66th ASH Annual Meeting: 701. Experimental Transplantation: Basic and Translational: GVHD, GVL and Alloimmunity

Symposia: Experimental Transplantation: Basic and Translational Oral and Poster Abstracts
Oral

Research, Fundamental Science, Translational Research, Immune mechanism, Diseases, Immunology, Adverse Events, Lymphoid Malignancies, Computational biology, Biological Processes, Myeloid Malignancies, Molecular biology, Technology and Procedures, Study Population, Human, Omics technologies

Room 6B (San Diego Convention Center)

Moderators:

Antiopi Varelias, PhD, QIMR Berghofer Medical Research Institute and Tomomi Toubai, MD, PhD, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital

Disclosures:

No relevant conflicts of interest to declare.

2:45 PM

901

Memory CD4⁺ T Cells Recognize Divergent HLA-DP Immunopeptidomes and Contribute to Leukemia Control after Allogeneic HCT

Kulvara Kittisares, MD^1,2^*, Pietro Crivello, PhD¹^*, Thorben Walther¹^*, Maryam Mohamaddokht^1,3^*, Thuja Arrieta Bolaños, PhD¹^*, Luisa Betke, PhD¹^*, Dominik Lux⁴^*, Thilo Bracht, PhD^4,5^*, Malte Bayer, PhD^4,5^*, Sarah Flossdorf⁶^*, Effie Wang Petersdorf, MD⁷^*, Amin T. Turki, MD^1,8^*, Peter Horn, MD⁹^*, Johannes Köster, PhD¹⁰^*, Astrid M. Westendorf, PhD¹¹^*, J.H. Frederik Falkenburg, MD, PhD¹², Marieke Griffioen, PhD¹²^*, Barbara Sitek, PhD^4,5^*, Thomas Schroeder¹³^*, Marie Bleakley, PhD, MBBS, MMSc⁷, Katharina Fleischhauer, MD^1,14^* and Esteban Arrieta-Bolanos^14,15^*

¹Institute for Experimental Cellular Therapy, University Hospital Essen, Essen, Germany
²Department of Transfusion Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
³Institute of Neurophysiology, Charité Universitätsmedizin Berlin, Berlin, Germany
⁴Medical Proteome Center, Center for Protein Diagnostics (PRODI), Ruhr University Bochum, Bochum, Germany
⁵Klinik für Anästhesiologie, Intensivmedizin und Schmerztherapie, Universitätsklinikum Knappschaftskrankenhaus Bochum, Bochum, Germany
⁶Institute for Medical Informatics, Biometry and Epidemiology (IMIBE), University of Duisburg-Essen, Essen, Germany
⁷Translational Science and Therapeutics, Fred Hutchinson Cancer Center, Seattle, WA
⁸Institute for AI in Medicine, University Hospital Essen, Essen, Germany
⁹Institute for Transfusion Medicine, University Hospital Essen, Essen, Germany
¹⁰Bioinformatics and Computational Oncology, Institute for Artificial Intelligence in Medicine (IKIM), University of Duisburg-Essen, Essen, Germany
¹¹Institute of Medical Microbiology, University Hospital Essen, University of Duisburg-Esse, Essen, Germany
¹²Hematology, Leiden University Medical Center, Leiden, Netherlands
¹³Department of Hematology and Stem Cell Transplantation, University Hospital Essen, Essen, Germany
¹⁴German Cancer Consortium (DKTK), partner site Essen/Düsseldorf, Essen, Germany
¹⁵Institute for Experimental Cellular Therapy, Essen University Hospital, Essen, Germany

3:00 PM

902

Ropeginterferon Alfa-2b Induces Apoptosis and Differentiation of Leukemia Stem Cells and Separates GVL Effects from Gvhd after Allogeneic Hematopoietic Cell Transplantation

Yumika Saito, MD¹^*, Daigo Hashimoto, MD², Keisuke Kojima, MD³^*, Shihori Tsukamoto, MD³^*, Tomoe Ichiki, MD³^*, Toru Miyajima, MD¹^*, Wenyu Li³^*, Shinpei Harada, MD³^*, Zixuan Zhang³^*, Hajime Senjo, MD⁴, Yuta Hasegawa, MD, PhD³^*, Takahide Ara, MD, PhD³^* and Takanori Teshima, MD, PhD³

¹Department of Hematology, Hokkaido University Faculty of Medicine and Graduate School of Medicine, Sapporo, HOK, Japan
²Department of Hematology, Hokkaido University, Sapporo, Japan
³Department of Hematology, Hokkaido University Faculty of Medicine and Graduate School of Medicine, Sapporo, Japan
⁴Department of Hematology, Hokkaido University, Kita-Ku, Japan

3:15 PM

903

Early Initiation of Calcineurin Inhibitor Induces CD8⁺ Transitory Exhausted-like and CD4⁺ Cytotoxic T Cells, Maintaining Responsiveness to PD-1 Blockade and Contributing to the Development of Chronic Gvhd after Post-Transplant Cyclophosphamide

Hajime Senjo, MD^1,2, Daigo Hashimoto, MD³, Shihori Tsukamoto, MD⁴^*, Keisuke Kojima, MD⁴^*, Shimpei I Kubota, MD, PhD⁵^*, Ayumu Ito, MD, PhD⁶^*, Tomoe Ichiki, MD⁴^*, Satomi Okada, MD⁴^*, Yumika Saito, MD⁷^*, Toru Miyajima, MD⁷^*, Shinpei Harada, MD⁴^*, Wenyu Li⁴^*, Zixuan Zhang⁴^*, Yuta Hasegawa, MD, PhD⁴^*, Hiroyuki Ohigashi, MD, PhD⁸^*, Takahide Ara, MD, PhD⁴^*, Yoshinori Hasegawa, PhD⁹^*, Yoshihiro Inamoto, MD, PhD¹⁰, Masaaki Murakami, VMD, PhD⁵^*, Takahiro Fukuda⁶^* and Takanori Teshima, MD, PhD¹¹

¹Department of Hematology, Hokkaido University, Kita-Ku, Japan
²Department of Hematology, Kushiro Rosai Hospital, Kushiro, Japan
³Department of Hematology, Hokkaido University, Sapporo, Japan
⁴Department of Hematology, Hokkaido University Faculty of Medicine and Graduate School of Medicine, Sapporo, Japan
⁵Molecular Psychoneuroimmunology, Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan
⁶Department of Hematopoietic Stem Cell Transplantation, National Cancer Center Hospital, Tokyo, Japan
⁷Department of Hematology, Hokkaido University Faculty of Medicine and Graduate School of Medicine, Sapporo, HOK, Japan
⁸Department of Hematology, Hokkaido University Hospital, Sapporo, HOK, JPN
⁹Department of Applied Genomics, Kazusa DNA Research Institute, Chiba, Japan
¹⁰Department of Blood and Marrow Transplantation and Cellular Therapy, Fujita Health University, Aichi, Japan
¹¹Department of Hematology, Hokkaido University Faculty of Medicine, Sapporo, Japan

3:30 PM

904

CD33 Antibody-Modified Nanoparticles Encapsulated IL-15 Induce ISG15 to Promote MHC I Expression in Leukemia Cells Via Innate Immunity Pathway Inducing Graft-Versus-Leukemia without Aggravating Graft-Versus-Host Disease

Ruowen Wei, PhD¹^*, Ao Zhang¹^*, Moran Wang, PhD¹^*, Xie-Na Cao, PhD¹^*, Ruiqi Zhu, PhD¹^*, Shengling Ma, MD, PhD², Linghui Xia¹^* and Wei Shi, PhD¹^*

¹Institute of Hematology, Union Hospital, Tongji Medical School, Huazhong University of Science and Technology, Wuhan, China
²Section of Hematology-Oncology, Baylor College of Medicine, HOUSTON, TX

3:45 PM

905

Donor XCR1⁺ and CD11b⁺ Dendritic Cells Determine the Severity of Th1 and Th17-Dependent Acute Gvhd within the Gastrointestinal Tract

Motoko Koyama, MD, PhD¹, Shuichiro Takahashi, MD, PhD^2,3^*, Takayuki Inoue, MD, PhD^3,4^*, Kathleen S Ensbey³^*, Samuel R. W. Legg³^*, Tomoko Sekiguchi³^*, Ethan Nelson³^*, Nicole S Nemychenkov³^*, Tanvi Joshi³^*, Simone A Minnie, PhD¹, Albert C Yeh, MD^3,5, Julie R Boiko, MD, MS^3,5, Ping Zhang, MD^3,6^*, Mark B Headley, PhD³^*, Jisun Paik, PhD⁷^*, John K Amory, MD⁸^* and Geoffrey R. Hill, MD^3,5

¹Translational Sciences and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA
²Division of Hematology, Department of Internal Medicine, Asahikawa Medical University, Asahikawa, Japan
³Translational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA
⁴Division of Respiratory Medicine and Hematology, Hyogo Medical University, Nishinomiya, Japan
⁵University of Washington, Seattle, WA
⁶QIMR Berghofer Medical Research Institute, Brisbane, Australia
⁷Department of Comparative Medicine, University of Washington, Seattle, WA
⁸Department of Medicine, University of Washington, Seattle, WA

4:00 PM

906

IL-33⁺ Stromal Cells in the Lymphoid Tissues Program Donor CD4⁺ T Cell Exhaustion That Blunts Subsequent IL-33⁺ Target Tissue-Driven Pathology but Not Graft Vs. Lymphoma Responses

Gaelen Dwyer, MD, PhD^1,2, Lisa Mathews¹^*, Bailey Chalmers¹^*, Afsana Naaz, PhD³^*, Amanda Poholek, PhD³^*, Craig Byersdorfer, MD, PhD^4,5, Faruk Sacirbegovic, PhD⁶^*, Warren Shlomchik, MD⁷ and Heth Turnquist, PhD³^*

¹University of Pittsburgh, Pittsburgh, PA
²University of Michigan, Ann Arbor, MI
³University of Pittsburgh, Pittsburgh
⁴Department of Pediatrics, University of Minnesota, Pittsburgh, PA
⁵University of Minnesota, Minneapolis
⁶Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh
⁷Department of Medicine, Division of Hematology/Oncology, University of Pittsburgh, Pittsburgh, PA

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^*signifies non-member of ASH

701.O2.6 701. Experimental Transplantation: Basic and Translational: GVHD, GVL and Alloimmunity