Alexandros Rampotas, MBBS, MRCP^1*, Zoë Wong, BSc^2*, Isaac Gannon^1*, Camelia Benlabiod, PhD^2*, Yuqi Shen^2*, Charlotte Brierley^2*, Aude-Anais Olijnik^3*, Saif Khan^1*, Nawshad Hayder, MSc, BSc^2*, Gordon Weng-Kit Cheung^1*, Marina Mitsikakou, MRes^4*, Manuel Rodriguez-Justo^5*, Abdullah O Khan^2*, Adam J Mead, PhD, MRCP, FRCPath⁶, Jonathan Lambert, PhD, BSc, BMBS, FRCP, FRCPath^7*, Claire Roddie, MD^8*, Bethan Psaila, MD, PhD⁹ and Martin A Pule, MD^10*

¹UCL Cancer Institute, University College London, London, United Kingdom
²MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom
³MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom
⁴Haematology Department, UCL Cancer Institute, London, United Kingdom
⁵Research Department of Pathology, UCL Cancer Institute, London, United Kingdom
⁶Haematopoietic Stem Cell Laboratory, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom
⁷Department of Haematology, University College Hospital, University College of London Hospitals NHS Foundation Trust, London, United Kingdom
⁸University College London Cancer Institute, London, United Kingdom
⁹Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom
¹⁰Research Department of Haematology, University College London Cancer Institute, London, United Kingdom

Benjamin Rolles, MD¹, Aswin Sekar, MD, PhD², Laura Serrano-Ron^3*, Noorul Mifra Ameerul Faiz^4*, Andrea Perry^5,6*, Addison Clare Hillerbrandt^4*, Jessica Hem^4*, Jonas Jutzi, MD, PhD⁴, Anna E. Marneth, PhD^4,7, Abhishek Niroula, PhD^6,8,9*, Alexander G. Bick, MD, PhD^10*, Christopher J. Gibson, MD^2,6, Gabriel K. Griffin, MD^11*, Md Mesbah Uddin^6,12*, Pradeep Natarajan^6,12*, Benjamin Levine Ebert, MD, PhD^2,6,13, Peter van Galen, PhD^4,6, Fatima Al-Shahrour^3*, Sahand Hormoz, PhD^5,6,14* and Ann Mullally, MD^15,16

¹Division of Hematology, Department of Medicine, Brigham and Women's Hospital/Harvard Medical School, Boston, MA
²Department of Medical Oncology, Dana-Farber Cancer Institute, Boston
³Bioinformatics Unit, Spanish National Cancer Research Center (CNIO), Madrid, Spain
⁴Division of Hematology, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston
⁵Department of Data Sciences, Dana-Farber Cancer Institute, Boston
⁶Broad Institute of MIT and Harvard, Cambridge
⁷Department of Laboratory Medicine, Division Laboratory of Hematology, Radboud University Medical Center, Nijmegen, Netherlands
⁸Department of Medical Biochemistry and Cell Biology, Institute of Biomedicine, University of Gothenburg, Gothenburg, Sweden
⁹SciLifeLab, University of Gothenburg, Gothenburg
¹⁰Department of Medicine, Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN
¹¹Department of Pathology, Dana-Farber Cancer Institute, Boston, MA
¹²Cardiovascular Research Center and Center for Genomic Medicine, Massachusetts General Hospital and Harvard Medical School, Boston
¹³Howard Hughes Medical Institute, Dana-Farber Cancer Institute, Boston
¹⁴Department of Systems Biology, Harvard Medical School, Boston
¹⁵Division of Hematology, Department of Medicine, Stanford University School of Medicine, Stanford
¹⁶Hematology Division, VA Palo Alto Health Care System, Palo Alto

Cara Clementelli^1*, MD Babu Mia^2*, Sarah Haines^3*, Christoph Schaniel, PhD^1,4, Malgorzata Olszewska^1*, Joann Arandela^1*, Sebastian Elghaity-beckley^1*, Sophie Klingborg^1,4*, Zinedine Hoque^1,4*, Min Lu^1,4, Eirini Papapetrou, MD, PhD^5,6, Ronald Hoffman, MD^1,7 and Bridget Kelly Marcellino, MD, PhD^7,8

¹The Tisch Cancer Institute, Division of Hematology & Oncology, Icahn School of Medicine at Mount Sinai, New York, NY
²The Tisch Cancer Institute, Division of Hematology & Oncology, Icahn School of Medicine at Mount Sinai, NEW YORK, NY
³Children’s Hospital of Philadelphia, Philadelphia, PA
⁴Myeloproliferative Neoplasms Research Consortium, New York, NY
⁵Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY
⁶Center for the Advancement of Blood Cancer Therapies, Institute for Regenerative Medicine, Icahn School of Medicine at Mount Sinai, New York, NY
⁷Myeloproliferative Neoplasms (MPN) Research Consortium, New York, NY
⁸Division of Hematology & Oncology, Icahn School of Medicine at Mount Sinai, New York, NY

Yiru Yan, PhD^1*, Jinqin Liu^1*, Lin Yang, PhD^1*, Gang Huang, PhD^2,3, Xiaofan Zhu, MD⁴, Raajit Rampal, MD, PhD^5,6,7, Zhijian Xiao, MD^8* and Bing Li^1*

¹State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences &Peking Union Medical College, Tianjin, China
²Department of Cell Systems and Anatomy, UT Health San Antonio, San Antonio, TX
³Department of Pathology and Laboratory Medicine, UT Health San Antonio, San Antonio, TX
⁴State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, CAMS & PUMC, Tianjin, China
⁵Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Institute, New York, NY
⁶Memorial Sloan Kettering Cancer Center, New York, NY
⁷Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY
⁸State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences&Peking Union Medical College, Tianjin, China

Fan He, PhD¹, Shuyang Lin, BS^2*, Tim Kong, MSc², Daniel Fisher, PhD^2*, Alexander Kim, MSc^3*, Molly Brakhane, MSc¹, Christopher Letson, PhD^2*, Yanbo Yu, PhD^4*, Noelle Champagne, BS^2*, Mary Fulbright, MSc^2*, Varun Ramesh^2*, Angelo Laranjeira^2*, Maggie Cox^2*, Katrina Ashworth^5*, Stephen Sykes, PhD⁵, Jorge Di Paola, MD⁵ and Stephen Oh, MD, PhD⁶

¹Division of Hematology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO
²Division of Hematology, Department of Medicine, Washington University School of Medicine, St Louis, MO
³Department of Radiation Oncology, Washington University School of Medicine, St Louis, MO
⁴Department of Radiology, Washington University School of Medicine, St Louis, MO
⁵Department of Pediatrics, Washington University School of Medicine, St Louis, MO
⁶Washington University School of Medicine, Saint Louis, MO

Rosalin Cooper^1,2*, Emily Thomas^3*, Dawood Muhammad^1,3*, Carlo Pescia^1*, Anna Sozanska^2*, Oliver McCallion^4*, Hosuk Ryou^3*, Renuka Teague^4*, Alan King Lun Liu^2*, Joanna Hester^4*, Fadi Issa^4*, Bethan Psaila, MD, PhD⁵, Adam J Mead, PhD, MRCP, FRCPath⁶, Jens Rittscher^3*, Dan Woodcock^4* and Daniel Royston, DPhil, FRCPath, MBBChir^1,2

¹Nuffield Division of Clinical Laboratory Sciences, University of Oxford, Oxford, United Kingdom
²Oxford University Hospitals, Oxford, United Kingdom
³Institute of Biomedical Engineering, University of Oxford, Oxford, United Kingdom
⁴Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom
⁵Medical Research Council (MRC) Weatherall Institute of Molecular Medicine (WIMM), University of Oxford, Oxford, ENG, United Kingdom
⁶Medical Research Council (MRC) Weatherall Institute of Molecular Medicine (WIMM), University of Oxford, Oxford, United Kingdom