Andreas Reiter, MD¹, Jean-Jacques Kiladjian, MD, PhD², Jay M Patel, PharmD BCOP³, William Shomali, MD⁴, Alessandro Rambaldi, M.D.⁵, Srdan Verstovsek, MD, PhD^6*, Stephen Oh, MD, PhD^7*, Kensuke Usuki, MD, PhD⁸, Claire N Harrison⁹, Ellen K. Ritchie, MD¹⁰, Luke P. Akard, MD¹¹, Juan Carlos Hernandez Boluda, MD, PhD^12*, Françoise Huguet, M.D.^13*, Natalia Oliveira, MBA^14*, Huiling Zhen, PhD^15*, Tracy I. George, MD¹⁶, Philomena Colucci, DO, MS^15*, Aidan Gilmartin^15*, Jason Gotlib, MD^4* and Alessandro M. Vannucchi, MD^17*

¹Department of Hematology and Oncology, University Medical Centre Mannheim, Mannheim, Germany
²Hopital Saint-Louis, Paris, France
³Adaptive Biotechnologies, Salt Lake City, UT
⁴Division of Hematology, Stanford Cancer Institute/ Stanford University School of Medicine, Stanford, CA
⁵Department of Oncology and Hematology, University of Milan and Azienda Socio-Sanitaria Territoriale Papa Giovanni XXIII, Bergamo BG, Italy
⁶University of Texas MD Anderson Cancer Center, Houston, TX
⁷Washington University School of Medicine, St. Louis, MO
⁸NTT Medical Center Tokyo, Tokyo, Japan
⁹Guy’s and St. Thomas’ NHS Foundation Trust, London, ENG, United Kingdom
¹⁰Division of Hematology and Medical Oncology, Weill Cornell Medicine/New York Presbyterian Hospital, New York, NY
¹¹Indiana Blood and Marrow Transplantation, Franciscan Health, Indianapolis, IN
¹²Hospital Clínico Universitario-INCLIVA, Valencia, Spain
¹³Hematology department, Institut Universaitaire du Cancer, CHU de Toulouse, Toulouse, France
¹⁴Incyte International Biosciences Sàrl, Morges, Switzerland
¹⁵Incyte Corporation, Wilmington, DE
¹⁶ARUP Laboratories, University of Utah School of Medicine, Salt Lake City, UT
¹⁷University of Florence, CRIMM, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy

Jennifer O Sullivan^1,2*, Amy Wood^3*, Sean Wen, BSc, MSc, PhD^4*, Angela Hamblin, MD, PhD^5*, Sonia Fox, BSc^6*, Christina Yap, PhD^7*, Mary Frances McMullin, MD, FRCPath, FRCP⁸, Nicholas C. P. Cross, PhD⁹, Claire N Harrison¹⁰ and Adam J Mead, MRCP, FRCPath, PhD¹¹

¹Dept of Haematology, Guys and St Thomas’ NHS Foundation Trust, London, United Kingdom
²Medical Research Council (MRC) Weatherall Institute of Molecular Medicine (WIMM) and NIHR Biomedical Research Centre, University of Oxford, Oxford, United Kingdom
³Weatherall Institute of Molecular Medicine, Oxford, United Kingdom
⁴Haematopoietic Stem Cell Biology Laboratory, Medical Research Council Molecular Haematology Unit, Medical Research Council Weatherall Institute of Molecular Medicine, University of Oxford, Cambridge, ENG, United Kingdom
⁵Cancer and Haematology Centre, The Churchill Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom
⁶Cancer Research UK Clinical Trials Unit, Institute of Cancer and Genomic Science, Birmingham, ENG, GBR
⁷The Institute of Cancer Research, ICR’s Clinical Trials and Statistics Unit, Sutton, ENG, GBR
⁸Haematology, Belfast City Hospital, Queen's University Belfast, Belfast, United Kingdom
⁹University of Southampton, Salisbury, GBR
¹⁰Guy’s and St. Thomas’ NHS Foundation Trust, London, ENG, United Kingdom
¹¹Medical Research Council (MRC) Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, National Institute for Health Research Biomedical Research Centre, University of Oxford, Oxford, United Kingdom

Claire N Harrison¹, Jean-Jacques Kiladjian, MD, PhD², Francesca Palandri, MD^3*, JE Hamer-Maansson, MSPH^4*, Evan M. Braunstein, MD, PhD^4* and Francesco Passamonti^5*

¹Guy’s and St. Thomas’ NHS Foundation Trust, London, ENG, United Kingdom
²Hopital Saint-Louis, Paris, France
³IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia “Seràgnoli”, Bologna, Italy, Bologna, Italy
⁴Incyte Corporation, Wilmington, DE
⁵University of Insubria, Varese, Italy

Pankit Vachhani, MD^1*, Abdulraheem Yacoub, MD^2*, Elie Traer, MD, PhD³, Lina Benajiba^4,5*, Francesco Passamonti^6*, Ashwin Kishtagari, MBBS⁷, Mojtaba Akhtari^8*, James McCloskey, MD^9*, Sarah Buckley, MD^10*, Purvi Suthar^10*, Karisse Roman-Torres^10* and John Mascarenhas, MD^11*

¹O’Neal Comprehensive Cancer Center, University of Alabama, Birmingham, AL
²The University of Kansas Clinical Cancer Research Center, Leawood, KS
³Knight Cancer Institute, Oregon Health & Sciences University, Portland, OR
⁴Centre d'Investigations Cliniques, INSERM CIC 1427, Université Paris Cité, APHP, Hôpital Saint-Louis, Paris, France
⁵INSERM UMR 944, Institut de Recherche Saint-Louis, Paris, France
⁶University of Milan, Milan, Italy
⁷Division of Hematology & Oncology, Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Franklin, TN
⁸Cancer Center, Loma Linda University Medical Center, Loma Linda, CA
⁹John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, NJ
¹⁰CTI BioPharma Corp., a Sobi company, Seattle, WA
¹¹Department of Medicine, Division of Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai, New York, NY

Ayalew Tefferi, MD, Animesh D. Pardanani, MBBS, PhD, Kebede Begna, MD, Aref Al-Kali, MD, William J. Hogan, MD, Mark R. Litzow, MD and Naseema Gangat, MBBS

Division of Hematology, Mayo Clinic, Rochester, MN

Tanner Robison, PhD¹, Annabel Levinson^1*, Winston Lee, MD, PhD^2*, Kristen Marie Pettit, MD³, Dariya Malyarenko^1*, Timothy D Johnson, PhD^4*, Thomas Chenevert^1*, Brian Ross^1*, Moshe Talpaz, MD⁵ and Gary Luker^1*

¹University of Michigan, Ann Arbor, MI
²Pathology, City of Hope, Duarte, CA
³Rogel Cancer Center, University of Michigan, Ann Arbor, MI
⁴Biostatistics, University of Michigan, Ann Arbor, MI
⁵Division of Hematology-Oncology, University of Michigan Rogel Cancer Center, Ann Arbor, MI

Gaurav Goyal, MD¹, Anne Reiner, MPH^2*, Dana Bossert^3*, Allison Sigler^4*, Justin Buthorn^4*, Mario Lacouture, MD^5*, Veronica Rotemberg^6*, Jasmine H Francis, MD^7*, Ronald S. Go, MD⁸, Raajit K. Rampal, MD, PhD⁹ and Eli L. Diamond, MD^3*

¹Division of Hematology/Oncology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL
²Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY
³Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, NY
⁴Memorial Sloan Kettering Cancer Center, New York, NY
⁵Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY
⁶Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York
⁷Ophthalmic Oncology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY
⁸Mayo Clinic, Rochester, MN
⁹Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Institute, New York, NY

Hosuk Ryou^1*, Korsuk Sirinukunwattana^2*, Ruby Wood^2*, Alan Aberdeen^2*, Jens Rittscher^3*, Olga Weinberg^4*, Robert Hasserjian⁵, Olga Pozdnyakova^5*, Frank Peale^6*, Brian Higgins^6*, Pontus Lundberg^7*, Kerstin Trunzer^7*, Claire N Harrison⁸ and Daniel Royston, DPhil, FRCPath, MBBChir^1*

¹Nuffield Division of Clinical Laboratory Sciences (NDCLS), University of Oxford, Oxford, United Kingdom
²Ground Truth Labs Ltd., Oxford, United Kingdom
³Institute of Biomedical Engineering (IBME), University of Oxford, Oxford, United Kingdom
⁴University of Texas Southwestern Medical Center, Dallas, TX
⁵Harvard Medical School, Boston, MA
⁶Genentech Inc., South San Francisco, CA
⁷F. Hoffmann-La Roche Ltd., Basel, Switzerland
⁸Guy’s and St. Thomas’ NHS Foundation Trust, London, ENG, United Kingdom

Gaurav Goyal, MD¹, Aldo Adrian Acosta Medina, MD², Xinxin Cao^3*, Dana Bossert^4*, Matthew P. Collin Sr., MD, PhD⁵, Polyzois Makras^6*, Omar Abdel-Wahab, MD⁷, Jithma Prasad Abeykoon, MD⁸, Rodothea Amerikanou, MBBChir^9*, Corrie Bach^10*, N. Nora Bennani, MD², Benjamin Heath Durham, MD¹¹, Jasmine H Francis, MD^12*, C Christopher Hook, MD², Min Lang^3*, Mario Lacouture, MD^13*, Kseniya Petrova-drus, MD, PhD^14*, Karen L Rech, MD^2*, Veronica Rotemberg^15*, Gordon J Ruan, MD², Mithun V Shah, MD, PhD¹⁶, Mariko Yabe, MD, PhD^14*, Jason R Young, MD^17*, Saurabh Zanwar, M.B.B.S., M.D.¹⁸, Ronald S. Go, MD² and Eli L. Diamond, MD^4*

¹Division of Hematology/Oncology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL
²Mayo Clinic, Rochester, MN
³Department of Hematology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
⁴Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, NY
⁵Northern Centre for Bone Marrow Transplantation, Newcastle University, Newcastle Upon Tyne, GBR
⁶251 Hellenic Air Force General Hospital, Athens, GRC
⁷Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY
⁸Mayo Clinic, Boston, MN
⁹University College London, London, United Kingdom
¹⁰Mayo Clinic, Rochester, MN, Rochester, MN
¹¹Memorial Sloan Kettering Cancer Center, New York, NY
¹²Ophthalmic Oncology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY
¹³Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY
¹⁴Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY
¹⁵Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York
¹⁶Division of Hematology, Mayo Clinic, Rochester, MN
¹⁷Mayo Clinic, Jacksonville, FL
¹⁸Division of Hematology, Department of Internal Medicine, Mayo Clinic, Rochester, MN

Oscar Borsani, MD^1,2, Daniela Pietra, PhD^3*, Ilaria Carola Casetti, MD, PhD^1*, Daniele Vanni, MD^1*, Giacomo Riccaboni, MD^1*, Silvia Catricalà, PhD^2*, Grazia Bossi, MD^4*, Luca Arcaini^2,5* and Elisa Rumi, MD^1,2*

¹Department of Molecular Medicine, University of Pavia, Pavia, Italy
²Division of Hematology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
³U.O.C Ematologia 1, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
⁴Department of Pediatrics, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
⁵Department of Molecular Medicine, University of Pavia and Division of Hematology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy

Patrick Harrington^1,2*, Andrea Duminuco^1*, Joshua Au Yeung^3*, Sukhraj Singh Virdee^1*, Raj Vaghela^1*, Susan Asirvatham^4*, Rosemarie Bone^1*, Claire Woodley^1*, Kyaw Htin Thaw^5*, Llywelyn Cadman-Davies^1*, Jennifer O'Sullivan^1*, Priya Sriskandarajah^1*, Natalia Curto-Garcia^6*, Shahram Kordasti^1*, Hugues de Lavallade^1*, Deepti H. Radia^4*, James Teo^3* and Claire N Harrison⁷

¹Department of Clinical Haematology, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom
²School of Cancer and Pharmaceutical Science, King's College London, London, United Kingdom
³Guy's & St Thomas' NHS Foundation Trust, London, United Kingdom
⁴Department of Haematology, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom
⁵Haematology Department, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom
⁶Haematology Department, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom, London, United Kingdom
⁷Guy’s and St. Thomas’ NHS Foundation Trust, London, ENG, United Kingdom

Harinder Gill, MD, MBBS, FRCP, FRCPath¹, Lester Au^1*, Garret Man Kit Leung^1*, Dorothy Tsai^1*, Rita Yim, PhD^1*, Lynn Chin^1*, Vivian Li^1*, Paul Lee^1*, Albert Chun Fung Sin^2*, Hsin An Hou, MD^3*, Chih-Cheng Chen⁴ and Yok Lam Kwong, MD^1*

¹Department of Medicine, The University of Hong Kong, Hong Kong, Hong Kong
²Department of Pathology, The University of Hong Kong, Hong Kong, Hong Kong
³Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
⁴Chang Gung Memorial Hospital-Chiayi, Chiayi, Taiwan

Heinz Gisslinger, MD^1*, Christoph Klade, PhD^2*, Pencho Georgiev^3*, Dorota Krochmalczyk, MD^4*, Liana Gercheva-Kyuchukova, MD^5*, Miklos Egyed, MD^6*, Petr Dulicek, MD^7*, Arpad Illes, MD^8*, Halyna Pylypenko, MD^9*, Liliya Sivcheva, MD^10*, Jiri Mayer, Prof, MD¹¹, Vera Yablokova, MD^12*, Kurt Krejcy, MD^2*, Victoria Empson, MSc^13*, Hans Hasselbalch, MD^14*, Robert Kralovics, PhD^15* and Jean-Jacques Kiladjian, MD, PhD¹⁶

¹Department of Internal Medicine I, Division of Hematology and Blood Coagulation, Medical University of Vienna, Vienna, Austria
²AOP Health, Vienna, Austria
³Medical University of Plovdiv, Plovdiv, Bulgaria
⁴Department of Hematology, Collegium Medicum, Jagiellonian University, Krakow, Poland
⁵Multiprofile Hospital For Active Treatment "Sveta Marina", Varna, Bulgaria
⁶Somogy County Mór Kaposi General Hospital, Kaposvár, Hungary
⁷Department of Clinical Hematology, University Hospital Hradec Kralove, Hradec Kralove, Czech Republic
⁸Department of Hematology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary
⁹Department of Hematology, Regional Treatment and Diagnostics Hematology Centre, Cherkasy Regional Oncology Centre, Cherkasy, Ukraine
¹⁰First Department of Internal Medicine, Multiprofile Hospital for Active Treatment - HristoBotev, Vratsa, Bulgaria
¹¹Clinic of Internal Medicine - Hematology and Oncology, University Hospital Brno, Brno, Czech Republic
¹²Department of Hematology, Yaroslavl Regional Clinical Hospital, Yaroslavl, Russian Federation
¹³AOP Health, Vienna, Vienna, Austria
¹⁴Roskilde Hospital, University of Copenhagen, Copenhagen, Denmark
¹⁵Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria
¹⁶Université de Paris, AP-HP, Hôpital Saint-Louis, Centre d’Investigations Cliniques, Paris, France

Naseema Gangat, MBBS¹, James M. Foran, MD², Anna B. Halpern, MD³, Raajit K. Rampal, MD, PhD⁴, Natasha Novikov, MD, PhD^5*, Akshay Buch, PhD^5*, Olivia Pelletier, MBA^5*, William Savage, MD, PhD⁵ and Ayalew Tefferi, MD⁶

¹Division of Hematology, Mayo Clinic, Rochester, MN, USA, Rochester, MN
²Hematology/Oncology, Mayo Clinic, Jacksonville, FL
³University of Washington, Seattle, WA
⁴Memorial Sloan Kettering Cancer Center, New York, NY
⁵Disc Medicine, Watertown, MA
⁶Division of Hematology, Mayo Clinic, Rochester, MN

Aaron T. Gerds, MD, MS¹, Claire N Harrison², Jean-Jacques Kiladjian, MD, PhD³, Ruben A. Mesa, MD⁴, Rami S. Komrokji, MD⁵, Prithviraj Bose, MD⁶, Fabian Sanabria^7*, Niloufar Marsousi^7*, Yinzhi Lai^8* and Francesco Passamonti, MD^9*

¹Cleveland Clinic, Cleveland, OH
²Guy's and Saint Thomas' NHS Foundation Trust, London, United Kingdom
³Hôpital Saint-Louis, Université de Paris, Paris, France
⁴Atrium Health Wake Forest Baptist Comprehensive Cancer Center, Winston-Salem, NC
⁵Department of Malignant Hematology, Moffitt Cancer Center, Tampa, FL
⁶MD Anderson Cancer Center, The University of Texas, Houston, TX
⁷Bristol Myers Squibb, Boudry, Switzerland
⁸Bristol Myers Squibb, Princeton, NJ
⁹University of Milano Statale, Milano, Italy

Stephen T. Oh, MD, PhD¹, Jamile Shammo, MD², Vikas Gupta, MD³, Mary Frances McMullin^4*, Prithviraj Bose, MD^5,6, Ruben A. Mesa, MD⁷, Alessandro Lucchesi, MD^8*, Sarah Buckley, MD^9*, Purvi Suthar^9*, Karisse Roman-Torres^9*, John Mascarenhas, MD^10* and Francisca Ferrer Marin, MD, PhD¹¹

¹Department of Medicine, Washington University School of Medicine, Saint Louis, MO
²Feinberg School of Medicine, Northwestern University, chicago, IL
³Leukemia Program, Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada
⁴Queen's University Belfast, Belfast, Northern Ireland, United Kingdom
⁵The University of Texas MD Anderson Cancer Center, Houston, TX
⁶Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
⁷Atrium Health Wake Forest Baptist Comprehensive Cancer Center, Winston-Salem, NC
⁸Hematology Unit, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", Meldola, Italy
⁹CTI BioPharma Corp., a Sobi company, Seattle, WA
¹⁰Department of Medicine, Division of Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai, New York, NY
¹¹Hematology Department, Hospital Morales Meseguer, Centro de Investigación Biomédica en Red de Enfermedades Raras, Universidad Católica San Antonio de Murcia, Murcia, Spain

Pankit Vachhani, MD¹, Tsewang Tashi, MD², Gary J. Schiller, MD³, Stephanie Lee, MD, MSc, FRCPC⁴, Miguel Piris Villaespesa, MD, PhD^5*, Helena Pomares, MD, PhD^6*, Cristina Bulai Livideanu^7*, Jonathan Lambert, PhD, BSc, BMBS, FRCP, FRCPath^8*, Anthony M. Hunter, MD^9*, Tracy I. George, MD¹⁰, Cristina Papayannidis, MD^11*, Khalid Shoumariyeh, MD^12*, Rita Petroro^13*, Jenna Zhang, PhD^13*, Amanda Pilla^13*, Hina Jolin^13*, Rachael Easton^13* and Vinod Pullarkat, MD¹⁴

¹O'Neal Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL
²University of Utah, Huntsman Cancer Institute, Salt Lake City, UT
³Hematological Malignancy/ Stem Cell Transplant Program, David Geffen School of Medicine, UCLA, Los Angeles, CA
⁴University of Toronto/St. Michael's Hospital, Toronto, Canada
⁵Hospital Ramón y Cajal, Madrid, Spain
⁶Hematology Department. Institut Català d’Oncologia, Hospital Duran i Reynals. Institut d’Investigació Biomèdica de Bellvitge (IDIBELL). Universitat de Barcelona., Barcelona, Spain
⁷Department of Dermatology, CEREMAST Toulouse, CHU Toulouse, Toulouse, France
⁸Department of Haematology, University College Hospital, University College of London Hospitals NHS Foundation Trust, London, United Kingdom
⁹Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta
¹⁰ARUP Laboratories, University of Utah School of Medicine, Salt Lake City, UT
¹¹IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia “Seràgnoli”, Bologna, ITA
¹²Department of Medicine I, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany
¹³Cogent Biosciences, Waltham, MA
¹⁴Department of Hematology and Hematopoietic Cell Transplantation and Gehr Family Center for Leukemia Research, City of Hope Comprehensive Cancer Center, Duarte, CA

Joan How, MD¹, Orly Leiva, BS², Anna E. Marneth, PhD^1,3, Baransel Kamaz, MD^4*, Chulwoo J. Kim^5*, Lachelle D. Weeks, MD, PhD⁶, Mohammed Wazir⁷, Maximilian Stahl, MD⁸, Daniel J. DeAngelo⁹, R. Coleman Lindsley¹⁰, Marlise R. Luskin, MD⁶ and Gabriela S. Hobbs, MD¹¹

¹Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Boston, MA
²New York University Grossman School of Medicine, Boston, MA
³Department of Laboratory Medicine, Division Laboratory of Hematology, Radboud University Medical Center, Nijmegen, Netherlands
⁴Brigham and Women's Hospital, Boston
⁵Department of Medicine, Division of Hematology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA
⁶Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
⁷Department of Medicine, Division of General Internal Medicine, Brigham and Women's Hospital, Boston, MA
⁸Dana Farber Institute, Boston, MA
⁹Dana-Farber Cancer Institute, Boston, MA
¹⁰Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA
¹¹Division of Hematology/Oncology, Massachusetts General Hospital, Boston, MA

Reema K Tawfiq, MD¹, Jason R Young, MD^2*, Madeline Mahowald, MD^3*, Saurabh Zanwar, M.B.B.S., M.D.⁴, Gordon J Ruan, MD¹, Karen L Rech, MD^1*, Matthew J Koster^1*, Lucinda Gruber^1*, Aishwarya Ravindran, MD^5*, Mithun V Shah, MD, PhD⁶, N. Nora Bennani, MD⁶, Robert Vassallo^1*, Jay Ryu^1*, Caroline Davidge-Pitts, MD^1*, Surendra Dasari, PhD^7*, Thomas E. Witzig, MD¹, Ronald S. Go, MD¹, Gaurav Goyal, MD⁸ and Jithma Prasad Abeykoon, MD¹

¹Mayo Clinic, Rochester, MN
²Mayo Clinic, Jacksonville, FL
³UF Health, Jacksonville, FL
⁴Division of Hematology, Department of Internal Medicine, Mayo Clinic, Rochester, MN
⁵University of Alabama at Birmingham, Birmingham, AL
⁶Division of Hematology, Mayo Clinic, Rochester, MN
⁷Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN
⁸Division of Hematology/Oncology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL

Orly Leiva, MD¹, Andrew M. Brunner, MD², Joan How, MD³, Gabriela S. Hobbs, MD⁴ and Jeffrey S Berger, MD^5*

¹NYU Grossman School of Medicine, NY, NY
²Division of Hematology/Oncology, Dana-Farber Cancer Institute, Boston, MA
³Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Boston, MA
⁴Division of Hematology/Oncology, Massachusetts General Hospital, Boston, MA
⁵New York University Grossman School of Medicine, New York, NY

Lucia Masarova, MD¹, Tom Liu, MS^2*, Mirko Fillbrunn, PhD^3*, Weilong Li, PhD^4*, Gautam Sajeev, D.Sc^3*, Sumati Rao, PhD^2*, Boris Gorsh, PharmD^2* and James Signorovitch, PhD^3*

¹Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
²GSK plc, Collegeville, PA
³Analysis Group, Boston, MA
⁴Analysis Group, New York, NY

Barbara Mora, MD^1*, Giacomo Pellegrini^1,2*, Matteo Franchi^2,3*, Olivia Leoni^4*, Daniela D'Ippoliti^5*, Valeria Di Fabrizio^6*, Fabrizio Gemmi^6*, Claudia Szasz^6*, Margherita Maffioli, MD^1*, Carmelo Gurnari, MD⁷, Enrico Attardi, MD^7*, Giovanni Corrao^2,3*, Paola Guglielmelli, MD, PhD⁸, Maria Teresa Voso, MD⁷, Alessandro Maria Vannucchi⁹ and Francesco Passamonti^10,11*

¹Hematology, ASST Sette Laghi, Varese, Italy
²National Center for Healthcare Research and Pharmacoepidemiology, University of Milano-Bicocca, Milan, Italy
³Unit of Biostatistics, Epidemiology and Public Health, Department of Statistics and Quantitative Methods, University of Milano-Bicocca, Milan, Italy
⁴Directorate General for Health, Lombardy Region, Milan, Italy
⁵Department of Epidemiology, Lazio Regional Health Service, Lazio Region, Rome, Italy
⁶Observatory for quality and equity, Tuscany Regional health agency, Tuscany Region, Florence, Italy
⁷Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy
⁸CRIMM, Center of Research and Innovation of Myeloproliferative Neoplasms, University of Florence, AOU Careggi, Florence, Italy
⁹Department of Experimental and Clinical Medicine, Centro di Ricerca e Innovazione Malattie Mieloproliferative (CRIMM), AOU Careggi, University of Florence, Firenze, Italy
¹⁰University of Milan, Milan, Italy
¹¹I.R.C.C.S. Ca’ Granda Ospedale Maggiore Policlinico Foundation, Milan, Italy

Julian Thalhammer, MD^1*, Perrine Marec-Bérard, MD^2*, Mohamed Barkaoui^3*, Eric Jeziorski^4*, Angelique Rome, MD^5*, Anne Pagnier, MD^6*, Pierre Simon Rohrlich^7*, Nathalie Aladjidi, MD^8*, Charlotte Rigaud, MD^9*, Amaury Leruste, MD^10*, Saba Azarnoush, MD^11*, Thomas Lauvray, MD^12*, Solenne Le Louet, MD^13*, Virginie Gandemer^14*, Pauline Treguier, MD^15*, Ludovic Mansuy, MD^16*, Marlène Pasquet, MD^17*, Laura Olivier^17*, Florentina Isfan^18*, Cécile Renard, MD^2*, Alexandra Salmon, MD^19*, Laurence Blanc, MD^20*, Wadih Abou Chahla, MD^21*, Anne Lambilliotte, MD^21*, Coralie Mallebranche, MD^22*, Caroline Thomas, MD^23*, Despina Moshous, MD, PhD^24*, Genevieve de Saint-Basile, MD PhD^25,26*, Jean-Francois Emile^27*, Sébastien Héritier, MD^3* and Jean Donadieu, MD, PhD^3,13

¹Institute of Hematology and Pediatric Oncology, Lyon, AL, France
²Institute of Hematology and Pediatric Oncology, Lyon, France
³Trousseau Hospital, French Reference Center for Langerhans Cell Histiocytosis, Paris, France
⁴CHU Montpellier, Montpeller, FRA
⁵Department of Pediatric Hematology and Oncology, Centre Hospitalo-Universitaire de Marseille, Marseille, France
⁶Department of Pediatric Hematology and Oncology, Centre Hospitalo-Universitaire de Grenoble, Grenoble, France
⁷Department of Pediatric Hematology and Oncology, Centre Hospitalo-Universitaire de Nice, Nice, FRA
⁸Hôpital des Enfants, Hôpital Pellegrin, CHU Bordeaux, Bordeaux, FRA
⁹Gustave Roussy, Villejuif, France
¹⁰SIREDO Pediatric Oncology Center, Institut Curie, Paris, France
¹¹Pediatric Immuno-Oncology, Robert-Debré Hospital, Paris, France
¹²Department of Pediatric Hematology and Oncology, Centre Hospitalo-Universitaire de Limoges, Limoges, France
¹³Hopital Trousseau, Paris, France
¹⁴CHU Hopital Sud, Rennes, FRA
¹⁵Department of Pediatric Hematology and Oncology, Centre Hospitalo-Universitaire de Rouen, Paris, France
¹⁶Department of Pediatric Hematology and Oncology, Centre Hospitalo-Universitaire de Nancy, Nancy, France
¹⁷Department of Pediatric Hematology and Oncology, Centre Hospitalo-Universitaire de Toulouse, Toulouse, France
¹⁸Department of Pediatric Hematology and Oncology, Centre Hospitalo-Universitaire de Clermont-Ferrand, Clermont-Ferrand, France
¹⁹CHRU Strasbourg, Strasbourg, France
²⁰20 Department of Pediatric Hematology and Oncology, Centre Hospitalo-Universitaire de Poitiers, Poitiers, FRA
²¹Department of Pediatric Hematology, Centre Hospitalo-Universitaire de Lille, Lille, France
²²immuno-hemato-oncology Unit, Univ Angers, Nantes Université, Inserm, CNRS, CRCI2NA, SFR ICAT, CHU Angers,, Angers, FRA
²³CHU Nantes, Nantes, FRA
²⁴APHP-Université de Paris Cité, Hôpital Necker Enfants Malades,, Unité d’Immuno Hématologie Rhumatologie Pédiatriques, Paris, France
²⁵Imagine Institut UMR 1163, Paris, France
²⁶Hôpital Necker-Enfants Malades, Paris, France
²⁷APHP, Hôpital Ambroise-paré, Boulogne, France

Deevyashali Parekh, MBBS^1*, Howard Lin^1*, Kenneth L. McClain, MD, PhD², Nitya Gulati^1*, Olive S. Eckstein, MD^1*, Nader Kim El-Mallawany, MD¹, Jennifer Elise Agrusa, MD, MS^3* and Carl E Allen, MD¹

¹Baylor College of Medicine, Houston, TX
²Texas Childrens Cancer and Hematology Centers, Houston, TX
³Texas Children's Hospital, Houston, TX

Sung-Eun Lee, MD^1*, Sung-Soo Yoon, MD, PhD², Deok-Hwan Yang^3*, Gyeong Won Lee^4*, Seug Yun Yoon^5*, Sang Kyun Sohn, MD, Ph.D.^6*, Ho-Jin Shin, MD^7*, Sung Hwa Bae, MD^8*, Chul Won Choi^9*, Eun-Ji Choi, MD, PhD¹⁰, June-Won Cheong¹¹, Soo-Mee Bang, MD, PhD¹², Joon Seong Park, MD^13*, Sukjoong Oh, MD¹⁴, Yong Park, MD, PhD¹⁵ and Young Hoon Park^16*

¹Leukemia Research Institute, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of (South)
²Seoul National University Hospital, Seoul, South Korea
³Department of Internal Medicine, Chonnam National University Hwasun Hospital, Chonnam National University Medical School, Jeollanam-do, Korea, Republic of (South)
⁴Department of Internal Medicine, Gyeongsang National University Hospital, Gyeongsang National University College of Medicine, Jinju, Korea, Republic of (South)
⁵Department of Internal Medicine, Soonchunhyang University Seoul Hospital, Seoul, New Jersey, KOR
⁶Department of Hematology, Kyungpook National University Hospital, Daegu, Korea, Republic of (South)
⁷Pusan National University Hospital, Busan, Korea, Republic of (South)
⁸Department of Internal Medicine, Daegu Catholic, University Hospital, Daegu Catholic University School of Medicine, Daegu, KOR
⁹Department of Internal Medicine, Korea University Medical Center, Seoul, KOR
¹⁰Asan Medical Center, University of Ulsan College of Medicine, Seoul, KOR
¹¹Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea, Republic of (South)
¹²Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, KOR
¹³Department of Hematology-Oncology, Ajou University School of Medicine, Suwon, Korea, Republic of (South)
¹⁴Hanyang University Medical Center, Seoul, KOR
¹⁵Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea, Republic of (South)
¹⁶Ewha Womans University Mokdong Hospital, Seoul, Korea, Republic of (South)

Eoghan Molloy^1*, William Shomali, MD², Maggie J Cox^3*, Joseph Butterfield^4*, Julien Catherine^5*, Michael W. Deininger, MD, PhD⁶, Juehua Gao, MD, Ph.D^7*, Grzegorz Helbig^8*, Gabriela S. Hobbs, MD⁹, Fuli Jia^10*, Jean Emmanuel Kahn, PhD, MD^11*, Paneez Khoury^12*, Hirsh Komarow, MD^13*, Andrew T. Kuykendall, MD¹⁴, Orly Leiva, MD¹⁵, Guillaume Lefèvre^16*, Hana I Lim, MD, MS¹⁷, Bridget K Marcellino, MD, PhD¹⁸, Irina Maric, MD, MSc¹⁹, John Mascarenhas, MD^20*, Elena Mishchenko^21*, Stephen T. Oh, MD, PhD²², Eric Padron, MD¹⁴, Sandhya R Panch, MD²³, Ami Patel, MD²⁴, Cecelia Perkins, MPH^25*, Thanai Pongdee, MD⁴, Florence Roufosse^26*, Andrew I. Schafer, MD²⁷, Brady L. Stein, MD⁷, Srdan Verstovsek, MD, PhD^28*, Sa A. Wang²⁹, Ling Zhang, MD³⁰, Jason Gotlib, MD, MS³¹ and Amy D Klion, MD^32*

¹Cork University Hospital, Wilton, Cork, Ireland
²Stanford Cancer Institute/Stanford University School of Medicine, Stanford, CA
³Division of Hematology, Department of Medicine, Washington University School of Medicine, St Louis, MO
⁴Division of Allergic Diseases, Mayo Clinic, Rochester, MN
⁵Universite Libre de Bruxelles, Brussels, Belgium
⁶Division of Hematology and Hematologic Malignancies, University of Wisconsin Milwaukee, Milwaukee, WI
⁷Northwestern University Feinberg School of Medicine, Chicago, IL
⁸Faculty of Medicine, Medical University of Silesia in Katowice, Katowice, Poland
⁹Division of Hematology/Oncology, Massachusetts General Hospital, Boston, MA
¹⁰MD Anderson Cancer Center, Houston, TX
¹¹Hopital Foch, Suresnes, FRA
¹²National Institutes of Health, National Institute of Allergy and Infectious Disease, Bethesda, MD
¹³National Institutes of Health, Bethesda, MD
¹⁴Department of Malignant Hematology, Moffitt Cancer Center, Tampa, FL
¹⁵New York University Grossman School of Medicine, New York City, NY
¹⁶Laboratoire d'Immunologie, CHU de Lille, Lille, France
¹⁷Cornell University, New York, NY
¹⁸Mount Sinai School of Medicine, New York, NY
¹⁹Hematology Section, Department of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, MD
²⁰Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY
²¹Lady Davis Carmel Medical Center, Haifa, ISR
²²Department of Medicine, Washington University School of Medicine, Saint Louis, MO
²³Hematology /Transfusion, Fred Hutchinson Cancer Center, Seattle, WA
²⁴Division of Hematology and Hemtologic Malignancies, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT
²⁵Stanford University, Palo Alto, CA
²⁶Department of Internal Medicine, Hopital Erasme, Université Libre de Bruxelles, Brussels, BEL
²⁷Weill Cornell Medicine, New York, NY
²⁸Kartos Therapeutics, Inc., Redwood City, CA
²⁹Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX
³⁰Department of Pathology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL
³¹Department of Medicine, Division of Hematology, Stanford University School of Medicine, Stanford, CA
³²Laboratory of Parasitic Diseases, National Institutes of Health, Bethesda, MD

Anqi Zhang, PhD^1*, Ting Sun^2,3*, Renchi Yang, MD^3,4,5 and Lei Zhang, MD^2,3,6

¹Institute of Hematology and Blood Disease Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, TX, China
²Tianjin Institutes of Health Science, Tianjin, China
³Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China
⁴State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences&Peking Union Medical College, Tianjin, China
⁵Institute of Hematology & Blood Disease, Tianjin, CHN
⁶State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Tianjin Key Laboratory of Gene Therapy for Blood Diseases, CAMS Key Laboratory of Gene Therapy for Blood Diseases, Tianjin, China

Minghui Duan^1*, Lan Ma^2*, Qiuling Wu, PhD^3*, Hong Liang^4*, Wei Wang, MD^5*, Shaoling Wu^6*, Lijun Mu^7*, Hai Lin^8*, Hebing Zhou^9*, Hong-Xia Shi, MD^10*, Jinghua Wang^11* and Hongmei Jing²

¹Department of Hematology, Department of Hematology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
²Peking University Third Hospital, Beijing, China
³Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, AL, China
⁴Department of Hematology & Oncology,Harbin Institute of Hematology & Oncology, haerbin, China
⁵The Affiliated Hospital of Qingdao University, Qingdao, China
⁶Department of Hematology, The Hospital Affiliated of Qingdao University, Qingdao, China
⁷The Second Hospital of Dalian Medical University, Dalian, China
⁸Department of hematology, First Hospital of Jilin University, Jilin, China
⁹Department of Hematology, Beijing Luhe Hospital, Capital Medical University, Beijing, China
¹⁰Peking University People’s Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, China
¹¹The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China, Harbin, China

Scott Veitch, MBBS, BSc, FRCPath, MRCP^1*, Susan Asirvatham^2*, Priya Sriskandarajah^2*, Chandan Saha^2*, Clare Oni^2*, Clive Grattan^3* and Deepti H. Radia^2*

¹Department of Haematology, Guy's and St Thomas' NHS Foundation Trust, London, ENG, United Kingdom
²Department of Haematology, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom
³St John's Institute of Dermatology, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom

Julie Braish, MBBS^1*, Prithviraj Bose, MD², Naveen Pemmaraju, MD³, Sherry Pierce, BSN, BA^4*, Koji Sasaki, MD⁴, Keyur P. Patel, MBBS, PhD⁵, Hagop Kantarjian, MD⁴ and Lucia Masarova, MD⁴

¹MD Anderson Cancer Center, Houston, TX
²The University of Texas MD Anderson Cancer Center, Houston, TX
³Department of Leukemia, MD Anderson Cancer Center, Houston, TX
⁴Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
⁵Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX

Priya Bhatia Shetty, PhD, MS^1*, Erin Peckham-Gregory, PhD, MPH^1,2*, Erik Stricker, PhD^1*, Howard Lin^1*, Brooks Scull, MS^1,2*, Erik Ehli^3*, Christel Davis^3*, Kenneth L. McClain, MD, PhD^1,4, Philip J. Lupo, PhD^2,5*, Carl E Allen, MD^1,2 and Michael E. Scheurer, PhD^2,6

¹Baylor College of Medicine, Houston, TX
²Texas Children's Hospital, Houston, TX
³Avera Institute for Human Genetics, Sioux Falls, SD
⁴Texas Childrens Cancer and Hematology Centers, Houston, TX
⁵Division of Hematology-Oncology, Department of Pediatrics, Baylor College of Medicine, Houston, TX
⁶Department of Pediatrics, Baylor College of Medicine, Houston, TX