Lodovico Terzi Di Bergamo^1*, Gabriela Forestieri^1*, Jui Wan Loh^2*, Amartya Singh^3*, Valeria Spina^4*, Federico Jauk, MD^1*, Antonella Zucchetto, PhD^5*, Adalgisa Condoluci, MD¹, Alessio Bruscaggin, PhD^1*, Katia Pini^1*, Deborah Piffaretti, PhD^6*, Elisa Civanelli, MSc^7*, Chiara Tarantelli, PhD^7*, Matin Salehi^1*, Ilaria Romano, MD¹, Maria Cristina Pirosa, MD¹, Simone Bocchetta, PhD^1*, Georgia Alice Galimberti^8*, Tamara Bittolo, PhD^5*, Erika Tissino, PhD^9*, Lorenzo De Paoli^10*, Clara Deambrogi^11*, Anna Maria Frustaci, MD^12*, Francesco Autore, MD, PhD^13*, Michele Merli^14*, Lydia Scarfo, MD¹⁵, Silvia Rasi^16*, Marina Deodato, MD^12*, Jakob Passweg Sr.¹⁷, Riccardo Moia, MD^18*, Claudio Martines, PhD^19*, Paolo Ghia²⁰, Franco Cavalli, MD^21*, Emanuele Zucca, MD²², Bernhard Gerber^23*, Georg Stussi, MD^23*, Marco Montillo²⁴, Francesco Passamonti, MD^25*, Michael Gregor, MD^26*, Luca Laurenti, MD^27*, Alessandra Tedeschi, MD^12*, Alexandar Tzankov, MD, PhD^28*, Francesco Bertoni, MD²⁹, Gianluca Gaidano, MD, PhD³⁰, Dimitar G Efremov, MD, PhD³¹, Valter Gattei, MD^5,32, Hossein Khiabanian, PhD^3* and Davide Rossi, MD, PhD¹

¹Institute of Oncology Research, Laboratory of Experimental Hematology, Bellinzona, Switzerland
²Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore, Singapore
³Rutgers University, New Brunswick, NJ
⁴Laboratorio di Diagnostica Molecolare, Servizio di Genetica Medica EOLAB, Ente Ospedaliero Cantonale, Bellinzona, Switzerland
⁵Clinical and Experimental Onco-Hematology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy
⁶Institute of Oncology Research, Laboratory of Experimental Hematology, Bellinzona, AL, Switzerland
⁷Institute of Oncology Research, Faculty of Biomedical Sciences, USI, Bellinzona, Switzerland
⁸Institute of Oncology Research, Bellinzona, Switzerland
⁹Clinical and Experimental Onco-Hematology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Pn, Italy
¹⁰Division of Hematology, Department of Translational Medicine, University of Eastern Piedmont, Novara, Italy
¹¹Division of Hematology, Department of Translational Medicine, Università del Piemonte Orientale, Novara, ITA
¹²Department of Hematology, Niguarda Cancer Center, ASST Grande Ospedale Metropolitano Niguarda, Milano, Italy
¹³Hematology Section, Department of Radiological and Hematological Science, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy
¹⁴Hematology, University Hospital "Ospedale di Circolo e Fondazione Macchi" - ASST Sette Laghi, Varese, Italy
¹⁵Division of Experimental Oncology, IRCCS Ospedale San Raffaele Milan Italy., Milano, Italy
¹⁶Division of Hematology, Department of Translational Medicine, Università del Piemonte Orientale, Novara, Novara, ITA
¹⁷University Hospital Basel, Basel, Switzerland
¹⁸Novara, Italy
¹⁹Molecular Hematology, International Centre for Genetic Engineering and Biotechnology, Trieste, Italy
²⁰Medical School, Università Vita-Salute San Raffaele, Milano, Italy
²¹Fondazione per l’Istituto Oncologico di Ricerca, Bellinzona, Switzerland
²²IOSI-Oncology Inst. of Southern Switzerland, Bellinzona, Ticino, Switzerland
²³Oncology Institute of Southern Switzerland (IOSI), Ente Ospedaliero Cantonale, Bellinzona, Switzerland
²⁴Department of Hematology, ASST Grande Ospedale Metropolitano Niguarda, Italy, Milano, Italy
²⁵Ospedale Di Circolo E Fondazione Macchi, Varese, ITA
²⁶Division of Hematology, Cantonal Hospital of Lucerne, Lucerne, Switzerland, Lucerne, Switzerland
²⁷Hematology Section, Department of Radiological and Hematological Sciences, Catholic University of Sacred Heart, Rome, Italy
²⁸Medical Genetics and Pathology, University of Basel, Basel, Switzerland
²⁹Institute of Oncology Research, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland
³⁰Division of Hematology, Department of Translational Medicine, Università del Piemonte Orientale, Novara, Italy
³¹Molecular Hematology, International Centre for Genetic Engineering and Biotechnology, Trieste, TS, Italy
³²Clinical and Experimental Onco-Hematology Unit, Centro di Riferimento Oncologico, I.R.C.C.S., Aviano, Italy

Shih-Shih Chen, PhD¹, Susan Buhl^2*, Anita Kar Yun Ng³, Laila Schipper^1*, Bianca Cinquemani^4*, Nikhil Trepeta^5*, Martina Cardillo, PhD^3*, Gonzalo Blanco^3*, Kelly Wong^1*, Yu-Ju Chen^1*, Xiao J. Yan³, Matthew Scharff^6* and Nicholas Chiorazzi³

¹Institute of Molecular Medicine, The Feinstein Institutes for Medical Research, Northwell Health System, Manhasset, NY, Manhasset, NY
²Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY
³Karches Center for Oncology Research, The Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY
⁴Institute of Molecular Medicine, The Feinstein Institutes for Medical Research, Northwell Health System, Manhasset, NY, Manhasset
⁵Institute of molecular medicine, The Feinstein Institutes for Medical Research, Northwell Health System, Manhasset, NY, Manhasset, NY
⁶Albert Einstein College of Medicine, Bronx, NY

Filippo Vit, MSc^1*, Tamara Bittolo, PhD^1*, Antonella Zucchetto, PhD^1*, Robel Papotti, PhD^1*, Erika Tissino, PhD^2*, Federico Pozzo, PhD^1*, Andrea Stacchetti, PhD^1*, Francesca Rossi, PhD^1*, Massimo Degan, PhD^1*, Eva Zaina^1*, Ilaria Cattarossi^1*, Paola Varaschin^1*, Paola Nanni^1*, Michele Berton^1*, Alessandra Braida^1*, Roberta Laureana, MD^3*, Annalisa Chiarenza^4*, Jacopo Olivieri, MD^5*, Azzurra Anna Romeo, MD^6*, Annalisa Biagi, MD^6*, Giovanni D'Arena, MD^7*, Enrica Antonia Martino^8*, Pietro Bulian^9*, Massimo Gentile, MD^8,10*, Massimiliano Postorino, MD^11*, Laura Ballotta, MD^12*, Francesco Zaja, MD^12*, Francesco Di Raimondo, MD, Prof¹³, Maria Ilaria Del Principe^3*, Valter Gattei, MD¹ and Riccardo Bomben, PhD^1*

¹Clinical and Experimental Onco-Hematology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy
²Clinical and Experimental Onco-Hematology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Pn, Italy
³Hematology, Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy
⁴Hematology and Bone Marrow Transplatation Unit, U.O.C. Ematologia, A.O.U. Poiliclinico G.Rodolico-S.Marco, Catania, Italy
⁵Clinica Ematologica, Centro Trapianti e Terapie Cellulari "Carlo Melzi", Azienda Sanitaria Universitaria Integrata di Udine, Udine, Italy
⁶Hematology and Transplant Unit, Ospedale S.M.Goretti, AUSL Latina, Italy, Latina, Italy
⁷Haematology Unit, ASL di Salerno - PO San Luca, Salerno, Italy
⁸Hematology Unit, Azienda Ospedaliera Annunziata, Cosenza, Italy, Cosenza, Italy
⁹Clinical and Experimental Onco-Hematology Unit, Centro di Riferimento Oncologico, Aviano, Italy
¹⁰Department of Pharmacy, Health and Nutritional Science, University of Calabria, Rende, Italy
¹¹Department of Onco-hematology, Fondazione Policlinico Tor Vergata, Rome, Italy
¹²Department of Medical, Surgical and Health Sciences, University of Trieste, Italy, Trieste, Italy
¹³Division of Hematology, Policlinico, Department of Surgery and Medical Specialties, University of Catania, Catania, Catania, Italy, Catania, Italy

Elisa Ten Hacken, PhD^1,2, Johan Gustafsson, PhD^3,4,5*, Chiara Tomasoni, PhD^1*, Gabriela Brunsting Hoffmann^6*, Kayla Cruz^6*, Wesley S Lu, BS^7*, Shuqiang Li^8*, Nicholas Haradhvala, PhD^3*, Connor Johnson, BA^3*, Stephanie Deng^2*, Xia Bu, PhD^2*, Donna S. Neuberg, ScD⁹, Othman Al-Sawaf, MD¹⁰, Barbara F. Eichhorst, MD¹⁰, Clare Sun, MD¹¹, Erin M. Parry, MD, PhD^2,3,12,13, Gordon J. Freeman, PhD^2,13*, Gad Getz, PhD^3,14,15* and Catherine J. Wu, MD^2,3,12,13*

¹Division of Hematology and Medical Oncology, Weill Cornell Medical College, Weill Cornell Medicine, New York City, NY
²Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
³Broad Institute of MIT and Harvard, Cambridge, MA
⁴TIMM Laboratory at Sahlgrenska Center for Cancer Research, University of Gothenburg, Gothenburg, Sweden
⁵Department of Medical Biochemistry and Cell Biology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
⁶Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA
⁷Translational Immunogenomics Lab, Dana-Farber Cancer Institute, Boston, MA
⁸Dana Farber Cancer Institute, Translational Immunogenomics Laboratory, Boston, MA
⁹Department of Data Science, Dana-Farber Cancer Institute, Boston, MA
¹⁰Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf; German CLL Study Group, University of Cologne, Cologne, Germany, Cologne, Germany
¹¹National Heart, Lung, and Blood Institute, National Heart, Lung and Blood Institute, Bethesda, MD
¹²Brigham and Women's Hospital, Boston, MA
¹³Harvard Medical School, Boston, MA
¹⁴Department of Pathology, Massachusetts General Hospital, Boston, MA
¹⁵Krantz Family Center for Cancer Research and Dept. of Pathology, Massachusetts General Hospital, Boston, MA

Tiana Huynh^1*, Sonia Rodriguez-Rodriguez, PhD^2*, Carly Roleder^1*, Sarah Whelan^3*, May Tan^3*, Ernestine Lee, PhD^3*, Paul Munson^3* and Alexey V. Danilov, MD, PhD⁴

¹City of Hope, Duarte, CA
²Stem Cell Biology & Regenerative Medicine, Beckman Research Institute of City of Hope, Duarte, CA
³Nurix Therapeutics, Inc., San Francisco, CA
⁴City of Hope National Medical Center, Duarte, CA

Matthew J. Cortese, MD, MPH, MD, MPH¹, Jacob P Wright^2*, Cory Mavis, MSc^3*, Taylor K Mandeville, BA^3*, Alex Niu, MD^4*, Dae-Kyum Kim, PhD^5*, Spencer Rosario, PhD^6* and Francisco Hernandez-Ilizaliturri, MD⁴

¹Department of Medicine - Lymphoma Section, Department of Cancer Genetics & Genomics, Roswell Park Comprehensive Cancer Center, Amherst, NY
²Department of Biological Sciences, State University of New York (University at Buffalo), Buffalo, NY
³Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY
⁴Department of Medicine (Lymphoma Section), Roswell Park Comprehensive Cancer Center, Buffalo, NY
⁵Department of Cancer Genetics and Genomics, Roswell Park Comprehensive Cancer Center, Buffalo, NY
⁶Department of Biostatistics and Bioinformatics, Roswell Park Comprehensive Cancer Center, Buffalo, NY