66th ASH Annual Meeting: 101. Red Cells and Erythropoiesis, Excluding Iron: Erythropoiesis in Disease

Symposia: Red Cells and Erythropoiesis, Excluding Iron Oral and Poster Abstracts
Oral

Research, Fundamental Science, Translational Research, Autoimmune hemolytic anemia, CHIP, Genetic Disorders, Genomics, Bioinformatics, Other Pathogens, Hematopoiesis, Diseases, Immune Disorders, Infectious Diseases, Metabolism, Biological Processes, Metabolic Disorders, Molecular biology, Technology and Procedures, Multi-systemic interactions, Pathogenesis

Room 28 A-D (San Diego Convention Center)

Moderators:

Sioban Keel, MD, University of Washington and Roberta Russo, CEINGE - Biotecnologie Avanzate

Disclosures:

Russo: Novo Nordisk: Consultancy; Agios Pharmaceuticals: Research Funding.

This session contains presentations describing changes to erythropoiesis in different anemias and potential targets for therapeutic intervention.

4:30 PM

937

Sting and Vdac Inhibitors Ameliorate Ineffective Erythropoiesis in a Mouse Model of Anemia Induced By Mutation in EKLF/KLF1

Tasleem Arif, Ph.D¹^*, Kaustav Mukherjee, PhD²^*, Li Xue, MS²^* and James J Bieker, Ph.D²

¹Sylvester Comprehensive Cancer Center, Department of Biochemistry and Molecular Biology, Miller School of Medicine, University of Miami, Miami, FL
²Cell, Developmental, and Regenerative Biology, Mount Sinai School of Medicine, New York, NY

4:45 PM

938

The LSD1 Inhibitor RN1 Rescues Congenital Dyserythropoietic Anemia Type II

Lei Yu¹^*, Yu Wang²^*, Richard King, M.D.³, Greggory Myers, B.S.², Beth McGee⁴^*, Ann Friedman, B.S.¹^*, Ginette Balbin-Cuesta, MD, PhD^5,6, Zesen Lin, BS⁷, Claire Drysdale, BSc^2,5, Xiaofang Liu⁸^*, Claire Kerpet, B.S.¹^*, Kaiwen Deng⁸^*, Aaron Robida⁹^*, James Engel, Ph.D.² and Rami Khoriaty, MD^10,11,12,13

¹Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI
²Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI
³Department of Internal Medicine, University of Michigan, Ann Arbor, MI
⁴Howard Hughes Medical Institute, Ann Arbor, MI
⁵Medical Scientist Training Program, University of Michigan Medical School, Ann Arbor, MI
⁶Cellular and Molecular Biology Program, University of Michigan Medical School, Northville, MI
⁷Department of Pharmacology, University of Michigan Medical School, Ann Arbor, MI
⁸University of Michigan, Ann Arbor, MI
⁹Center for Chemical Genomics, University of Michigan Life Sciences Institute, Ann Arbor, MI
¹⁰Department of Internal Medicine, Regents of The University of Michigan, Ann Arbor, MI
¹¹Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI
¹²Cellular and Molecular Biology Program, University of Michigan, Ann Arbor, MI
¹³Rogel Cancer Center, University of Michigan, Ann Arbor, MI

5:00 PM

939

Multiomic Analyses of Erythropoiesis and Anemia Mechanisms Reveal a Signaling Network with Converging Cytokine and Sphingolipid Inflammatory Pathways

Ruiqi Liao, PhD¹^*, Daniel J Nesbitt^2,3^*, Joshua J Coon, PhD^2,3,4^*, Katherine Overmyer, PhD^3,4^*, Yusuf A Hannun, MD^5,6^*, Chiara Luberto, PhD⁷^* and Emery H. Bresnick¹

¹School of Medicine and Public Health, Wisconsin Blood Cancer Research Institute, Department of Cell and Regenerative Biology, Carbone Cancer Center, University of Wisconsin-Madison, Madison, WI
²Department of Chemistry, University of Wisconsin-Madison, Madison, WI
³Department of Biomolecular Chemistry, National Center for Quantitative Biology of Complex Systems, University of Wisconsin-Madison, Madison, WI
⁴Morgridge Institute for Research, Madison, WI
⁵Northport Veterans Affairs Medical Center, Northport, NY
⁶Department of Medicine, Stony Brook University, Stony Brook, NY
⁷Department of Physiology and Biophysics, Stony Brook University, Stony Brook, NY

5:15 PM

940

An Essential Role for the N-Terminus of GATA1 in Metabolic Regulation during Erythropoiesis

Te Ling, PhD¹, Lavanya Bezavada, MS¹^*, Rashid Mehmood, PhD¹^*, Kevin Zhang, BA², Jeremy Chase Crawford, PhD³^*, Yan Ju, PhD¹^*, Chun-Wei David Chen, PhD⁴, Yichao Li, PhD¹^*, Yong Cheng, PhD¹ and John D. Crispino, PhD¹

¹Department of Hematology, St. Jude Children's Research Hospital, Memphis, TN
²Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN
³Department of Host Microbe Interactions, St. Jude Children's Research Hospital, Memphis, TN
⁴Department of Systems Biology, Beckman Research Institute, City of Hope, Duarte, CA

5:30 PM

941

The BET Proteins Brd4 and CBP Contribute to Severity of Anemia in EKLF/KLF1 Mutants By Driving Selective Release of Paused RNA Polymerase II

Kaustav Mukherjee, PhD¹^*, Li Xue, MS²^*, Haocheng Fang, B.S.³^*, Jan Frayne, PhD⁴^* and James J Bieker, Ph.D²

¹Institute for Regenerative Medicine, Cell, Developmental, and Regenerative Biology, Mount Sinai School of Medicine, New York, NY
²Cell, Developmental, and Regenerative Biology, Mount Sinai School of Medicine, New York, NY
³Department of Biostatistics and Bioinformatics, Emory University Rollins School of Public Health, Atlanta, GA
⁴Department of Biochemistry, University of Bristol, Bristol, United Kingdom

5:45 PM

942

Cross-Linking of Erythrocyte CD44 Promotes Plasmodium Falciparum Invasion

Angel K. Kongsomboonvech¹^*, Praveesh Valissery, PhD¹^*, Nichole D. Salinas²^*, Niraj Tolia, PhD, FASTMH²^* and Elizabeth S. Egan, MD, PhD^1,3,4

¹Department of Pediatrics, Stanford University School of Medicine, Stanford, CA
²Host-Pathogen Interactions and Structural Vaccinology Section, Laboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD
³Department of Microbiology & Immunology, Stanford University School of Medicine, Stanford, CA
⁴Chan Zuckerberg Biohub-San Francisco, San Francisco, CA

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^*signifies non-member of ASH

101.O1.6 101. Red Cells and Erythropoiesis, Excluding Iron: Erythropoiesis in Disease