Medical School, Houston
²Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
³Department of Internal Medicine, The University of Texas Health Science Center at Houston, Houston, TX
⁴MD Anderson Cancer Center, Houston, TX
⁵Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX
⁶Department of Hematopathology, The University of Texas M. D. Anderson Cancer Center, Houston, TX
⁷The University of Texas MD Anderson Cancer Center, Houston, TX
⁸University of Texas MD Anderson Cancer Center, Department of Leukemia, Houston, TX

Allison M. Winter, MD¹, Olivia Landever^1*, Hiruni Mendries^1*, Willem Van Heeckeren, MD, PhD^2*, Chieh-Lin Fu, MD³, Robert M. Dean, MD¹, Taylor R. Brooks, MD¹, Deepa Jagadeesh, MD¹, Paolo F. Caimi¹ and Brian T. Hill, MD¹

¹Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH
²Department of Hematology and Medical Oncology, Cleveland Clinic Taussig Cancer Institute, Cleveland, OH
³Maroone Cancer Center, Cleveland Clinic Florida, Weston, FL

Yuqin Song, MD¹, Keshu Zhou, MD^2*, Hongmei Jing, MD³, Geoffrey Chong⁴, Jianqiu Wu, PhD^5*, Wei Liu, MD^6*, Zengjun Li^7*, Ming Jiang, PhD^8*, Mei Lan, MD^9*, Kaiyang Ding^10*, Guohui CUI^11*, Tingyu Wang^12*, Xutao Guo, MD^13*, Sujun Gao^14*, Constantine S. Tam, MBBS, MD¹⁵, Haiyan Yang, PhD¹⁶, Fang Zhu^17*, Wei Yang^18*, Jian-Qing Mi¹⁹, Liping Su²⁰, Ke Fang^21*, Ziyi Liu^21*, Lindsey Roeker, MD²², Chan Y. Cheah, MBBS DMSc²³, Jianyong Li, MD²⁴ and Lu-Gui Qiu, MD⁶

¹Department of Lymphoma, Peking University Cancer Hospital, BEIJING, China
²Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, China
³Peking University Third Hospital, Beijing, China
⁴Olivia Newton-John Cancer Wellness & Research Centre, Austin Hospital, Heidelberg, VIC, Australia
⁵Department of Oncology, Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research & Nanjing Medical University Affiliated Cancer Hospital, Nanjing, AL, China
⁶State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology& Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China
⁷Cancer Hospital of Shandong First Medical University, Jinan, China
⁸West China Hospital，Sichuan University, Chengdu, China
⁹The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, CHN
¹⁰Department of Hematological, Anhui Province Cancer Hospital, Hefei, China
¹¹Union Hospital, Tongji Medical College,Huazhong University of Science and Technology, WUHAN, CHN
¹²State Key Laboratory of Experimental Hematology, Institute of Hematology & Blood Diseases Hospital Chinese Academy of Medical Sci, Tian Jin, China
¹³Department of Hematology, Nanfang Hospital of Southern Medical University, GuangZhou, China
¹⁴Department of Hematology, The First Hospital of Jilin University, Changchun, China
¹⁵Monash University, Melbourne, VIC, Australia
¹⁶Department of Lymphoma, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, China
¹⁷Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Sc, Wuhan, CHN
¹⁸Department of Hematology, Shengjing Hospital of China Medical University, Shenyang, China
¹⁹Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
²⁰Shanxi Province Cancer Hospital, Taiyuan, China
²¹Dizal Pharmaceutical, Shanghai, China
²²Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY
²³Sir Charles Gairdner Hospital, Perth, Western Australia, Australia
²⁴First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, China

Mazyar Shadman, MD, MPH^1,2, Talha Munir, MBBS, PhD³, Tadeusz Robak^4*, Jennifer R. Brown, MD, PhD⁵, Brad S. Kahl, MD⁶, Paolo Ghia, MD, PhD^7,8, Tian Tian, PhD^9*, Andy Szeto^9*, Roman Korolkiewicz^10*, Constantine S. Tam^11* and Wojciech Jurczak, MD, PhD¹²

¹Fred Hutchinson Cancer Research Center, Seattle, WA
²Division of Hematology and Oncology, University of Washington, Seattle, WA
³Department of Haematology, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom
⁴Department of Hematology, Medical University of Lodz, Lodz, Poland
⁵Dana-Farber Cancer Institute, Boston, MA
⁶Washington University School of Medicine, Saint Louis, MO
⁷IRCCS Ospedale San Raffaele, Milan, Italy
⁸Università Vita-Salute San Raffaele, Milano, Italy
⁹BeiGene USA, Inc, San Mateo, CA
¹⁰BeiGene USA, Inc, San Mateo
¹¹Alfred Health and Monash University, Melbourne, VIC, Australia
¹²Maria Sklodowska-Curie National Research Institute of Oncology, Krakow, Malopolskie, Poland

Lukas Peter Frenzel^1*, Laura Beckmann, MD^1*, Sandra Robrecht, PhD^2*, Can Zhang, PhD^3*, Anna Maria Fink, MD^3*, Othman Al-Sawaf, MD³, Christof Schneider, MD^4*, Brenda Chyla⁵, Hyun Yong Jin, PhD^6*, Yanwen Jiang^6*, Tim H. H. Brummendorf, MD⁷, Michael Hallek, MD^8*, Barbara F. Eichhorst, MD⁸, Kirsten Fischer, MD^9*, Fabian Beier, MD^10,11* and Susanne Isfort^12*

¹Faculty of Medicine and Cologne University Hospital, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, University of Cologne, Cologne, Germany, Cologne, Germany
²German CLL Study Group, University of Cologne, Cologne, Germany
³Faculty of Medicine and Cologne University Hospital, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, University of Cologne, Cologne, Germany, Cologne, Germany, Cologne, Germany
⁴Department of Internal Medicine III, Division of CLL, University Hospital Ulm, Ulm, Germany
⁵AbbVie Inc, North Chicago, IL
⁶Genentech, Inc., South San Francisco, CA
⁷Department of Hematology, Oncology, Hemostaseology, and Stem Cell Transplantation, Faculty of Medicine, University Medical Center Aachen, Aachen, Germany
⁸Department I of Internal Medicine, Faculty of Medicine and Cologne University Hospital, Cologne, Germany
⁹Faculty, Cologne, Germany
¹⁰Department of Hematology, Oncology, Hemostaseology and Stem Cell Transplantation, RWTH Aachen University, Medical Faculty, Aachen, Germany
¹¹Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf (CIO ABCD), Aachen, Germany
¹²Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School (MHH), Hannover, Germany

Lugui Qiu¹, Zhuogang Liu^2*, Shuhua Yi, MD^3*, Thanh Nguyen, MD^4*, Wen-Juan Yu^5*, Keshu Zhou, MD^6*, Haiwen Huang, MD^7*, Udomsak Bunworasate, MD^8*, Man Huynh, MD^9*, Hui Zhou, MD¹⁰, Su-Peng Yeh, MD^11*, Yiqiu Wang, MD^12*, Xiaofeng Liu, MS^12* and Wei Fu, MM^12*

¹State Key Laboratory of Experimental Hematology, National Clinical Medical Research Center for Blood Diseases, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China
²Department of Hematology, Shengjing Hospital of China Medical University, Shenyang, China
³State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical Colleg, Tianjin, China
⁴National Institute of Hematology and Blood Transfusion, Hanoi, Viet Nam
⁵Department of Hematology, Department of Hematology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
⁶Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, China
⁷Department of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, China
⁸Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
⁹Blood Transfusion Hematology Hospital, Hochiminh City, Viet Nam
¹⁰Department of Lymphoma & Hematology, Hunan Cancer Hospital and Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China
¹¹Division of Hematology and Oncology, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan
¹²AstraZeneca, Shanghai, China

Rodrigo Fonseca, MD^1*, Diana Zamora, MD^2*, Fan Leng^3*, Christie C Ngo^4*, Jose F. Leis, MD, PhD⁵, Mazie Tsang, MD⁶ and Talal Hilal, MD⁷

¹Internal Medicine, Mayo Clinic Arizona, Scottsdale, AZ
²Creighton University, Phoenix, AZ
³Division of Information Technology, Mayo Clinic, Rochester, MN
⁴Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN
⁵Mayo Clinic, Phoenix, AZ
⁶Division of Hematology and Oncology, Department of Medicine, Mayo Clinic, Phoenix, AZ
⁷Division of Hematology and Oncology, Mayo Clinic Arizona, Phoenix, AZ

Jing-Zhou Hou, MD, PhD¹, Rushir Choksi, MD^1*, Anupama Vasudevan, BDS, MPH, PhD^2*, Anna Rui, MPH^2*, Poras Davé, MHA^2*, Mike Gart, MBA^2*, Brandon Wang, MBA^2*, Prateesh Varughese, PharmD, MBA^2* and Simon Blanc, MD²

¹University of Pittsburgh Medical Center, Pittsburgh, PA
²IntegraConnect PrecisionQ, West Palm Beach, FL

Paolo Ghia, MD, PhD¹, Loic Ysebaert, MD, PhD^2*, Ann Janssens, MD, PhD^3*, Mohamed Fouad^4*, Claudio Schioppa^5*, Jose-Angel Hernandez Rivas, MD, PhD^6* and Alessandra Tedeschi, MD^7*

¹Università Vita-Salute San Raffaele, Milano, Italy
²Hematology Department, Institut Universitaire du Cancer Toulouse Oncopole, Toulouse, France
³UZ Leuven Gasthuisberg, Leuven, Belgium
⁴Johnson & Johnson Middle East FZ-LLC, Dubai, United Arab Emirates
⁵Janssen Pharmaceutica NV, Beerse, Belgium
⁶Hospital Universitario Infanta Leonor, Universidad Complutense, Madrid, Spain
⁷Department of Hematology, Niguarda Cancer Center, ASST Grande Ospedale Metropolitano Niguarda, Milano, Italy

Constantine S. Tam, MD, MBBS¹, Stephen S. Opat, MBBS, FRACP, FRCPA², Eileen Grace Merriman, MD, FRACP, FRCPA^3*, Jan A. Burger, MD, PhD ⁴, Emma Verner, MBBS^5*, Paula Marlton^6*, David Gottlieb, MD, MBBS, FRACP, FRCPA^7*, Ian W. Flinn, MD, PhD⁸, Sumit Madan, MD⁹, Matthew Ku, MBBS, PhD^10*, Radha Prathikanti, MPH, MBA^11*, Heather Allewelt, MD^11*, Tian Tian, PhD^11*, Remus Vezan, MD, PhD^11* and Gavin Cull, MBBS, DM, FRACP, FRCPA¹²

¹Alfred Hospital and Monash University, Melbourne, VIC, Australia
²Lymphoma Research Group, School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC, Australia
³NorthShore Hospital, Auckland, New Zealand
⁴The University of Texas MD Anderson Cancer Center, Houston, TX
⁵Concord Repatriation General Hospital, University of Sydney, Concord, NSW, Australia
⁶Princess Alexandra Hospital and University of Queensland, Brisbane, QLD, Australia
⁷Westmead Institute for Medical Research, Sydney, NSW, Australia
⁸Tennessee Oncology/OneOncology, Nashville, TN
⁹Banner MD Anderson Cancer Center at Banner Gateway Medical Center, Gilbert, AZ
¹⁰St Vincent’s Hospital, Melbourne, VIC, Australia
¹¹BeiGene USA, Inc, San Mateo, CA
¹²Sir Charles Gairdner Hospital, Perth, Australia

Luc-Matthieu Fornecker, MD, PhD^1*, Rémi Letestu, MD, PhD^2*, Nanthara Shritaran, MS^3*, Emmanuelle Ferrant^4*, Fressia Honeyman, MD^5*, Therese Aurran-Schleinitz, MD^6*, Fatiha Merabet, MD^7*, Pierre Morel, MD, PhD^8*, Abderrazak El Yamani, MD^9*, Jehan Dupuis, MD^10*, Kamel Laribi, MD^11*, Stephane Lepretre, MD^12*, Lysiane Molina, MD^13*, Hugo Legendre, MD^14*, Chadi Al Nawakil, MD^15*, Bruno Villemagne, MD^16*, Anne-Sophie Michallet, MD, PhD^17*, Béatrice Mahé, MD^18*, Omar Benbrahim, MD^19*, Laurence Sanhes, MD^20*, Caroline Dartigeas, MD^21*, Aline Clavert, MD^22* and Vincent Levy, MD, PhD^15*

¹Institut De Cancérologie Strasbourg Europe, Hematology Department, Strasbourg, France
²avicenne hospital, Avicenne, France
³Unité de Recherche Clinique, Hopital Avicenne, Bobigny, France
⁴Hospices Civils de Lyon, Centre Hospitalier Lyon Sud, Service d’Hématologie Clinique, Pierre-Bénite, France
⁵Institut de cancérologie de la loire, ST PRIEST EN JAREZ CEDEX, FRA
⁶Institut Paoli Calmettes, Marseille, France
⁷andre mignot hospital, LE CHESNAY, FRA
⁸Centre Hospitalier Universitaire Amiens-Picardie, Amiens, France
⁹Centre Hospitalier de Blois, Blois, FRA
¹⁰APHP, Creteil, Creteil, FRA
¹¹Hematology Department, Le Mans Hospital, Le Mans, France
¹²Centre Henri Becquerel, Rouen, FRA
¹³CHU grenoble, grenoble, France
¹⁴CHU de la réunion, Saint Pierre, FRA
¹⁵Département de Recherche Clinique, Hôpitaux Universitaire Paris Seine Saint Denis (HUPSSD), Hôpital Avicenne, Université Sorbonne Paris Nord, Bobigny, France
¹⁶CH la roche sur yon, La Roche Sur Yon, FRA
¹⁷Centre Leon Berard, LYON, France
¹⁸CHU nantes, Nantes, FRA
¹⁹HOPITAL LA SOURCE, La Source, FRA
²⁰Centre Hospitalier Perpignan, Perpignan, France
²¹Service Hematologie, Tours, FRA
²²CHU Angers, Angers, FRA

Christina-Nefeli Kontandreopoulou^1*, Christos Stafylidis, MD, MSc^1*, Vassiliki Labropoulou^2*, Stavroula Smilakou^3*, Dimitra Vlachopoulou^1*, Iraklis Patsialos, MD^1*, Stavroula Syriopoulou^1*, Alexandros Gkikas, MD^2*, Eleftherios N. Athanasopoulos^4*, Anastasios Vogiatzakis^3*, Eleni Panousi^3*, Georgios Kyriakakis^1*, Amalia Anastasopoulou^1*, Marina Mantzourani, MD, PhD^1* and Panagiotis T Diamantopoulos, MD, PhD¹

¹Hematology Unit, First Department of Internal Medicine, National and Kapodistrian University of Athens, Laikon General Hospital, Athens, Greece
²School of Health Sciences, Faculty of Medicine, Hematology Division, University of Patras, Patras, Greece
³Department of Microbiology, Laikon General Hospital, Athens, Greece
⁴Laboratory of Biochemistry, Department of Chemistry, University of Patras, Patras, Greece

Piers E.M. Patten, MBChB, FRCP, FRCPath, PhD^1,2*, Arnon P. Kater, MD, PhD³, Jennifer A. Woyach, MD⁴, Jianyong Li, MD⁵, Talha Munir, MBBS, PhD⁶, Tommi Salmi, MD^7*, Patrick Hoang Phuong^8*, Tian Tian, PhD^8* and Mazyar Shadman, MD, MPH^9,10

¹Comprehensive Cancer Centre, King's College London, London, United Kingdom
²King's College Hospital, London, United Kingdom
³Lymphoma and Myeloma Research Amsterdam, Amsterdam, Netherlands
⁴The Ohio State University Comprehensive Cancer Center, Columbus, OH
⁵First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, China
⁶Department of Haematology, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom
⁷BeiGene International GmbH, Basel, Switzerland
⁸BeiGene USA, Inc, San Mateo, CA
⁹Fred Hutchinson Cancer Research Center, Seattle, WA
¹⁰Division of Hematology and Oncology, University of Washington, Seattle, WA

Matthew S. Davids, MD, MMSc¹, John M. Burke², Jennifer A. Woyach, MD³, Mina Shahkarami^4*, Katherine Eakle^4*, Jinnie Ko^4*, Vivek S. Chopra^4*, Weize Huang^4*, Rona Farighi^4*, Richard H. Ko^4*, Jeff P. Sharman, MD⁵ and William G. Wierda⁶

¹Department of Medical Oncology, Dana-Farber Cancer Institute, Inc., Boston, MA
²Rocky Mountain Cancer Centers, Aurora, CO
³Division of Hematology, Ohio State University Comprehensive Cancer Center, Columbus, OH
⁴Genentech, Inc., South San Francisco, CA
⁵Willamette Valley Cancer Institute, Sarah Cannon Research, Eugene, OR
⁶The University of Texas MD Anderson Cancer Center, Houston, TX