Alisa Maier^1*, Lukas Ulrich^1*, Binje Vick, PhD^2,3*, William David Keay, PhD^1,3*, Johannes Adrian Hildebrand, PhD^4*, Carolin Dorothea Strobl, PhD^1*, Verena Passerini, PhD^1*, Louisa Adolph, MD^1*, Michael Heide^1*, Tabea Felicitas Freyholdt^1*, Gerulf Hänel, PhD^1*, Axel Lechner, MD^5*, Susanne Thieme, PhD^6*, Leon Kaulen, MD^7*, Louisa von Baumgarten, MD^7*, Daniel J Hodson, MD-PhD⁸, Martina Rudelius, MD^9*, Irmela Jeremias, MD^2,3,10 and Oliver Weigert, MD^1,3

¹Department of Medicine III, Hospital of the Ludwig-Maximilians-University (LMU), Munich, Germany
²Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Munich, German Research Center for Environmental Health (HMGU), Munich, Germany
³German Cancer Consortium (DKTK), partner site Munich, a partnership between DKFZ and the Hospital of the Ludwig-Maximilians-University (LMU), Munich, Germany
⁴ELLF, Department of Medicine III, Ludwig Maximilian University Hospital of Munich, Munich, Germany
⁵Department of Otorhinolaryngology, Hospital of the Ludwig-Maximilians-University (LMU), Munich, Germany
⁶Department of Genomics, Gene Center, Ludwig-Maximilians-University (LMU), Munich, Germany
⁷Department of Neurosurgery, Hospital of the Ludwig-Maximilians-University (LMU), Munich, Germany
⁸Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom
⁹Institute of Pathology, Hospital of the Ludwig-Maximilians-University (LMU), Munich, Germany
¹⁰Department of Pediatrics, Dr. von Hauner Children’s Hospital, University Hospital, LMU Munich, Munich, Germany

Rahul Lakhotia, MBBS¹, Stefania Pittaluga, MD, PhD^2*, James D. Phelan, PhD^1*, Allison Graeter, MD³, Christopher Melani, MD⁴, Max J Gordon, MD^1*, Jagan R. Muppidi, MD, PhD^5*, Sam Y. Ng, MD, PhD¹, Sumaya Berg, RN^1*, Sarah Evans, RN^1*, Amynah Pradhan, NP^1*, Atekelt Tadese, PA^1*, Candis Morrison, NP, PhD^1*, Bonita Bryant^1*, Yandan Yang, PhD^1*, Theresa Davies-Hill^2*, Liza Lindenberg, MD^6*, Mark Ahlman^7*, Esther Mena, MD^6*, Ethan Bergvall^8*, Nick Micheletti, MS^9*, Laura M Yee^9*, Allison P. Jacob, MSc¹⁰, Monica Gallucci^10*, Heidi Simmons, PhD¹⁰, Alexander Bagaev, PhD^11*, Mark Meerson, MSc^12*, Ekaterina Postovalova, PhD^12*, Olga Kudryashova^12*, Nikita Kotlov, PhD^11*, Nathan H. Fowler, MD^13*, Elaine S. Jaffe, MD¹⁴, Louis M. Staudt, MD, PhD¹⁵, Wyndham H. Wilson, MD, PhD^1* and Mark Roschewski, MD¹⁶

¹Lymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD
²Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD
³University of South Florida, Tampa, FL
⁴Lymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Derwood, MD
⁵Lymphoid Malignancies Branch, National Institutes of Health, Bethesda, MD
⁶Molecular Imaging Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD
⁷Radiology and Imaging, Medical College of Georgia, Augusta, GA, Augusta, GA
⁸Section of Nuclear Medicine, University of Virginia, Charlottesville, VA, Bethesda, MD
⁹Office of Collaborative Biostatistics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD
¹⁰Adaptive Biotechnologies, Seattle, WA
¹¹BostonGene Corp., Waltham, MA
¹²BostonGene, Corp., Waltham, MA
¹³BostonGene, Waltham, MA
¹⁴Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Great Falls, VA
¹⁵Metabolism Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD
¹⁶National Cancer Institute, Bethesda, MD

Tim Versteegen^1*, Philipp Nakov, MD^1*, Nikos Darzentas, PhD^1*, Guranda Chitadze, MD, PhD^1*, Ingram Iaccarino^2*, Wolfram Klapper, MD, Prof^2*, Natalie Schub^3*, Monika Brüggemann, MD^1*, Friedrich Stoelzel, MD³, Claudia D Baldus, MD^1*, Christiane Pott, MD^1* and Mouhamad Khouja, MSc^1*

¹Department of Internal Medicine II (Hematology/Oncology), University Hospital Schleswig-Holstein, Kiel, Germany
²Department of Pathology, Hematopathology Section and Lymph Node Registry, University Hospital Schleswig-Holstein, Kiel, Germany
³Division of Stem Cell Transplantation and Cellular Immunotherapies, University Hospital Schleswig-Holstein, Kiel, Germany

Maria Cristina Pirosa, MD¹, Matin Salehi^1*, Alessio Bruscaggin, PhD^1*, Lodovico Terzi Di Bergamo^1*, Federico Jauk, MD^1*, Gabriela Forestieri^1*, Simone Bocchetta, PhD^1*, Deborah Piffaretti, PhD^2*, Riccardo Moia, MD^3*, Vanessa Cristaldi, PhD^4*, Martina di Trani^5*, Georgia Alice Galimberti^1*, Katia Pini^1*, Valeria Spina^6*, Claudia Giordano, MD^7*, Adalgisa Condoluci, MD¹, Salvatore Annunziata^8*, Fabrizio Bergesio^9*, Renzo Boldorini^10*, Eugenio Borsatti^11*, Pietro Bulian^12*, Stephane Chauvie, PhD^9*, Marco Cuzzocrea^13*, Bernhard Gerber^14*, Michal Kurlapski^15*, Luigi Maria Larocca^16*, Andrea Rinaldi^17*, Marcello Rodari^18*, Grzegorz Romanowicz^19*, Gian Mauro Sacchetti^20*, Anastasios Stathis, MD^14*, Georg Stüssi, MD^14*, Ilaria Zangrilli^21*, Eleonora Calabretta^5*, Francesco Corrado, MD^5*, Antonello Pinto^22*, Luca Mazzucchelli^23*, Valter Gattei, MD²⁴, Jan Maciej Zaucha^15*, Armando Santoro, MD^25*, Stefan Hohaus^21*, Franco Cavalli, MD^26*, Emanuele Zucca, MD¹⁴, Gianluca Gaidano, MD, PhD³, Carmelo Carlo-Stella, MD⁵, Alexandar Tzankov, MD, PhD^27*, Luca Ceriani, MD^13* and Davide Rossi, MD, PhD¹

¹Institute of Oncology Research, Laboratory of Experimental Hematology, Bellinzona, Switzerland
²Institute of Oncology Research, Laboratory of Experimental Hematology, Bellinzona, AL, Switzerland
³Division of Hematology, Department of Translational Medicine, Università del Piemonte Orientale, Novara, Italy
⁴Department of Biomedical Sciences, University of Humanitas, Milan, Italy
⁵Department of Biomedical Sciences, Humanitas University, Milan, Italy
⁶Laboratorio di Diagnostica Molecolare, Servizio di Genetica Medica EOLAB, Ente Ospedaliero Cantonale, Bellinzona, Switzerland
⁷Department of Clinical Medicine and Surgery, Federico II University Medical School, Naples, ITA
⁸UOC Medicina Nucleare, GSTeP Radiopharmacy TracerGLab, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy
⁹Medical Physics Division, AO Santa Croce e Carle, Cuneo, Italy
¹⁰Division of pathology, University of Eastern Piedmont, Novara, Italy
¹¹Nuclear Medicine, Centro di Riferimento Oncologico, Aviano, Italy
¹²Clinical and Experimental Onco-Hematology Unit, Centro di Riferimento Oncologico, Aviano, Italy
¹³Imaging Institute of Southern Switzerland, Clinic of Nuclear Medicine and Molecular Imaging, Bellinzona, Switzerland
¹⁴Oncology Institute of Southern Switzerland (IOSI), Ente Ospedaliero Cantonale, Bellinzona, Switzerland
¹⁵Department of Hematology and Bone Marrow Transplantation, Medical University of Gdańsk, Gdańsk, Poland
¹⁶Fondazione Policlinico Universitario A. Gemelli. IRCCS, Rome, ITA
¹⁷Genomics Facility, Institute of Oncology Research, Bellinzona, Switzerland, Bellinzona, Switzerland
¹⁸Nuclear Medicine Unit, IRCCS Humanitas Research Hospital, Rozzano, Italy
¹⁹Department of Nuclear Medicine, Medical University of Gdańsk, Gdańsk, Poland
²⁰Divsion of Nuclear Medicine, AOU Maggiore della Carità, Novara, ITA
²¹Sezione di Ematologia, Dipartimento di Scienze Radiologiche ed Ematologiche, Università Cattolica del Sacro Cuore, Rome, Italy
²²Hematology-Oncology and Stem Cell Transplantation Unit, National Cancer Institut, Napoli, ITA
²³Division of Pathology, Ente Ospedaliero Cantonale, Bellinzona, Switzerland
²⁴Clinical and Experimental Onco-Hematology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy
²⁵IRCCS Humanitas Research Hospital, Rozzano, Italy
²⁶Fondazione per l’Istituto Oncologico di Ricerca, Bellinzona, Switzerland
²⁷Institute for Pathology, University Hospital Basel, Basel, Switzerland

Jinhua Liang, PhD^1*, Kai-Xin Du, MD^2*, Yue Li^3*, Tong-Yao Xing, MD^3*, Hao-Rui Shen^3*, Jiazhu Wu^4*, Hua Yin^4*, Li Wang^4*, Jianyong Li, MD⁵ and Xu Wei, MD, PhD⁴

¹Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, NANJING, China
²The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
³Department of Hematology, the First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, China
⁴Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, China
⁵First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, China

Yaxiao Lu^1*, Ning Zhang^1*, Yidan Zhang^1*, Xiyue Xu, PhD^2*, Xianhuo Wang, MD^1* and Huilai Zhang, MD³

¹Tianjin Medical University Cancer Institute and Hospital, Tianjin, China
²Tianjin Medical University Cancer Institute and Hospital, Tianjin, AL, China
³Tianjin Medical University Cancer Institute and Hospital, Tianjin, Tianjin, China

Jing Quan Lim, PhD^1,2*, Dachuan Huang, PhD, BSc, MSc^1*, Kelila Xin Ye Chai, MSc^2*, Phyu The, BSc^3*, Kerry May Huifen Lim^2*, Wendy Lee, PhD^4*, Liang Wei Wang^5*, Nur Ayuni Muhammad Taib^6*, Beng Hooi Phang^6*, Wee-Joo Chng^7,8, Olaf Rötzschke, PhD^4*, Jason Yongsheng Chan², Soon Thye Lim^9*, Jin-Xin BEI, PhD^10*, Siok-Bian Ng^11* and Choon Kiat Ong^12*

¹Duke-NUS Medical School, Singapore, Singapore
²National Cancer Centre Singapore, Singapore, Singapore
³Pathology, National University of Singapore, Singapore, Singapore
⁴Singapore Immunology Network, Agency for Science, Technology and Research, Singapore, Singapore
⁵Singapore Immunology Network, Singapore, SGP
⁶National Cancer Centre Singapore, Singapore, SGP
⁷Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore
⁸Department of Haematology-Oncology, National University Cancer Institute, Singapore, Singapore
⁹Division of Medical Oncology, National Cancer Centre Singapore, Singapore, Singapore
¹⁰SKL of Oncology In South China, Sun Yat-Sen University Cancer Center, Guangzhou, CHN
¹¹Department of Pathology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
¹²National Cancer Centre Singapore, Singapore, Singapore, SGP

Mathieu Viennot^1*, Marion Chanussot-Godey^1*, Vinciane Rainville^2*, Sandrine Le Noir, PhD^3*, Melody Caillot, PhD^1*, Fanny Drieux, MD, PhD^1*, Elena-Liana Veresezan, MD^1*, Roman Vion, MD^4*, Pierre-Julien Viailly, PhD^2*, Vincent Camus, MD, PhD^5*, Hervé Tilly², Eric Pinaud, PhD^3*, Fabrice Jardin, MD, PhD^2* and Philippe Ruminy, PhD^1*

¹Inserm U1245, Centre Henri Becquerel, UNIROUEN, University of Normandie, Rouen, France
²INSERM U1245, Cancer and Brain Genomics, Centre Henri Becquerel, University of Rouen, Rouen, France
³UMR6101 Cnrs-université De Limoges, Laboratoire Contrôle de la Réponse Immune B et des Lymphoproliférations (CRIBL), Université de Limoges, Limoges, France
⁴Inserm U1245, Departement of Oncology, Centre Henri Becquerel, UNIROUEN, University of Normandie, Rouen, France
⁵Centre Henri Becquerel, Department of Hematology, Rouen, France

Edward Poynton^1*, Esraa Jamal^1*, Findlay Bewicke-Copley^1*, William Lavelle^1*, Lucy Pickard^1*, Andrew Clear^1*, Maria Calaminici^1*, Christopher P Fox, MD, PhD^2* and Jessica Okosun, MB BChir PhD¹

¹Barts Cancer Institute, Queen Mary University of London, London, United Kingdom
²School of Medicine, University of Nottingham, Nottingham, United Kingdom

Shinya Rai, MD, PhD¹, Gerben Duns, PhD^1*, Fabian Frontzek, MD^1*, Jasper Wong^1*, Yifan Yin^1*, Shannon Healy^1*, Michael Yu Li, BS^1*, Makoto Kishida^1*, Elena Viganò^1*, Manabu Fujisawa, MD, PhD¹, Bruce Woolcock^1*, Adele Telenius, MPhil, BSc^1*, Barbara Meissner, PhD^1*, Merrill Boyle, BSc^1*, Hisae Nakamura^1*, Luke O`Brien^1*, Andrew Lytle^1*, Pedro Farinha^1,2, Graham W. Slack, MD^1,2*, Laura K. Hilton, PhD^1*, Ryan Morin, PhD³, Leandro Venturutti, PhD¹, Tomohiro Aoki, MD, PhD⁴, Kerry J. Savage, MD, MSc¹, David W. Scott, MBChB, PhD¹ and Christian Steidl, MD, PhD¹

¹Centre for Lymphoid Cancer, BC Cancer, Vancouver, BC, Canada
²Department of Pathology, University of British Columbia, Vancouver, BC, Canada
³Simon Fraser University, Burnaby, BC, Canada
⁴Princess Margaret Cancer Centre, Toronto, ON, Canada

Gonzalo Lopez, PhD^1*, Nicholas J. Boddicker, PhD², Rahat Hasan^1*, Chris Huang, PhD^1*, Arnaud Amzallag, PhD^3*, Rajasekhar N.V.S. Suragani, PhD⁴, Anita K. Gandhi, PhD⁵, Anne J. Novak, PhD⁶, James R. Cerhan, MD, PhD⁷ and Maroof Hasan^1*

¹Bristol Myers Squibb, Summit, NJ
²Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN
³Bristol Myers Squibb, Cambridge, MA
⁴Hematology Translational Medicine, Bristol Myers Squibb, Cambridge, MA
⁵Hematology, Translational Medicine, Bristol Myers Squibb, Summit, NJ
⁶Division of Hematology, Mayo Clinic, Rochester, MN
⁷Division of Epidemiology / Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN

Zachary R Hunter, PhD¹, Andres Felipe Ramirez Gamero, MD^1*, Maria Luisa Guerrera, MD¹, Nickolas Tsakmaklis^1*, Amanda Kofides, BA^1*, Xia Liu, MD^1*, Shirong Liu, MD, PhD¹, Abigail Peachey^1*, Hao Sun¹, Catherine A. Flynn, NP^1*, Kirsten Meid, MPH^1*, Joshua Gutine^2*, Christopher J Patterson, MPH, MBA^1*, Shayna R Sarosiek¹, Jorge J. Castillo, MD¹ and Steven P. Treon, MD, PhD, FRCP¹

¹Dana-Farber Cancer Institute, Bing Center for Waldenström Macroglobulinemia, Boston, MA
²Massachusetts General Hospital, Boston

Yu Uemura, PhD^1*, Miwako Nishio, PhD^2*, Runa Shimomaki^3*, Mayumi Yoshimori, PhD^4*, Ayaka Ohashi, PhD^5*, Aika Fuseya^6*, Yoshishige Miyabe^5* and Ayako Arai, MD, PhD^7,8

¹Division of Hematology and Oncology, St. Marianna University School of Medicine, Kawasaki, Japan
²Department of Hematology and Biophysical Systems Analysis, Institute of Science Tokyo, Tokyo, Japan
³Tokyo Medical and Dental University (TMDU), Tokyo, Japan
⁴Department of Hematology and Biophysical Systems Analysis, Tokyo Medical and Dental University (TMDU), Tokyo, Japan
⁵Department of Immunology and Parasitology, St. Marianna University School of Medicine, Kawasaki, Japan
⁶St. Marianna University School of Medicine, Kawasaki, Japan
⁷Department of Hematology, Tokyo Med. & Dental Univ., Kawasaki-Shi, Japan
⁸Department of Hematology and Oncology, St. Marianna University School of Medicine, Kawasaki, Kanagawa, Japan

Robert Andrew Harkins, MD, MS¹, Dai Chihara, MD, PhD² and Christopher R. Flowers, MD, MS²

¹Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
²Department of Lymphoma and Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX

Arghavan Ashouri, PhD^1*, Pathum Kossinna^1*, Xuyao Li^1*, Jianfan Nie^1*, Mohamed Ghaith Majjani^1*, Joanna Kokalovski^2*, Leandro Venturutti, PhD^3,4, Zahi Touma, MD, PhD^2,5* and Federico Gaiti, PhD¹

¹Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada
²Schroeder Arthritis Institute, Krembil Research Institute, University Health Network, Toronto, ON, Canada
³Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada
⁴Centre for Lymphoid Cancer, BC Cancer, Vancouver, BC, Canada
⁵Division of Rheumatology, University of Toronto, Toronto, ON, Canada

Maria Luisa Guerrera, MD¹, Xia Liu, MD^1*, John M Hatcher, PhD^1*, Nickolas Tsakmaklis^1*, Amanda Kofides, BA^1*, Abigail Peachey^1*, Hao Sun¹, Shirong Liu, MD, PhD¹, Christopher J Patterson, MPH, MBA^1*, Eugenio Morelli, MD², Jorge J. Castillo, MD¹, Shayna R Sarosiek¹, Catherine A. Flynn, NP^1*, Kirsten Meid, MPH^1*, Andrew R. Branagan, MD³, Ruben D. Carrasco, MD, PhD^4*, Kenneth C. Anderson, MD⁵, Nikhil C. Munshi, MD⁵, Steven P. Treon, MD, PhD, FRCP¹ and Zachary R Hunter, PhD¹

¹Dana-Farber Cancer Institute, Bing Center for Waldenström Macroglobulinemia, Boston, MA
²Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Torino, Italy
³Center for Multiple Myeloma, Massachusetts General Hospital Cancer Center, Boston, MA
⁴Department of Pathology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA
⁵Dana-Farber Cancer Institute, The Jerome Lipper Multiple Myeloma Center, Boston, MA

Jana Karolova, MD^1,2*, Dmitry Kazantsev, MSc, PhD^2*, Lucie Winkowska, PhD^3*, Kristina Forsterova, MSc, PhD^1*, Liliana Tuskova^1,2*, Diana Malarikova, MD^1,2*, Veronika Valkova, MD, PhD^4*, Andrea Janikova, MD, PhD^5*, Ales Obr, MD, PhD^6*, Marek Trneny, Prof., MD, CSc.¹ and Pavel Klener^1,7*

¹1st Department of Medicine – Department of Hematology, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic
²Institute of Pathological Physiology, First Faculty of Medicine, Charles University, Prague, Czech Republic
³CLIP, Department of Pediatric Hematology and Oncology, Second Faculty of Medicine, Charles University/University Hospital Motol, Prague, Czech Republic
⁴Institute of Hematology and Blood Transfusion, Prague, Czech Republic
⁵Department of Hematology and Oncology, Faculty of Medicine Masaryk University and University Hospital, Brno, Czech Republic
⁶Department of Hemato-Oncology, Faculty of Medicine and Dentistry, Palacky University and University Hospital Olomouc, Olomouc, Czech Republic
⁷Institute of Pathological Physiology, First Faculty of Medicine, Charles University, Praha 2, Czech Republic

Andrew L. Feldman, MD¹, Guangzhen Hu, PhD^1*, Surendra Dasari, PhD^2*, Lisa M. Rimsza, MD^3*, David W. Scott, MBChB, PhD⁴, Jimena B. Gimenez, MD^1*, Farah M. Salama^1*, Min Shi, MD, PhD^1*, Elías Campo⁵, Wing Chung Chan, MD⁶, James R. Cook, MD, PhD⁷, Giorgio Inghirami, MD^8*, Elaine S. Jaffe, MD^9*, Ryan Morin, PhD¹⁰, Phillipp W. Raess, MD, PhD^11*, Andreas Rosenwald^12*, Kerry J. Savage, MD, MSc¹³, Louis M. Staudt, MD, PhD¹⁴, George W. Wright, PhD^15*, Catalina Amador, MD^16*, Jan Delabie, MD, PhD^17*, Timothy C. Greiner, MS, MD^18*, Javeed Iqbal, PhD, MSc^18*, Laura K. Hilton, PhD^19*, Sarah L. Ondrejka, DO⁷, German Ott, MD^20*, Stefania Pittaluga, MD, PhD^21*, Graham W. Slack, MD^19*, Susan L. Slager, PhD²², Joo Y. Song, MD^6*, Hao-Wei Wang, MD, PhD^23*, Ahmed A. Aljudi, MD^24*, Stephen M. Ansell, MD, PhD²², Carlos Barrionuevo, MD^25*, James R. Cerhan, MD, PhD²⁶, Jennifer R. Chapman-Fredricks, MD^27*, Weina Chen, MD, PhD^28*, Laurence de Leval, MD, PhD²⁹, Alejandro A. Gru, MD^30*, David L. Jaye, MD³¹, Liuyan Jiang, MD^32*, Brad S. Kahl, MD³³, Kennosuke Karube, MD, PhD^34*, Young Hyeh Ko, MD^35*, Eric Mou, MD^36*, Matthew J. Maurer, DSc^2*, L. Jeffrey Medeiros, MD³⁷, Roberto N. Miranda, MD^37*, Naoki Oishi, MD, PhD^38*, Perry M. Anamarija, MD^39*, Akira Satou, MD^40*, Xueju Wang, MD, PhD^41*, Ryan A. Wilcox, MD, PhD^42*, Xiaojun Wu, MD, PhD^43*, Tadashi Yoshino, MD, PhD^44* and Yu Zeng, MD, PhD^45*

¹Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine and Science, Rochester, MN
²Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN
³Department of Pathology and Laboratory Medicine, University of Arizona College of Medicine and Science, Tucson, AZ
⁴Centre for Lymphoid Cancer, British Columbia Cancer, Vancouver, BC, Canada
⁵Universitat de Barcelona (UB), Barcelona, Spain
⁶Department of Pathology, City of Hope National Medical Center, Duarte, CA
⁷Department of Pathology and Laboratory Medicine, Cleveland Clinic, Cleveland, OH
⁸Weill Cornell Medicine, New York, NY
⁹Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, Bethesda, MD
¹⁰Simon Fraser University, Burnaby, BC, Canada
¹¹Department of Pathology and Laboratory Medicine, Oregon Health & Science University, Portland, OR
¹²Institute of Pathology, University Hospital of Wuerzburg, and Comprehensive Cancer Center Mainfranken, Würzburg, Germany
¹³Division of Medical Oncology, University of British Columbia, Vancouver, BC, Canada
¹⁴Metabolism Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD
¹⁵Biometric Research Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, MD
¹⁶Division of Hematopathology, University of Miami, Miami, FL
¹⁷Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada
¹⁸Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE
¹⁹Centre for Lymphoid Cancer, BC Cancer, Vancouver, BC, Canada
²⁰Department of Clinical Pathology, Robert-Bosch-Krankenhaus, and Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany
²¹Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD
²²Division of Hematology, Mayo Clinic, Rochester, MN
²³Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD
²⁴Department of Pathology, Childrens Healthcare of Atlanta, Atlanta, GA
²⁵Departamento de Patología, Instituto Nacional de Enfermedades Neoplásicas, Lima, PER
²⁶Division of Epidemiology / Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN
²⁷Department of Pathology and Laboratory Medicine, University of Miami Miller School of Medicine, Miami, FL
²⁸Department of Pathology, UT Southwestern Medical Center, Dallas, TX
²⁹Hôpital Universitaire de Lausanne, Lausanne, Switzerland
³⁰Dermatopathology Section, Columbia University Irving Medical Center/New York Presbyterian, New York, NY
³¹Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA
³²Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine and Science, Jacksonville
³³Department of Medicine, Washington University School of Medicine, St. Louis, MO
³⁴Department of Pathology and Laboratory Medicine, Nagoya University, Nagoya, Japan
³⁵Department of Pathology, Korea University College of Medicine, Seoul, Korea, Republic of (South)
³⁶Division of Hematology, Oncology, and Blood & Marrow Transplantation, University of Iowa, Iowa City, IA
³⁷Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX
³⁸Department of Pathology, University of Yamanashi, Chuo, JPN
³⁹Department of Pathology, University of Michigan, Ann Arbor, MI
⁴⁰Aichi Medical University School of Medicine, Aichi, JPN
⁴¹Jilin University, Changchun, CHN
⁴²Division of Hematology/Oncology, University of Michigan Cancer Center, Ann Arbor, MI
⁴³Department of Pathology, Johns Hopkins Medicine, Baltimore, MD
⁴⁴Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
⁴⁵Department of Pathology, Tongji University School of Medicine, Shanghai, China

Robel Papotti, PhD^1*, Filippo Vit, MSc^1*, Federico Pozzo, PhD^1*, Tamara Bittolo, PhD^1*, Stefania Bettelli^2*, Samantha Pozzi, MD^3*, Luca Braglia, PhD^3*, Elisa Forti^2*, Arianna Di Napoli, MD^4*, M. Christina Cox, MD, PhD^5*, Tamar Tadmor, MD^6*, Giovanna Mansueto, MD^7*, Pellegrino Musto^8*, Leonardo Flenghi, MD^9*, Martina Quintini, MD^9*, Sara Galimberti, MD^10*, Valentina Donati, MD^11*, Michele Spina, MD^12*, Alberto Zamò, MD^13*, Andreas Rosenwald, MD^13*, Riccardo Bomben, PhD^1*, Stefano Sacchi, MD^3* and Valter Gattei, MD¹

¹Clinical and Experimental Onco-Hematology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy
²Molecular Pathology and Predictive Medicine, Modena University Hospital, Modena, Italy
³Oncohematology and Osteoncology Unit, Modena University Hospital, Modena, Italy
⁴Sapienza University of Rome-sant'Andrea Hospital, Rome, ITA
⁵Hematology, Policlinico Tor Vergata, Rome, Italy
⁶Hematology Unit, Bnai Zion Medical Center, Haifa, Israel
⁷IRCCS Centro Oncologico Basilicata, Rionero In Vulture, ITA
⁸Unit of Hematology and Stem Cell Transplantation, AOUC Policlinico, Bari, Italy
⁹Hematology Unit, Azienda Ospedaliera di Perugia, Perugia, ITA
¹⁰Department of Clinical and Experimental Medicine, Hematology, University of Pisa, Pisa, Italy
¹¹Pathology Unit, University of Pisa, Pisa, ITA
¹²Division of Medical Oncology, IRCCS Centro Di Riferimento Oncologico, Aviano, Italy
¹³Institute of Pathology, Julius-Maximilians-Universität Würzburg, Würzburg, Germany

Joo Y. Song, MD¹, Jibin Zhang, Ph.D.^2*, David W. Scott, MBChB, PhD³, Graham W. Slack, MD^4*, Pedro Farinha⁴, Andreas Rosenwald, MD^5*, German Ott, MD^6*, Sarah L. Ondrejka, DO⁷, James R. Cook, MD, PhD⁷, Elías Campo⁸, Catalina Amador, MD^9*, Jennifer R. Chapman-Fredricks, MD^10*, Elaine S. Jaffe, MD¹¹, Timothy C. Greiner, MS, MD^12*, Victoria Bedell^13*, Alanna Maguire, PhD¹⁴, Phillipp W. Raess, MD, PhD^15*, Weiwei Zhang, Ph.D^12*, Madhu P. Menon, MD, PhD^16*, Julia Davidson^17*, Krystie Chew^18*, Alex F. Herrera, MD¹⁷, Andrew L. Feldman, MD¹⁹, Anamarija M. Perry, MD²⁰, Alexandra M. Levine, MD¹⁷, John Carpten, PhD^17*, Steven T. Rosen, MD²¹, Lisa M. Rimsza, MD²² and Wing Chung Chan, MD¹

¹Department of Pathology, City of Hope National Medical Center, Duarte, CA
²City of Hope National Medical Center, Duarte, CA
³Centre for Lymphoid Cancer, British Columbia Cancer, Vancouver, BC, Canada
⁴Department of Pathology, University of British Columbia, Vancouver, BC, Canada
⁵Comprehensive Cancer Center Mainfranken, University Hospital Würzburg, Würzburg, Germany
⁶Department of Clinical Pathology, Robert-Bosch-Krankenhaus, and Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany
⁷Department of Pathology and Laboratory Medicine, Cleveland Clinic, Cleveland, OH
⁸Hematopathology Section, Pathology Department, Hospital Clínic de Barcelona, Barcelona, Spain
⁹Division of Hematopathology, University of Miami, Miami, FL
¹⁰Department of Pathology and Laboratory Medicine, University of Miami, Miami, FL
¹¹Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Great Falls, VA
¹²Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE
¹³Department of Pathology, City of Hope, Duarte, CA
¹⁴Mayo Clinic, Phoenix, AZ
¹⁵Department of Pathology and Laboratory Medicine, Oregon Health & Science University, Portland, OR
¹⁶ARUP, Salt Lake city, UT
¹⁷City of Hope, Duarte, CA
¹⁸City of Hope, Los Angeles
¹⁹Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN
²⁰Department of Pathology, University of Michigan, Ann Arbor, MI
²¹Department of Hematology and Hematopoietic Cell Transplantation, Beckman Research Institute, City of Hope, Duarte, CA
²²Department of Pathology and Laboratory Medicine, The University of Arizona, Tucson, AZ

Janek S. Walker, PhD¹, Kerstin Wenzl, PhD^2*, Joseph P. Novak^3*, Matthew E. Stokes^2*, Melissa A. Hopper, BS, MS¹, Abigail R. Dropik, BS¹, Miranda S. Laverty^4*, Allison M. Bock, MD⁵, Vivekananda Sarangi^1*, Maria Ortiz^6*, Nicholas Stong^7*, Chris Huang, PhD^2*, Matthew J. Maurer, DSc⁸, Brian K. Link, MD^9*, Stephen M. Ansell, MD, PhD³, Thomas M. Habermann, MD³, Thomas E. Witzig, MD¹⁰, Rebecca L. King, MD¹¹, Grzegorz S. Nowakowski, MD³, James R. Cerhan, MD, PhD¹², Anita K. Gandhi, PhD¹³ and Anne J. Novak, PhD³

¹Mayo Clinic, Rochester, MN
²Bristol Myers Squibb, Summit, NJ
³Division of Hematology, Mayo Clinic, Rochester, MN
⁴Mayo Clinic, Rochester
⁵Huntsman Cancer Institute, University of Utah, Salt Lake City, UT
⁶Bristol Myers Squibb, Seville, Spain
⁷Bristol Myers Squibb, Princeton, NJ
⁸Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN
⁹Division of Hematology, Oncology, and Blood & Marrow Transplantation, University of Iowa, Iowa City, IA
¹⁰Division of Hematology, Mayo Clinic, Stabile 628, Rochester, MN
¹¹Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN
¹²Division of Epidemiology / Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN
¹³Hematology, Translational Medicine, Bristol Myers Squibb, Summit, NJ

Ethan C. Whipp, MSc^1*, Krithik Tella^2*, Aidan Macaskill^3*, Steven Sher^4*, Casey Cempre^5*, Jean Truxall, BS^5*, Mehdi Gharghabi, PharmD^5*, Fang Hao^6*, Alexander R. Marr, BS⁵, Madeline Halpin, BS^5*, Pearlly S. Yan, PhD^7*, Jennifer A. Woyach, MD⁸ and Rosa Lapalombella, PhD⁵

¹Comprehensive Cancer Center - Wexner Medical Center, The Ohio State University, Columbus, OH
²College of Medicine Division of Hematology, Ohio State University, Columbus, OH
³College of Medicine - Division of Hematology, Ohio State University, Columbus, OH
⁴THE OHIO STATE UNIVERSITY, COLUMBUS, OH
⁵The Ohio State University, Columbus, OH
⁶College of Pharmacy - Division of Pharmaceutics & Pharmacology, Ohio State University, Columbus
⁷The Ohio State University Medical Center, Columbus, OH
⁸Division of Hematology, Ohio State University Comprehensive Cancer Center, Columbus, OH

Adriana Velasova^1*, Lucie Dlouha^2*, Iva Hamova^1,2*, Kristyna Kupcova^1,2*, Petra Zemankova^3*, Petr Nehasil^3*, Jana Senavova^1,2*, Katerina Benesova, MD, PhD^4*, Petra Svozilkova^5*, Jarmila Heissigerova^5*, Marek Trneny, Prof., MD, CSc.⁶ and Ondrej Havranek, MD, PhD^1,7

¹BIOCEV, First Faculty of Medicine, Charles University, Prague, Czech Republic
²First Department of Medicine-Hematology, General University Hospital, Prague, Czech Republic
³Institute of Medical Biochemistry and Laboratory Diagnostics, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic
⁴1st Department of Medicine – Department of Hematology, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic
⁵Department of Ophthalmology, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic
⁶First Department of Internal Medicine - Hematology, General University Hospital and First Faculty of Medicine, Charles University, Prague, Czech Republic
⁷First Department of Internal Medicine-Hematology, General University Hospital and First Faculty of Medicine, Charles University, Vestec, Czech Republic

Riccardo Dondolin, MD^1*, Federico Garrou^2*, Mohammad Almasri^3*, Chiara Cosentino^3*, Donatella Talotta^3*, Riccardo Bruna, MD^4*, Giulia Maria Rivolta^5*, Jana Nabki^5*, Bashar Al Deeban^3*, Alessio Bruscaggin, PhD^6*, Lodovico Terzi Di Bergamo^7*, Annalisa Andorno^8*, Francesca Mercalli^8*, Monica Leutner^9*, Angela Lorenzi^10*, Abdurraouf Mahmoud^1*, Wael Al Essa^5*, Clara Deambrogi^1*, Silvia Rasi^11*, Renzo Boldorini^12*, Davide Rossi, MD, PhD¹³, Gian Mauro Sacchetti^14*, Gianluca Gaidano, MD, PhD¹⁵ and Riccardo Moia, MD^3*

¹Division of Hematology, Department of Translational Medicine, Università del Piemonte Orientale, Novara, ITA
²Divsion of Nuclear Medicine, AOU Maggiore della Carità, Novara, Novara, Italy
³Division of Hematology, Department of Translational Medicine, Università del Piemonte Orientale, Novara, Italy
⁴Division of Hematology, Department of Translational Medicine, University of Eastern Piedmont and AOU Maggiore della Carità, Novara, ITA
⁵Università Del Piemonte Orientale, Novara, ITA
⁶Institute of Oncology Research, Laboratory of Experimental Hematology, Bellinzona, Switzerland
⁷Institute of Oncology Research, Bellinzona, CHE
⁸Division of Pathology, Università Del Piemonte Orientale, Novara, ITA
⁹Division of Pathology, Azienda Sanitaria Locale del VCO, Verbania, Italy
¹⁰Division of Hematology, Azienda Sanitaria Locale Del VCO, Verbania, Italy, Verbania, ITA
¹¹Division of Hematology, Department of Translational Medicine, Università del Piemonte Orientale, Novara, Novara, ITA
¹²Division of pathology, University of Eastern Piedmont, Novara, Italy
¹³Oncology Institute of Southern Switzerland, Bellinzona, Switzerland
¹⁴Divsion of Nuclear Medicine, AOU Maggiore della Carità, Novara, ITA
¹⁵Division of Hematology, Department of Translational Medicine, University of Eastern Piedmont, Novara, Italy

Juan Pablo Alderuccio, MD¹, Andrey Tyshevich, MSc^2*, Daniel Cassidy, MD^3*, Catalina Amador, MD^4*, Ksenia Zornikova, PhD^5*, Danil Ivanov, MSc^6*, Laura Medina Andara, MD^7*, Dmitry Grachev, MSc^6*, Asaad Trabolsi, MD⁸, Michele D. Stanchina, DO, MS⁹, Alexander Nesmelov, PhD^5*, Dan Morgenstern Kaplan, MD, MSc¹⁰, Konstantin Chernyshov, PhD^6*, Nikita Kotlov, PhD^5*, Craig H. Moskowitz, MD¹¹, Alexander Bagaev, PhD^5*, Krystle Nomie, PhD^2*, Nathan H. Fowler, MD^12*, Jennifer Rose Chapman-Fredricks, MD^13* and Izidore S. Lossos, MD¹⁴

¹Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL
²BostonGene, Corp., Waltham, MA
³University of Miami, Sylvester Comprehensive Cancer Center, Miami
⁴Division of Hematopathology, University of Miami, Miami, FL
⁵BostonGene Corp., Waltham, MA
⁶BostonGene, Corp., Waltham
⁷Sylvester Comprehensive Cancer Center, Miami
⁸University of Miami, Sylvester Comprehensive Cancer Center, Miami, FL
⁹Sylvester Comprehensive Cancer Center, Division of Hematology, University of Miami, Miller School of Medicine, Miami, FL
¹⁰Internal Medicine Residency program, division of internal medicine, Department of Medicine, University of Miami/ Jackson Memorial Hospital, Miami
¹¹Department of Medicine, Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL
¹²BostonGene, Waltham, MA
¹³Department of Pathology, University of Miami Sylvester Comprehensive Cancer Center, Miami, FL
¹⁴Division of Hematology, Sylvester Comprehensive Cancer Center, Miami, FL

Tony Z. Zhuang, MD¹, Lei Feng, MS^2*, Dai Chihara, MD, PhD³, Chijioke Nze, MD, MPH³, Amy A. Ayers, MPH^3*, Mansoor Noorani, MD^3*, James D. Ayres^4*, Daniela E. Duenas, MD^5*, Kumudha Balakrishnan, MPhil, MSc, PhD^3*, Ekaterina Nesterenko, MD, PhD^6*, Mark Meerson, MSc^6*, Ksenia Zornikova, PhD^7*, Krystle Nomie, PhD^7*, Nikita Kotlov, PhD^7*, Nathan Fowler, MD⁶, Maria Alma Rodriguez, MD^3*, Sattva S. Neelapu, MD³, Christopher R. Flowers, MD, MS³ and Paolo Strati, MD³

¹Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
²Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX
³Department of Lymphoma and Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX
⁴Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX
⁵Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX
⁶BostonGene, Corp., Waltham, MA
⁷BostonGene Corp., Waltham, MA

Takuto Mori, MD^1,2*, Kazuyuki Shimada, MD, PhD³, Kaito Mimura, MD^1*, Nobuyuki Kakiuchi, MD, PhD^4*, Hirona Maeda^4*, Akifumi Takaori-Kondo, MD, PhD⁵, Seishi Ogawa, MD, PhD^4,6,7, Akihiro Tomita, MD, PhD^8* and Kenichi Yoshida, MD, PhD¹

¹Division of Cancer Evolution, National Cancer Center Research Institute, Tokyo, Japan
²Department of Hematology, Graduate School of Medicine, Kyoto University, Kobe, Japan
³Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan
⁴Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
⁵Department of Hematology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
⁶Kyoto University, Sakyoku, KYO, Japan
⁷Center for Hematology and Regenerative Medicine, Department of Medicine (MedH), Karolinska Institutet, Huddinge, Sweden
⁸Department of Hematology, Fujita Health University School of Medicine, Toyoake, Japan

Johanna A.A. Bult, BSc^1*, Yujie Zhong, MSc^2*, Fleur A. De Groot^3*, Ruben A.L. De Groen, MSc^4*, Nick Veltmaat, MSc^5*, Diana Al-Sarayfi^5*, Wouter Plattel, MD, PhD^5*, Joost L. Kluiver, PhD^2*, Anke Van Den Berg, PhD⁶, Stefano Rosati^7*, Arjan Diepstra⁸, Joost S.P. Vermaat⁹ and Marcel Nijland, MD, PhD^10*

¹University Medical Center Groningen, Groningen, NLD
²Department of Pathology and Medical Biology, University Medical Center Groningen, Groningen, Netherlands
³Leiden University Medical Center, Leiden, NLD
⁴Department of Hematology, Leiden University Medical Center, Leiden, Zuid-Holland, Netherlands
⁵Department of Hematology, University Medical Center Groningen, Groningen, Netherlands
⁶Department of Pathology and Medical Biology, Univ. Med. Center Groningen, Groningen, NLD
⁷University Medical Center Groningen, University of Groningen, Groningen, NLD
⁸Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands
⁹Department of Hematology, Leiden University Medical Center, Leiden, Netherlands
¹⁰University Medical Center Groningen and University of Groningen, Groningen, Netherlands

Emma Kroeze^1*, Michelle M Kleisman^1*, Lennart A. Kester, PhD^1*, Edwin Sonneveld, PhD^1*, Marco J. Koudijs, PhD^1*, Uri Ilan, MD^1*, Auke Beishuizen, MD¹, Melanie M Hagleitner, MD^1*, Roland P. Kuiper, PhD^1,2 and Jan LC Loeffen, MD, PhD^1*

¹Princess Maxima Center for pediatric oncology, Utrecht, Netherlands
²Department of Genetics, Utrecht University Medical Center, Utrecht, Netherlands

Zachary R Hunter, PhD¹, Nickolas Tsakmaklis^1*, Maria Luisa Guerrera, MD¹, Amanda Kofides, BA^1*, Xia Liu, MD^1*, Shirong Liu, MD, PhD¹, Abigail Peachey^1*, Andres Felipe Ramirez Gamero, MD^1*, John M Hatcher, PhD^1*, Catherine A. Flynn, NP^1*, Kirsten Meid, MPH^1*, Christopher J Patterson, MPH, MBA^1*, Mariateresa Fulciniti, PhD², Mehmet K. Samur, PhD³, Kenneth C. Anderson, MD⁴, Nikhil C. Munshi, MD⁵, Shayna R Sarosiek¹, Jorge J. Castillo, MD¹ and Steven P. Treon, MD, PhD, FRCP¹

¹Dana-Farber Cancer Institute, Bing Center for Waldenström Macroglobulinemia, Boston, MA
²Jerome Lipper Multiple Myeloma Center, Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA
³Dana-Farber Cancer Institute, Jerome Lipper Multiple Myeloma Center, Boston, MA
⁴Dana-Farber Cancer Institute, The Jerome Lipper Multiple Myeloma Center, Boston, MA
⁵Dana Farber Cancer Institute, The Jerome Lipper Myeloma Center, Boston, MA

Angelica Johansson^1*, Daniel Nilsson^1*, Lina M Olsson, PhD^1*, Edith Gustafsson^1*, Niamh Nihlsson^1*, Anna Janska^1*, Anna Porwit, MD, PhD^2*, Peter Hollander, MD, PhD^3*, Mats Jerkeman, MD, PhD⁴ and Sara Ek, PhD^1*

¹Department of Immunotechnology, Lund University, Lund, Sweden
²Lund University, Lund, SWE
³Department of Immunology, Genetics and Pathology, Cancer Immunotherapy Unit, Uppsala University, Uppsala, Sweden
⁴Dept of Oncology and Pathology, Institute of Clinical Sciences, Lund University, Lund, Sweden