Divij Verma, PhD¹, Rachel Zeig Owens^2*, David G Goldfarb^3*, Kith Pradhan, PhD^4*, Srabani Sahu, MS^1*, Susheian Kelly^2*, Orsi Giricz, PhD, MSc^5,6, Sakshi Jasra, MD⁷, Yiyu Zou^2*, Colette Prophete^8*, Lidiane Torres^9*, Srinivas Aluri, PhD¹⁰, Samarpana Chakraborty¹¹, Shanisha Gordon Mitchell^1*, Rajni Kumari^12*, Jingli Wang, PhD^8*, Alexander J Silver, BA, PhD^13,14, Charles Hall, PhD^2*, Ryan Bender^15*, Ola Landgren¹⁶, Lee Greenberger^17*, Advaitha Madireddy, PhD¹⁸, Aditi Shastri, MD^1,19, Lindsay Lafave, PhD^8*, Anna Nolan^20*, Michael R. Savona, MD^21*, Ulrich Steidl^8,22, David Prezant^23* and Amit Verma, MD^1,24

¹Blood Cancer Institute, Department of Oncology, Albert Einstein College of Medicine, Bronx, NY
²Albert Einstein College of Medicine, Bronx, NY
³Montefiore Medical Center, Bronx, NY
⁴Department of Oncology, Blood Cancer Institute, Albert Einstein College of Medicine, Bronx, NY
⁵Albert Einstein College of Medicine, Bronx
⁶The Leukemia & Lymphoma Society, Rye Brook, NY
⁷Department of Hematology/Oncology, University of Vermont Larner College of Medicine, Burlington, VT
⁸Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY
⁹Department of Cell Biology, Albert Einstein College of Medicine, New York, NY
¹⁰Montefiore Einstein Cancer Center, Blood Cancer Institute, Department of Oncology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY
¹¹Albert Einstein College of Medicine, New York, NY
¹²Albert einstein College of Medicine, Bronx
¹³Vanderbilt University Medical Center, Nashville, TN
¹⁴Vanderbilt University School of Medicine, Nashville, TN
¹⁵Genoptix, Carlsbad, CA
¹⁶Sylvester Comprehensive Cancer Center, Miami, FL
¹⁷Leukemia and Lymphoma Society, New York
¹⁸Rutgers Cancer Institute of New Jersey, Robert Wood Johnson Medical School, New Brunswick, NJ
¹⁹Montefiore Einstein Comprehensive Cancer Center, Blood Cancer Institute, Department of Oncology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY
²⁰NYU School of Medicine, New York, NY
²¹Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN
²²Department of Oncology, Montefiore Medical Center, Bronx, NY
²³FDNY World Trade Center Health Program, Fire Dept. of the City of New York (FDNY), New York, NY
²⁴Department of Medical Oncology, Albert Einstein College of Medicine, Bronx, NY

Xuesen Zheng, PhD^1*, Prodromos Chatzikyriakou^1*, Louis-Francois Handfield^1*, Maroof Hasan^2*, Diego A. Pereira-Martins, Ph.D.^1,3*, Sarah J Mackie^1*, Maria del Pilar Casares Alaez^1*, Isabel Weinhäuser, PhD^1,3*, Nogayhan Seymen^4*, Kai Yi Mok^1*, Viktorija Uksaite^1*, Marta Rzepkowska^1*, Laarni Bogaanay^5*, Matthew Sadler^6*, Jovan Mircetic^7*, Martin Bornhäuser, MD^7*, James Carmichael^2*, Daniel Bromage^6*, Pramila Krishnamurthy, MD^5*, Rajasekhar N.V.S. Suragani, PhD⁸, Ghulam Mufti^1,5*, Giorgio Napolitani, PhD^1*, Anita K. Gandhi, PhD⁹ and Lynn Quek, MD, Ph.D.^5,10*

¹Comprehensive Cancer Centre, School of Cancer and Pharmaceutical Sciences, King's College London, London, United Kingdom
²Bristol Myers Squibb, Summit, NJ
³Department of Experimental Hematology, University Medical Center Groningen, Groningen, Netherlands
⁴Comprehensive Cancer Centre, King's College London, London, United Kingdom
⁵King's College Hospital, London, United Kingdom
⁶British Heart Foundation Centre, School of Cardiovascular and Metabolic Medicine & Sciences, King's College London, London, United Kingdom
⁷University Hospital Carl Gustav Carus, Technical University Dresden, Dresden, Germany
⁸Hematology Translational Medicine, Bristol Myers Squibb, Cambridge, MA
⁹Hematology, Translational Medicine, Bristol Myers Squibb, Summit, NJ
¹⁰Myeloid Leukaemia Genomics and Biology Group, School of Cancer and Pharmaceutical Sciences, King's College London, London, United Kingdom

Sean Wen^1,2*, Marcin Karpinski^1*, Dimitrios Vitsios^1*, Sebastian Wasilewski^1*, Slavé Petrovski^1*, Andrew R. Harper^1,3*, Margarete A. Fabre^1,4*, George S Vassiliou, MD, PhD^4,5 and Jonathan Mitchell^1*

¹Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, United Kingdom
²Department of Haematology, Wellcome-MRC Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, United Kingdom
³Clinical Development, Research and Early Development, Respiratory and Immunology (R&I), BioPharmaceuticals R&D, AstraZeneca, Cambridge, United Kingdom
⁴Department of Haematology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom
⁵Department of Haematology and Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom

Gordon Gaa Lam Wong, BS^1,2*, Blair Gage^3,4*, Mahmoud El-Maklizi^5*, Ash Hagerman^5,6*, Gregory Kent^7,8*, Hyerin Kim^2*, Nathan Mbong^2*, Liqing Jin^2*, Olga Gan^2*, Clinton Robbins^5,6*, Gordon Keller^7,8*, Robert J Vanner, MD, PhD^2,9, Eric Richard Lechman^10* and John Edgar Dick^2,11

¹Department of Molecular Genetics, University of Toronto, Thornhill, ON, Canada
²Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada
³Sprott Centre for Stem Cell Research, Ottawa Hospital Research Institute, Regenerative Medicine Program, Ottawa, ON, Canada
⁴Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, Canada
⁵Peter Munk Cardiac Centre, Toronto General Research Institute, University Health Network, Toronto, ON, Canada
⁶Department of Immunology, University of Toronto, Toronto, ON, Canada
⁷McEwen Stem Cell Institute, University Health Network, Toronto, ON, Canada
⁸Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada
⁹Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada
¹⁰UPMC Hillman Cancer Center, Pittsburgh, PA
¹¹Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada

June-Wha Rhee^1*, Sitong Chen, MPH^1*, Raju Pillai, MD^2*, Alysia Bosworth, BA^1*, Artem Oganesyan^1*, Liezl Atencio^1*, Caitlyn Estrada^1*, Mareen Kassabian^1*, Lanie Lindenfeld^1*, Scott R. Goldsmith, MD³, Michael Rosenzweig, MD³, Alex F. Herrera, MD⁴, Matthew Mei, MD⁵, Ryotaro Nakamura, MD⁶, F. Lennie Wong, PhD⁴, Stephen J. Forman, MD, FACP⁷ and Saro Armenian, DO, MPH¹

¹City of Hope National Medical Center, Duarte, CA
²Department of Pathology, City of Hope National Comprehensive Cancer Center, Duarte, CA
³Judy and Bernard Briskin Center for Multiple Myeloma Research, City of Hope, Duarte, CA
⁴City of Hope, Duarte, CA
⁵City of Hope Cancer Center, Duarte, CA
⁶Hematology and HCT, City of Hope National Medical Center, Duarte, CA
⁷Department of Hematology and Hematopoietic Cell Transplantation, Gehr Family Center for Leukemia Research, City of Hope National Medical Center, Duarte, CA

Venkatasubramaniam Sundaramurthy, MS^1,2,3, Yue Yuan, MD PhD^4,5*, Liting Liu, MS^1,3*, Art Schuermans, B.Sc^6,7,8*, Seyedmohammad Saadatagah, MD^4,5*, Zhi Yu, MB, PhD^6,7*, Alejandra G Martell, AAS^1,3*, Xiaoyan Zhang, MS^1,3*, Jia Song, MD MS^4,5*, Christie M. Ballantyne, MD^4,5,9*, Michael C Honigberg, MD, MPP^6,7,10*, Pradeep Natarajan, MD, MMSc^6,7,10*, Na Li, PhD^4,5* and Margaret Goodell, PhD^1,3,4,11

¹Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston
²Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX
³Stem Cells and Regenerative Medicine Center, Baylor College of Medicine, Houston
⁴Cardiovascular Research Institute, Baylor College of Medicine, Houston
⁵Department of Medicine, Baylor College of Medicine, Houston
⁶Program in Medical and Population Genetics and Cardiovascular Disease Initiative, Broad Institute of Harvard and MIT, Boston
⁷Cardiovascular Research Center and Center for Genomic Medicine, Massachusetts General Hospital, Boston
⁸Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium
⁹Center for Translational Research in Inflammatory Diseases, Baylor College of Medicine, Houston
¹⁰Department of Medicine, Harvard Medical School, Boston
¹¹Department of Molecular and Human Genetics, Baylor College of Medicine, Houston