-Author name in bold denotes the presenting author
-Asterisk * with author name denotes a Non-ASH member
Clinically Relevant Abstract denotes an abstract that is clinically relevant.

PhD Trainee denotes that this is a recommended PHD Trainee Session.

Ticketed Session denotes that this is a ticketed session.

654.O2.6 654. Multiple Myeloma: Pharmacologic Therapies: Targeting BCMA

Symposia: Multiple Myeloma: Pharmacologic Therapies Program: Oral and Poster Abstracts
Type: Oral
Hematology Disease Topics & Pathways:
Research, Clinical trials, Combination therapy, Adult, Antibody Therapy, Drug development, Bispecific Antibody Therapy, Clinical Research, Plasma Cell Disorders, Diseases, Treatment Considerations, Biological therapies, Lymphoid Malignancies, Adverse Events, Study Population, Human, Measurable Residual Disease
Sunday, December 8, 2024: 9:30 AM-11:00 AM
Pacific Ballroom Salons 18-19 (Marriott Marquis San Diego Marina)
Moderators:
Joshua Richter, MD, Icahn School of Medicine at Mount Sinai and Andrew J. Yee, MD, Massachusetts General Hospital Cancer Center
Disclosures:
Richter: Johnson & Johnson - Janssen: Consultancy, Speakers Bureau; Sanofi: Consultancy, Speakers Bureau; Bristol-Myers Squibb: Consultancy, Speakers Bureau; Pfizer: Consultancy; Karyopharm: Consultancy; AbbVie: Consultancy; Takeda: Consultancy; Regeneron: Consultancy; Adaptive Biotechnologies: Speakers Bureau; Genentech: Consultancy. Yee: AbbVie: Consultancy; Adaptive Biotechnologies: Consultancy; Amgen: Consultancy; BMS: Consultancy; GSK: Consultancy; J&J: Consultancy; Karyopharm: Consultancy; Pfizer: Consultancy; Prothena: Consultancy; Regeneron: Consultancy; Sanofi: Consultancy; Sebia: Consultancy; Takeda: Consultancy.

This session features presentations exploring the novel use of anti-BCMA therapies in newly diagnosed and relapsed multiple myeloma.
9:30 AM

Marc S. Raab, M.D.1*, Niels Weinhold, PhD2*, K. Martin Kortüm, MD3*, Jan Krönke, MD4,5, Lilli Podola6*, Uta Bertsch, MD6*, Jan H. Frenking, MD2*, Julia Mersi, MD7*, Stefanie Huhn, PhD6*, Michael Hundemer, MD6*, Gunhild Mechtersheimer, MD8*, Roland Fenk, MD, PhD9*, Katja C. Weisel, MD10, Natalie Schub11*, Florian Bassermann, MD12*, Monika Engelhardt, MD13, Raphael Teipel, MD14*, Mathias Hänel, MD15, Hans Salwender, MD16*, Bas D Koster, MD, PhD17, Elena Ershova18*, Caline Sakabedoyan19*, Isobel Barrott20*, Agnes Balogh18*, Sanjay Vara, BSc20*, Tobias Kampfenkel, MD, MHBA21*, Hartmut Goldschmidt, MD1, Hermann Einsele, MD7 and Leo Rasche, MD7*

1Heidelberg Myeloma Center, Heidelberg, Germany
2Heidelberg Myeloma Center, Department of Medicine V, University Hospital Heidelberg, Heidelberg, Germany
3Department of Internal Medicine II, University Hospital of Würzburg, Wuerzburg, Germany
4Ulm University, Ulm, Germany
5Department for Hematology, Oncology, and Tumor Immunology, Charité – Universitätsmedizin Berlin, Berlin, Germany
6Heidelberg Myeloma Center, Department of Medicine V, Heidelberg University Hospital, Heidelberg, Germany
7Department of Internal Medicine II, University Hospital of Würzburg, Würzburg, Germany
8Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany
9Department for Hematology, Oncology and Clinical Immunology, Medical Faculty, Heinrich Heine University Dusseldorf, Moorenstr. 5, 40225, Hamburg, Germany
10University Medical Center of Hamburg-Eppendorf, Hamburg, Germany
11Department of Internal Medicine II, Division of Stem Cell Transplantation and Immunotherapy, UKSH Campus, Kiel, Germany
12Department of Medicine III, Klinikum Rechts der Isar, Technische Universität München, München, Germany German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
13Department of Hematology, Oncology and Stem Cell Transplantation, Medical Centre - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
14Medizinische Klinik und Poliklinik 1, Universitätsklinikum Carl Gustav Carus an der TU Dresden, Dresden, Germany
15Department of Internal Medicine III, Klinikum Chemnitz, Chemnitz, Germany
16Asklepios Tumorzentrum Hamburg, AK Altona and AK St Georg, Hamburg, Germany
17Janssen Research & Development, LLC, Leiden, Netherlands
18Janssen Research & Development, LLC, Beerse, Belgium
19Janssen Research & Development, LLC, Paris, France
20Janssen Research & Development, LLC, High Wycombe, United Kingdom
21Janssen Research & Development, Neuss, Germany

9:45 AM

Elena Zamagni, MD1*, Tobias Silzle, MD2*, Ivan Špička3*, Sabrin Tahri, MD4*, Sarah Lonergan4*, Inger S. Nijhof, MD, PhD5*, Antonietta Pia Falcone, MD, PhD6*, Evangelos Terpos7*, Jakub Radocha, MD, PhD8*, Roberto Mina9*, Guldane Cengiz Seval, MD10*, Meral Beksac, MD11, Cesar Rodriguez, MD12*, Marcelo C. Pasquini, MD, MS13,14, Michel Delforge15*, Vania Hungria, MD, PhD16, Donna Reece, MD17, Philippe Moreau, MD, PhD18*, Yael C. Cohen19, Kihyun Kim, MD20*, Dominik Dytfeld21*, Jiří Minařík22, Irene Strassl23*, Jelena Bila, MD24*, Martin Schreder, MD25*, Janusz Krawczyk, MD26, Fredrik Schjesvold, MD, PhD27, Caroline Cicin-Sain28*, Christoph Driessen29, Gordon Cook30*, Lugui Qiu, MD31, Gonzalo Martin Garate, MD32*, Agoston Gyula Szabo, MD, PhD33, Roman Hájek34, Marc S. Raab, M.D.35*, Silvia Mangiacavalli, MD36*, Hermann Einsele, MD37, Andrew Spencer, MBBS38*, Mario Boccadoro, MD39,40, Helen Vassalou41*, Lixia Pei42*, Yingqi Shi43*, Maria Krevvata, PhD44*, Ryan Gruber44*, Caline Sakabedoyan45*, Margaret Cobb46*, Jagoda Jasielec43*, Himal Amin43*, Rachel Kobos, MD43, Pieter Sonneveld, MD47 and Niels W.C.J. van de Donk, MD, PhD48*

1IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia "Seràgnoli", and Dipartimento di Scienze Mediche e Chirurgiche, Università di Bologna, Bologna, Italy
2Department of Medical Oncology and Hematology, Cantonal Hospital St. Gallen, St. Gallen, Switzerland
3Charles University and General Hospital, Prague, Czech Republic
4European Myeloma Network, Rotterdam, Netherlands
5Department of Internal Medicine-Hematology, St Antonius Hospital Nieuwegein, Nieuwegein, Netherlands
6Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Casa Sollievo della Sofferenza, Unità di Ematologia, San Giovanni Rotondo, Italy
7University of Athens, School of Medicine, Athens, Greece
84th Department of Internal Medicine – Hematology, University Hospital Hradec Kralove and Faculty of Medicine in Hradec Kralove, Charles University Czech Republic, Hradec Kralove, Czech Republic
9AOU Città della Salute e della Scienza di Torino, University of Torino, Torino, Italy
10Department of Hematology, Ankara University Faculty of Medicine, Department of Hematology, Mamak, Ankara, Turkey
11Department of Hematology, Ankara University Faculty of Medicine, Department of Hematology, Ankara, Turkey
12Department of Medicine, Hematology and Medical Oncology, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY
13Division of Hematology and Oncology, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI
14Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI
15University of Leuven, Leuven, Belgium
16Clinica São Germano, São Paulo, Brazil
17Princess Margaret Cancer Centre, Toronto, ON, Canada
18University Hospital Hôtel-Dieu, Nantes, France
19Department of Hematology, Tel-Aviv Sourasky (Ichilov) Medical Center, and Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
20Department of Medicine, Sungkyunkwan University School of Medicine, Samsung Medical Center, Seoul, Korea, Republic of (South)
21The Department of Hematology and Bone Marrow Transplantation, Poznan University of Medical Sciences, Poznań, Poland
22Department of Hematooncology, University Hospital and Palacky University Olomouc, Olomouc, Czech Republic
23Division of Hematology with Stem Cell Transplantation, Hemostaseology and Medical Oncology, Department of Internal Medicine I, Ordensklinikum Linz, Linz, Austria
24Faculty of Medicine, University of Belgrade, University Clinical Centre of Serbia, Belgrade, Serbia
25First Department of Medicine, Klinik Ottakring, Vienna, Austria
26Department of Haematology, University Hospital Galway, H91 Galway, Ireland; National University of Ireland, H91, Galway, Ireland
27Oslo Myeloma Center, and KG Jebsen Center for B-cell Malignancies, University of Oslo, Oslo, Norway
28Department Oncology/Hematology, Kantonsspital St. Gallen, St. Gallen, Switzerland, Zurich, CHE
29Cantonal Hospital St. Gallen, St. Gallen, Switzerland
30Cancer Research UK Clinical Trials Unit, Leeds Institute of Clinical Trials Research, University of Leeds, Leeds, United Kingdom
31Department of Lymphoma, Chinese Academy of Medical Sciences, Blood Diseases Hospital (Institute of Hematology), Tianjin, China
32Department of Hematology, Hospital Alemán, Buenos Aires, Argentina
33Department of Hematology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
34University Hospital Ostrava and Faculty of Medicine, University of Ostrava, Ostrava, Czech Republic
35Heidelberg Myeloma Center, Department of Medicine V, University Hospital Heidelberg, Heidelberg, Germany
36IRCCS Fondazione Policlinico San Matteo, Pavia, Italy
37Department of Internal Medicine II, University Hospital Wuerzburg, Wuerzburg, Germany
38Alfred Health-Monash University, Melbourne, VIC, Australia
39Myeloma Unit, Division of Hematology, University of Torino, Azienda Ospedaliero-Universitaria Città della Salute e della Scienza di Torino, Torino, Italy
40European Myeloma Network, EMN, Italy
41Health Data Specialists, Dublin, Ireland
42Janssen Research& Development, LLC, Raritan, NJ
43Janssen Research & Development, LLC, Raritan, NJ
44Janssen Research & Development, LLC, Spring House, PA
45Janssen Research & Development, LLC, Paris, France
46Janssen Research & Development, LLC, High Wycombe, United Kingdom
47Erasmus MC Cancer Institute, Rotterdam, Netherlands
48Department of Hematology, Amsterdam University Medical Center, Vrije Universiteit Amsterdam, Amsterdam, Netherlands

10:00 AM

Anita D'Souza, MD, MS1*, Luciano J. Costa, MD, PhD2, Jesús F. San-Miguel, MD, PhD3, Jesus G Berdeja, MD4, Daniel Morillo Giles, MD5*, Cyrille Touzeau, MD, PhD6*, John T McKay, DO7*, Bhagirathbhai R. Dholaria, MBBS8, Thomas G. Martin, MD9, Aurore Perrot, MD, PhD10, Albert Oriol11*, Anna Sureda Balari, MD, PhD12, Thomas Prior, PhD13*, Debopriya Ghosh, PhD14*, Lijuan Kang, PhD13*, Julie S Larsen, PharmD15*, Hein Ludlage, MSc16*, Lien Vandenberk, PhD17*, Lingling Chen, MD13*, Bas D Koster, MD, PhD18, Weili Sun, PhD15, Rachel Kobos, MD19, Emma Searle, MD, PhD20*, Jeffrey V Matous, MD21, Ajai Chari, MD9 and Tobias Kampfenkel, MD, MHBA22*

1Medical College of Wisconsin, Milwaukee, WI
2University of Alabama at Birmingham, Birmingham, AL
3Cancer Center Clinica Universidad de Navarra, CIMA, IDISNA, Pamplona, Spain
4Tennessee Oncology, Sarah Cannon Research Institute, Nashville, TN
5START Madrid-FJD Early Phase Unit, Fundación Jiménez Díaz University Hospital, Madrid, Spain
6Centre Hospitalier Universitaire de Nantes, Nantes, France
7Wake Forest University School of Medicine, Winston-Salem, NC
8Vanderbilt University Medical Center, Nashville, TN
9University of California, San Francisco, San Francisco, CA
10Centre Hospitalier Universitaire de Toulouse, Oncopole, Toulouse, France
11Institut Català d'Oncologia and Institut Josep Carreras, Hospital Germans Trias i Pujol, Baldona, Barcelona, Spain
12Institut Català d'Oncologia – Hospitalet, IDIBELL, University of Barcelona, Barcelona, Spain
13Janssen Research & Development, Spring House, PA
14Janssen Research & Development, Raritan, NJ
15Janssen Research & Development, Los Angeles, CA
16Janssen-Cilag Benelux, Leiden, Netherlands
17Janssen Research & Development, Antwerp, Belgium
18Janssen Biologics Europe, Leiden, Netherlands
19Janssen Research & Development, LLC, Raritan, NJ
20The University of Manchester, Manchester, United Kingdom
21Sarah Cannon Research Institute, Colorado Blood Cancer Institute, Denver, CO
22Janssen Research & Development, Neuss, Germany

10:15 AM

Cesar Rodriguez, MD1*, Michal Mielnik, MD2*, Dickran Kazandjian, MD3, Wojt Janowski, MD4*, Michael S.Y. Low, MBBS, PhD5, Matthew Pianko6, Junichiro Yuda, MD, PhD7*, Carrie Van Der Weyden, MBBS (Hons), FRACP, FRCPA8*, Larry D Anderson Jr., MD, PhD9, Rahul Banerjee, MD, FACP10, Laura Rosinol Dachs, MD PhD11*, Claudio Cerchione, MD12, Malin Hultcrantz, MD13, Anita D'Souza, MD, MS14*, Amandeep Godara15, Ariel Grajales-Cruz16*, Ziyi Jin, MS17*, Akshanth R Polepally, PhD18*, Aarif Ahsan17*, Shane Lee, MS17*, Kristin D'Amico17*, Orlando Bueno, MD, PhD17, Chetasi Talati, MD19*, Anders Erik Svensson, MD17*, Leanne Fleming, PhD17*, Katja C. Weisel, MD20, Marek Hus21* and Peter M. Voorhees, MD22

1Division of Hematology-Oncology, Department of Internal Medicine, Mount Sinai, New York, NY
2Department of Hematooncology and Bone Marrow Transplantation, Medical University of Lublin, Lublin, Poland
3Myeloma Division, Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL
4Calvary Mater Newcastle, Newcastle, NSW, Australia
5School of Clinical Sciences at Monash Health, Monash University, Clayton, AUS
6Rogel Cancer Center, University of Michigan, Ann Arbor, MI
7National Cancer Center Hospital East, Kashiwa, Japan
8Department of Hematology, Peter MacCallum Cancer Center, Melbourne, VIC, AUS
9Myeloma, Waldenstrom's, and Amyloidosis Program, Simmons Comprehensive Cancer Center, UT Southwestern Medical Center, Dallas, TX
10University of Washington, Fred Hutchinson Cancer Center, Seattle, WA
11Hematology Department, Hospital Clinic de Barcelona and Insitut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
12Hematology Unit, Istituto Romagnolo per lo Studio dei Tumori "Dino Amadori" - IRST IRCCS, Meldola (FC), Italy
13Myeloma Service, Division of Hematologic Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY
14Division of Hematology and Oncology, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI
15Huntsman Cancer Institute, Salt Lake City, UT
16Department of Malignant Hematology, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL
17AbbVie Inc., North Chicago, IL
18AbbVie Inc., Danville, CA
19AbbVie, Inc., North Chicago, IL
20Department of Oncology, Hematology and Bone Marrow Transplantation with Section of Pneumology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
21Department of Hemato Oncology and Bone Marrow Transplantation, Medical University of Lublin, Lubin, Poland
22Levine Cancer Institute, Atrium Health Wake Forest University School of Medicine, Charlotte, NC

10:30 AM

Saad Z. Usmani, MD1, Michal Mielnik, MD2*, Mamta Garg, MD3*, Irwindeep Sandhu, MD4*, Al-Ola Abdallah, MD5, Youngil Koh, MD, PhD6, Albert Oriol7,8*, Hang Quach, MD, FRACP, FRCPA, MBBS9, Katja C. Weisel, MD10, Aranzazu Alonso Alonso, MD11*, Enrique M Ocio, MD, PhD8*, Wojciech Janowski, MD12*, Chang-Ki Min13*, Karthik Ramasamy14, Ricarda García Sánchez, MD15*, Paula Rodríguez-Otero, MD, PhD16*, Chris Brawley, MSc17*, Jacqueline L Egger, PhD17*, Morrys C Kaisermann, MD, PhD18* and Marek Hus, MD, PhD19*

1Myeloma Service, Division of Hematologic Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY
2Department of Hematooncology and Bone Marrow Transplantation, Medical University of Lublin, Lublin, Poland
3Leicester Royal Infirmary, Leicester, United Kingdom
4University of Alberta, Edmonton, AB, Canada
5US Myeloma Innovations Research Collaborative (USMIRC), Kansas City, KS
6Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea, Republic of (South)
7Institut Català d'Oncologia and Institut Josep Carreras, Hospital Germans Trias i Pujol, Baldona, Barcelona, Spain
8Hospital Universitario Marqués de Valdecilla (IDIVAL), Universidad de Cantabria, Santander, Spain
9St. Vincent's Hospital Melbourne, East Melbourne, Australia
10University Medical Center of Hamburg-Eppendorf, Hamburg, Germany
11Hospital Universitario Quirónsalud Madrid, Madrid, Spain
12Calvary Mater Newcastle, Newcastle, NSW, Australia
13Department of Hematology, Seoul St. Mary's Hospital,The Catholic University of Korea, Seoul, Korea, Republic of (South)
14Oxford Translational Myeloma Centre, NDORMS, University of Oxford and Churchill Hospital, Headington, Oxford, United Kingdom
15Department of Hematology, Hospital Virgen de la Victoria, Málaga, Spain
16Clinica Universidad de Navarra, Madrid, Spain
17GSK, London, United Kingdom
18GSK, Upper Providence, PA
19Medical University of Lublin, Lublin, Poland

10:45 AM

Peter T. Tan, MBBS1, LI Bao2*, Qingsong Yin, PhD3*, Chunrui Li4*, Sorab Jehangir Shavaksha5*, H. Miles Prince6*, Zhen Cai7*, SHAN GAO, PhD, MD8*, Qian Wang3*, Di Wang4*, YI LI9*, Mingfei Zhang10*, Qiumei Deng11*, Qiaoyang Lu10*, Chengjun Jiang10*, Fang Ren10*, Danqing Wu10*, Shuqi Zeng10*, Yonghong Zhu10*, Yi Tao12*, Yuanfang Liu, MD, PhD13* and Jian-Qing Mi12

1One Clinical Research Pty Ltd, Nedlands, Australia
2Beijing Jishuitan Hospital, Beijing, Beijing, CHN
3Department of Hematology, The Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, China
4Tongji Hospital, Tongji Medical College of Huazhong University of Science & Technology, China, Wuhan, China
55Sunshine Coast Haematology and Oncology Clinic (SCHOC), Australia, Buderim, QLD, Australia
6Epworth Healthcare and University of Melbourne, Melbourne, VIC, Australia
7Department of Haematology, First Affiliated Hospital of Zhejiang University, Hangzhou, China
8Beijing Jishuitan Hospital, Beijing, Beijing, China
9The First Affiliated Hospital, Zhejiang University School of Medicine, China, Hangzhou, China
10Shanghai EpimAb Biotherapeutics, Shanghai, China, Shanghai, China
11Epimab Biotherapeutics, Shanghai, China
12Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
13Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Centre for Translational Medicine at Shanghai, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China

*signifies non-member of ASH