-Author name in bold denotes the presenting author
-Asterisk * with author name denotes a Non-ASH member
Clinically Relevant Abstract denotes an abstract that is clinically relevant.

PhD Trainee denotes that this is a recommended PHD Trainee Session.

Ticketed Session denotes that this is a ticketed session.

509.O1.6 509. Bone Marrow Failure and Cancer Predisposition Syndromes: Congenital: Clinical and Translational Insights from Patients and Models

Symposia: Bone Marrow Failure and Cancer Predisposition Syndromes: Congenital Program: Oral and Poster Abstracts
Type: Oral
Hematology Disease Topics & Pathways:
Research, Clinical trials, Acute Myeloid Malignancies, AML, Fundamental Science, Translational Research, Epidemiology, Bone Marrow Failure Syndromes, Inherited Marrow Failure Syndromes, CHIP, Clinical Research, Genetic Disorders, Aplastic Anemia, Genomics, Diseases, Treatment Considerations, Biological therapies, Registries, Non-Biological therapies, Myeloid Malignancies, Biological Processes, Molecular biology, Study Population, Human, Transplantation (Allogeneic and Autologous)
Sunday, December 8, 2024: 9:30 AM-11:00 AM
Room 11 (San Diego Convention Center)
Moderators:
Madhavi Lakkaraja, MD, MPH, Fred Hutchinson Cancer Center and Fernanda Gutierrez-Rodrigues, PhD, National Institute of Health
Disclosures:
No relevant conflicts of interest to declare.

This session will feature novel clinical and translational findings related to inherited bone marrow failure  and cancer predisposition syndromes.
9:30 AM

Nicholas C. Lee, MD1, Fernanda Gutierrez-Rodrigues, PhD1, Ruba Shalhoub2*, Tania Rene Machado, RN, BSN3*, Jennifer Lotter, ms1, Lemlem Alemu1*, Diego Quinones Raffo, BS1*, Geraldine Aubert, PhD4*, Colin O. Wu, PhD2*, Bhavisha A. Patel, MD1, Neal S. Young, MD1 and Emma M. Groarke, MD1

1Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD
2Office of Biostatistics Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD
3Office of Research Nurses, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD
4Repeat Dx, North Vancouver, Canada

9:45 AM

Yael Kusne, MD, PhD1, Talha Badar, MD2, Terra L. Lasho, PhD3, Ludovica Marando, MD, PhD4, Abhishek A. Mangaonkar, MBBS3, Christy Finke, BS5*, James M. Foran, MD6, Aref Al-Kali, MD3, Hassan B Alkhateeb, MD5*, Naseema Gangat, MBBS5, Jeanne Palmer, MD7, David Viswanatha, MD8, Mark R. Litzow, MD5, Timothy Chlon, PhD9, Alejandro Ferrer, PhD3 and Mrinal M. Patnaik, MD, MBBS3

1Mayo Clinic, Phoenix, AZ
2Department of Hematology/Oncology, Mayo Clinic, Jacksonville, FL
3Mayo Clinic, Rochester, MN
4Mayo Clinic, Rochester
5Division of Hematology, Mayo Clinic, Rochester, MN
6Division of Hematology & Medical Oncology, Mayo Clinic, Jacksonville, FL
7Mayo Clinic - Arizona, Scottsdale, AZ
8Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester
9Cincinnati Children's Hospital Medical Center, Cincinnati, OH

10:00 AM

Felicia Andresen, MD1, Jie He, MS2*, Edie Weller, PhD2*, Ben Goldberg, MS2*, Christopher R. Reilly, MD3, Taizo A. Nakano, MD4, Alison A. Bertuch, MD, PhD5,6, Amy E. Geddis, MD, PHD7*, Margret Joos1*, Katherine Coyne1*, Karyn Brundige, MSN, CPNP1*, Sara Loveless8*, Leah Cheng1*, Kasiani C Myers, MD8,9 and Akiko Shimamura, MD, PhD10

1Department of Pediatric Hematology/Oncology, Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, MA
2Biostatistics and Research Design Center at BCH and Department of Pediatrics at Harvard Medical School, Boston, MA
3Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
4Center for Cancer and Blood Disorders, Children's Hospital Colorado, Aurora, CO
5Texas Children's Hospital, Houston, TX
6Department of Pediatrics, Division of Hematology/Oncology, Baylor College of Medicine, Houston, TX
7Cancer and Blood Disorders Center, Seattle Children's Hospital, Seattle, WA
8Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH
9Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH
10Boston Children's Hospital, Boston, MA

10:15 AM

Juncal Fernandez Orth, PhD1,2*, Cansu Koyunlar3*, Julia Miriam Weiss, PhD1*, Emanuele Gioacchino3*, Hans De Looper3*, Geoffroy Andrieux, PhD4*, Mariëtte Ter Borg3*, Joke Zink3*, Irene Gonzalez-Menendez5,6*, Remco Hoogenboezem, MSc7*, Baris Yigit1*, Kirsten Gussinklo3*, Roger Mulet-Lazaro, PhD7*, Marc Raaijmakers, MD3, Irene Gonzalez Menendez5*, Charlotte Wantzen1*, Sophie Pfeiffer1*, Christian Molnar1*, Eric Bindels3*, Sheila Bohler1*, Mathijs Arnoud Sanders, PhD3*, Leticia Quintanilla-Fend, MD5,6, Marcin Wlodarski, MD, PhD1,8, Melanie Boerries, MD, PhD4,9*, Ivo Paul Touw, PhD3, Charlotte Marie Niemeyer, MD10, Miriam Erlacher11,12 and Emma De Pater, PhD3*

1Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, Medical Center, University Medical Center Freiburg, Germany, Freiburg, Germany
2Department of Pediatrics and Adolescent Medicine, University Medical Center Ulm, Ulm, Germany, Ulm, Germany
3Department of Hematology, Erasmus Medical Center Cancer Institute, Rotterdam, Netherlands
4Institute of Medical Bioinformatics and Systems Medicine, Medical Center, Freiburg, Germany
5Institute of Pathology and Neuropathology and Comprehensive Cancer Center Tübingen, Eberhard-Karls-University, Tübingen, Germany
6Cluster of Excellence iFIT (EXC2180) "Image-Guided and Functionally Instructed Tumor Therapies", Eberhard-Karls-University, Tübingen, Germany
7Department of Hematology, Erasmus MC Cancer Institute, University Medical Center Rotterdam, Rotterdam, Netherlands
8St. Jude Children's Research Hospital, Memphis, TN
9German Cancer Consortium (DKTK), Medical Center Freiburg, Freiburg, Germany
10Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, Medical Center, University Medical Center Freiburg, Germany, Freiburg, Baden Württemberg, Germany
11Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, University Medical Center Freiburg, Freiburg, Germany
12Section experimental Pediatric Oncology, Department of Pediatrics and Adolescent Medicine, Ulm, Germany

10:30 AM

Neha Nagpal, PhD1,2,3* and Suneet Agarwal, MD, PhD1,2,3

1Hematology/Oncology, Stem Cell Program, and Manton Center for Orphan Disease Research, Boston Children's Hospital, Boston, MA
2Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA
3Pediatrics, Harvard Medical School, Boston, MA

10:45 AM

Rachel M Hendricks, BS1*, Jung Kim, PhD1*, Jeremy S Haley, MS2*, Mark Louie Ramos, PhD3*, Uyenlinh L Mirshahi, PhD2*, David J Carey, PhD2*, Douglas R Stewart, MD1* and Lisa J McReynolds, MD, PhD1

1Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD
2Department of Molecular and Functional Genomics, Department of Genomic Health, Weis Center for Research, Geisinger Medical Center, Danville, PA
3Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD

*signifies non-member of ASH