66th ASH Annual Meeting: 201. Granulocytes, Monocytes, and Macrophages: Uncovering Pathways Impacting Inflammation, Myeloid Proliferation and Severe Congenital Neutropenia

Symposia: Granulocytes, Monocytes, and Macrophages Oral and Poster Abstracts
Oral

Research, Fundamental Science, Acute Myeloid Malignancies, AML, Translational Research, Inherited Marrow Failure Syndromes, Drug development, Genetic Disorders, Clinical Research, Bioinformatics, Hematopoiesis, Diseases, Immune Disorders, Neutropenia, Treatment Considerations, Adverse Events, Biological Processes, Myeloid Malignancies, Molecular biology, Technology and Procedures, Gene editing, Omics technologies

Grand Hall D (Manchester Grand Hyatt San Diego)

Moderators:

Julia T. Warren, MD, PhD, and Carlo Dufour, MD, IRCCS Istituto Giannina Gaslini

Disclosures:

Warren: X4 Pharmaceuticals: Consultancy, Research Funding. Dufour: Novartis: Consultancy; Sobi: Consultancy; Pfizer: Consultancy, Speakers Bureau; Gilead: Consultancy; Ono: Consultancy; Rockets: Consultancy.

In this exciting oral session new molecular pathways involved in inflammation and in myeloid cell proliferation will be presented. New disease-genes and agent potentially restoring granulopoiesis will be also illustrated.

9:30 AM

415

Path of Differentiation Distinctly Influences Macrophage Identity

Katie Frenis, PhD^1,2,3, Brianna Badalamenti, MS^1,3^*, Edroaldo Lummertz Da Rocha, PhD⁴^*, Chen Weng, PhD^5,6,7,8^*, Dahai Wang, PhD^1,9^*, Sara Fierstein, MS^1,10^*, R. Grant Rowe, MD, PhD^1,2,9,11,12 and Vijay G. Sankaran, MD, PhD^7,8,13,14

¹Stem Cell Program, Boston Children's Hospital, Boston, MA
²Harvard Medical School, Boston, MA
³Boston Children's Hospital, Boston, MA
⁴Federal University of Santa Catarina, Florianopolis, BRA
⁵Whitehead Institute for Biomedical Research, Cambridge, MA
⁶Division of Hematology/Oncology, Boston Children’s Hospital, Harvard Medical School, Boston, MA
⁷Broad Institute of MIT and Harvard, Cambridge, MA
⁸Howard Hughes Medical Institute, Boston, MA
⁹Pediatric Hematology-Oncology, Boston Children's Hospital, Boston, MA
¹⁰Division of Pediatric Hematology-Oncology, Boston Children's Hospital, Boston, MA
¹¹Dana-Farber Boston Children’s Cancer and Blood Disorders Center, Boston, MA
¹²Stem Cell Transplantation Program, Boston Children’s Hospital, Boston, MA
¹³Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, MA
¹⁴Division of Pediatric Oncology, Dana-Farber Cancer Institute / Harvard Medical School, Boston, MA

9:45 AM

416

CEBPA Regulates Molecular Kinetics of RNA Polymerase I in Myeloid Progenitors

Charles Antony, PhD¹, Subin S George¹^*, Justin Blum¹^*, Patrick Somers¹^*, Dexter Wu-Corts¹^*, Santosh Adhikari, PhD²^*, Maxim Pimkin, MD, PhD³, Mustafa Mir, PhD²^* and Vikram R Paralkar, MD¹

¹Department of Medicine, University of Pennsylvania, Philadelphia, PA
²The Children’s Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA
³Dana-Farber Cancer Institute, Brookline, MA

10:00 AM

417

Autosomal Recessive COPZ1 Mutations Cause Isolated Severe Neutropenia or Complex Syndrome with Severe Neutropenia

Natalia Alejandra Borbaran Bravo, MSc¹^*, Ekaterina Deordieva, MD, PhD²^*, Larissa Doll³^*, Mohammad Elgamacy, PhD^4,5^*, Benjamin Dannenmann, PhD³^*, Joana Azevedo⁶^*, Alberto Iannuzzo⁷^*, Selket Delafontaine^8,9^*, Moritz Lehners¹⁰^*, Marius Kolodziej¹¹^*, Birte Hernandez Alvarez¹²^*, Anna-Sophia Hellmuth⁵^*, Malte Ulrich Ritter¹³^*, Betül Findik³^*, Viktoria Zakharova¹⁴^*, Sandro Bräuning⁵^*, Sergey Kandabarau³^*, Claudia Lengerke, MD¹⁵, Robert Feil¹⁶^*, Isabelle Meyts, MD, PhD^8,17^*, Jerome Delon⁷^*, Markus Templin¹⁸^*, Marc Sturm¹⁹^*, Olaf Rieß¹⁹^*, Cornelia Zeidler, MD²⁰^*, Karl Welte, MD, PhD^20,21, Anna Shcherbina²²^*, Maksim Klimiankou, PhD²¹^* and Julia Skokowa, MD, PhD²¹

¹Department of Oncology, Hematology, Clinical Immunology, and Rheumatology, University hospital tuebingen, Tubingen, Germany
²Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Moscow, Russian Federation
³Department of Oncology, Hematology, Clinical Immunology, and Rheumatology, University Hospital Tuebingen, Tuebingen, Germany
⁴Department Protein Evolution, Max Planck Institute for Biology Tuebingen,, Tuebingen, Germany
⁵Department of Oncology, Hematology, Clinical Immunology, and Rheumatology, University Hospital Tuebingen, Tuebingen, DEU
⁶Faculty of Medicine, University of Coimbra, Coimbra, Portugal
⁷Université Paris Cité, CNRS, Inserm, Institut Cochin, Paris, FRA
⁸Department of Pediatrics, University Hospital Leuven, Leuven, Belgium
⁹Laboratory for Inborn Errors of Immunity-Department of Microbiology Immunology Transplantation, KU Leuven, Leuven, BEL
¹⁰Interfaculty Institute of Biochemistry, University of Tuebingen, Tueingen, DEU
¹¹NMI Natural and Medical Sciences Institute,, University of Tuebingen, Reutlingen, Germany
¹²Department Protein Evolution, Max Planck Institute for Biology, Tuebingen, Germany
¹³Department of Oncology, Hematology, Clinical Immunology, and Rheumatology, University Hospital Tuebingen, Tuebingen, BW, Germany
¹⁴National Medical Research Center for Endocrinology, Clinical data analysis department, Moscow, Russian Federation
¹⁵Department for Internal Medicine II, Hematology, Oncology, Clinical Immunology and Rheumatology, University Hospital Tuebingen, Tuebingen, Germany
¹⁶Interfaculty Institute of Biochemistry, University of Tuebingen, Tuebingen, DEU
¹⁷Laboratory for Inborn Errors of Immunity-Department of Microbiology Immunology Transplantation, KU Leuven, Leuven, AL, BEL
¹⁸NMI Natural and Medical Sciences Institute, University of Tuebingen, Reutlingen, DEU
¹⁹Institute of Medical Genetics and Applied Genomics, University Hospital Tuebingen, Tuebingen, DEU
²⁰University Children’s Hospital Tübingen, Tübingen, Germany
²¹Department of Oncology, Hematology, Immunology, Rheumatology and Clinical Immunology, University Hospital Tübingen, Tübingen, Germany
²²2Department of Immunology, Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Moscow, RUS

10:15 AM

418

CXCR4 Antagonism Corrects Peripheral Neutropenia and Mature Neutrophil Accumulation in Bone Marrow in a Pharmacological Mouse Model of CXCR2 Loss-of-Function

Chi Nguyen, PhD¹^*, Robert Johnson²^*, Katarina Zmajkovicova¹^*, Angelina Sekirnik³^*, Sarah Taplin⁴^*, Myriam Defontis⁵^*, Jacob R. Bledsoe⁶, Lars Karlsson¹^* and Arthur G. Taveras²^*

¹X4 Pharmaceuticals (Austria) GmbH, Vienna, Austria
²X4 Pharmaceuticals Inc., Boston, MA
³Research & Development Consultant for X4 Pharmaceuticals, Boston, MA
⁴Integrated Biologix GmbH, Basel, Switzerland
⁵Defontis Veterinary Clinical Pathology, Bully, France
⁶Department of Pathology, Boston Children's Hospital, Boston, MA

10:30 AM

419

Flavopiridol Restores Granulopoiesis in an Experimental Model of Severe Congenital Neutropenia

Benjamin Dannenmann, PhD¹^*, Masoud Nasri, PhD^1,2^*, Larissa Doll¹^*, Betül Findik¹^*, Franka Bernhard¹^*, Sergey Kandabarau¹^*, Maksim Klimiankou, PhD³^*, Claudia Lengerke, MD¹, Cornelia Zeidler, MD⁴^*, Karl Welte, MD, PhD^3,5 and Julia Skokowa, MD, PhD^2,3

¹Department of Oncology, Hematology, Clinical Immunology, and Rheumatology, University Hospital Tuebingen, Tuebingen, Germany
²Gene and RNA Therapy Center (GRTC), University Hospital Tuebingen, Tuebingen, Germany
³Department of Oncology, Hematology, Immunology, Rheumatology and Clinical Immunology, University Hospital Tübingen, Tübingen, Germany
⁴Severe Chronic Neutropenia International Registry, Hannover Medical School, Hannover, Germany
⁵University Children’s Hospital Tübingen, Tübingen, Germany

10:45 AM

420

A Single-Cell Transcriptomic Atlas of Cytokine Storm in CAR-T Therapy, COVID-19, and SLE

Xia Li¹^*, Haikun Lin^1,2^*, Boxiang Wu^1,2^*, Xinyi Lai¹^*, Yinnan Tong¹^*, Jinyan Huang³^*, Pengxu Qian⁴^*, Yongxian Hu¹^* and He Huang, MD¹^*

¹Bone Marrow Transplantation Center of The First Affiliated Hospital & Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou, China
²Zhejiang University-University of Edinburgh Institute, Zhejiang University School of Medicine, Zhejiang University, Haining, China
³Biomedical big data center, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
⁴Bone Marrow Transplantation Center of The First Affiliated Hospital & Liangzhu Laboratory, Zhejiang University School of Medicine, HANGZHOU, China

See more of: Oral and Poster Abstracts

<< Previous Session | Next Session >>

^*signifies non-member of ASH

201.O2.6 201. Granulocytes, Monocytes, and Macrophages: Uncovering Pathways Impacting Inflammation, Myeloid Proliferation and Severe Congenital Neutropenia