66th ASH Annual Meeting: 330. Vascular Biology, Thrombosis, and Thrombotic Microangiopathies: Basic and Translational: Poster I

Symposia: Vascular Biology, Thrombosis, and Thrombotic Microangiopathies: Basic and Translational Oral and Poster Abstracts
Poster

Research, Bleeding and Clotting, Viral, Fundamental Science, Clinical trials, Adult, Bacterial, Translational Research, Epidemiology, Assays, Clinical Research, Thromboembolism, Diseases, Immune mechanism, Thrombocytopenias, SARS-CoV-2/COVID-19, Patient-reported outcomes, Infectious Diseases, Thrombotic disorders, Real-world evidence, Adverse Events, Biological Processes, Emerging technologies, Technology and Procedures, Molecular biology, Study Population, Human, Pathogenesis, Imaging, Molecular testing

Halls G-H (San Diego Convention Center)

1224

Sars-CoV2 Associated Thromboinflammatory Biomarkers for the Prediction of in-Hospital and Long-Term Mortality in Acute Coronary Syndrome (ACS): Development of a Risk Assessment Score

Marina Marchetti, PhD^1,2^*, Patricia Gomez-Rosas, MD^2,3,4^*, Irene Pescetelli⁵^*, Laura Russo²^*, Sara Gamba²^*, Cristina Verzeroli²^*, Francesco Moretti⁵^*, Dario Pellegrini^6,7^*, Luigi Fiocca⁵^*, Aurelia Grosu⁵^*, Giulio Guagliumi⁸^* and Anna Falanga, MD⁹

¹School of Medicine and Surgery, University, Milan, Italy
²Department of Immunohematology and Transfusion Medicine, Papa Giovanni XXIII Hospital, Bergamo, Italy
³Maastricht University Medical Center (MUMC+), Cardiovascular Research Institute Maastricht (CARIM), Maastricht, Netherlands
⁴Hospital de Oncologia, Unidad Medica de Alta Especialidad (UMAE), Centro Medico Nacional Siglo XXI, Instituto Mexicano del Seguro Social (IMSS), Mexico City, Mexico
⁵Interventional Cardiology, Cardiovascular Department, Papa Giovanni XXIII Hospital, Bergamo, Italy
⁶Coronary Care Unit and Laboratory of Clinical and Experimental Cardiology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
⁷Department of Molecular Medicine, Cardiology Unit, University of Pavia, Pavia, Italy
⁸IRCCS Ospedale Galeazzi-Sant’Ambrogio, Milan, Italy
⁹School of Medicine, University of Milano Bicocca, Milan, Italy

1225

Complement Biosensors Can be Used to Identify Classical Pathway and Alternative Pathway Dysregulation in Complement-Mediated Thrombotic Microangiopathy

Michael Cole, MD, DPhil¹, Nikhil Ranjan, PhD¹, Gloria F. Gerber, MD², Xiang-Zuo Pan¹^*, Daniel Flores-Guerrero³^*, Shruti Chaturvedi, MBBS⁴, C. John Sperati, MD⁵^*, Keith R. McCrae, MD⁶ and Robert A. Brodsky, MD⁷

¹Division of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD
²Division of Hematology, Department of Medicine, Johns Hopkins Hospital, Baltimore, MD
³Department of Medicine, Division of Hematology, Johns Hopkins University School of Medicine, Baltimore, MD
⁴Division of Hematology, Department of Medicine, Johns Hopkins University, BALTIMORE, MD
⁵Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD
⁶Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, OH
⁷Division of Hematology, Johns Hopkins Medicine, Baltimore, MD

1226

“Endothelialized” Hemostasis-on-a-Chip Reveals Rapid Platelet Recruitment By Locally Concentrated Ultra-Large Von Willebrand Factor (VWF) Release from Endothelial Cells Surpasses Plasma and Platelet VWF in Initiating Hemostasis

Theodora T. Alese¹^*, Yumiko Sakurai, MSc^2,3^*, Elaissa L. Hardy, PhD^2,3,4^* and Wilbur Lam, MD, PhD^2,3,4

¹Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Washington, MD
²Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA
³Department of Pediatrics, Division of Pediatric Hematology/Oncology, Emory University School of Medicine, Atlanta, GA
⁴Aflac Cancer and Blood Disorders Center, Children’s Healthcare of Atlanta, Atlanta, GA

1227

Clonal Persistence of Anti-PF4 Antibodies in VITT Represents an MGTS-like State

Adam Kanack, PhD¹, Guillaume Roberge, MD²^*, Emily Mauch, BS¹^*, Noah Splinter, MS¹^*, Geoffrey D. Wool, MD, PhD³^*, Gemlyn George, MD⁴, Mouhamed Yazan Abou-Ismail, MD^5,6, Kristi J. Smock, MD⁷, David L. Green, MD⁸^*, Krishna Gundabolu, MBBS⁹, Jon Coker, PhD¹⁰^*, Mindy Kohlhagen, BS¹^*, David Murray, MD, PhD¹^* and Anand Padmanabhan, MBBS, PhD¹

¹Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN
²Department of Internal Medicine, Centre Hospitalier Universitaire de Québec, Québec, QC, CAN
³Department of Pathology, University of Chicago, Chicago, IL
⁴University of Colorado, Aurora, CO
⁵University of Utah, Salt Lake City, UT
⁶Division of Hematology and Hematologic Malignancies, Department of Internal Medicine, University of Utah, Salt Lake City, UT
⁷Department of Pathology, University of Utah Health Sciences Center, Salt Lake Cty, UT
⁸NYU Langone Health, New York, NY
⁹Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center College of Medicine, Omaha, NE
¹⁰Xylo Technologies, Mayo Clinic, Rochester, MN

1228

Phenotypic and Transcriptomic Profiling of MPN Endothelium

Salma A Abosabie^1,2^*, Lourdes M Mendez, MD, PhD³^* and Anish V Sharda, MBBS⁴

¹Section of Hematology, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT
²Section of Experimental Biomedicine, Faculty of Medicine, Julius Maximilians University of Würzburg, Wuerzburg, Germany
³Section of Hematology, Department of Internal Medicine, Yale School of Medicine, New Haven, CT
⁴Yale Comprehensive Cancer Center, Yale University School of Medicine, New Haven, CT

1229

A Subset of Antibodies to the Spike Protein's Receptor-Binding Domain in Severe COVID-19 Activate Platelets

Wen Zhu, MD, PhD¹^*, Yongwei Zheng, PhD²^*, Mei Yu, PhD³^*, Nathan Witman, MS³^*, Anand Padmanabhan, MBBS, PhD^4,5, Lisa Baumann Kreuziger, MD, MS⁶, Gilbert C. White, MD³, Tongjun Gu, PhD³, Alexander Fields, MD⁷^*, Lucy Kornblith, MD⁷^*, Richard H. Aster, M.D.³, Weiguo Cui, PhD⁸^*, Shawn M. Jobe, MD, PhD³, Mary Beth Graham, MD⁹^*, Demin Wang, Ph.D.³ and Renren Wen, PhD³

¹MedSphere Corp, Skokie, IL
²Guangzhou Bio-gene Technology Company, Guangzhou, China
³Versiti Blood Research Institute, Milwaukee, WI
⁴Department of Laboratory Medicine, Mayo Clinic, Rochester, MN
⁵Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN
⁶Versiti, Menomonee Falls, WI
⁷Department of Surgery, University of California San Francisco, San Francisco, CA
⁸Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago
⁹Department of Medicine, Division of Infectious Disease, Medical College of Wisconsin, Milwaukee, WI

1230

Enhanced Thrombotic Susceptibility, Endotheliopathy, and Abnormal Cognitive Behavior for up to 5 Months after Sars-Cov-2 Infection in a Mouse Model of Long COVID

Roberto Aiolfi, PhD¹, Antonella Zampolli, Ph.D.²^*, Miriam Hauer-Jensen²^*, Jose A. Fernandez, MD, PhD¹^*, Xiao Xu, MS¹^*, Angel Gandarilla²^*, Julia C.O. Mosnier²^*, Amanda J. Roberts, Ph.D.¹^*, Juan Carlos de la Torre, Ph.D.²^* and Laurent O. Mosnier, PhD³

¹The Scripps Research Institute, La Jolla, CA
²The Scripps Research Institute, La Jolla
³Dept. Molecular Medicine (IMM-315), The Scripps Research Institute, La Jolla, CA

1231

Platelet Factor 4 Enhances Endothelial Cell Antimicrobial Activity in Vitro and Promotes Bacterial Clearance In Vivo, Improving Sepsis Outcomes

Anh T.P. Ngo, PhD^1,2, Veronica Bochenek, BA³^*, Hyunjun Kim, MS³^*, Nate Levine³^*, Samir Maarouf³^*, Jenna Oberg³^*, Manuela Roggiani, PhD⁴^*, Amrita Sarkar, PhD³, Lubica Rauova, MD, PhD^3,5, Caroline Diorio, MD⁶, Zachary Martinez⁶^*, Mark Goulian, PhD⁴^*, Mortimer Poncz, MD^3,5, Victor Nizet, MD¹^* and Kandace Gollomp, MD^3,5

¹Division of Host-Microbe Systems and Therapeutics, University of California San Diego, La Jolla, CA
²Division of Hematology, Children's Hospital of Philadelphia, San Diego, CA
³Division of Hematology, Children's Hospital of Philadelphia, Philadelphia, PA
⁴Department of Biology, University of Pennsylvania School of Arts & Sciences, Philadelphia, PA
⁵Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA
⁶Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, PA

1232

Coagulation Abnormalities in Post-Acute COVID-19 Syndrome: A Cross-Sectional Study

Yucan Li^1,2^*, Zhengqi Jiang¹^*, Fengjiao Han^3,4^*, Qiuyu Guo³^*, Qi Feng^3,5^*, Tichao Shan^1,6^*, Jun Peng^5,7^* and Miao Xu, MD, PhD^3,7^*

¹Qilu Hospital of Shandong University, jinan, China
²Shandong University/Qilu Hospital, jinan, China
³Shandong University/Qilu Hospital, Jinan, China
⁴Department of Hematology, Cheeloo College of Medicine, Qilu Hospital of Shandong University, Jinan, China
⁵Qilu Hospital of Shandong University, Jinan, China
⁶Department of Critical Care Medicine, Qilu Hospital of Shandong University, Jinan, China
⁷Department of Hematology, Qilu Hospital of Shandong University, Jinan, China

1233

Platelet Endoplasmic Reticulum Stress Promotes Thrombosis in an in Vitro Laser-Induced Endothelial Injury Model

Alexander Dupuy, PhD¹^*, Paul Coleman, PhD²^*, Jennifer Gamble, PhD²^*, Lining Ju, PhD³^* and Freda H Passam, MD, PhD^4,5

¹University of Sydney, Camperdown, NSW, Australia
²Centenary Institute, Camperdown, AUS
³Faculty of Engineering, University of Sydney, Darlington, Australia
⁴Central Clinical School, Faculty of Medicine and Health, University of Sydney, Camperdown, NSW, Australia
⁵Institute of Haematology, Royal Prince Alfred Hospital, Camperdown, NSW, Australia

1234

Plasma Hypercoagulability and Hypofibrinolysis Are Associated with Increased Markers of Inflammation in Pediatric VTE: Findings from the Kids-DOTT Trial Biobank

Marisol Betensky, MD, MPH^1,2, Neil Goldenberg, MD, PhD¹, Vera Ignjatovic, PhD, BSc³, Maua Mosha, MPH⁴^* and Steven Bruzek, MSc¹^*

¹Johns Hopkins All Children's Hospital, St. Petersburg, FL
²Johns Hopkins University School of Medicine, Baltimore, MD
³Johns Hopkins All Children's Hospital, Saint Petersburg, FL
⁴Data Coordinating Center for Pediatric Multicenter Studies, Johns Hopkins All Children’s Hospital Institute for Clinical and Translational Research, St. Petersburg, FL

1235

Markers of Activated Coagulation Factor XII Are Inversely Associated with Progression of Atrial Fibrillation in the Race V Study

Magdolna Nagy¹^*, Vanessa Weberndoerfer^1,2^*, Jens Posma³^*, Sander Van Kuijk²^*, Bao-Oanh Nguyen⁴^*, Hugo Ten Cate^1,2^*, Isabelle C Van Gelder⁴^*, Harry Crijns^1,5^*, Michiel Rienstra⁴^* and Henri M.H. Spronk¹

¹Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, Netherlands
²Maastricht University Medical Center+, Maastricht, Netherlands
³Center for Thrombosis and Hemostasis, Johannes Gutenberg University Medical Center, Mainz, Germany
⁴University Medical Center Groningen, Groningen, Netherlands
⁵Maastricht University Medical Center +, Maastricht, Netherlands

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^*signifies non-member of ASH

330.P1.37 330. Vascular Biology, Thrombosis, and Thrombotic Microangiopathies: Basic and Translational: Poster I