Investigation of the Impact of Medication on the Mental Health of Hemophiliacs

Objective: To examine the influence of medication, disease and social characteristics on the mental health of individuals with haemophilia.

Methods: The study utilized the Hemophilia Psychological Status and Quality of Life Survey Scale, consisting of five sections: General demographic information, disease-related data, GAD-7 Anxiety Screening Scale, PHQ-9 Depression Scale, and Psychological Resilience Scale (CD-RISC). What's more, statistical analyses were performed using SPSS 26.0 linear regression to analyze the relationship between variant gene types and patients' anxiety, depression, and psychological tolerance.

Results: 171 valid responses were collected. The majority (96.5%) were male, with a median age of 29.The patients' level of psychological resilience was significantly and positively correlated with education (r = 0.173, P = 0.024), and coagulation factor usage was significantly and positively correlated with CD-RISC scores (r = 0.490, P = 0.033). Patients with target joints combined wrist and shoulder of knee had significantly higher GAD-7 and PHQ-9 scale scores (d₁= 1.61, d₂= 1.78) compared to patients with other target joints combined of knee. Target Joint type and haemorrhage had a significant effect on the GAD-7 scores (β=0.248, P=0.001). The number of target joints was significantly and positively correlated with patients' PHQ-9 scores (r=0.203, P=0.025). There was no significant difference in the use of domestic or imported recombinant factor. Blood-derived and recombinant factors did not show significant differences between the scores.Linear regression analysis of the relationship between the type of mutated gene and the level of anxiety, depression, and psychological resilience of the patients yielded p-values greater than 0.05 and did not pass the F-test, invalidating the model.

Conclution: The level of patient education and the dose of coagulation factor medication can increase the level of psychological resilience in haemophiliacs. The use of domestic coagulation factor or not, the type of coagulation factor, and whether recombinant coagulation factor did not significantly affect the psychological resilience level of haemophiliac patients. The use of prophylactic medication can reduce anxiety and depression to a certain extent in patients over 14 years of age. The type of target joints and bleeding status affected the level of anxiety and depression.Types of mutated genes are not associated with anxiety, depression, and levels of psychological resilience.