-Author name in bold denotes the presenting author
-Asterisk * with author name denotes a Non-ASH member
Clinically Relevant Abstract denotes an abstract that is clinically relevant.

PhD Trainee denotes that this is a recommended PHD Trainee Session.

Ticketed Session denotes that this is a ticketed session.

653A.O3.6 653. Multiple Myeloma: Clinical and Epidemiological: Exploring T Cell Redirecting Therapies, Mutation Profiles and Early Relapse

Symposia: Multiple Myeloma: Clinical and Epidemiological Program: Oral and Poster Abstracts
Type: Oral
Hematology Disease Topics & Pathways:
Research, Clinical trials, Adult, Epidemiology, Clinical Practice (Health Services and Quality), Translational Research, Lymphomas, Clinical Research, Health outcomes research, Plasma Cell Disorders, Chimeric Antigen Receptor (CAR)-T Cell Therapies, Diseases, Real-world evidence, Treatment Considerations, Biological therapies, Immunology, Adverse Events, Lymphoid Malignancies, Biological Processes, Technology and Procedures, Molecular biology, Study Population, Human, Molecular testing
Monday, December 9, 2024: 2:45 PM-4:15 PM
Pacific Ballroom Salons 24-26 (Marriott Marquis San Diego Marina)
Moderators:
Carlyn Rose Tan, MD, and Marc J Braunstein, MD, PhD, NYU Long Island School of Medicine, NYU Winthrop Hospital, NYU Langone Health
Disclosures:
Tan: Janssen: Honoraria, Research Funding; Sanofi: Honoraria; Takeda: Research Funding. Braunstein: J&J (Janssen): Consultancy, Honoraria, Research Funding, Speakers Bureau; Epizyme: Consultancy, Honoraria; Abbvie: Consultancy, Honoraria; Sanofi: Consultancy, Honoraria; CTI Biopharma: Consultancy, Honoraria; Pfizer: Consultancy, Honoraria; Lava Therapeutics: Consultancy, Honoraria; Seagen: Consultancy, Honoraria; Cardinal Health: Consultancy, Honoraria; AstraZeneca: Consultancy, Honoraria; Guidepoint Global: Consultancy, Honoraria; Bristol Myers Squibb: Consultancy, Honoraria.

In this session attendees will learn from experts in T cell redirecting therapies for multiple myeloma, including discussion of predictive markers of responses to bispecific antibodies and CAR T-cell therapies. In addition, results will be presents from a retrospective analysis from the European Myeloma Network/Harmony Alliance analysis of early relapses in newly diagnosed myeloma, as well as a randomized trial of a 3-shot influenza vaccine series for myeloma.
2:45 PM

Kai Rejeski, MD1,2, Doris K. Hansen, MD3, David M. Cordas Dos Santos, MD4*, Andre De Menezes Silva Corraes, MD5*, Omar Castaneda, MD3, Christen M Dillard, MD6*, Winfried Alsdorf7*, Jan H. Frenking, MD8*, Anna Purcarea, MD9*, Saurabh Chhabra, MBBS10*, Ciara Louise Freeman, PhD, MSc, FRCPC, MRCP3, Mirco Julian Friedrich, MD, PhD8*, Mahmoud R. Gaballa, MD11, Rebecca Gonzalez, PharmD12*, Syed Hamza Bin Waqar, MD12*, Yi Lisa Hwa, APRN, DNP, CNP5, Michael D. Jain, MD, PhD13, Ricardo D. Parrondo, MD14, Oren Pasvolsky, MD15, Wajma Shahbaz, MD1*, Roni Shouval, MD, PhD2, Genevieve Spiess, PAC5*, Haily Stephens, PAC5*, Sebastian Theurich, MD1*, Florian Bassermann, MD16*, Judith S. Hecker, MD17*, Marc S. Raab8*, Katja C. Weisel, MD7, Frederick L. Locke, MD13, Marion Subklewe, MD18, Krina K. Patel, MD, MSc19 and Yi Lin, MD, PhD5

1Department of Medicine III, LMU University Hospital, LMU Munich, Munich, Germany
2Adult Bone Marrow Transplantation Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY
3Department of Blood and Marrow Transplantation and Cellular Immunotherapy, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL
4Dana-Farber Cancer Institute, Boston, MA
5Division of Hematology, Mayo Clinic, Rochester, MN
6Department of Lymphoma & Myeloma, MD Anderson Cancer Center, Houston, TX
7University Medical Center Hamburg-Eppendorf, Hamburg, Germany
8Heidelberg Myeloma Center, Department of Medicine V, University Hospital Heidelberg, Heidelberg, Germany
9Department of Medicine III and Center for Translational Cancer Research, Technical University of Munich (TUM), School of Medicine and Health, Munich, Germany
10Division of Hematology/Oncology, Mayo Clinic Arizona, Phoenix, AZ
11Department of Lymphoma & Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX
12Department of Blood and Marrow Transplant and Cellular Immunotherapy, Moffitt Cancer Center, Tampa, FL
13Department of Blood and Marrow Transplantation and Cellular Immunotherapy, Moffitt Cancer Center, Tampa, FL
14Division of Hematology-Oncology, Mayo Clinic-Florida, Jacksonville, FL
15Department of Lymphoma and Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX
16Hospital Rechts der Isar, Internal Medicine III - Hematology and Oncology, Technical University of Munich, Munich, Germany
17Department of Medicine III, Hematology and Oncology, Technical University of Munich (TUM), School of Medicine and Health, Munich, Germany
18Department of Medicine III, LMU University Hospital, Munich, Germany
19M.D. Anderson Cancer Center, MD Anderson Cancer Center, Houston, TX

3:00 PM

Doris K. Hansen, MD1, Ciara Louise Freeman, PhD, MSc, FRCPC, MRCP1, Meghan Menges2*, Brett Reid3*, Julieta Abraham-Miranda, PhD2*, Kayla Reid, MS4*, Luis Cuadrado Delgado5*, Gabriel De Avila6*, Laura B. Oswald, PhD7*, Ariel F. Grajales-Cruz, MD4, Brandon Blue4, Rebecca Gonzalez, PharmD8*, Salvatore Corallo2*, David R. Noyes, MS9*, Mark B. Meads, PhD10*, Hien Liu, MD1, Taiga Nishihori, MD3, Kenneth H. Shain, MD, PhD10, Rachid Baz, MD11, Melissa Alsina, MD12*, Omar Castaneda, MD1, Frederick L. Locke, MD8 and Lauren C. Peres, PhD, MPH13*

1Department of Blood and Marrow Transplantation and Cellular Immunotherapy, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL
2Department of Clinical Science, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL
3Moffitt Cancer Center, Tampa, FL
4H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL
5Moffitt Cancer Center, Tampa
6H Lee Moffitt Cancer Center and Research Institute, Tampa, FL
7Department of Health Outcomes and Behavior, Moffitt Cancer Center, Tampa, FL
8Department of Blood and Marrow Transplant and Cellular Immunotherapy, Moffitt Cancer Center, Tampa, FL
9Department of Malignant Hematology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL
10H. Lee Moffitt Cancer Center, Tampa, FL
11H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL
12Department of Blood and Marrow Transplant and Cellular Immunotherapy, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL
13Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, FL

3:15 PM

Danai Dima, MD1, Mariola A Vazquez-Martinez, MD2, James A Davis, PharmD3*, Utkarsh Goel, MBBS1, Aimaz Afrough4*, Aishwarya Sannareddy, MBBS4*, Oren Pasvolsky, MD5, Beatrice Razzo, MD6, Rahul Banerjee, MD, FACP7, Jack Khouri, MD1, Ariel Grajales-Cruz2*, Alex Lieberman-Cribbin8*, Masooma Shifa Rana9*, Kelley Julian, PharmD10*, Shaun DeJarnette11*, Andrew J Portuguese, MD7, Mahmoud R. Gaballa, MD5, Gabriel De Avila2*, Sandra Susanibar-Adaniya, MD6, Shahzad Raza, MD1, Megan M Herr, PhD12, Evguenia Ouchveridze, MD11, Tiffany Richards, PhD, NP5, Hitomi Hosoya, MD, PhD9, Lekha Mikkilineni, MD, MA9, Gurbakhash Kaur, MD, MA13, Daniel Schrum, PharmD14*, Omar Castaneda, MD15, Adriana Rossi, MD, MSc16, Chenyu Lin, MD14, Peter A. Forsberg, MD17, Yi Lin, MD, PhD18, Shebli Atrash, MD19, Douglas W Sborov, MD10, Kenneth H. Shain, MD, PhD2, Peter M. Voorhees, MD19, Shambavi Richard, MD16, Alfred L. Garfall, MD6, Doris K. Hansen, MD2, Surbhi Sidana, MD9, Krina K. Patel, MD, MSc5, Andrew J. Cowan, MD7, Larry D Anderson Jr., MD, PhD20, Hans C. Lee, MD5, Faiz Anwer, MD1, Christopher Ferreri, MD19 and Leyla O. Shune, MD11

1Cleveland Clinic Taussig Cancer Institute, Cleveland, OH
2H Lee Moffitt Cancer Center and Research Institute, Tampa, FL
3Medical University of South Carolina Hollings Cancer Center, Charleston, SC
4UT Southwestern Simmons Cancer Center, Dallas, TX
5The University of Texas MD Anderson Cancer Center, Houston, TX
6University of Pennsylvania Abramson Cancer Center, Philadelphia, PA
7University of Washington Fred Hutchinson Cancer Center, Seattle, WA
8Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY
9Stanford University, Stanford, CA
10University of Utah Huntsman Cancer Institute, Salt Lake City, UT
11University of Kansas Medical Center, Kansas City, KS
12Roswell Park Comprehensive Cancer Center, Buffalo, NY
13Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX
14Duke University Cancer Institute, Durham, NC
15Department of Blood and Marrow Transplantation and Cellular Immunotherapy, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL
16Icahn School of Medicine at Mount Sinai Tisch Cancer Institute, New York, NY
17University of Colorado Cancer Center, Aurora, CO
18Division of Hematology, Mayo Clinic, Rochester, MN
19Atrium Health Levine Cancer Institute, Charlotte, NC
20Harold C. Simmons Comprehensive Cancer Center, UT Southwestern Medical Center, Dallas, TX

3:30 PM

Elias K. Mai, MD1*, Andrea Manubens, PhD2*, Mattia D'Agostino, MD3*, David A. Cairns, PhD4*, Alessandra Larocca, MD, PhD3*, Juan José Lahuerta Palacios, MD, PhD5*, Ruth Wester, MD, PhD6*, Uta Bertsch, MD1,7*, Anders Waage, MD, PhD8*, Elena Zamagni, MD9,10*, María-Victoria Mateos, MD, PhD11, Daniele Dall'Olio, PhD12*, Niels W.C.J. van de Donk, MD, PhD13*, Graham Jackson, MD14*, Serena Rocchi, MD, PhD9,10*, Hans Salwender, MD15*, Joan Bladé, MD, PhD16*, Bronno van der Holt, PhD6,17*, Gastone Castellani, PhD10*, Katja C. Weisel, MD18, Francesca Gay, MD, PhD3*, Sonja Zweegman, MD, PhD13, Michele Cavo, MD9,10*, Jesus Maria Hernandez Rivas, MD19,20, Benedetto Bruno, MD, PhD3, Gordon Cook, PhD, DSc4*, Martin F Kaiser, MD21, Hartmut Goldschmidt, MD1,7, Mario Boccadoro, MD22, Jesús F. San-Miguel, MD, PhD23 and Pieter Sonneveld, MD6

1Internal Medicine V, Hematology, Oncology and Rheumatology, Heidelberg University Hospital, Heidelberg, Germany
2Clínica Universidad de Navarra, Cancer Center Clínica Universidad de Navarra, Madrid, Spain
3Division of Hematology, AOU Città della Salute e della Scienza di Torino, University of Torino and Department of Molecular Biotechnology and Health Sciences, University of Torino, Torino, Italy
4Leeds Cancer Research UK Clinical Trials Unit, Leeds Institute of Clinical Trials Research, University of Leeds, Leeds, United Kingdom
5Research Institute of the Hospital Universitario 12 de Octubre and Board of the Spanish Myeloma Group (PETHEMA/GEM), Madrid, Spain
6Department of Hematology, Erasmus MC Cancer Institute, Rotterdam, Netherlands
7National Center for Tumor Diseases Heidelberg, Heidelberg, Germany
8Institute of Clinical and Molecular Medicine, Norwegian University of Science and Technology, and Research Department, St Olavs Hospital, Trondheim, Norway
9IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia “Seràgnoli”, Bologna, Italy
10Dipartimento di Scienze Mediche e Chirurgiche, Università di Bologna, Bologna, Italy
11Complejo Asistencial Universitario de Salamanca/IBSAL/CIC/CIBERONC, Salamanca, Spain
12IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy
13Department of Hematology, Amsterdam UMC, Cancer Center Amsterdam, Vrije Universiteit Amsterdam, Amsterdam, Netherlands
14University of Newcastle upon Tyne, Newcastle upon Tyne, United Kingdom
15Asklepios Tumorzentrum Hamburg, AK Altona, AK St Georg, Hamburg, Germany
16Hospital Clinic, IDIBAPS, Barcelona, Spain
17HOVON Foundation, Rotterdam, Netherlands
18Department of Oncology, Hematology and BMT, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
19Department of Medicine, University of Salamanca, Institute of Biomedical Research of Salamanca (IBSAL), University of Salamanca – Cancer Research Center of Salamanca (IBMCC, USAL-CSIG), Salamanca, Spain
20Hematology Department, Hospital Universitario de Salamanca (CAUSA/IBSAL), Salamanca, Spain
21The Institute of Cancer Research, London, United Kingdom and the Royal Marsden Hospital, London, United Kingdom
22European Myeloma Network, EMN, Italy
23Clínica Universidad de Navarra, CIMA, IDISNA, CIBER-ONC (CB16/12/00369), Pamplona, Spain

3:45 PM

Jana Wobst1*, Marietta Truger1*, Natalie Wossidlo, PhD1*, Constance Regina Baer, PhD1, Stephan Hutter, PhD1*, Manja Meggendorfer, PhD2, Wolfgang Kern, MD1, Torsten Haferlach, MD1 and Claudia Haferlach, MD1

1MLL Munich Leukemia Laboratory, Munich, Germany
2MLL Munich Leukemia Laboratory, Munich, Bavaria, Germany

4:00 PM

Bruno Paiva, PhD1*, Irene Manrique2*, Ethan G. Thompson, PhD3*, Timothy B. Campbell, MD, PhD4, Camila Guerrero, PhD1*, Nathan Martin3*, Larry D Anderson Jr., MD, PhD5, Jesus G Berdeja, MD6, Sagar Lonial, MD7*, Noopur Raje8, Yi Lin, MD, PhD9, Philippe Moreau, MD, PhD10*, Jesús F. San-Miguel, MD, PhD11, Nikhil C. Munshi, MD12 and Shari Kaiser13*

1Department of Hematology, Centre for Applied Medical Research, Cancer Center Clinica Universidad de Navarra, University of Navarra, IdiSNA, CIBERONC, Pamplona, Spain
2Clinica Universidad De Navarra, Centro De Investigacion Medica Aplicada (CIMA),, Pamplona, ESP
3Bristol Myers Squibb, Princeton, NJ
4Bristol-Myers Squibb, Brisbane, CA
5Harold C. Simmons Comprehensive Cancer Center, UT Southwestern Medical Center, Dallas, TX
6Sarah Cannon Center For Blood Cancers, Nashville, TN
7Winship Cancer Institute of Emory University, Atlanta, GA
8Harvard Medical School, Massachusetts General Hospital Cancer Center, Boston, MA
9Division of Hematology, Mayo Clinic, Rochester, MN
10Department of Hematology, Nantes University Hospital, Nantes, France
11Clínica Universidad de Navarra, Centro de Investigación Médica Aplicada, Universidad de Navarra, CCUN, IDISNA, CIBER-ONC CB16/12/00369, Pamplona, Spain, Pamplona, Spain
12Dana-Farber Cancer Institute, Boston, MA
13Bristol Myers Squibb, Seattle, WA

*signifies non-member of ASH