-Author name in bold denotes the presenting author
-Asterisk * with author name denotes a Non-ASH member
Clinically Relevant Abstract denotes an abstract that is clinically relevant.

PhD Trainee denotes that this is a recommended PHD Trainee Session.

Ticketed Session denotes that this is a ticketed session.

642A.O2.6 642. Chronic Lymphocytic Leukemia: Clinical and Epidemiological: Mutations, Prognosis and MRD in CLL

Symposia: Chronic Lymphocytic Leukemia: Clinical and Epidemiological Program: Oral and Poster Abstracts
Type: Oral
Hematology Disease Topics & Pathways:
Research, Clinical trials, Lymphoid Leukemias, Combination therapy, Adult, CLL, Clinical Research, Health outcomes research, Diseases, Therapy sequence, Treatment Considerations, Real-world evidence, Lymphoid Malignancies, Technology and Procedures, Human, Study Population, Measurable Residual Disease , Molecular testing
Sunday, December 8, 2024: 12:00 PM-1:30 PM
Marriott Grand Ballroom 8-9 (Marriott Marquis San Diego Marina)
Moderators:
Allison M. Winter, MD, and Alexey V. Danilov, MD, PhD, City of Hope National Medical Center
Disclosures:
Winter: BeiGene: Consultancy; BTG Pharmaceuticals: Consultancy; AstraZeneca: Consultancy; ADC Therapeutics: Consultancy. Danilov: Abbvie: Consultancy, Research Funding; ADCT: Consultancy; AstraZeneca: Consultancy, Research Funding; BeiGene: Consultancy; Bayer Oncology: Research Funding; Bristol Meyers Squibb: Consultancy, Research Funding; Genentech: Consultancy; Cyclacel: Research Funding; GenMab: Consultancy, Research Funding; Incyte: Consultancy; Janssen: Consultancy; Lilly Oncology: Consultancy, Research Funding; MEI Pharma: Consultancy, Research Funding; Merck: Consultancy; Morphosys: Consultancy; Takeda Oncology: Research Funding; TG Therapeutics: Research Funding; Nurix: Consultancy, Research Funding; Prelude: Consultancy.

Novel agents, prognostic markers, and QOL in CLL.
12:00 PM

Roberta Santos Azevedo1*, Mariia Mikhaleva, MD2*, Kiyomi Mashima, MD, PhD2, Stephen Martindale, BS2*, Stacey M. Fernandes, BS2*, Svitlana Tyekucheva, PhD2,3*, Inhye E. Ahn, MD2,4, Matthew S. Davids, MD, MMSc2,4 and Jennifer R. Brown, MD, PhD2,4

1Department of Medical Oncology, Dana-Farber Cancer Institute, Boston
2Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
3Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston
4Department of Medicine, Harvard Medical School, Boston, MA

12:15 PM

Anne Sophie Michallet, MD, PhD1,2*, Remi Letestu3*, Magali Legarff4*, Stéphane Morisset5*, Therese Aurran-Schleinitz, MD6*, Kamel Laribi7*, Vincent Levy, MD, PhD8*, Laurence Simon9*, Damien Roos Weil, MD10*, Marie Sarah Dilhuydy, MD11*, Cecile Tomowiak, MD12*, Caroline Dartigeas, MD13*, Romain Guieze, MD, PhD14*, Olivier Tournilhac15*, Emmanuelle Ferrant16*, Sophie De Guibert17*, Pierre Feugier, MD, PhD18*, Fatiha Merabet, MD19*, Stéphane Lepretre20*, Philippe Carassou21*, Julie Gay22*, Benedicte Hivert23*, Luc-Matthieu Fornecker, MD, PhD24*, Jehan Dupuis, MD25*, Lysiane Molina, MD26*, Bruno Villemagne, MD27*, Guillaume Cartron, MD, PhD28*, Bernard Drenou, MD29*, Omar Benbrahim, MD30*, Xavier Cahu31*, Florence Nguyen Khac32*, Valerie Rouillé33*, Loic Ysebaert, MD, PhD34* and Anne Quinquenel35*

1Hematology department, Robert Debré University Hospital, Reims, France
2UFR Médecine, Université Reims Champagne-Ardenne, Reims, France
3avicennes hospital, Avicennes, France
4APHP La pitié salpetriere, Paris, France
5Centre Léon Bérard, Fi-LMC, Lyon, France
6IPC, marseille, France
7CH Le Mans, Le mans, France
8Centre de Recherche Clinique, Hôpital Avicenne, AP-HP et Université Sorbonne, Paris, France
9hospital Corbeil essonnes, Corbeil-Essonnes, FRA
10Clinical Hematology, APHP, La Pitié Salpétriere, Sorbonne Universite, Paris, FRA
11CHU Bordeaux, PESSAC, FRA
12Hematology department & CIC 1402, Poitiers University Hospital, Poitiers, France
13CHU Bretonneau, Tours, FRA
14CHU Estaing, Clermont Ferrand, FRA
15CHU Estaing, Clermont-Ferrand University Hospital, CLERMONT FERRAND, AURA, France
16Department of Hematology, Lyon Sud Hospital, Pierre Benite, France
17Centre Hospitalier Pontchaillou, Rennes, FRA
18CHU Brabois - Service d'Hématologie - Université Henri Poincaré, Nancy, France
19andre mignot hospital, LE CHESNAY, FRA
20centre henri becquerel, Rouen, FRA
21Centre Hospitalier Regional Metz-Thionville, Hopital Mercy, Metz, France
22CH Côte basque, Bayonne, FRA
23GHICL, Lille, FRA
24Institut De Cancérologie Strasbourg Europe, Hematology Department, Strasbourg, France
25APHP, Creteil, Creteil, FRA
26CHU grenoble, grenoble, France
27CH la roche sur yon, La Roche Sur Yon, FRA
28Centre Hospitalier Universitaire de Montpellier, Montpellier, France
29Laboratoire d'Hématologie, Groupe Hospitalier de la Région Mulhouse Sud Alsace, Mulhouse, France
30HOPITAL LA SOURCE, La Source, FRA
31hospital cesson sevigne, cesson sevigne, France
32Hôpital Pitié-Salpêtrière, Service d'Hématologie, Paris, France
33CHU montpellier, montpellier, France
34Hematology Department, Institut Universitaire du Cancer Toulouse Oncopole, Toulouse, France
35CHU reims, reims, France

12:30 PM

Talha Munir, MBBS, PhD1,2,3,4, Abraham Mullasseril Varghese, MBBS, MRCP , PhD4, Adrian Bloor, Phd FRCP FRCPath5*, David Allsup, MD6*, Kate Cwynarski, MBBS, PhD, FRCP, FRCPath7,8*, Andrew Pettitt9*, Shankara Paneesha10*, Christopher P Fox, PhD11, Toby A. Eyre12*, Francesco Forconi13*, Nagah Elmusharaf14*, Ben Kennedy15*, Prof. John G. Gribben, MD, DSc16, Nicholas Pemberton17*, Oonagh Sheehy18*, Gavin Preston, PhD, MBBS, FRCP, FRCPath19*, Anna Schuh, MD20, Anna Hockaday21*, David A. Cairns, PhD22*, Sharon Jackson21*, Natasha Greatorex21*, Sean Girvan21*, Sue Bell21*, David Stones21*, Nichola McWhirter23*, Surita Dalal, PhD24*, Andrew Rawstron, PhD25*, Piers Patten, FRCP, FRCPath, PhD26 and Peter Hillmen27*

1Department of Haematology, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom
2Department of Haematology, St. James's University Hospital, Leeds, United Kingdom
3Haematology, Haematological Malignancy Diagnostic Service (HMDS), St. James’s Institute of Oncology, Leeds, United Kingdom
4Department of Haematology, St James's University Hospital, Leeds, United Kingdom
5The Christie NHS Foundation Trust, Manchester, United Kingdom
6Castle Hill Hospital, Cottingham, GBR
7Consultant Haematologist UCLH Honorary Associate Professor UCL Chair NCRI T cell Lymphoma SubGroup, University College London Hospital, London, United Kingdom
8Department Of Hematology, Royal Free Hospital, London, United Kingdom
9Royal Liverpool University Hospital, Liverpool, GBR
10Birmingham Centre for Cellular Therapy and Transplant (BCCTT), Birmingham, United Kingdom
11Department of Haematology, Nottingham University Hospital, Nottingham, United Kingdom
12Department of Clinical Haematology, Oxford University Hospitals NHS Trust, Old Road, United Kingdom
13School of Cancer Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom
14University Hospital of Wales, Cardiff, GBR
15Leicester Royal Infirmary, Leicester, GBR
16Barts Cancer Institute, Barts and The London School of Medicine, Queen Mary, University of London, London, United Kingdom
17Worcestershire Acute Hospitals NHS Trust, Worcester, United Kingdom
18Belfast Health and Social Care Trust, Belfast, United Kingdom
19Aberdeen Royal Infirmary, NHS Grampian, Aberdeen, United Kingdom
20Department of Oncology, University of Oxford, Oxford, United Kingdom
21Leeds Cancer Research UK Clinical Trials Unit, Leeds Institute of Clinical Trials Research, University of Leeds, Leeds, United Kingdom
22Cancer Research UK Clinical Trials Unit, Leeds Institute of Clinical Trials Research, University of Leeds, Leeds, United Kingdom
23HMDS, St James's Hospital, Leeds, United Kingdom
24Leeds Institute of Medical Research, University of Leeds, Leeds, United Kingdom
25Haematological Malignancy Diagnostic Service, Leeds Cancer Centre, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom
26King’s College Hospital, London, GBR
27The Leeds Teaching Hospitals, St. James Institute of Oncology, Waltham, MA

12:45 PM

Christian Brieghel, MD, PhD1*, Julie Dubois, MD, PhD2*, Ida Kappel Buhl, MD, PhD3*, Kazem Nasserinejad, PhD4,5*, Dennis De Rooij6*, Karl Nyrén, PhD7*, Hoa T Tran, MD, PhD8*, Sabina Kersting, MD, PhD9*, Mattias Mattsson, MD10*, Juha Ranti, MD11*, Rogier Mous, MD PhD12*, Gerrit Jan Veldhuis, MD13*, Caspar da Cunha-Bang, MD, PhD1*, Mark-David Levin14, Valtteri Wirta, PhD7*, Richard Rosenquist, MD, PhD15, Arnon P. Kater, MD, PhD16 and Carsten Utoft Niemann, MD, PhD1*

1Department of Hematology, Rigshospitalet, Copenhagen, Denmark
2Department of Hematology, University of Amsterdam, Amsterdam, Netherlands
3Center for Genomic Medicine, Rigshospitalet, Glostrup, Denmark
4Department of Hematology, Erasmus MC, University Medical Center, Rotterdam, Netherlands
5HOVON foundation, Rotterdam, Netherlands
6Department of Hematology, Cancer Center Amsterdam, Amsterdam UMC, Amsterdam, NLD
7Science for Life Laboratory; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden
8Akershus University Hospital, LøRenskog, NOR
9Department of Hematology, Haga Ziekenhuis, Den Haag, Netherlands
10Department of Hematology, Uppsala University Hospital, Uppsala, Sweden
11Department of Hematology, Turku University Central Hospital, Turku, Finland
12Department of Hematology, University Medical Center Utrecht, Utrecht, Netherlands
13Department of Hematology, Antonius Ziekenhuis, Sneek, Netherlands
14Department of Internal Medicine, Albert Schweitzer Hospital, Dordrecht, Netherlands
15Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
16Amsterdam University Medical Center, Amsterdam, on behalf of HOVON, Netherlands

1:00 PM

Sungchul Daniel Choi, MD1, Yue Ren, MS1*, Svitlana Tyekucheva, PhD1*, Stacey M. Fernandes, BS2*, Mariia Mikhaleva, MD1*, Kiyomi Mashima, MD, PhD1, Rayan Fardoun, MS1*, Samantha J. Shupe, BS1*, Stephen Martindale, BS1*, Matthew S. Davids, MD, MMSc3, Jennifer R. Brown, MD, PhD1 and Inhye E. Ahn, MD1

1Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
2Dana-Farber Cancer Institute, Boston, MA
3Department of Medical Oncology, Dana-Farber Cancer Institute, Inc., Boston, MA

1:15 PM

Benjamin F. Frost1,2,3*, Noelle Frey, MD, MS1,4, Elizabeth O. Hexner, MD, MSTR1,5, Stephen J. Schuster, MD1,5,6, Sunita D. Nasta, MD1,5,6, Alison W Loren, MD1,7, Jakub Svoboda, MD1,5,6, Daniel J. Landsburg, MD1,5,6, Bruce Levine, PhD1,3, Joseph A. Fraietta, PhD1,8*, J. Joseph Melenhorst, PhD1,3,9, Elizabeth Veloso, BSN3*, Wei-Ting Hwang1*, Carl H. June, MD1,3,5, David L. Porter, MD1,3,5,6 and Saar Gill, MD, PhD1,4,8

1Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA
2Department of Medicine, Brigham and Women's Hospital, Boston, MA
3Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA
4University of Pennsylvania, Philadelphia, PA
5Abramson Cancer Center, Department of Medicine, Division of Hematology-Oncology, University of Pennsylvania, Philadelphia, PA
6Lymphoma Program, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA
7Abramson Cancer Center, University of Pennsylvania Medical Center, Philadelphia, PA
8Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA
9Center for Immunotherapy and Precision Immuno-Oncology, Cell Therapy & Immuno-Engineering Program, Lerner Research Institute, Cleveland Clinic, Cleveland, OH

*signifies non-member of ASH