66th ASH Annual Meeting: 301. Platelets and Megakaryocytes: Basic and Translational: Megakarocyte and Platelet Biology: From Formation to Function

Symposia: Platelets and Megakaryocytes: Basic and Translational Oral and Poster Abstracts
Oral

Research, Fundamental Science, Bleeding and Clotting, Autoimmune disorders, Bleeding disorders, Translational Research, CHIP, Platelet disorders, Bioinformatics, Genomics, Hematopoiesis, Thrombocytopenias, Immune Disorders, Immune mechanism, Diseases, Thrombotic disorders, Immunology, Computational biology, Biological Processes, Molecular biology, Technology and Procedures, Profiling, Imaging, Omics technologies

Room 28 A-D (San Diego Convention Center)

Moderators:

Harvey G. Roweth, PhD, ARRAY(0xe31c7b8) and Molly Mollica, PhD, University of Maryland

Disclosures:

No relevant conflicts of interest to declare.

9:30 AM

421

Tolerance of Whole Genome Duplication in Megakaryocytes, and Consequences for Their Genome Integrity

Antonio Rodriguez-Romera¹^*, Rong Li, PhD¹^*, Nah-Young Shin, PhD²^*, Sally-Ann Clark, PhD, BSc³^*, Assunta Adamo, PhD, MSc, BSc¹^*, Affaf Aliouat, PhD¹^*, Abdullah Khan¹, Aude-Anais Olijnik¹^*, Jill Brown¹^*, Lucia Sommerova¹^*, Natalie Jooss¹^*, Akiko Shimamura, MD, PhD^2,4, Xin Lu, PhD⁵^*, Guanlin Wang, PhD⁶^*, Stefan N. Constantinescu, MD, PhD⁷, Ketan Patel, PhD¹^*, Adam J Mead, PhD, MRCP, FRCPath⁸, Alan B. Cantor, MD, PhD⁹ and Bethan Psaila, MD, PhD¹⁰

¹MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom
²Pediatric Hematology-Oncology Department, Children's Hospital and Dana-Farber Cancer Institute, Boston, MA
³Medical Research Council (MRC) Weatherall Institute of Molecular Medicine (WIMM) and NIHR Biomedical Research Centre, University of Oxford, Oxford, United Kingdom
⁴Boston Children's Hospital, Boston, MA
⁵Ludwig Institute for Cancer Research, University of Oxford, Oxford, United Kingdom
⁶Fudan University, Institute of Metabolism and Integrative Biology, Shanghai, China
⁷Ludwig Institute for Cancer Research, Brussels, Belgium
⁸Medical Research Council (MRC) Weatherall Institute of Molecular Medicine (WIMM), University of Oxford, Oxford, United Kingdom
⁹Pediatric Hematology-Oncology, Children's Hospital and Dana-Farber Cancer Institute, Boston, MA
¹⁰Medical Research Council (MRC) Weatherall Institute of Molecular Medicine (WIMM), University of Oxford, Oxford, ENG, United Kingdom

9:45 AM

422

Tet2 Age-Associated Somatic Mutations Impair Megakaryopoiesis and Platelet Function in Clonal Hematopoiesis

Virginia Camacho, PhD, BA^1,2, Estelle Carminita, PhD^1,3^*, Maria Barrachina, PhD^4,5, Isabelle C Becker, PhD, MSc^1,2, Joseph E. Italiano, PhD² and Kellie R Machlus, PhD^1,2

¹Vascular Biology Program, Boston Children's Hospital, Boston, MA
²Harvard Medical School, Boston, MA
³Surgery Departement, Harvard Medical School, Boston, MA
⁴Surgery Department, Harvard Medical School, Boston
⁵Vascular Biology Program, Boston Children's Hospital, Boston

10:00 AM

423

Elucidating the Structural Dynamics and Native Modifications of α2-Macroglobulin from Native Platelet Samples By Cryo-EM Coupled with "Build and Retrieve" (BaR) Data Processing

Xu Han, PhD, Chih-Chia Su, PhD^*, Zhemin Zhang, PhD^*, Masaru Miyagi, PhD^*, Edward Yu, PhD^* and Marvin T. Nieman, PhD

Department of Pharmacology, Case Western Reserve University, Cleveland, OH

10:15 AM

424

Mechanistic Insights and Clinical Implications of the Thrombotic Risks of a Highly Prevalent GRK5 Variant Affecting Platelets

Yanki Yarman¹, Xuefei Zhao¹, Hyun Sook Ahn²^*, Hannah Thomson¹^*, Meghan Roberts¹^*, Deborah L. French, PhD³^*, Jeffrey Benovic, PhD¹^*, Timothy J. Stalker, PhD¹, Mortimer Poncz, MD⁴ and Peisong Ma, PhD¹

¹Thomas Jefferson University, Philadelphia, PA
²Children's Hospital of Philadelphia, Philadelphia, PA
³Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA
⁴Division of Hematology, Children's Hospital of Philadelphia, Philadelphia, PA

10:30 AM

425

β2-Adrenergic Receptor Agonist Terbutaline Regulates Macrophage Polarization Via HMGB1 in Immune Thrombocytopenia

Qiuyu Guo, MD^*, Ye-Jun Wu, MD^*, Gao-Chao Zhang^*, Yu-Xiu Chen^*, Meng-Lin Li^*, Meng-Yu Xiao^*, Jian-Ying Zhou^*, Lu-Lu Wang^*, Mengtong Zang, MS^*, Zhuo-Yu An^*, Hai-Xia Fu^*, Xiao-Jun Huang, MD and Xiao-Hui Zhang, MD, PhD

Peking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, China

10:45 AM

426

Differentiation Route Generates Functional Biased Platelets and Responses Distinctly to Varying Physiological Demands

Jingkun Liu^1,2^*, Liping Wang^1,2^*, Yanxun Su^1,2^*, Kunying Chen^1,2^*, Jing-Jing Li³^*, Bo O. Zhou, PhD⁴^*, Yueying Li, PhD^1,2^* and Qian-Fei Wang, PhD^1,2

¹China National Center for Bioinformation, Beijing, China
²Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China
³State Key Laboratory of Experimental Hematology, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China
⁴Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences., Shanghai, China

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^*signifies non-member of ASH

301.O1.6 301. Platelets and Megakaryocytes: Basic and Translational: Megakarocyte and Platelet Biology: From Formation to Function