Cornelis A.M. van Bergen^1*, Edwin Quinten, BS^1*, Julieta Haydeé Sepulveda Yanez, MSc^2*, Ramin Monajemi, MSc^3*, Roberta Menafra, PhD^4*, Susan L. Kloet, PhD^4*, Szymon M. Kiełbasa, PhD^3* and Hendrik Veelken, MD, PhD ⁵

¹Hematology, Leiden University Medical Center, Leiden, Netherlands
²Leiden University Medical Center, Leiden, NLD
³Biomedical Data Sciences, Leiden University Medical Center, Leiden, Netherlands
⁴Human Genetics, Leiden University Medical Center, Leiden, Netherlands
⁵Leiden University Medical Center, Leiden, Netherlands

Marwan Kwok, MD, PhD, FRCPath, MRCP^1,2,3,4,5, Catherine Gutierrez, MD, PhD^1,2,3, Neil Ruthen^1*, Peyton Waddicor^1,2*, Tamara Ouspenskaia^3*, Christina Curran^1,6*, Doris Fu^3,7*, Binyamin Knisbacher, PhD^3,8, Anat Biran, PhD^1*, Adi Nagler, PhD^1,2,3*, Aviv Liani^1,6*, Sarah Chen^3*, Gregory Lazarian, PharmD^1,9,10*, Elizabeth Witten^11*, Gabriela Brunsting Hoffmann^1*, Emma Lin^1*, Lucas Pomerance^1,2*, Shuqiang Li, PhD^1,3,12*, Lili Wang, MD, PhD^13,14, Kenneth J. Livak, PhD^1,12*, Donna S. Neuberg, ScD¹⁵, Gad Getz, PhD^3,16,17*, Elisa Ten Hacken, PhD^1,18 and Catherine J. Wu, MD^1,2,3*

¹Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
²Harvard Medical School, Boston, MA
³Broad Institute of MIT and Harvard, Cambridge, MA
⁴Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, United Kingdom
⁵Centre for Clinical Haematology, Queen Elizabeth Hospital Birmingham, Birmingham
⁶Northeastern University, Boston, MA
⁷Massachusetts Institute of Technology, Cambridge, MA
⁸Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat Gan, Israel
⁹INSERM U978, Université Sorbonne Paris Nord, Bobigny, France
¹⁰Hematology Laboratory, Avicenne University Hospital, Assistance Publique – Hôpitaux de Paris, Bobigny, France
¹¹Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA
¹²Translational Immunogenomics Lab, Dana-Farber Cancer Institute, Boston, MA
¹³Department of Systems Biology, City of Hope Comprehensive Cancer Center, Duarte, CA
¹⁴Department of Systems Biology, City of Hope, Duarte, CA
¹⁵Department of Data Science, Dana-Farber Cancer Institute, Boston, MA
¹⁶Department of Pathology, Massachusetts General Hospital, Boston, MA
¹⁷Krantz Family Center for Cancer Research and Dept. of Pathology, Massachusetts General Hospital, Boston, MA
¹⁸Division of Hematology and Medical Oncology, Weill Cornell Medical College, Weill Cornell Medicine, New York City, NY

Claudio Martines, PhD^1*, Supriya Chakraborty, PhD^1*, Giulia Felician, PhD^1*, Karin Hofmann, MS^1*, Sasha Blasutig, MS^1*, Ivan Negara^1*, Alice Bonato, PhD^1*, Marija Vujovikj, MS^2*, Alberto Zamò, MD^3*, Andreas Rosenwald, MD^4*, Aleksandar J Dimovski, MD, PhD^2* and Dimitar G Efremov, MD, PhD⁵

¹Molecular Hematology, International Centre for Genetic Engineering and Biotechnology, Trieste, Italy
²RCGEB, Macedonian Academy of Sciences and Arts, Skopje, MKD
³Institute of Pathology, Julius-Maximilians-Universität Würzburg, Würzburg, Germany
⁴Comprehensive Cancer Center Mainfranken, University Hospital Würzburg, Würzburg, Germany
⁵Molecular Hematology, International Centre for Genetic Engineering and Biotechnology, Trieste, TS, Italy

Prajish Iyer, PhD¹, Brian Jiang^2*, Girish Venkataraman, MD, MBBS³, Joo Y. Song, MD⁴, Wing Chung Chan, MD⁵, Tanya Siddiqi, MD^6,7, Steven T. Rosen, MD^8,9, Alexey Danilov, MD, PhD^10,11, Antje Gohla^12* and Lili Wang, MD, PhD¹³

¹Department of Systems Biology, Beckman Research Institute, City of Hope National Comprehensive Cancer, Monrovia, CA
²Department of Systems Biology, Beckman Research Institute, City of Hope National Comprehensive Cancer, Monrovia
³Department of Pathology, University of Chicago, Chicago, IL
⁴Department of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, CA
⁵Department of Pathology, City of Hope National Medical Center, Duarte, CA
⁶Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA
⁷Toni Stephenson Lymphoma Center, Beckman Research Institute, Duarte
⁸City of Hope Comprehensive Cancer Center, Toni Stephenson Lymphoma Center, Beckman Research Institute, Duarte, CA
⁹Department of Hematology and Hematopoietic Cell Transplantation, Beckman Research Institute, City of Hope, Duarte, CA
¹⁰City of Hope Comprehensive Cancer Center, La Canada Flintridge, CA
¹¹Toni Stephenson Lymphoma Center, Beckman Research Institute, City of Hope Comprehensive Cancer Center, Duarte, CA
¹²University of Wuerzburg, Wuerzburg, DEU
¹³Department of Systems Biology, City of Hope, Duarte, CA

Elisa Ten Hacken, PhD^1,2, Johan Gustafsson, PhD^3,4,5*, Chiara Tomasoni, PhD^1*, Gabriela Brunsting Hoffmann^6*, Kayla Cruz^6*, Wesley S Lu, BS^7*, Shuqiang Li^8*, Nicholas Haradhvala, PhD^3*, Connor Johnson, BA^3*, Stephanie Deng^2*, Xia Bu, PhD^2*, Donna S. Neuberg, ScD⁹, Othman Al-Sawaf, MD¹⁰, Barbara F. Eichhorst, MD¹⁰, Clare Sun, MD¹¹, Erin M. Parry, MD, PhD^2,3,12,13, Gordon J. Freeman, PhD^2,13*, Gad Getz, PhD^3,14,15* and Catherine J. Wu, MD^2,3,12,13*

¹Division of Hematology and Medical Oncology, Weill Cornell Medical College, Weill Cornell Medicine, New York City, NY
²Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
³Broad Institute of MIT and Harvard, Cambridge, MA
⁴TIMM Laboratory at Sahlgrenska Center for Cancer Research, University of Gothenburg, Gothenburg, Sweden
⁵Department of Medical Biochemistry and Cell Biology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
⁶Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA
⁷Translational Immunogenomics Lab, Dana-Farber Cancer Institute, Boston, MA
⁸Dana Farber Cancer Institute, Translational Immunogenomics Laboratory, Boston, MA
⁹Department of Data Science, Dana-Farber Cancer Institute, Boston, MA
¹⁰Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf; German CLL Study Group, University of Cologne, Cologne, Germany, Cologne, Germany
¹¹National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD
¹²Brigham and Women's Hospital, Boston, MA
¹³Harvard Medical School, Boston, MA
¹⁴Department of Pathology, Massachusetts General Hospital, Boston, MA
¹⁵Krantz Family Center for Cancer Research and Dept. of Pathology, Massachusetts General Hospital, Boston, MA

Chiara Cosentino^1*, Samir Mouhssine^2*, Mohammad Almasri^1*, Ilaria Romano, MD^3,4, Lodovico Terzi Di Bergamo^5*, Jana Nabki^2*, Luca Cividini^2*, Bashar Al Deeban^1*, Francesca Maiellaro^1*, Abel Mehari Sium^1*, Annalisa Gaglio^6*, Francesca Perutelli, MD^7*, Valentina Griggio^7*, Riccardo Dondolin, MD^8*, Matteo Bellia^8*, Silvia Rasi^9*, Eleonora Secomandi^2*, Sreekar Kogila^1*, Joseph Ghanej^2*, Elisa Albi^10*, Candida Vitale, MD, PhD^11*, Lydia Scarfo, MD^12,13, Paolo Ghia, MD, PhD^14,15, Marta Coscia, MD, PhD^11,16*, Valter Gattei, MD¹⁷, Antonella Zucchetto, PhD^17*, Davide Rossi, MD, PhD¹⁸, Gianluca Gaidano, MD, PhD¹⁹ and Riccardo Moia, MD^1*

¹Division of Hematology, Department of Translational Medicine, Università del Piemonte Orientale, Novara, Italy
²Università Del Piemonte Orientale, Novara, ITA
³Institute of Oncology Research, Laboratory of Experimental Hematology, Bellinzona, Switzerland
⁴Swiss Group for Clinical Cancer Research (SAKK), Bern, Switzerland, Bern, Switzerland
⁵Institute of Oncology Research, Bellinzona, CHE
⁶Clinical and Experimental Onco-Haematology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy
⁷A.O.U. Città della Salute e della Scienza di Torino e Dipartimento di Biotecnologie Molecolari e Scienze per la Salute, Università di Torino, Torino, Italy
⁸Division of Hematology, Department of Translational Medicine, Università del Piemonte Orientale, Novara, ITA
⁹Division of Hematology, Department of Translational Medicine, Università del Piemonte Orientale, Novara, Novara, ITA
¹⁰Strategic Research Program on CLL, IRCCS Ospedale San Raffaele, Milano, Italy
¹¹Division of Hematology, A.O.U. Città della Salute e della Scienza di Torino and Department of Molecular Biotechnology and Health Sciences, University of Torino, Turin, Italy
¹²Università Vita Salute San Raffaele, Milano, Italy
¹³Division of Experimental Oncology, IRCCS Ospedale San Raffaele Milan Italy., Milano, Italy
¹⁴Università Vita-Salute San Raffaele, Milano, Italy
¹⁵Division of Experimental Oncology, B cell neoplasia, IRCCS Ospedale San Raffaele, Milan, Italy
¹⁶Hematology Division, ASST Sette Laghi, Ospedale di Circolo, Varese, Italy
¹⁷Clinical and Experimental Onco-Hematology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy
¹⁸Oncology Institute of Southern Switzerland, Bellinzona, Switzerland
¹⁹Division of Hematology, Department of Translational Medicine, University of Eastern Piedmont, Novara, Italy