66th ASH Annual Meeting: 101. Red Cells and Erythropoiesis, Excluding Iron: Regulation of Erythropoiesis

Symposia: Red Cells and Erythropoiesis, Excluding Iron Oral and Poster Abstracts
Oral

Research, Fundamental Science, Genomics, Bioinformatics, Computational biology, Biological Processes, Molecular biology, Technology and Procedures, Multi-systemic interactions, Imaging, Omics technologies

Room 6DE (San Diego Convention Center)

Moderators:

Katie Seu, PhD, ARRAY(0xf1c0328) and Scott A. Peslak, MD, PhD, Hospital of the University of Pennsylvania

Disclosures:

Peslak: Blueprint Medicines: Research Funding; Agios Pharmaceuticals: Consultancy, Membership on an entity's Board of Directors or advisory committees; Fulcrum Therapeutics: Consultancy.

This session contains presentations concerning the regulation erythroid gene expression and the regulation of enucleation during terminal erythroid maturation.

12:00 PM

535

A Short Isoform of Tensin1 Is a Novel Regulator of F-Actin Assembly in Human Erythroblasts That Promotes Enucleation

Velia M Fowler, PhD¹, Arit Ghosh, PhD¹^*, Megan Coffin¹^*, Dimitri Diaz¹^*, Vincent P Schulz, PhD²^* and Patrick G. Gallagher, MD³

¹Department of Biological Sciences, University of Delaware, Newark, DE
²Yale School of Medicine, New Haven, CT
³Center for Perinatal Research, Nationwide Childrens, Ohio State University, Columbus, OH

12:15 PM

536

HEXIM1 Regulates Early Erythropoiesis and Participates in Multiple Complexes in Erythroid Cells

Nabil F. Rahman, BS, MS^1,2, Deanna Abid³^*, Xiurui Lv, MBBS, MS³, Kristin Murphy, PhD⁴^*, Michael Getman³^*, Kathleen E. McGrath, PhD⁴, Patrick G. Gallagher, MD⁵, Mohandas Narla, DSc⁶, Lionel Blanc, PhD⁷, James Palis, MD⁴, Stephano Mello⁸^* and Laurie A. Steiner, MD³

¹Department of Pediatrics, University of Rochester School of Medicine & Dentistry, Rochester, NY
²Department of Pathology, University of Rochester School of Medicine & Dentistry, Rochester, NY
³Department of Pediatrics, University of Rochester, Rochester, NY
⁴University of Rochester, Rochester, NY
⁵Center for Perinatal Research, Nationwide Childrens, Ohio State University, New Albany, OH
⁶New York Blood Center, New York, NY
⁷Institute of Molecular Medicine, The Feinstein Institute For Medical Research, Manhasset, NY
⁸Department of Biomedical Genetics, Univesrity of Rochester, Rochester, NY

12:30 PM

537

LDB1 Establishes Multi-Enhancer Networks to Regulate Erythroid Gene Expression

Nicholas Aboreden, BS, MS¹^*, Jessica Lam, PhD²^*, Viraat Goel³^*, Siqing Wang, PhD⁴^*, Xiaokang Wang, PhD⁴^*, Susannah Midla⁴^*, Alma Quijano²^*, Cheryl A. Keller, PhD^5,6^*, Belinda M. Giardine⁶^*, Ross C. Hardison, PhD⁶^*, Haoyue Zhang, PhD⁷^*, Anders Hansen, PhD⁸^* and Gerd A. Blobel, MD, PhD¹

¹Department of Pediatrics (Hematology), Children's Hospital of Philadelphia, Philadelphia, PA
²University of Pennsylvania, Philadelphia
³Massachusetts Institute of Technology, Boston
⁴Children's Hospital of Philadelphia, Philadelphia
⁵Genomics Research Incubator, The Pennsylvania State University, University Park, PA
⁶Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA
⁷Shenzhen Bay Laboratory, Guangdong, China
⁸MIT Biological Engineering, Cambridge, MA

12:45 PM

538

Polycomb Repressive Complex 2 Regulates Differentiation-Stage-Specific Autophagy Gene Expression and Safeguards Normal Erythropoiesis

Jiazhuo Li, PhD¹, Panpan Zhu¹^*, Zhiling Shi¹^*, Longping Wen²^*, Stuart H Orkin, MD^3,4,5 and Huafeng Xie¹^*

¹Center for Medical Research on Innovation and Translation, Department of Hematology, Institute of Clinical Medicine, the Second Affiliated Hospital, School of Medicine, South China University of Technology, Guangzhou, China
²Medical Research Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University,, Guangzhou, China
³Dana-Farber Cancer Institute, Inc., Boston, MA
⁴Department of Hematology/Oncology, Harvard Medical School/Boston Children's Hospital, Boston, MA
⁵Howard Hughes Medical Institute, Boston

1:00 PM

539

A Novel Role of LKB1 in Erythroblast Enucleation

Yuanlin Xu¹^*, Jingxin Zhang²^*, Yan Li²^*, Huan Zhang³^*, Peijun Jia²^*, Yazhe Zhen²^*, Wanxin Li²^*, Tingting Zheng²^*, Ying Zhang²^*, Yihan Wang²^*, Yilin Zhang²^*, Yanyan Liu, MD, PhD⁴^*, Xiuli An, MD, PhD⁵ and Shijie Zhang³^*

¹Department of Internal Medicine, Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou, Henan, China
²School of Life Sciences, Zhengzhou University, Zhengzhou, China
³School of life science, Zhengzhou University, Zhengzhou, China
⁴Department of Internal Medicine, Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou, China
⁵Laboratory of Membrane Biology, New York Blood Center, New York, American Samoa

1:15 PM

540

STAT5 Facilitates Terminal Erythroid Maturation in Concert with the Integrator Complex

Xiurui Lv, MBBS, MS¹, Kristin Murphy, PhD²^*, Alexander Parks³^*, Nabil F. Rahman, BS, MS⁴, MaryClaire Haseley⁵^*, Michael Getman¹^*, Apoorva Baluapuri⁶^*, Karen Adelman⁷^*, Eric J Wagner⁵^* and Laurie A. Steiner, MD¹

¹Department of Pediatrics, University of Rochester, Rochester, NY
²University of Rochester, Rochester, NY
³University of Rochester, Rochester
⁴Department of Pathology, University of Rochester School of Medicine & Dentistry, Rochester, NY
⁵Department of Biochemistry and Biophysics, University of Rochester, Rochester, NY
⁶Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA
⁷Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Cambridge, MA

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^*signifies non-member of ASH

101.O3.6 101. Red Cells and Erythropoiesis, Excluding Iron: Regulation of Erythropoiesis