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Cell Intrinsic Mechanisms Driving Hematologic Aging

Symposia: Scientific Workshop on Aging and Hematology Program: Scientific Workshops
Friday, December 6, 2024: 2:03 PM-2:45 PM
Room 7 (San Diego Convention Center)
Moderators:
Tanya M. Wildes, MD, MSc, University of Nebraska Medical Center and Francesca Cottini, MD, The Ohio State University
Disclosures:
Wildes: Janssen: Consultancy; Sanofi: Consultancy; Pfizer: Consultancy. Cottini: Sanofi: Honoraria, Membership on an entity's Board of Directors or advisory committees.

This session will focus on cell intrinsic changes, such as mutations, epigenetic signaling, or impaired protein homeostasis, that occur in clonal hematologic-derived populations drive aging and predispose those individuals to hematologic disease.
Moderator Introduction and Session 1 Initial Audience Voting

Tanya M. Wildes, MD, MSc

University of Nebraska Medical Center, Omaha, NE
Clonal Mutations Drive Hematopoietic Stem and Progenitor Cell Fitness

Kristina Kirschner, PhD

Department of Hematology, Mayo Clinic, Rochester, MN; Mayo Clinic, Rochester, MN
Defective Misfolded Protein Response and Impaired Proteostasis Drive Hematopoietic Stem Cell Aging

Fanny Jiahua Jiahua Zhou, BS, MS

Division of Regenerative Medicine, Department of Medicine, Stem Cell Discovery Center, Sanford Stem Cell Institute, Moores Cancer Center, University of California San Diego, San Diego, CA
DNA Damage Signaling and Telomere Dysfunction in B Cell Malignancies

Enrico Derenzini, MD, PhD

European Institute of Oncology, Milan, Italy
Panel Discussion
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