66th ASH Annual Meeting: 102. Iron Homeostasis and Biology: Poster II

Symposia: Iron Homeostasis and Biology Oral and Poster Abstracts
Poster

Research, Iron Deficiency, Fundamental Science, Translational Research, Genetic Disorders, Thalassemia, Hemoglobinopathies, Hematopoiesis, Diseases, Treatment Considerations, Metabolism, Biological Processes, Technology and Procedures, Metabolic Disorders, Molecular biology, Pathogenesis

Halls G-H (San Diego Convention Center)

2467

Uncoupling Alas2 from Iron-Regulatory Proteins Demonstrates the Protective Role of Alas2 Iron-Responsive Element in Protoporphyrias

Sarah Ducamp, PhD¹, Dean R. Campagna²^*, Paul J. Schmidt, PhD² and Mark D. Fleming, MD, DPhil¹

¹Department of Pathology, Boston Children's Hospital and Harvard Medical School, Boston, MA
²Department of Pathology, Boston Children's Hospital, Boston, MA

2468

TFR2 Coordinates Erythroid Iron Availability and Erythropoietin Receptor Sensitivity By Monoferric Transferrin Forms

Amaliris Guerra, PhD¹^*, Pankaj Sharma¹^*, Xiuli An, MD, PhD², Nermi L. Parrow, PhD³, Robert E. Fleming, MD⁴, Yelena Ginzburg, MD⁵ and Stefano Rivella, PhD¹

¹Children's Hospital of Philadelphia, Philadelphia, PA
²Laboratory of Membrane Biology, Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY
³Saint Louis University School of Medicine, Saint Louis, MO
⁴Pediatrics, Biochemistry, Saint Louis University School of Medicine, Saint Louis, MO
⁵Division of Hematology & Medical Oncology, Tisch Cancer Institute/ Icahn School of Medicine at Mount Sinai, New York, NY

2469

Mitochondrial Iron Transport Via MFRN1 Is Required for Erythroid Cell Cycle Progression Even Under Iron-Replete Conditions Sufficient for Hemoglobinization

Mark Perfetto¹^*, Aidan Danoff²^*, Muhammad Ishfaq³^*, Aiden Mohideen³^*, Meilin Chen³^*, Amber Stratman⁴^*, Satoshi Okawa³^* and Yvette Y. Yien, PhD⁵

¹University of Pittsburgh, Pittsburgh
²University of Delaware, Newark, DE
³University of Pittsburgh, Pittsburgh, PA
⁴Washington University at St. Louis, Saint Louis, MO
⁵University of Pittsburgh School of Medicine, Pittsburgh, PA

2470

Osteoblast-Derived Erythroferrone Regulates Stress Erythropoiesis

Pinanong Na Phatthalung¹^*, Yelena Ginzburg, MD^2,3, Gabrielle van Caloen, PhD²^*, Marina Planoutene²^*, Anisa A. Gumerova, MD, PhD, DSc⁴^*, Ronit Witztum, MD^2,4^*, Eva Ingber²^*, Farhath Sultana, PhD⁴^*, Funda Korkmaz, MD⁴^*, Maayan Levy²^*, Tony Yuen, PhD^3,4^* and Mone Zaidi, MD, PhD^3,4^*

¹Division of Hematology and Medical Oncology, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, AL, Thailand
²Division of Hematology and Medical Oncology, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY
³Center of Translational Medicine and Pharmacology, Icahn School of Medicine at Mount Sinai, New York, NY
⁴The Mount Sinai Bone Program, Departments of Pharmacological Sciences and of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY

2471

Role of CYB5R3 in Erythropoiesis-Associated Heme Biosynthesis

Fabliha Ahmed Chowdhury, PhD¹, Malini Sharma, BA², Katherine C Wood, PhD¹, Megan P Miller³^*, Shuai Yuan, PhD⁴^* and Adam C Straub, PhD¹^*

¹Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA
²University of Pittsburgh School of Medicine, Pittsburgh, PA
³University of Pittsburgh, Department of Pharmacology and Chemical Biology, Pittsburgh
⁴University of Pittsburgh, Department of Pharmacology and Chemical Biology, Pittsburgh, PA

2472

Effect of Monoferric Transferrins on Fetal Iron Homeostasis and Erythropoiesis

Benjamin Shapleigh, MD¹^*, Faris Ali, MD², Nisha Ajit George, PhD²^*, Adin Karahodzic²^*, Nermi L. Parrow, PhD³ and Robert E. Fleming, MD⁴

¹Pediatrics, Saint Louis University School of Medicine, St Louis, MO
²Saint Louis University School of Medicine, St Louis, MO
³Saint Louis University School of Medicine, Saint Louis, MO
⁴Pediatrics, Biochemistry, Saint Louis University School of Medicine, Saint Louis, MO

2473

TMPRSS6 Inhibition Rapidly Reverses Liver Iron Overload and Prevents an Increase of Splenic Pro-Inflammatory Macrophages in a Mouse Model of Beta-Thalassemia

Heinrich E. Lob, PhD¹, Leigh Spencer Noakes²^*, Marilena Preda¹^*, Larisa Ivanova¹^*, Beth Crowell¹^*, Aris N Economides²^* and Sarah J Hatsell¹^*

¹Regeneron Pharmaceuticals, Inc., Tarrytown, NY
²Regeneron Pharmaceutials, Inc., Tarrytown, NY

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^*signifies non-member of ASH