66th ASH Annual Meeting: 603. Lymphoid Oncogenesis: Basic: Molecular Insights into Lymphomas and CLL

Symposia: Lymphoid Oncogenesis: Basic Oral and Poster Abstracts
Oral

Research, Fundamental Science, Lymphoid Leukemias, Translational Research, Lymphomas, Non-Hodgkin lymphoma, CHIP, Assays, CLL, B Cell lymphoma, Genomics, Bioinformatics, Education, T Cell lymphoma, Hematopoiesis, Diseases, Indolent lymphoma, Cell expansion, Aggressive lymphoma, Immunology, Lymphoid Malignancies, Biological Processes, Emerging technologies, Molecular biology, Technology and Procedures, Gene editing, Multi-systemic interactions, Pathogenesis, Imaging, Molecular testing

Marriott Grand Ballroom 8-9 (Marriott Marquis San Diego Marina)

Moderators:

Darko Barisic, and Panagiotis Ntziachristos, PhD, Ghent University

Disclosures:

No relevant conflicts of interest to declare.

Focus on oncogenesis of non hodgkin lymphomas

9:30 AM

The Follicular Lymphoma and Chronic Lymphocytic Leukemia Proliferative Microenvironment at Single-Cell Resolution

Antonio Ferreira, PhD¹, Shumei Wang, MSc²^*, Larysa Poluben, MD, PhD³^*, Joshua D Brandstadter, MD, PhD, MSc⁴, Eric Perkey, MD, PhD⁵, Steven Sotirakos⁶^*, Mai Drew⁶^*, Li Pan⁶^*, Madeleine Lemieux⁷^*, David Dorfman, MD, PhD⁸, Brent Shoji⁶^*, Ivan Maillard, MD, PhD⁹, Steve Blacklow¹⁰^* and Jon C. Aster, MD, PhD¹¹

¹Harvard Medical School/ Brigham and Women’s Hospital, Boston, MA
²Brigham and Women’s Hospital, Boston, MA
³Beth Israel Deaconess Medical Center, Boston
⁴Center for Cytokine Storm Treatment & Laboratory, Perelman School of Medicine, University of Pennsylvania, SWARTHMORE, PA
⁵University of Chicago, Chicago
⁶Brigham and Women's Hospital, Boston, MA
⁷Bioinfo, Plantagenet, ON, CAN
⁸Brigham & Women's Hospital, Boston, MA
⁹Division of Hematology/Oncology, Department of Medicine, University of Pennsylvania, Philadelphia, PA
¹⁰Dana-Faber Cancer Institute, Boston, MA
¹¹Brigham and Women's Hosp., Boston, MA

9:45 AM

Tracing Clonal Hematopoiesis and Tumor-Specific Mutations in Hematopoietic Progenitors of B Cell Non-Hodgkin Lymphoma (NHL) Patients

Laura Wiegand¹^*, Patricia Silva¹^*, Daniel Noerenberg¹^*, Friederike Christen¹^*, Marlon Tilgner¹^*, Robert Altwasser¹^*, Klara Kopp¹^*, Benjamin N. Locher¹^*, Pelle F. Löwe¹^*, Catarina M. Stein¹^*, Vanessa Storzer¹^*, Franziska Briest¹^*, Jana Ihlow²^*, Anna Dolnik¹^*, Naveed Ishaque³^*, Ulrich Keller^1,4^*, Livius Penter, MD^1,4, Lars Bullinger^1,4, Raphael Hablesreiter¹^* and Frederik Damm^1,4^*

¹Department of Hematology, Oncology, and Cancer Immunology, Charité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany
²Institute of Pathology, Charité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany
³Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Digital Health Center, Berlin, Germany
⁴German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Heidelberg, Germany

10:00 AM

Cell Growth Trajectories of B-Cell Lymphomas Are Defined By Oscillations between MYC- and BCL6-Dependent States

Zhangliang Cheng, BSc¹^*, Kohei Kume, PhD¹^*, Vignesh Shanmugam, MD² and Markus Müschen, MD¹

¹Center of Molecular and Cellular Oncology, Yale University, New Haven, CT
²Broad Institute of MIT and Harvard, Cambridge, MA

10:15 AM

SF3B1 Mutation Drives Loss of Y Chromosome in Chronic Lymphocytic Leukemia

Mike Fernandez, BS^1,2, Lei Yu, PhD³^*, Qiong Jia, MS³^*, Xuesong Wang, MS³^*, Kevyn Hart, BS⁴, Zhenyu Jia, PhD³^*, Ren-Jang Lin, PhD⁵^* and Lili Wang, MD, PhD⁴

¹Irell & Manella Graduate School of Biological Sciences, City of Hope Comprehensive Cancer Center, Duarte, CA
²Department of Systems Biology, City of Hope Comprehensive Cancer Center, Monrovia, CA
³Department of Botany and Plant Sciences, University of California Riverside, Riverside, CA
⁴Department of Systems Biology, City of Hope Comprehensive Cancer Center, Duarte, CA
⁵Center for RNA Biology & Therapeutics, City of Hope Comprehensive Cancer Hospital, Duarte, CA

10:30 AM

Differential Role of Crebbp Missense and Truncating Mutations in the Malignant Transformation of Germinal Center B Cells

Chuanjiang Yu, PhD¹^*, Mara Holloman¹^*, Andrew Kim¹^*, Yunchao Chang, PhD²^*, Antony Holmes, PhD, BSc, MSc¹^*, Bowen Cai¹^*, Stefanie N Meyer, PhD¹^*, Katia Basso, PhD¹^*, Govind Bhagat, MD³, Riccardo Dalla-Favera, MD^1,3,4,5,6, Charles G. Mullighan, MBBS, MSc, MD² and Laura Pasqualucci, MD^1,3,6

¹Institute for Cancer Genetics, Columbia University, New York, NY
²Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN
³Department of Pathology & Cell Biology, Columbia University, New York, NY
⁴Department of Microbiology & Immunology, Columbia University, New York, NY
⁵Department of Genetics & Development, Columbia University, New York
⁶Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY

10:45 AM

Mechanism of Hyperactive PLCγ1 Signaling in T-Cell Leukemia/Lymphoma

Longhui Zeng, PhD¹^*, Xinyan Zhang²^*, Yiwei Xiong²^*, Nicole Hajicek³^*, John Sondek³^* and Xiaolei Su^2,4^*

¹Department of Cell Biology, Yale University, New Haven, CT
²Department of Cell Biology, Yale School of Medicine, New Haven, CT
³Department of Pharmacology, The University of North Carolina at Chapel Hill, Chapel Hill, NC
⁴Yale Cancer Center, Yale University, New Haven, CT

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^*signifies non-member of ASH

603.O2.6 603. Lymphoid Oncogenesis: Basic: Molecular Insights into Lymphomas and CLL