66th ASH Annual Meeting: 330. Vascular Biology, Thrombosis, and Thrombotic Microangiopathies: Basic and Translational: Platelets and Endothelium in Thrombotic Disorders

Symposia: Vascular Biology, Thrombosis, and Thrombotic Microangiopathies: Basic and Translational Oral and Poster Abstracts
Oral

Research, Fundamental Science, Bleeding and Clotting, Bleeding disorders, Translational Research, Platelet disorders, Thromboembolism, Diseases, Immune mechanism, SARS-CoV-2/COVID-19, Thrombotic disorders, Infectious Diseases, Immunology, VWD, Biological Processes, Molecular biology, Technology and Procedures, Pathogenesis, Imaging, Molecular testing

Room 25 (San Diego Convention Center)

Moderators:

Alec A Schmaier, MD, PhD, Beth Israel Deaconess Medical Center and Brian R. Branchford, MD, ARRAY(0xe992768)

Disclosures:

Branchford: Novo Nordisk: Honoraria; Kedrion: Honoraria, Research Funding.

2:00 PM

181

TMEM16E and TMEM16F Regulate the Generation and Procoagulant Activity of Extracellular Vesicles during Endothelial Cell Inflammation

Papa F Anderson^1,2^*, Kobe Tray^1,2^*, Ivan Aivasovsky, MD^1,2^*, Allison M Gabbert, PhD^1,2,3^* and Alec A Schmaier, MD, PhD^1,2,3

¹Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA
²Division of Hemostasis and Thrombosis, Beth Israel Deaconess Medical Center, Boston, MA
³Harvard Medical School, Boston, MA

2:15 PM

182

An Important Role for P-Selectin in Thrombotic Microangiopathy

Raymond Adili, MD¹, Nicole Roads¹^*, Hallie Lazaro¹^*, Junmei Chen, PhD¹, Dominic W. Chung, Ph.D^1,2^* and José A. López, M.D^1,2

¹Bloodworks Research Institute, Seattle, WA
²University of Washington, Seattle, WA

2:30 PM

183

Piezo1-Mediated Thromboprotection Is Markedly Influenced By Laminar Shear Forces in Vitro and in Vivo

Kelsey D Sack, MD, PhD^1,2, Calum MacRae, MD, PhD³^* and Robert Flaumenhaft, MD, PhD⁴

¹Division of Hemostasis and Thrombosis, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Belmont, MA
²Division of Pulmonary and Critical Care, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA
³Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA
⁴Division of Hemostasis and Thrombosis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA

2:45 PM

184

HDL and HDL-Mimetic Nanoparticles Prevent Induced TTP and Interrupt the Course of Ongoing Episodes of the Disease

Reheman Adili, MD¹, Nicole Roads¹^*, Hallie Lazaro¹^*, Jeffrey Harris¹^*, Minhua Ling, PhD¹^*, Junmei Chen, PhD¹, José A. López, M.D^1,2 and Dominic W. Chung, Ph.D^1,2^*

¹Bloodworks Research Institute, Seattle, WA
²University of Washington, Seattle, WA

3:00 PM

185

Antiphospholipid Syndrome (APS) Is a Platelet Factor 4 (PF4)-Centric Immunothrombotic Disorder

Conroy O Field, MS^1,2, Amrita Sarkar, PhD², Khalil Bdeir, PhD³^*, Keith R. McCrae, MD^4,5, Thomas L. Ortel, MD, PhD⁶, M. Anna Kowalska, PhD^2,7^*, Lubica Rauova, MD, PhD^2,8, Douglas B. Cines, MD³, Kandace Gollomp, MD^2,8 and Mortimer Poncz, MD^2,8

¹Perelman School of Medicine Pharmacology Graduate Group, University of Pennsylvania, Philadelphia, PA
²Division of Hematology, Children's Hospital of Philadelphia, Philadelphia, PA
³Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA
⁴Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, OH
⁵Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH
⁶Division of Hematology, Duke University School of Medicine, Durham, NC
⁷Institute of Medical Biology, Polish Academy of Science, Lodz, Poland
⁸Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA

3:15 PM

186

Platelets-Derived Integrin and Tetraspanin-Rich Tethers (PITTs) Drive Pulmonary Inflammation

Christian Hackenbroch^1,2^*, Charly Kusch, PhD^1,3^*, Denise Johnson, M.Sc.^1,3^*, Paquita Nurden, MD, PhD⁴^*, Carina Gross, PhD^1,3^*, Philipp Burkard, PhD³^*, Lukas Johannes Weiss, MD^3,5^*, Markus Sauer, PhD^1,6^*, Harald Schulze, PhD³, Alan T. Nurden, PhD⁴^*, David Stegner, PhD^1,3^* and Bernhard Nieswandt, PhD^1,3^*

¹Rudolf Virchow Center for Integrative and Translational Bioimaging, University of Würzburg, Würzburg, Germany
²Institute of Experimental Biomedicine, University Hospital Würzburg, Würzburg, AL, Germany
³Institute of Experimental Biomedicine, University Hospital Würzburg, Würzburg, Germany
⁴Institut Hospitalo-Universitaire LIRYC, Hôpital Xavier Arnozan, Pessac, France
⁵Department of Internal Medicine I, University Hospital Würzburg, Würzburg, Germany
⁶Department of Biotechnology and Biophysics, University of Würzburg, Würzburg, Germany

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^*signifies non-member of ASH

330.O2.6 330. Vascular Biology, Thrombosis, and Thrombotic Microangiopathies: Basic and Translational: Platelets and Endothelium in Thrombotic Disorders