66th ASH Annual Meeting: 203. Lymphocytes and Acquired or Congenital Immunodeficiency Disorders: Know Thy(mus) Self, Know Thy Enemy: From Lymphocyte Genetic Variation to Disease

Symposia: Lymphocytes and Acquired or Congenital Immunodeficiency Disorders Oral and Poster Abstracts
Oral

Research, Fundamental Science, Viral, Autoimmune disorders, Bleeding and Clotting, Translational Research, Genetic Disorders, Genomics, Bioinformatics, Clinical Research, Diseases, Immune Disorders, Immunodeficiency, Immune mechanism, Thrombocytopenias, Infectious Diseases, Immunology, White blood cell disorders, Lymphoid Malignancies, Biological Processes, Myeloid Malignancies, Technology and Procedures, Profiling, Pathogenesis

Room 11 (San Diego Convention Center)

Moderators:

Andres Chang, MD, PhD, Emory University and Chuanfeng Wu, MD, PhD, National Institutes of Health

Disclosures:

Chang: AstraZeneca: Consultancy, Honoraria.

12:00 PM

121

Cancer Versus Cardiac Mortality Risk with Adult Thymectomy

Kameron Allen Kooshesh, MD, BA^1,2,3,4, Brody Foy, DPhil⁵, Richard Baylis, MD, PhD⁶^*, Karin Gustafsson, PhD^1,2,3,4^*, Daniel Zlotoff, MD, PhD⁷^*, Tomas Neilan, MD⁷^* and David Scadden, MD^1,2,3,4

¹Harvard Stem Cell Institute, Cambridge, MA
²Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA
³Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA
⁴Harvard Medical School, Boston, MA
⁵Department of Laboratory Medicine & Pathology, University of Washington, Seattle, WA
⁶Division of Cardiology, University of California San Francisco, San Francisco, CA
⁷Division of Cardiology, Massachusetts General Hospital, Boston, MA

12:15 PM

122

DICE: Transcriptomic Profiling and Analysis of Impact of Genetic Variation on Rare Immune Cell Populations

Benjamin J Schmiedel, PhD¹, Zubin Roy¹^*, Vicente Fajardo Rosas¹^*, Cristian Gonzalez-Colin¹^*, Job Rocha¹^* and Pandurangan Vijayanand, MD, PhD²^*

¹La Jolla Institute for Immunology, La Jolla, CA
²La Jolla Institute For Immunology, La Jolla, CA

12:30 PM

123

Loss of LDH-a Accelerated CD8⁺ T Memory Cell Differentiation but Impairs Anti-Tumor Responses

Rushil Shah, BS¹^*, Konstantinos Aliazis, PhD²^*, Leda Xanthi Katopodi, MS³^*, Anthos A Christofides, MD, PhD¹^*, Halil-Ibrahim Aksoylar, PhD⁴^*, Dimitra Karagkouni, PhD^5,6^*, Rinku Pal, BS⁷^*, Lequn Li, MD, PhD⁸^*, Nikolaos Patsoukis, PhD⁷^*, Ioannis S Vlachos, PhD^3,6,9^*, Pankaj Seth, PhD¹⁰^* and Vassiliki A Boussiotis, MD, PhD¹¹

¹Beth Israel Deaconess Medical Center, Harvard Medical School, BOSTON, MA
²Hematology-Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Brookline, MA
³Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA
⁴Hematology-Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, BOSTON, MA
⁵Department of Pathology, Cancer Research Institute, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA
⁶Broad Institute of Harvard and MIT, Cambridge, MA
⁷Hematology-Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA
⁸Beth Isreal Deaconess Medical Center, Boston, MA
⁹Beth Israel Deaconess Medical Center, Boston, MA
¹⁰Janssen Research & Development, Spring House, PA
¹¹Hematology-Oncology, Beth Israel Deaconess Medical Center, Boston, MA

12:45 PM

124

T-Cell Transcriptomic Signatures in Adults with Primary Untreated Immune Thrombocytopenia Segregate By Age, Revealing Distinct Druggable Pathways

Lipei Shao, PhD¹^*, Aaron Boothby, MD², S. Lawrence Bailey, BS³^*, Aastha Chauhan⁴^*, Martin Boechenek⁵^*, Terry B. Gernsheimer, MD⁶, John W. Semple, PhD⁷, James L. Zehnder, MD⁸, V. Koneti Rao, MD⁹, Jin Ping, PhD¹^*, David F. Stroncek, MD, MS¹⁰, Moritz Stolla, MD¹¹ and Sandya R. Panch, MD, MPH¹²

¹Department of Transfusion Medicine, National Institutes of Health, Bethesda, MD
²University of Washington/Fred Hutchinson Cancer Center, Saint Paul, MN
³Bloodworks NW, Seattle, WA
⁴Bloodworks NW Research Institute, Seattle, WA
⁵BloodWorks NW, Seattle, WA
⁶University of Washington and Fred Hutchinson Cancer Center, Seattle, WA
⁷Division of Hematology and Transfusion Medicine, Lund University, Lund, Sweden
⁸Department of Pathology, Stanford University, Stanford, CA
⁹NIAID National Institutes of Health, Bethesda, MD
¹⁰Center for Cellular Engineering, National Institutes of Health Clinical Center, Bethesda, MD
¹¹Bloodworks and University of Washington, Seattle, WA
¹²Fred Hutchinson Cancer Center, Seattle, WA

1:00 PM

125

Imbalanced Expression of TACI Isoforms Regulated By TNFRSF13B Variants Promotes the Progression of Epstein-Barr Virus-Associated Lymphoproliferative Diseases

Xinyue Deng^1,2^*, Qiang Gao^1,2^*, Kefeng Shen^1,2^*, Wei Mu^1,2^*, Tong Ge, MD, PhD^1,2^*, Jiachen Wang, MD, PhD^1,2^*, Jianfeng Zhou, MD, PhD^1,2^*, Yicheng Zhang^1,2^*, Dengju Li, PhD^1,2 and Min Xiao, MD, PhD^1,2^*

¹Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
²Department of Scientific Research Management, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

1:15 PM

126

NT-I7, a Long-Acting Interleukin-7 Molecule, Promotes T Cell Reconstitution Following Radiation Injury through Thymic-Dependent and Independent Pathways

Yujing Zou, PhD¹^*, Jonathan Bardahl, DO²^*, Yiqun Jiao¹^*, James Yang²^*, Danika Dai²^*, Alexandra Wolfarth³^*, Danielle Borgonia⁴^*, Byung Ha Lee, PhD³^* and Benny J. Chen, MD⁵

¹Duke University, Durham, NC
²Duke University, Durham
³NeoImmuneTech, Inc, Rockville, MD
⁴NeoImmuneTech, Rockville, MD
⁵Duke Univ. Medical Center, Durham, NC

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^*signifies non-member of ASH

203.O1.6 203. Lymphocytes and Acquired or Congenital Immunodeficiency Disorders: Know Thy(mus) Self, Know Thy Enemy: From Lymphocyte Genetic Variation to Disease