Linlin Zhang^1*, Huizhi Zhao^1*, Shihui Wang^1*, Xueting Wu^1*, Qianqian Yang^1*, Ying Cheng^1*, Jiangwei Zhao^1*, Shijie Zhang^1*, Huan Zhang^1*, Lixiang Chen^1*, Xiuli An, MD, PhD² and Xiaoli Qu, PhD^3*

¹School of life science, Zhengzhou University, Zhengzhou, China
²Laboratory of Membrane Biology, Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY
³School of life science, Zhengzhou University, Zhengzhou, Henan, China

Marilou Tetard, PhD^1*, Nana A Peterson^1*, Tim Lin^1*, John G. Doench, PhD^2* and Elizabeth S. Egan, MD, PhD^1,3,4

¹Department of Pediatrics, Stanford University School of Medicine, Stanford, CA
²Broad Institute of MIT and Harvard, Cambridge, MA
³Department of Microbiology & Immunology, Stanford University School of Medicine, Stanford, CA
⁴Chan Zuckerberg Biohub-San Francisco, San Francisco, CA

Xu Han, PhD^1*, Kehan Ren, PhD¹, Pan Wang, Ph.D.^1*, Honghao Bi, PhD², Inci Aydemir, MD^1*, Ermin Li, Ph.D.^1* and Peng Ji, MD, PhD¹

¹Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL
²Northwestern University, Wilmette, IL

Christian Andrea Di Buduo, PhD^1*, Francesca Careddu, PhD^2*, Samuele Metti^3*, Cesare Perotti^4*, Claudia Del Fante, MD, PhD^5*, Paola Braghetta^6*, Giampaolo Minetti^7*, Luca Malcovati, MD^8,9 and Alessandra Balduini^10,11

¹University of Pavia, Pavia, ITA
²University of Pavia, Pavia, AL, ITA
³University of Padova, Padova, Italy
⁴Immunohematology and Transfusion Center, Fondazione IRCCS Policlinico S. Matteo, Pavia, Italy
⁵Immunohaematology and Transfusion Service Center for transplant immunology, Pavia, ITA
⁶University of Padova, Padova, ITA
⁷University of Pavia - Biochemistry, Pavia, PV, ITA
⁸Department of Molecular Medicine, University of Pavia, Piazzale Golgi 2, Italy
⁹Department of Hematology, IRCCS S. Matteo Hospital Foundation, Pavia, Italy
¹⁰Tufts University, Medford, MA
¹¹University of Pavia, Pavia, Italy

Zohreh Safari, PhD^1*, Stephen C Rogers, PhD^2*, Mary E Brummet^1*, Daniel Bennett^3*, Emioluwa Odunaiya^3*, Adaora Eziemefe^3*, Jacqueline Nguyen^3*, Sarah Enjati^1*, Olivia Conelius^4*, Angelo D'Alessandro, PhD⁵, Aaron Issaian^6,7*, Monika monikA.dzieciatkow^8*, Fabia Gamboni^9*, Jason Held, PhD^10*, Isakson Brant^11*, Luke S Dunaway, PhD^12*, Miriam Cortese Krott, PhD^13* and Allan Doctor, MD¹⁴

¹University of Maryland school of Medicine, Baltimore, MD
²University of Maryland School of Medicine, Baltimore, MD
³university of MARYLAND, BALTIMORE, BALTIMORE, MD
⁴university of MARYLAND School of medicine, BALTIMORE, BALTIMORE, MD
⁵Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, CO
⁶University of Colorado Anschutz Medical Campus, Aurora, CO
⁷University of Colorado Denver - Anschutz Medical Campus, Aurora, CO, USA, Aurora, CO
⁸Department of Biochemistry and Molecular Genetics, University of Colorado Denver, Aurora, CO
⁹University of Colorado, Aurora, CO
¹⁰Washington University in St. Louis, St. Louis, MO
¹¹University of Virginia School of Medicine, Charlottesville, VA
¹²Cardiovascular Research Center, University of Virginia, Charlottesville, VA
¹³Heinrich-Heine-Universität Düsseldorf, Düsseldorf, Germany
¹⁴university of Maryland School of Medicine, Baltimore, MD

Naoual Ouazzani Chahdi^1*, Silvia Neri^1*, Thomas T.R.L Klei^2*, Sjaak Philipsen^3*, Simon Tol^1*, Judy Geissler^1*, Boukje M. Beuger^1*, Wassim El Nemer, PhD⁴, Catarina Martins Freire^5*, Timothy Satchwell, PhD^5*, Ashley Mark Toye, PhD^5*, Carmen van Der Zwaan^1*, Arjan Hoogendijk^1*, Heleen van Beusekom^6*, Taco W. Kuijpers^1,7*, Erfan Nur, MD, PhD^1,8, Joost Meijers, PhD^9,10, Hanke Matlung^1*, Arthur Svendsen^1*, Emile Van Den Akker^1* and Robin van Bruggen^1*

¹Department of Molecular Hematology, Sanquin Research and Landsteiner Laboratory, Amsterdam, Netherlands
²Sanquin Research and Landsteiner Laboratory, Amsterdam, Netherlands
³Erasmus University Medical Center, Rotterdam, NLD
⁴French Blood Establishment(EFS), Marseille, France
⁵School of Biochemistry, University of Bristol, Bristol, United Kingdom
⁶Department of Cell Biology, Erasmus MC, Rotterdam, Netherlands
⁷Pediatric Immunology, Emma Children's Hospital, Amsterdam University Medical Centers, Amsterdam, Netherlands
⁸Department of Hematology, Amsterdam UMC location University of Amsterdam, Amsterdam, Netherlands
⁹Department of Experimental Vascular Medicine, Amsterdam UMC, Amsterdam, NLD
¹⁰Synapse Research Institute, Maastricht, Netherlands

Lionel Blanc, PhD^1,2, Marjorie Leduc, PhD^3*, Hongxia Yan, PhD⁴, Julien Papoin, MS^5,6*, Morgane le-Gall, MS^7*, Emilie-Fleur Gauthier, PhD^3* and Mohandas Narla, DSc⁴

¹Institute of Molecular Medicine, The Feinstein Institutes for Medical Research, Manhasset, NY
²Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY
³Plateforme Proteom'IC Institut Cochin, Université Paris Cité, INSERM U1016, CNRS UMR8104, Paris, France
⁴Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY
⁵Feinstein Institutes for Medical Research, Northwell, Manhasset, NY
⁶HEMATIM site CHU, University of Picardy Jules Verne, Amiens, France
⁷Plateforme Proteom'IC, Institut Cochin, Paris, France

Daniel J Navarrete, BA^1,2*, Chi Yong Kim^2*, Mario Gonzalez^2*, Barbara Baro^2*, Christian Doerig^3*, Shao-En Ong^4*, Martin Golkowski^4,5* and Elizabeth S. Egan, MD, PhD^1,2,6

¹Department of Microbiology & Immunology, Stanford University School of Medicine, Stanford, CA
²Department of Pediatrics, Stanford University School of Medicine, Stanford, CA
³School of Health and Biomedical Sciences, RMIT University, Melbourne, Australia
⁴Department of Pharmacology, University of Washington, Seattle, WA
⁵Department of Pharmacology & Toxicology, University of Utah, Salt Lake City, UT
⁶Chan Zuckerberg Biohub-San Francisco, San Francisco, CA

Alexander Röth, MD¹, Wilma Barcellini, MD^2*, Christine Ademokun^3*, Shripad Chitnis^4*, Sofiya Matviykiv^5*, Alessandra Vitaliti^5*, Chi Chen^6*, Vasiliki Katsanou^5*, Raghav Chawla, MD, PhD⁵ and Hanny Al-Samkari, MD⁷

¹Department of Hematology and Stem Cell Transplantation, West German Cancer Center, University Hospital Essen, University Duisburg-Essen, Essen, Germany
²Department of Hematology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy
³Imperial College Healthcare NHS Trust, London, United Kingdom
⁴Novartis Biomedical Research, Cambridge, MA
⁵Novartis BioMedical Research, Basel, Switzerland
⁶China Novartis Institutes for BioMedical Research Co Ltd, Shanghai, China
⁷Division of Hematology, Massachusetts General Hospital, Harvard Medical School, Boston, MA

Courtney Gatterdam^1*, Sana Emberesh^1*, Yasmin Elgammal, MD, MSc^1*, Carolyn Lutzko, PhD^2,3*, Lionel Blanc, PhD^4,5, Jose ANTONIO Cancelas, MD^6,7, Theodosia A. Kalfa, MD, PhD^1,3 and Katie Seu, PhD^1,3

¹Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
²Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
³Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH
⁴Institute of Molecular Medicine, The Feinstein Institute For Medical Research, Manhasset, NY
⁵Department of Molecular Medicine and Pediatrics, Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY
⁶Department of Internal Medicine, Harvard Medical School, Boston, MA
⁷Dana-Farber Cancer Institute, Boston, MA

Yui Chun Serena Wan, BS¹, Pengfei Liang, PhD², Gow Arepally, MD² and Huanghe Yang, PhD²

¹Duke University, Durham, NC
²Duke University School of Medicine, Durham, NC

Yi Xiang, PhD^1*, Min Wu, PhD², Yue Chen^2*, Scott A Reisman, PhD^2*, Srikanth Venkatraman, PhD^2*, Hua Yang, PhD^2* and Brian MacDonald, MD^2*

¹Disc Medicine Inc., Acton, MA
²Disc Medicine Inc., Watertown, MA

Chad Wiggins, PhD^1*, Kevin L. Webb^2*, Jacob L. Gasner^2*, Wyatt W. Pruter^2*, Sunil Navani^3*, Marcus A. Carden⁴ and Michael J. Joyner^2*

¹Mayo Clinic, East Lansing, MI
²Mayo Clinic, Rochester
³Novo Nordisk Ltd, Oxford, United Kingdom
⁴Novo Nordisk, Søborg, Denmark

Alina D. Peshkova, PhD, BS, MSc¹, Ekaterina K Rednikova, MD^2*, Rafael R. Khismatullin, MD, PhD^2*, Oleg V. Kim, PhD^3,4, Rustem I. Litvinov, MD, PhD^3* and John W. Weisel, PhD^3*

¹School of Medicine, Department of Pharmacology, University of Pennsylvania, Philadelphia, PA
²Institute of Fundamental Medicine and Biology, Kazan Federal University, Kazan, Russian Federation
³School of Medicine, Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, PA
⁴Department of Biomedical Engineering and Mechanics, Virginia Polytechnic Institute and State Uinversity, Blacksburg, VA

Davide Pio Abagnale^1*, Ugo De Martino^2*, Roberta Russo^3*, Raffaella Iannotta^2*, Fabrizio Pane⁴ and Novella Pugliese, MD^2*

¹Division of Hematology and SCT Unit, Federico II University, Naples, Italy
²Division of Hematology and SCT Unit, Federico II University, Naples, Italy, Naples, Italy
³Division of Hematology and SCT Unit, University Federico II, Naples, Italy, Naples, Italy
⁴Division of Hematology and SCT Unit, Federico II University, Naples, Naples, Italy

Bruno Fattizzo, MD¹, Anna Paola Iori^2*, Antonio De Vivo, MD^3*, Elisabetta Metafuni^4*, Amalia Figuera, MD^5*, Luana Marano, MD^6*, Esther Natalie Oliva, MD^7*, Maria Bruna Greve^8*, Francesco Lanza, MD^9*, Eros Di Bona, MD^10*, Jacopo Micozzi, MD^11*, Giovanni Caocci, MD¹², Francesca Fioritoni^13*, Fabio Ciceri, MD^14*, Angela Amendola^15*, Carmine Selleri, MD¹⁶, Francesco Longu^17*, Alessandra Tucci, MD¹⁸, Eloise Beggiato, MD^19*, Davide Rapezzi, MD^20*, Alessandro Cignetti^21*, Tiziana Anna Urbano^22*, Nicola Di Renzo^23*, Valeria Amico, MD^24*, Pierangelo Spedini^25*, Alessandro Rambaldi^26,27, Simona Raso, MD^28*, Cristina Clissa, MD^29*, Sergio Cabibbo^30*, Barbara Roncari^31*, Lucia Simoni^31*, Benedetta Campolo^32*, Fabio Carini^33*, Davide Mattiuzzi^33* and Wilma Barcellini, MD^34*

¹Hematology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, Italy
²Department of Translational and Precision Medicine, Policlinico Umberto I Hospital, Sapienza University of Rome, Roma, Roma, ITA
³Institute Of Hematology, Bologna, Italy
⁴Hematology Unit, Università Cattolica Del Sacro Cuore, Rome, ITA
⁵Hematology and Bone Marrow Transplatation Unit, A.O.U. Policlinico “G. Rodolico - S.Marco", Catania, 95123, ITA
⁶Hematology and BMT Unit, AORN San Giuseppe Moscati, Avellino, Italy
⁷Hematology, Melacrino Morelli Hospital, Reggio Calabria, AL, Italy
⁸Grande Ospedale Metropolitano di Reggio Calabria - Melacrino Morelli, Reggio Calabria, Italy
⁹Division of Hematology, Onco-hematologic Department, AUSL della Romagna, Ravenna, Italy
¹⁰UOC Oncoematologia, AULSS7 Pedemontana, Bassano del Grappa (VI), Vicenza, Italy
¹¹Division of Hematology, Department of Translational and Precision Medicine, Azienda Ospedaliera Policlinico Umberto I, Sapienza University of Rome, Rome, Italy
¹²University of Cagliari, Monserrato, Italy
¹³Department of Haematology, Pescara, ITA
¹⁴Hematology and Bone Marrow Transplantation Unit, I.R.C.C.S. San Raffaele Scientific Institute, Milan, Italy
¹⁵Ematologia, AOR San Carlo, Potenza, Potenza, ITA
¹⁶Hematology and Transplant Center, University Hospital “San Giovanni di Dio e Ruggi d’Aragona”, Salerno, Italy
¹⁷University of Sassari, Sassari, Missouri, ITA
¹⁸Department of Hematology, ASST Spedali Civili di Brescia, Brescia, Italy
¹⁹Hematology, AOU Città della Salute e della Scienza di Torino-Presidio Ospedaliero Molinette, Turin, Italy
²⁰Department of Hematology, S. Croce e Carle Hospital, Cuneo, Italy
²¹University Division of Hematology and Cell Therapy, A.O. Ordine Mauriziano, Turi, Torino, ITA
²²U.O. Ematologia Ospedale “S. Giuseppe Moscati”, Taranto, ASL TA1, Taranto, ITA
²³"Vito Fazzi" Hospital, Hematology and Stem Cell Transplant Unit, Lecce, Italy
²⁴Immunoematologia e Trasfusione Azienda Ospedaliera “San Pio”, Benevento, Italy, benevento, Italy
²⁵ASST Cremona, Ematologia, Cremona, ITA
²⁶UO Ematologia, ASST Papa Giovanni XXIII, Bergamo, Italy
²⁷Department of Oncology-Hematology, Azienda Socio-Sanitaria Territoriale Papa Giovanni XXIII, Bergamo, Italy
²⁸Department of Hematology and Rare Diseases, Azienda Ospedaliera Ospedali Riuniti Villa Sofia-Cervello, Palermo, Italy
²⁹Department of Medicine, Section of Hematology, University of Verona, Verona, Italy
³⁰ASP Ragusa- P.O. Giovanni Paolo II Ematologia, Ragusa, Italy
³¹IQVIA, Milano, Italy
³²Alexion AstraZeneca Rare Disease, Milan, ITA
³³Alexion Astrazeneca Rare Disease, Milano, Italy
³⁴Hematology Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy

Elisa Fermo, PhD^1*, Elena Trombetta^2*, Anna Marcello, PhD^1*, Cristina Vercellati, PhD^1*, Giulia Maria Ferrari^3*, Anna Zaninoni, BSc^1*, Valentina Brancaleoni, PhD^4*, Marta Tornese^2*, Wilma Barcellini, MD^5*, Tommaso Casini, MD^6*, Paola Consuelo Corti, MD^3* and Paola Bianchi, PhD, BSc⁷

¹Hematology Unit, Pathophysiology of Anemias Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy
²Flow Cytometry Service, Service Department, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy
³Pediatric Hematology and Bone Marrow Transplant Unit, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy
⁴SC Medicina Indirizzo Metabolico, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy
⁵Hematology Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy
⁶Department of Haematology-Oncology, Meyer University Children's Hospital, Florence, Italy
⁷Hematology Unit, Pathophysiology of Anemias Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milano, Italy

Nitya Dhanaraj^1* and Swati Goel, MD²

¹Department of Medicine, Montefiore Medical Center, Bronx, NY
²Montefiore Einstein Comprehensive Cancer Center, Blood Cancer Institute, Department of Oncology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY