66th ASH Annual Meeting: ASH Poster Walk on Deciphering the Hematopoietic Stem Cell Niche: From Normal Function to Malignancy Hosted by Blood Neoplasia (For In-person Participants)

ASH Poster Walks

Research, Fundamental Science, Acute Myeloid Malignancies, AML, MDS, Artificial intelligence (AI), Translational Research, MPN, CHIP, Assays, CML, Chronic Myeloid Malignancies, CMML, Hematopoiesis, Diseases, Metabolism, Myeloid Malignancies, Biological Processes, Molecular biology, Technology and Procedures, Profiling, Imaging, Molecular testing

Halls G-H - Blood Journals Studio (San Diego Convention Center)

Hematopoietic stem cells (HSCs) are pivotal in the production and lineage determination of blood cells, maintained by an intricate network of interactions within the bone marrow (BM) niche. Disruption of this tightly regulated environment leads to hematopoietic deregulation and the development of hematological malignancies. Recent advances in both in vitro and in vivo techniques have paved the way for innovative diagnostic and therapeutic strategies targeting hematological malignancies within their microenvironment.

The Poster Walk will showcase the latest high-impact research (featured in the posters) on the HSC niche, highlighting both basic research and clinical implications. It will provide a valuable platform for the exchange of knowledge and ideas, promoting greater understanding and collaboration within the ASH community as well as raising awareness and stimulate interest in this often under-represented but crucial area of hematology.

Join us in the Blood Studio located in the main Poster Hall for this in-person poster walk hosted by ASH’s Blood Neoplasia journal.

2676

Single-Cell Transcriptomics of Bone Marrow Mesenchymal Stromal Cells Identifies Altered CLCF1 Signaling in DNMT3A-Mutated Clonal Hematopoiesis

Anna Navarro Figueredo¹^*, Daniele Scarcella, MSc²^*, Michele C Buck, MSc¹^*, Maximilian Buser, PhD²^*, Jennifer Rivière, PhD¹^*, Michael Sterr, PhD³^*, Wencke Walter, PhD⁴, Priyansh Srivastava, MSc^5,6^*, Judith S. Hecker, MD¹^*, Ana Conesa, PhD^5,6^*, Mark van der Garde, PhD¹^*, Carsten Marr, PhD^7,8^* and Katharina S. Götze, MD⁹

¹Department of Medicine III, Hematology and Oncology, Technical University of Munich (TUM), School of Medicine and Health, Munich, Germany
²Institute of AI for Health, Helmholtz Zentrum Munich - German Research Center for Environmental Health, Neuherberg, Germany
³Institute of Diabetes and Regeneration Research, Helmholtz Diabetes Center, Helmholtz Center Munich, Neuherberg, Germany
⁴Munich Leukemia Laboratory, Munich, Germany
⁵BioBam Bioinformatics S.L., Valencia, Spain
⁶Institute for Integrative Systems Biology (CSIC-UV), Spanish National Research Council, Valencia, Spain
⁷Institute of AI for Health, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany
⁸Helmholtz AI, Helmholtz Zentrum Munich - German Research Center for Environmental Health, Neuherberg, Germany
⁹Department of Medicine III, TUM University Hospital, Technical University of Munich, Munich, Germany

2761

M2-like Macrophages Transfer Mitochondria to Acute Myeloid Leukaemia Cells Via Tunnelling Nanotubes Promoting Therapy Resistance

Ebubechukwu Osinachi Nwarunma, MSc, BSc¹^*, Katerina Miari, PhD²^*, Athanasia Papadopoulou, MSc³^*, Leandro Martinez, PhD⁴^*, Victoria Campbell, MD, PhD⁵^*, Samantha Hurwitz, PhD⁶, Tatiana Fourfouris, MSc⁶, Ki Jun Lee, MSc⁶, Carl Goodyear, PhD⁷^*, Theodoros Simakou, PhD⁷^*, Marcus Doohan, BSc⁷^*, Lucy MacDonald, PhD⁷^*, Timothy Humpton, PhD^3,8^*, Lesley Forrester, PhD⁹^*, Mariola Kurowska-Stolarska, PhD⁷^*, Ken I Mills, PhD, FRCPath¹⁰, Yong-Mi Kim, MD, PhD, MPH⁶, Helen Wheadon, PhD²^*, Monica L Guzman, PhD¹¹ and Mark T Williams, PhD^3,12^*

¹Department of Biological and Biomedical Sciences, Glasgow Caledonian University, Glasgow, SCO, United Kingdom
²Paul O’Gorman Leukaemia Research Centre, School of Cancer Sciences, University of Glasgow, Glasgow, United Kingdom
³Department of Biological and Biomedical Sciences, Glasgow Caledonian University, Glasgow, United Kingdom
⁴Division of Hematology and Oncology, Weill Cornell Medical College, New York, NY
⁵Department of Haematology, Western General Hospital, Edinburgh, United Kingdom
⁶Children's Hospital of Los Angeles, University of Southern California, Los Angeles, CA
⁷School of Infection & Immunity, University of Glasgow, Glasgow, United Kingdom
⁸Cancer Research UK Scotland Institute, Glasgow, United Kingdom
⁹Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, United Kingdom
¹⁰Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, NI, United Kingdom
¹¹Weill Cornell Medicine and The New York Presbyterian Hospital in New York City, New York, NY
¹²School of Cancer Sciences, University of Glasgow, Glasgow, United Kingdom

2752

Molecular Mechanisms Associated with Autophagy Inhibition to Overcome Resistance to FLT3 Inhibitors

Manuela Albuquerque De Melo, MSc¹^*, Diego A. Pereira-Martins, Ph.D.²^*, Brunno Gilberto Santos Macedo, MSc¹^*, Livia Bassani Lins de Miranda, Bsc³^*, Priscila Santos Scheucher, PhD¹^*, Isabel Weinhäuser, PhD⁴^*, Gerwin Huls², Jan Jacob Schuringa, Prof. Dr.², João Agostinho Machado-Neto, PhD³^* and Fabiola Traina, MD, PhD¹

¹Department of Medical Images, Hematology, and Oncology, University of São Paulo at Ribeirão Peto Medical School, Ribeirão Preto, Brazil
²Department of Experimental Hematology, Cancer Research Center Groningen, University Medical Center Groningen, Groningen, Netherlands
³Department of Pharmacology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil
⁴Department of Experimental Hematology, University Medical Center Groningen, Groningen, Netherlands

1809

A Study on the Effect of Luspatercept on Regulatory T Cells and Myeloid Derived Suppressor Cells in Low Risk Myelodysplastic Syndrome with Ring Sideroblasts

Stefania Leone^1,2^*, Francesco Grimaldi, MD³^*, Mara Memoli⁴^*, Flavia Carriero⁵^*, Giulia Scalia⁶^*, Annamaria Vincenzi⁷^*, Giuseppe Cerciello⁸^*, Fabrizio Pane⁹, Alessandra Picardi, MD¹⁰^*, Giuseppe Terrazzano⁵^*, Giuseppina Ruggiero¹¹^* and Valentina Rubino¹¹^*

¹University federico II of Naples, Naples, Italy
²AORN Cardarelli, Naples, Italy
³Department of Clinical Medicine and Surgery, Hematology Unit, University of Naples Federico II, Napoli, Italy
⁴Department of Medicine and Surgery, Hematology and Hematopoietic Stem Cell Transplant Center, University of Naples Federico II, Naples, Naples, Italy
⁵Department of Sciences, University of Basilicata, Potenza, Italy
⁶Centre for Advanced Biotechnology (CEINGE), Naples, Italy
⁷Aou-Federico II, Naples, Naples, ITA
⁸Hematology, "San Pio" Hospital of Benevento, Naples, ITA
⁹Division of Hematology and SCT Unit, Federico II University, Naples, Naples, Italy
¹⁰Stem Cell Transplant Program AORN Cardarelli, Naples and Biomedicine and Prevencion Department of Tor Vergata University, Rome, Naples / Rome, Italy
¹¹Department of Translational Medicine, University of Naples Federico II, Naples, Italy

2650

Resolution of Inflammation Increases Hematopoietic Stem Cell Number and Erythropoiesis

Kim Uyen Cong Nguyen, MSc^1,2, Angelo D'Alessandro, PhD^3,4 and Yann Gibert, PhD¹

¹Cancer Center and Research Institute, University of Mississippi Medical Center, Jackson, MS
²Cancer Center and Research Institute, University of Mississippi Medical Center, Brandon, MS
³Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, CO
⁴Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz School of Medicine, Aurora, CO

1302

Temporal Single Cell Analysis of Myeloid Leukemia Microenvironment

Christina M Kaszuba, MS^1,2, Cameron D Baker³^*, Benjamin J Rodems, MS^2,4^*, Sonali Sharma, PhD², Jane L. Liesveld, MD^2,5, Laura M. Calvi, M.D.^2,6, Michael W. Becker, MD^2,7, Craig T Jordan, PhD⁸, John M. Ashton, PhD, MBA²^* and Jeevisha Bajaj, Ph.D.^2,4

¹Department of Biomedical Engineering, University of Rochester, Dansville, NY
²Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY
³Genomics Research Center, University of Rochester Medical Center, Rochester, NY
⁴Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY
⁵Division of Hematology and Oncology, University of Rochester Medical Center, Rochester, NY
⁶Division of Endocrinology and Metabolism, Department of Medicine, University of Rochester Medical Center, Rochester, NY
⁷University of Rochester Medical Center, Rochester, NY
⁸Division of Hematology, University of Colorado Anschutz Medical Campus, Aurora, CO

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