-Author name in bold denotes the presenting author
-Asterisk * with author name denotes a Non-ASH member
Clinically Relevant Abstract denotes an abstract that is clinically relevant.

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Ticketed Session denotes that this is a ticketed session.

604A.O1.6 604. Molecular Pharmacology and Drug Resistance: Myeloid Neoplasms: Determinants of Venetoclax Resistance and Response

Symposia: Molecular Pharmacology and Drug Resistance: Myeloid Neoplasms Program: Oral and Poster Abstracts
Type: Oral
Hematology Disease Topics & Pathways:
Research, Clinical trials, Acute Myeloid Malignancies, AML, MDS, Combination therapy, Apoptosis, Adult, Fundamental Science, Translational Research, Drug development, Elderly, CHIP, Clinical Research, Chemotherapy, Genomics, Drug-drug interactions, Chronic Myeloid Malignancies, Education, Diseases, Immune mechanism, Treatment Considerations, Immunology, Non-Biological therapies, Metabolism, Myeloid Malignancies, Pharmacology, Biological Processes, Technology and Procedures, Molecular biology, Study Population, Human, Pathogenesis, Animal model, Measurable Residual Disease , Molecular testing, Omics technologies
Saturday, December 7, 2024: 9:30 AM-11:00 AM
Grand Hall B (Manchester Grand Hyatt San Diego)
Moderators:
Saravanan Ganesan, PhD, and Shruti Bhatt, PhD,
Disclosures:
No relevant conflicts of interest to declare.
9:30 AM

Taylor Scott Mills, PhD1*, Marlon Arnone, PhD1*, Simone Poeschel1*, Stefan Winter, PhD2*, Jessica Kuebler1*, Jan Frederic Weller, MD3*, Anna Maria Stanger, PhD1*, Matthias Schwab, MD1* and Claudia Lengerke, MD4

1Internal Medicine II, University Hospital Tuebingen, Tuebingen, Germany
2Internal Medicine II, University of Tuebingen, Tuebingen, Germany
3Department of Hematology, Oncology, Clinical Immunology and Rheumatology, University Hospital Tuebingen, Tuebingen, Germany
4Department of Oncology, Hematology, Clinical Immunology, and Rheumatology, University Hospital Tuebingen, Tuebingen, Germany

9:45 AM

Juan Jose Rodriguez Sevilla1*, Yang Liu2*, Irene Ganan-Gomez, PhD, MSc1*, Vera Adema, PhD3*, Kelly S. Chien, MD4, Guillermo Montalban-Bravo, MD3, Natthakan Thongon, PhD3, Guillermo Garcia-Manero, MD3, Rashmi Kanagal-Shamanna, MD5, Sanam Loghavi, MD6, Hui Yang, PhD, MD7, Linghua Wang, MD, PhD, MS8* and Simona Colla, PhD9

1Leukemia, MD Anderson Cancer Center, Houston, TX
2Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston
3Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
4Department of Leukemia, MD Anderson, Houston, TX
5Department of Hematopathology, The University of Texas M. D. Anderson Cancer Center, Houston, TX
6Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX
7Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX
8Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
9Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston

10:00 AM

Ing Soo Tiong, FRACP, FRCPA, MPhil1,2,3, Satwica Yerneni, BTech, MSc1,4*, Tamia Nguyen, BSc, MSc5,6*, Adam Ivey, PhD7*, Natasha S. Anstee, PhD8,9*, Emma Palfreyman, MBBS, FRACP, FRCPA10*, Ashish Bajel, MBBS, FRACP, FRCPA11,12, Emad Uddin Abro, MBBS, BSc, FRACP, FRCPA13*, Devendra Hiwase, MD, MBBS, PhD, FRACP, FRCPA14,15, Andrew H Wei, MBBS, PhD, FRACP, FRCPA9,12,16 and Piers Blombery, MBBS17,18

1Peter MacCallum Cancer Centre, Melbourne, Australia
2Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Australia
3The Royal Melbourne Hospital, Parkville, Australia
4The University of Melbourne, Melbourne, Australia
5The University of Melbourne, Parkville, Australia
6Department of Pathology, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia
7The Alfred Hospital and Monash University, Melbourne, VIC, Australia
8Department of Medical Biology, The University of Melbourne, Melbourne, Australia
9The Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC, Australia
10Royal Darwin Hospital, Tiwi, Australia
11Department of Medicine, University of Melbourne, Melbourne, Australia
12Department of Clinical Haematology, Peter MacCallum Cancer Centre and The Royal Melbourne Hospital, Melbourne, VIC, Australia
13Division of Cancer Services, Princess Alexandra Hospital, Brisbane, QLD, Australia
14South Australian Health and Medical Research Institute, Adelaide, SA, Australia
15Royal Adelaide Hospital, Adelaide, SA, Australia
16The University of Melbourne, Melbourne, VIC, Australia
17Molecular Haematology, Peter MacCallum Cancer Centre & Royal Melbourne Hospital, Melbourne, Australia
18Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, VIC, Australia

10:15 AM

Claudia Bruedigam, PhD1,2, Eunice Anne Dulatre, MSc1*, Carol Lee, BSc1*, Amy H Porter, MD1*, Elisa LSP Lim1,2*, Alexander Z Shi1,2*, Mark P Hodson, PhD3*, Florian H. Heidel, MD4,5 and Steven W Lane, MBBS, PhD, FRCPA, FRACP1,2,6

1Cancer Program, QIMR Berghofer Medical Research Institute, Brisbane, Australia
2The University of Queensland, Brisbane, Australia
3Metabolomics Group, QIMR Berghofer Medical Research Institute, Brisbane, Australia
4Leibniz Institute on Aging, Fritz-Lipmann-Institute, Jena, Germany
5Department of Hematology, Hemostasis, Oncology, and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany
6Cancer Care Services, Royal Brisbane and Women's Hospital, Brisbane, Australia

10:30 AM

Ahmed M Mamdouh1*, Fang Qi Lim2*, Yang Mi1*, Elyse A Olesinski3*, Yichen Wang1*, Shaista Shabbir Jasdanwala1*, Karanpreet Singh Bhatia1,4, Xiao Xian Lin5*, Valeriia Sapozhnikova, PhD6,7,8*, Philipp Mertins, PhD9*, Brandon D. Brown, MD10*, Yihua Qiu, MD11*, Anthony G. Letai12, Alexandre Puissant, PhD13, Steven M. Kornblau, MD11, Jan Krönke, MD6,14, Edward Ayoub, PhD15*, Koji Itahana, PhD16*, Michael Andreeff, MD, PhD15 and Shruti Bhatt, PhD1

1Department of Pharmacy and Pharmaceutical Sciences, National University of Singapore, Singapore, Singapore
2Department of Pharmacy and Pharmaceutical Sciences, National University of Singapore, Singapore, AL, Singapore
3Boston University Chobanian & Avedisian School of Medicine, Boston, MA
4Winship Cancer Institute, Emory University, Atlanta, GA
5Department of Pharmacy and Pharmaceutical Sciences, National University of Singapore, Singapore, Singapore, Singapore
6Department of Hematology, Oncology, and Cancer Immunology, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany
7German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
8Max Delbrück Center for Molecular Medicine, Berlin, Germany
9Core Unit Proteomics, Berlin Institute of Health at Charité, Universitätsmedizin Berlin and Max-Delbrück-Center for Molecular Medicine, Berlin, Germany
10Department of Pediatrics, MD Anderson Cancer Center, Houston, TX
11Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
12Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA
13Saint-Louis Research Institute, Paris, France
14German Cancer Consortium (DKTK) partner site Berlin and German Cancer Research Center (DKFZ), Heidelberg, Germany
15Section of Molecular Hematology and Therapy, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
16Cancer & Stem Cell Biology Program, Duke-NUS Graduate Medical School Singapore, Singapore, Singapore

10:45 AM

Yang Li, MD1,2,3*, Xin He, MD1*, Haojie Dong, PhD1*, Lei Zhang, PhD, MD4*, Umesh Yadav1*, Meng Liu5*, Lianjun Zhang, PhD6*, Guido Marcucci7, Shaoyuan Wang8,9* and Ling Li, PhD1

1Department of Hematological Malignancies Translational Science, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA
2Union Clinical Medical Colleges, Fujian Medical University, Fuzhou, China
3Department of Hematology, Fujian Institute of Hematology, Fujian Provincial Key Laboratory on Hematology, Fujian Medical University Union Hospital, Fuzhou, China
4City of Hope National Medical Center, Monrovia
5Department of Hematological Malignancies Translational Science, Beckman Research Institute, City of Hope National Medical Center, City of Hope, Monrovia, CA
6Department of Hematologic Malignancies Translational Science, Gehr Family Center for Leukemia Research, City of Hope National Medical Center and Beckman Research Institute, Duarte, CA
7Department of Hematologic Malignancies Translational Science, Duarte, CA
8Union Clinical Medical Colleges, Fujian Medical University, Fuzhou, China, Fuzhou, China
9Department of Hematology, Fujian Institute of Hematology, Fujian Medical Univers, Fuzhou, CHN

*signifies non-member of ASH