Samuel Urrutia, MD¹, Koji Sasaki, MD², Alex Bataller, MD, PhD^2*, Hagop M. Kantarjian, MD³, Guillermo Montalban-Bravo, MD², James McCloskey, MD⁴, Elizabeth A. Griffiths, MD⁵, Karen Yee, MD, FRCPC^6*, Amer M. Zeidan, MBBS, MHS⁷, Michael R. Savona, MD⁸, Aram Oganesian, PhD^9*, Yuri Sano, MD, PhD¹⁰, Harold N. Keer, MD, PhD¹⁰ and Guillermo Garcia-Manero, MD²

¹Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
²Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
³University of Texas MD Anderson Cancer Center, Houston, TX
⁴John Theurer Cancer Center at Hackensack University Medical Center, Hackensack, NJ
⁵Roswell Park Comprehensive Cancer Center, Buffalo, NY
⁶Princess Margaret Cancer Centre, University of Toronto, Toronto, Canada
⁷Department of Internal Medicine, Section of Hematology, Yale School of Medicine - Yale Cancer Center, New Haven, CT
⁸Vanderbilt University Medical Center, Nashville, TN
⁹OTSUKA AMERICA PHARMACEUTICALS, INC., Princeton, NJ
¹⁰Astex Pharmaceuticals, Inc., Pleasanton, CA

Guillermo Garcia-Manero, MD¹, James McCloskey, MD², Bart L. Scott, MD³, Elizabeth A. Griffiths, MD⁴, Bonnie Kiner-Strachan, MD⁵, Andrew M. Brunner, MD⁶, Amer M. Zeidan, MBBS, MHS⁷, Elie Traer, MD, PhD⁸, Yazan F. Madanat, MD⁹, Janelle Meyer, MD^10*, Harry Erba, MD, PhD^11*, Praneeth Baratam, MBBS¹², Uma Borate, MD¹³, Yuri Sano, MD, PhD¹⁴, Aram Oganesian, PhD, DABT^14*, Lixia Zhu^15*, Harold N. Keer, MD, PhD¹⁴ and Michael R. Savona, MD^16*

¹Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
²John Theurer Cancer Center at Hackensack University Medical Center, Hackensack, NJ
³Fred Hutchinson Cancer Center, Seattle, WA
⁴Roswell Park Comprehensive Cancer Center, Buffalo, NY
⁵New York University Langone Hospital Long Island, Mineola, NY
⁶Dana-Farber Cancer Institute, Boston, MA
⁷Smillow Cancer Hospital, New Haven, CT
⁸Knight Cancer Institute, Oregon Health & Science University, Portland, OR
⁹Harold C. Simmons Comprehensive Cancer Center, UT Southwestern Medical Center, Dallas, TX
¹⁰Oregon Oncology Specialists, Salem, OR
¹¹Duke Cancer Institute, Durham, NC
¹²Hollings Cancer Center, Charleston, SC
¹³The Ohio State University, Columbus, OH
¹⁴Taiho Oncology, Inc., Princeton, NJ
¹⁵Taiho Oncology, Inc.., Princeton, NJ
¹⁶Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN

Hongyan Tong, PhD^1,2,3,4, Xinping Zhou^1,2,3,5*, Yanjuan Lin^6*, Yan Gao^7*, Zheng Ge, MD, PhD⁸, Huang Li^9*, Jin Zhang^10*, Hai Cheng^11*, Guifang Ouyang^12*, Fanjun Meng^13*, Yulu Tian^14*, Yuemin Kuang^15*, Fengping Zhou^16*, Lixia Sheng^12*, Weimei Jin^5*, Gaixiang Xu^1,2,3,4*, Liya Ma^1,2,3,4*, Li Ye^1,2,3,17*, Chen Mei^5*, Jian Li^18* and Jie Jin, M.D.^2,19,20,21

¹Zhejiang Provincial Key Lab of Hematopoietic Malignancy, Zhejiang University, Hangzhou, China
²Zhejiang University Cancer Center, Hangzhou, China
³Zhejiang Provincial Clinical Research Center for Hematological disorders, Hangzhou, China
⁴Department of Hematology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
⁵Department of Hematology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
⁶Department of Hematology, Fujian Medical University Union Hospital, Fuzhou, China
⁷Department of Hematology, The Affiliated Hospital of Qingdao University, Qingdao, CHN
⁸Jiangsu Provincial People’s Hospital, Nanjing, China
⁹Department of Hematology, The Affiliated Jinhua Hospital of Wenzhou Medical University, Wenzhou, China
¹⁰Department of Hematology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China
¹¹Department of Hematology, The Affiliated Hospotal of Xuzhou Medical College, Xuzhou, China
¹²Department of Hematology, The First Affiliated Hospital of Ningbo University, Ningbo, China
¹³Department of Hematology, The Affiliated Hospital of Qingdao University,, Qiangdao, China
¹⁴Department of Hematology, Zhongda Hospital, Institute of Hematology Southeast University, School of Medicine, Southeast University,, Nanjing, China
¹⁵Department of Hematology, The Affiliated Jinhua Hospital of Wenzhou Medical University, Jinhua, China
¹⁶Department of Hematology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China
¹⁷Department of Hematology, The First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China
¹⁸Clinical Research Center, Ruijin Hospital Affiliated To Shanghai Jiao Tong Unive, Shanghai, China
¹⁹Department of Hematology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
²⁰Zhejiang Provincial Clinical Research Center For Hematological disorders, Hangzhou, China
²¹Zhejiang Provincial Key Laboratory of Hematopoietic Malignancy, Zhejiang University, Hangzhou, China

Benjamin Rolles, MD^1,2, Jan Philipp Bewersdorf, MD^3,4, Tariq Kewan, MD⁵, Ondrej Blaha, PhD^6*, Jessica M. Stempel, MD³, Luca Lanino, MD⁷, Najla H. Al Ali, Ms^8*, Amy E. DeZern, MD, MHS⁹, Mikkael A. Sekeres, MD¹⁰, Geoffrey L. Uy, MD¹¹, Hetty E. Carraway, MD, MBA¹², Pinkal Desai¹³, Elizabeth A. Griffiths, MD¹⁴, Eytan M. Stein, MD¹⁵, Andrew M. Brunner, MD¹⁶, Christine M. McMahon, MD¹⁷, Rory M. Shallis, MD³, Joshua F. Zeidner, MD¹⁸, Michael R. Savona, MD¹⁹, Stacey M. Frumm, MD²⁰, Shougat Barua^21*, Namrata S. Chandhok, MD¹⁰, Constantine Logothetis, MD¹¹, Aram Bidikian, MD³, Ted M. Getz, MD³, Gail J. Roboz, MD²², Eunice S. Wang, MD²³, Amyah C. Harris^16*, Maria L Amaya, MD, PhD¹⁷, Hayley Hawkins^24*, Somedeb Ball, MD¹⁹, Justin Grenet, MD, MPhil¹³, Zhuoer Xie, MD, MS²⁵, Yazan F Madanat, MD²⁶, Yasmin Abaza, MD²⁷, Talha Badar, MD²⁸, Torsten Haferlach, MD²⁹, Jaroslaw Maciejewski³⁰, David Sallman, MD³¹, Anoop K Enjeti, MBBS, FRCPA, MD, MRCP³², Kamal Al-Rabi, MD^33*, Khalid Halahleh, MD^33*, Devendra Hiwase, MD, MBBS, PhD, FRACP, FRCPA³⁴, Maria Diez-Campelo, MD, PhD^35*, David Valcarcel, MD, PhD³⁶, Claudia Haferlach, MD²⁹, Lisa Pleyer, MD^37*, Ioannis Kotsianidis, PhD³⁸, Vassiliki Pappa, MD³⁹, Valeria Santini, MD⁴⁰, Angela Consagra, MD^40*, Aref Al-Kali, MD⁴¹, Seishi Ogawa, MD, PhD⁴², Yasuhito Nannya, MD, PhD⁴², Matteo Giovanni Della Porta, MD^43*, Rami S. Komrokji, MD²⁵, Amer M. Zeidan, MBBS, MHS³ and Maximilian Stahl, MD²

¹Division of Hematology, Department of Medicine, Brigham and Women's Hospital/Harvard Medical School, Boston, MA
²Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
³Department of Internal Medicine, Section of Hematology, Yale University, New Haven
⁴Department of Medicine, Leukemia Service, Memorial Sloan Kettering Cancer Center, New York, NY
⁵Section of Hematology, Department of Internal Medicine, Yale School of Medicine, New Haven, CT
⁶School of Public Health, Yale Center for Analytical Sciences, Yale University, New Haven
⁷IRCCS Humanitas Research Hospital, Rozzano, Milano, Italy
⁸Department of Malignant Hematology, H. Lee Moffitt Cancer Center, Tampa
⁹Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore
¹⁰Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami
¹¹Washington University School of Medicine, Saint Louis
¹²Department of Hematology and Medical Oncology, Taussig Cancer Institute, Leukemia Program, Cleveland Clinic, Cleveland, OH
¹³Weill Cornell Medicine, New York City
¹⁴Roswell Park Comprehensive Cancer Center, Buffalo, NY
¹⁵Department of Medicine, Leukemia Service, Memorial Sloan Kettering Cancer Center, New York City
¹⁶Division of Hematology/Oncology, Massachusetts General Hospital, Harvard Medical School, Boston
¹⁷University of Colorado, Aurora
¹⁸Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill
¹⁹Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville
²⁰Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston
²¹Department of Medical Oncology, Dana-Farber Cancer Institute, Boston
²²Department of Medicine, Division of Hematology and Oncology, Weill Cornell Medicine, New York, NY
²³Roswell Park Comprehensive Cancer Center, Buffalo
²⁴Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN
²⁵Department of Malignant Hematology, H Lee Moffitt Cancer Center, Tampa, FL
²⁶Harold C. Simmons Comprehensive Cancer Center, UT Southwestern Medical Center, Dallas
²⁷Northwestern University, Chicago
²⁸Division of Hematology-Oncology, Mayo Clinic, Jacksonville
²⁹MLL Munich Leukemia Laboratory, Munich, Germany
³⁰Department of Hematology and Medical Oncology, Taussig Cancer Institute, Leukemia Program, Cleveland Clinic, Cleveland
³¹Department of Malignant Hematology, H Lee Moffitt Cancer Center and Research Institute, Tampa
³²Department of Haematology, Calvary Mater Hospital, Newcastle, Australia
³³King Hussein Cancer Center, Amman, Jordan
³⁴Department of Haematology, The Royal Adelaide Hospital, Adelaide, SA, Australia
³⁵Hematology Department, Institute of Biomedical Research of Salamanca, University Hospital of Salamanca, Salamanca, Spain
³⁶Department of Hematology and Oncology, University Hospital Vall d'Hebron, Barcelona, Spain
³⁷3rd Medical Department with Hematology, Medical Oncology, Hemostaseology, Rheumatology and Infectiology, Oncologic Center, Paracelsus Medical University, Salzburg, Austria
³⁸Department of Hematology, Democritus University of Thrace Medical School, Alexandroupolis, Greece
³⁹Hematology Division, Second Department of Internal Medicine, Attikon University Hospital, National and Kapodistrian University of Athens, Athens, Greece
⁴⁰MDS Unit, Hematology, AOU Careggi ‐ Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy
⁴¹Mayo Clinic, Rochester
⁴²Department of Pathology and Tumor Biology, Institute for the Advanced Study of Human Biology (WPI-ASHBi), Kyoto University, Kyoto, Japan
⁴³IRCCS Humanitas Clinical and Research Center, Rozzano, Italy

Elena Riva, PhD^1*, Michela Calvi, PhD^2,3*, Matteo Zampini, PhD^1,4*, Lorenzo Dall'Olio, PhD^5*, Alessandra Merlotti, PhD^6,7*, Antonio Russo, MD^3*, Giulia Maggioni, MD^3*, Lara Orlandi^2,3*, Alessandro Frigo^3*, Francesca Ficara, PhD^3,8*, Laura Crisafulli, PhD^1,8*, Elisabetta Sauta, PhD^3*, Saverio D'Amico, MSc^3*, Enrico Lugli, PhD^3*, Alessia Campagna, MD^3*, Marta Ubezio, MD^3*, Cristina Astrid Tentori, MD^3*, Gabriele Todisco, MD^3,9*, Luca Lanino, MD¹, Alessandro Buizza, MD^3*, Denise Ventura, MSc^1*, Nicole Pinocchio, MSc^1*, Elena Saba, PhD^1*, Armando Santoro, MD^10*, Valeria Santini, MD¹¹, Arjan A. van de Loosdrecht, MD, PhD^12*, Rami S. Komrokji, MD¹³, Guillermo Garcia-Manero, MD¹⁴, Pierre Fenaux, MD¹⁵, Lionel Ades, MD, PhD¹⁶, Uwe Platzbecker, MD¹⁷, Torsten Haferlach, MD¹⁸, Antonio Medina Almeida, MD, PhD¹⁹, Amer M. Zeidan, MBBS, MHS²⁰, Shahram Kordasti, MD, PhD^21,22, Daniel Remondini, PhD^6*, Gastone Castellani, PhD^23*, Clara Di Vito, PhD^2,3*, Domenico Mavilio, MD, PhD^2,3* and Matteo Giovanni Della Porta, MD^3,4*

¹IRCCS Humanitas Research Hospital, Rozzano, Milano, Italy
²Department of Medical Biotechnologies and Translational Medicine, University of Milan, Milan, Italy
³IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy
⁴Department of Biomedical Sciences, Humanitas University, Milan, Italy
⁵Data Science and Bioinformatics Laboratory, IRCCS Institute of Neurological Sciences of Bologna, Bologna, Italy
⁶Department of Physics and Astronomy, DIFA, University of Bologna, Bologna, Italy
⁷IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy
⁸Institute for Genetic and Biomedical Research, Milan Unit, CNR, Milan, Italy
⁹Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy
¹⁰IRCCS Humanitas Research Hospital, Rozzano, Italy
¹¹MDS Unit, Hematology, AOUC, University of Florence, Florence, Italy
¹²Department of Hematology, Amsterdam University Medical Center, Free University, Amsterdam, Netherlands
¹³Department of Malignant Hematology, Moffitt Cancer Center, Tampa, FL
¹⁴Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
¹⁵Hopital Saint Louis, Groupe Francophone des Myelodysplasies, Paris, France, PARIS, FRA
¹⁶Hopital Saint Louis, Paris, France
¹⁷Department for Hematology, Cell Therapy, Hemostaseology and Infectious Diseases, University of Leipzig Medical Center, Leipzig, Germany
¹⁸MLL Munich Leukemia Laboratory, Munich, Germany
¹⁹Hospital Da Luz Lisboa, Lisbon, Portugal
²⁰Department of Internal Medicine, Section of Hematology, Yale School of Medicine - Yale Cancer Center, New Haven, CT
²¹Department of Clinical Haematology, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom
²²Hematology Unit, Azienda Ospedaliero Universitaria delle Marche, Ancona, Italy
²³Dipartimento di Scienze Mediche e Chirurgiche, Università di Bologna, Bologna, Italy

Maria Julia Montoro, MD, PhD^1*, Laura Palomo, PhD^1*, Claudia Haferlach, MD², Pamela Acha^3*, Onyee Chan, MD^4*, Víctor Navarro^5*, Yasuo Kubota, MD, PhD^6*, Felicitas Schulz^7*, Robert Briski^8*, Najla H Al Ali, MS^9*, Blanca Xicoy^10*, Felix Lopez, MD^11*, Francesc Bosch, MD, PhD¹, Manja Meggendorfer, PhD¹², Teresa González, PhD^13*, Lea Naomi Eder^14*, Andres Jerez, MD, PhD^15*, Yu-Hung Wang, MD^16*, Alessia Campagna, MD^17*, Valeria Santini, MD¹⁸, Teresa Bernal^19*, Esperanza Such, PhD^20*, Hwei-Fang Tien, MD, PhD²¹, Anne Sophie Kubasch, MD²², Nicolas Díaz Varela, MD^19*, Uwe Platzbecker, MD²³, Detlef Haase, Prof. Dr. med.^24*, Maria Diez-Campelo, MD, PhD^13*, Matteo Giovanni Della Porta, MD^17*, Guillermo Garcia-Manero, MD²⁵, Daniel H Wiseman, MB ChB PhD MRCP FRCPath^26*, Ulrich Germing, MD^27*, Jaroslaw Maciejewski⁶, Rami S. Komrokji, MD⁹, Francesc Sole, PhD²⁸, Torsten Haferlach, MD² and David Valcarcel, MD, PhD²⁹

¹Department of Hematology, Vall d’Hebron University Hospital, Barcelona, Spain
²MLL Munich Leukemia Laboratory, Munich, Germany
³Myelodysplastic Syndromes Research Group, Josep Carreras Leukaemia Research Institute, Badalona, Spain
⁴H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL
⁵Oncology Data Science (ODysSey), Vall d'Hebron Institute of Oncology (VHIO), Hospital Universitario Vall d’Hebron, Barcelona, Spain
⁶Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH
⁷Department of Hematology, University Hospital of Düsseldorf, Düsseldorf, Germany
⁸University of Michigan, Grosse Pointe Woods, MI
⁹Department of Malignant Hematology, Moffitt Cancer Center, Tampa, FL
¹⁰Myelodysplastic Syndromes Research Group, Josep Carreras Laeukemia Research Institute, Badalona, Spain
¹¹Department of Hematology, Hospital del Mar, Barcelona, Spain
¹²MLL Munich Leukemia Laboratory, Munich, Bavaria, Germany
¹³University of Salamanca, IBSAL, IBMCC, CSIC, Cancer Research Center, Department of Hematology - Hospital Universitario de Salamanca, Salamanca, Spain
¹⁴Clinics of Hematology and Medical Oncology, University Medical Center Göttingen, Georg-August- University, Göttingen, Germany
¹⁵Hospital Morales Meseguer, Murcia, Murcia, ESP
¹⁶Department of Internal Medicine, Fra-Eastern Memorial Hospital, Taipei, Taiwan
¹⁷IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy
¹⁸MDS Unit, Hematology, AOUC, University of Florence, Florence, Italy
¹⁹Hospital Universitario Central de Asturias, Instituto Universitario (IUOPA), Instituto de Investigación del Principado de Asturias (ISPA), Oviedo, Spain
²⁰Hematology Research Group, Hospital Universitari I PolitèCnic La Fe; Dep. of Hematology, University, Valencia, Spain
²¹Department of Internal Medicine, Far-Eastern Memorial Hospital, New Taipei, Taiwan
²²Department of Hematology, Cellular Therapy, Hemostaseology and Infectious Diseases, University Leipzig Medical Center, Leipzig, Germany
²³Department for Hematology, Cell Therapy, Hemostaseology and Infectious Diseases, University of Leipzig Medical Center, Leipzig, Germany
²⁴Clinics of Hematology and Medical Oncology, INDIGHO laboratory, University Medical Center Göttingen (UMG), Göttingen, Germany
²⁵Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
²⁶The Christie NHS Foundation Trust, Manchester, United Kingdom
²⁷Department of Hematology, Oncology and Clinical Immunology, University Medical Center Düsseldorf, Heinrich-Heine-University, Düsseldorf, Germany
²⁸Josep Carreras Leukaemia Research Institute, Myelodysplastic Syndromes Research Group, Badalona, Spain
²⁹Department of Hematology, Vall d’Hebron Institute of Oncology, University Hospital Vall d’Hebron,, Barcelona, Spain