Taylor Scott Mills, PhD^1*, Marlon Arnone, PhD^1*, Simone Poeschel^1*, Stefan Winter, PhD^2*, Jessica Kuebler^1*, Jan Frederic Weller, MD^3*, Anna Maria Stanger, PhD^1*, Matthias Schwab, MD^1* and Claudia Lengerke, MD⁴

¹Internal Medicine II, University Hospital Tuebingen, Tuebingen, Germany
²Internal Medicine II, University of Tuebingen, Tuebingen, Germany
³Department of Hematology, Oncology, Clinical Immunology and Rheumatology, University Hospital Tuebingen, Tuebingen, Germany
⁴Department of Oncology, Hematology, Clinical Immunology, and Rheumatology, University Hospital Tuebingen, Tuebingen, Germany

Juan Jose Rodriguez Sevilla^1*, Yang Liu^2*, Irene Ganan-Gomez, PhD, MSc^1*, Vera Adema, PhD^3*, Kelly S. Chien, MD⁴, Guillermo Montalban-Bravo, MD³, Natthakan Thongon, PhD³, Guillermo Garcia-Manero, MD³, Rashmi Kanagal-Shamanna, MD⁵, Sanam Loghavi, MD⁶, Hui Yang, PhD, MD⁷, Linghua Wang, MD, PhD, MS^8* and Simona Colla, PhD⁹

¹Leukemia, MD Anderson Cancer Center, Houston, TX
²Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston
³Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
⁴Department of Leukemia, MD Anderson, Houston, TX
⁵Department of Hematopathology, The University of Texas M. D. Anderson Cancer Center, Houston, TX
⁶Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX
⁷Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX
⁸Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
⁹Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston

Ing Soo Tiong, FRACP, FRCPA, MPhil^1,2,3, Satwica Yerneni, BTech, MSc^1,4*, Tamia Nguyen, BSc, MSc^5,6*, Adam Ivey, PhD^7*, Natasha S. Anstee, PhD^8,9*, Emma Palfreyman, MBBS, FRACP, FRCPA^10*, Ashish Bajel, MBBS, FRACP, FRCPA^11,12, Emad Uddin Abro, MBBS, BSc, FRACP, FRCPA^13*, Devendra Hiwase, MD, MBBS, PhD, FRACP, FRCPA^14,15, Andrew H Wei, MBBS, PhD, FRACP, FRCPA^9,12,16 and Piers Blombery, MBBS^17,18

¹Peter MacCallum Cancer Centre, Melbourne, Australia
²Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Australia
³The Royal Melbourne Hospital, Parkville, Australia
⁴The University of Melbourne, Melbourne, Australia
⁵The University of Melbourne, Parkville, Australia
⁶Department of Pathology, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia
⁷The Alfred Hospital and Monash University, Melbourne, VIC, Australia
⁸Department of Medical Biology, The University of Melbourne, Melbourne, Australia
⁹The Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC, Australia
¹⁰Royal Darwin Hospital, Tiwi, Australia
¹¹Department of Medicine, University of Melbourne, Melbourne, Australia
¹²Department of Clinical Haematology, Peter MacCallum Cancer Centre and The Royal Melbourne Hospital, Melbourne, VIC, Australia
¹³Division of Cancer Services, Princess Alexandra Hospital, Brisbane, QLD, Australia
¹⁴South Australian Health and Medical Research Institute, Adelaide, SA, Australia
¹⁵Royal Adelaide Hospital, Adelaide, SA, Australia
¹⁶The University of Melbourne, Melbourne, VIC, Australia
¹⁷Molecular Haematology, Peter MacCallum Cancer Centre & Royal Melbourne Hospital, Melbourne, Australia
¹⁸Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, VIC, Australia

Claudia Bruedigam, PhD^1,2, Eunice Anne Dulatre, MSc^1*, Carol Lee, BSc^1*, Amy H Porter, MD^1*, Elisa LSP Lim^1,2*, Alexander Z Shi^1,2*, Mark P Hodson, PhD^3*, Florian H. Heidel, MD^4,5 and Steven W Lane, MBBS, PhD, FRCPA, FRACP^1,2,6

¹Cancer Program, QIMR Berghofer Medical Research Institute, Brisbane, Australia
²The University of Queensland, Brisbane, Australia
³Metabolomics Group, QIMR Berghofer Medical Research Institute, Brisbane, Australia
⁴Leibniz Institute on Aging, Fritz-Lipmann-Institute, Jena, Germany
⁵Department of Hematology, Hemostasis, Oncology, and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany
⁶Cancer Care Services, Royal Brisbane and Women's Hospital, Brisbane, Australia

Ahmed M Mamdouh^1*, Fang Qi Lim^2*, Yang Mi^1*, Elyse A Olesinski^3*, Yichen Wang^1*, Shaista Shabbir Jasdanwala^1*, Karanpreet Singh Bhatia^1,4, Xiao Xian Lin, BSc^5*, Valeriia Sapozhnikova, PhD^6,7,8*, Philipp Mertins, PhD^9*, Brandon D. Brown, MD^10*, Yihua Qiu, MD^11*, Anthony G. Letai¹², Alexandre Puissant, PhD¹³, Steven M. Kornblau, MD¹¹, Jan Krönke, MD^6,14, Edward Ayoub, PhD^15*, Koji Itahana, PhD^16*, Michael Andreeff, MD, PhD¹⁵ and Shruti Bhatt, PhD¹

¹Department of Pharmacy and Pharmaceutical Sciences, National University of Singapore, Singapore, Singapore
²Department of Pharmacy and Pharmaceutical Sciences, National University of Singapore, Singapore, AL, Singapore
³Boston University Chobanian & Avedisian School of Medicine, Boston, MA
⁴Winship Cancer Institute, Emory University, Atlanta, GA
⁵Department of Pharmacy and Pharmaceutical Sciences, National University of Singapore, Singapore, Singapore, Singapore
⁶Department of Hematology, Oncology, and Cancer Immunology, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany
⁷German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
⁸Max Delbrück Center for Molecular Medicine, Berlin, Germany
⁹Core Unit Proteomics, Berlin Institute of Health at Charité, Universitätsmedizin Berlin and Max-Delbrück-Center for Molecular Medicine, Berlin, Germany
¹⁰Department of Pediatrics, MD Anderson Cancer Center, Houston, TX
¹¹Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
¹²Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA
¹³Saint-Louis Research Institute, Paris, France
¹⁴German Cancer Consortium (DKTK) partner site Berlin and German Cancer Research Center (DKFZ), Heidelberg, Germany
¹⁵Section of Molecular Hematology and Therapy, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
¹⁶Cancer & Stem Cell Biology Program, Duke-NUS Graduate Medical School Singapore, Singapore, Singapore

Yang Li, MD^1,2,3*, Xin He, MD^1*, Haojie Dong, PhD^1*, Lei Zhang, PhD, MD^4*, Umesh Yadav^1*, Meng Liu^5*, Lianjun Zhang, PhD^6*, Guido Marcucci⁷, Shaoyuan Wang^8,9* and Ling Li, PhD¹

¹Department of Hematological Malignancies Translational Science, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA
²Union Clinical Medical Colleges, Fujian Medical University, Fuzhou, China
³Department of Hematology, Fujian Institute of Hematology, Fujian Provincial Key Laboratory on Hematology, Fujian Medical University Union Hospital, Fuzhou, China
⁴City of Hope National Medical Center, Monrovia
⁵Department of Hematological Malignancies Translational Science, Beckman Research Institute, City of Hope National Medical Center, City of Hope, Monrovia, CA
⁶Department of Hematologic Malignancies Translational Science, Gehr Family Center for Leukemia Research, City of Hope National Medical Center and Beckman Research Institute, Duarte, CA
⁷Department of Hematologic Malignancies Translational Science, Duarte, CA
⁸Union Clinical Medical Colleges, Fujian Medical University, Fuzhou, China, Fuzhou, China
⁹Department of Hematology, Fujian Institute of Hematology, Fujian Medical Univers, Fuzhou, CHN