Jusuf Imeri^1*, Paul Marcoux^1*, Matthias Huyghe^1*, Christophe Desterke, PhD^2,3*, Daianne Fantacini^4*, Frank Griscelli, PharmD, PhD^1,5*, Dimas T. Covas, MD, PhD^6,7,8, Lucas Edouardo Botelho de Souza^9,10*, Annelise Bennaceur Griscelli, MD, PhD^1,11,12* and Ali Turhan, MD, PhD¹³

¹Inserm U1310, Villejuif, France
²Faculty of Medicine, University Paris Saclay, Le Kremlin Bicetre, France
³Inserm U1310, Villejuif, FRA
⁴Ribeirao Preto School of Medicine, Blood Center, RibeirãO Preto, BRA
⁵Center for iPSC Therapies, CITHERA, Evry Genopole, France
⁶Biotechnology Cluster of Ribeirao Preto, Butantan Institute, Ribeirao Preto, Brazil
⁷Faculdade De Medicina De Ribeirao Preto -USP, Ribeirao Preto, Brazil
⁸Department of Clinical Medicine, Division of Hematology, School of Medicine of Ribeirão Preto - University of São Paulo (FMRP-USP), Ribeirão Preto, Brazil
⁹Ribeirão Preto/Ribeirão Preto School of Medicine/University of São Paulo - Ribeirão Preto/SP, Brazil., Blood Center, Ribeirao Preto, Brazil
¹⁰Biotechnology Nucleus of Ribeirão Preto, Butantan Institute, Ribeirao Preto, Brazil
¹¹Center for iPSC Therapies, Evry Genopole, France
¹²University Paris Saclay-Division of Hematology, 94805, Villejuif, FRA
¹³CITHERA, Center for iPSC Therapies, Evry, France

Pan Wang, Ph.D.^1*, Xu Han, PhD^1*, Kehan Ren¹, Ermin Li, Ph.D.^1*, Honghao Bi, PhD², Inci Aydemir^2* and Peng Ji, MD, PhD¹

¹Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL
²Northwestern University, Chicago, IL

Ivo Veletic, MD^1*, Taghi Manshouri, PhD^1*, Christopher D. Pacheco, BS^1*, C. Cameron Yin, MD, PhD², Ying Zhang, MD^1*, Ping Li, PhD^1*, Evan N. Cohen, PhD^2*, Javier A. Gomez^1*, Jared K. Burks, PhD^1*, Srdan Verstovsek, MD, PhD¹ and Zeev Estrov, MD¹

¹Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
²Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX

Shinobu Matsuura, PhD, DVM¹, Siyang Long, MS^2*, Iris Karkempetzaki^2,3*, Aikaterini Karagianni, MS, PhD^2,3*, Xiaosheng Yang, MS^2*, Nasi Huang, MD^2*, Yuchen Liu, PhD^4*, Chao Zhang, MS, PhD^4* and Katya Ravid, Dsc²

¹Cardiovascular Section/Department of Medicine, Boston University Chobanian and Avedisian School of Medicine, Boston, MA
²Whitaker Cardiovascular Institute, Boston University Chobanian and Avedisian School of Medicine, Boston, MA
³Department of Internal Medicine, University of Crete, School of Medicine, Heraklion, Greece
⁴Section of Computational Biomedicine/Department of Medicine, Boston University Chobanian and Avedisian School of Medicine, Boston, MA

Fan He, PhD¹, Tim Kong, MSc², Shuyang Lin^2*, Mary C. Fulbright^2*, Angelo B. A. Laranjeira^2*, Daniel A.C. Fisher^2*, Maggie J Cox^2*, Katrina Ashworth^3*, Jorge Di Paola, MD³ and Stephen T. Oh, MD, PhD⁴

¹Division of Hematology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO
²Division of Hematology, Department of Medicine, Washington University School of Medicine, St Louis, MO
³Department of Pediatrics, Washington University School of Medicine, St Louis, MO
⁴Department of Medicine, Washington University School of Medicine, Saint Louis, MO

Yanjie Li^1,2,3*, Hui Gao^1,3*, Yahui Liu^1,3,4*, Chunling Fu^1,3,4*, Wen Ju^3,4*, Kailin Xu^1,5,6*, Jianlin Qiao, PhD^1,3,7 and Lingyu Zeng^1,3,4,8*

¹Blood Diseases Institute, Xuzhou Medical University, Xuzhou, China
²Laboratory Center of Diagnostics, Xuzhou Medical University, Xuzhou, China
³Key Laboratory of Bone Marrow Stem Cell, Xuzhou, China
⁴Department of Hematology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China
⁵Key Laboratory of Bone Marrow Stem Cell, Jiangsu Province, China
⁶Department of Hematology, the Affiliated Hospital of Xuzhou Medical University, Xuzhou, China
⁷Department of Hematology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou City, Jiangsu Province, China
⁸College of Medical Technolog, Xuzhou Medical University, Xuzhou, China

Anitria Cotton, MBA, BS^1*, Ryan Collinson^2*, Lynne Wilson^2*, Zi Yun Ng^3*, Hun S Chuah^3*, Michael F. Leahy, FRACP³, Rebecca Howman^4*, Carolyn Grove^2,4,5, Hasib Sidiqi^6*, Malcolm Webb^7*, Darren Boey^2*, Olivia Ruhen^2*, Michael Phillips^8*, Matthew Linden^2*, Kathy Fuller, PhD^2*, Wendy N. Erber, MD PhD^2,5, Ronald Hoffman, MD⁹, John D. Crispino, PhD, MBA¹ and Belinda Guo^2*

¹Division of Experimental Hematology, St Jude Children's Research Hospital, Memphis, TN
²School of Biomedical Sciences, University of Western Australia, Crawley, Australia
³Royal Perth Hospital, Perth, Australia
⁴Sir Charles Gairdner Hospital, Crawley, Australia
⁵PathWest Laboratory Medicine, Nedlands, Australia
⁶Fiona Stanley Hospital, Murdoch, Australia
⁷Hollywood Private Hospital, Nedlands, Australia
⁸Centre for Medical Research, University of Western Australia, Crawley, Australia
⁹Icahn School of Medicine at Mount Sinai, New York

Joan How, MD¹, Anna E. Marneth, PhD^1,2, Baransel Kamaz, MD^3*, Chulwoo J. Kim^4*, Donna S. Neuberg, ScD⁵, Siyang Ren, MS^5*, Mohammed Wazir⁶, Lachelle D. Weeks, MD, PhD⁷, Maximilian Stahl, MD⁸, Daniel J. DeAngelo⁹, R. Coleman Lindsley¹⁰, Marlise R. Luskin, MD⁷, Sahand Hormoz, PhD^11* and Ann Mullally, MD¹

¹Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Boston, MA
²Department of Laboratory Medicine, Division Laboratory of Hematology, Radboud University Medical Center, Nijmegen, Netherlands
³Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA
⁴Department of Medicine, Division of Hematology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA
⁵Department of Data Science, Dana-Farber Cancer Institute, Boston, MA
⁶Department of Medicine, Division of General Internal Medicine, Brigham and Women's Hospital, Boston, MA
⁷Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
⁸Dana Farber Institute, Boston, MA
⁹Dana-Farber Cancer Institute, Boston, MA
¹⁰Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA
¹¹Harvard University, Boston, MA

Ranran Zhang, MD^1,2*, Yashaswini Janardhanan^3*, Rohit Haldar^3*, Leanne Cooper^3*, Sebastien Jaquelin, PhD^1*, Jasmin Straube, PhD^4*, Megan Bywater, PhD^1,3* and Steven W Lane, MD, PhD^3,5,6

¹The University of Queensland, Brisbane, QLD, Australia
²Cancer Program, QIMR berghofer medical research Institute, Brisbane, Australia
³Cancer Program, QIMR berghofer medical research Institute, Brisbane, QLD, Australia
⁴Cancer Program, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia
⁵Cancer Care Services, Royal Brisbane and Women's Hospital, Herston, QLD, Australia
⁶School of Biomedical Sciences, The University of Queensland, Brisbane, Australia

Xiaoli Wang, MD, PhD^1*, Andrew Davis^1*, Xiaoping Su, PhD^2*, Muharrem Muftuoglu, MD³, Cecile Krejsa, PhD⁴, John Mascarenhas, MD^1*, Michael Andreeff, MD PhD⁵ and Ronald Hoffman, MD¹

¹Department of Medicine, Division of Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai, New York, NY
²Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX
³Section of Molecular Hematology and Therapy, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
⁴Kartos Therapeutics and Telios Pharma, Redwood City, CA
⁵Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX

Blake Moses, PhD, Mike Dills^*, Ashlyn Wheeler^*, Radina Todorova^*, Savanna Macaluso^*, Tyler Damen, PhD^*, Samuel Cadena, PhD^*, Lorena Lerner, PhD^*, Jasbir Seehra, PhD^* and Jenn Lachey, PhD

Keros Therapeutics, Lexington, MA

Eduard Mas Marin, PhD, MSc, BSc, PharmD, BA¹, Sabrina Mir, BS^2*, Eli M Soyfer, MS³, Jane H Chen, BS^4*, Jianhong C Heidmann, BS^5*, Simran Bhardwaj^6*, Gajalakshmi Ramanathan, PhD^6* and Angela G. Fleischman, MD, PhD⁵

¹University of California, Irvine, IRVINE, CA
²School of Medicine, University of California, Irvine, Irvine, CA
³Medicine, Biological Chemistry, University of California, Irvine, Irvine, CA
⁴University of California, Irvine, Irvine
⁵Division of Hematology/Oncology, University of California, Irvine, Irvine, CA
⁶University of California, Irvine, Irvine, CA

Danny Jeyaraju, PhD^1*, Sheida Hayati^2*, Jia Wang^3*, Claire N Harrison⁴, Jean-Jacques Kiladjian, MD, PhD⁵, Christopher Hernandez^3*, Patrick Brown^3*, Daniel Lopes De Menezes, PhD^6*, Anita K. Gandhi, PhD³ and Rajasekhar N.V.S. Suragani, PhD⁷

¹Translational Development and Diagnostics, Bristol Myers Squibb, Summit, NJ
²Informatics and Predictive Sciences, Bristol Myers Squibb, Princeton, NJ
³Bristol Myers Squibb, Princeton, NJ
⁴Guy’s and St. Thomas’ NHS Foundation Trust, London, ENG, United Kingdom
⁵Hopital Saint-Louis, Paris, France
⁶Bristol Myers Squibb, San Francisco, CA
⁷Hematology, Translational Medicine and Disease Team, Bristol Myers Squibb, Summit, NJ

Francesca Palandri, MD^1*, Giulia Benevolo, MD^2*, Elena Maria Elli, MD^3*, Roberto Latagliata^4*, Giuseppe Auteri, MD^5,6*, Filippo Branzanti, MSc^1*, Mario Tiribelli, MD^7*, Francesco Cavazzini, MD^8*, Alessia Tieghi, MD^9*, Nicola Polverelli, MD¹⁰, Alessandra D'Addio, MD^11*, Elisabetta Abruzzese, MD¹², Federica Colombo, MD^13*, Marta Venturi^1,5*, Francesco Ramundo^14,15*, Rikard Mullai, MD^16*, Antonio Cuneo, MD^17*, Benedetto Bruno, MD, PhD¹⁸, Michele Cavo, MD^5,19*, Giuseppe Alberto Palumbo, MD^20*, Florian H Heidel, MD²¹, Massimo Breccia^22* and Valerio De Stefano, MD^15,23*

¹IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia “Seràgnoli”, Bologna, Italy, Bologna, Italy
²University Hematology Division, Città della Salute e della Scienza Hospital, Torino, Italy, Torino, Italy
³Fondazione IRCCS, San Gerardo dei Tintori, Monza, Monza, Italy
⁴Hematology Unit, Ospedale Belcolle, Viterbo, Italy, Rome, ITA
⁵Dipartimento di Medicina Specialistica, Diagnostica e Sperimentale, Università di Bologna, Bologna, Italy, Bologna, Italy
⁶IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia “Seràgnoli”, Bologna, Italy, Bologna, ITA
⁷Division of Hematology and BMT, Department of Medical Area, University of Udine, Udine, Italy
⁸Division of Hematology, University of Ferrara, Ferrara, Ferrara, ITA
⁹Department of Hematology, Azienda USL - IRCCS di Reggio Emilia, Reggio Emilia, Reggio Emilia, ITA
¹⁰Unit of Blood Diseases and Stem Cells Transplantation, Department of Clinical and Experimental Sciences, University of Brescia, ASST Spedali Civili of Brescia, Brescia, Brescia, Italy
¹¹Division of Hematology, Onco-hematologic Department, AUSL della Romagna, Ravenna, Ravenna, ITA
¹²Division of Hematology, Ospedale S. Eugenio, Roma, Roma, Italy
¹³Hematology Department, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy
¹⁴Hematology Division, Sapienza University, Policlinico Umberto I, Rome, Roma, Italy
¹⁵Institute of Hematology, Catholic University School of Medicine, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Roma, Italy
¹⁶Division of Hematology and BMT, Department of Medical Area, University of Udine, Udine, Udine, Italy
¹⁷Division of Hematology, University of Ferrara, Ferrara, Ferrara, Italy
¹⁸Division of Hematology and Stem Cell Transplant Unit, University Hospital AOU Città della Salute e della Scienza, Torino, Italy
¹⁹Dipartimento di Scienze Mediche e Chirurgiche, University of Bologna, Bologna, Italy
²⁰Department of Scienze Mediche, Chirurgiche e Tecnologie Avanzate “G.F. Ingrassia”, University of Catania, Catania, Catania, Italy
²¹Internal Medicine II, Hematology and Oncology, Friedrich-Schiller-University Medical Center, Jena, Germany, Greifswald, Germany
²²Division of Cellular Biotechnologies and Hematology, University Sapienza, Roma, Roma, Italy
²³Hematology Division, Sapienza University, Policlinico Umberto I, Rome, Rome, Italy

Mamta Garg, MD, MBBS, FRCP, FRCPath^1*, Siddharth Agarwal, MBBS^2* and Graham Asagba, MBBS FRCP FRCPath^1*

¹University Hospital Leicester, Leicester, United Kingdom
²Radiology, University of Nottingham, Nottigham, United Kingdom

Liqiang Zhang^1*, Kathryn McGinnis, BS^1*, Paul Gonzales, BS^1*, Maggie Murray, BS^1*, Emily Cluff, MS^1*, MD Babu Mia^2*, Christoph Schaniel, PhD^3*, Joseph Mascarenhas, PhD^1*, Alan M Miller, MD PhD⁴, Ronald Hoffman, MD⁵ and Stephen Gately, PhD^1*

¹Translational Drug Development (TD2), Scottsdale, AZ
²TISCH CANCER CENTER, Icahn School of Medicine at Mount Sinai, NEW YORK, NY
³The Tisch Cancer Institute, Division of Hematology and Medical Oncology, Icahn School of Medicine At Mount Sinai, New York, NY
⁴Translational Drug Development (TD2), Erie, CO
⁵Department of Medicine, Division of Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai, New York, NY

Garima Pandey, PhD¹, Lucia Mazzacurati, PhD^1*, Nathan P. Horvat, MD^1*, Tegan Rowsell, BS^1*, Narmin E. Amin, MS^1*, Guolin Zhang, PhD^1*, Afua Adutwumwa Akuffo, PhD^1*, Christelle M. Colin-Leitzinger, PhD^1*, Eric B. Haura, MD^1*, Andrew T. Kuykendall, MD^1,2, PK Epling-Burnette, PharmD, PhD^1* and Gary W. Reuther, PhD³

¹Moffitt Cancer Center, Tampa, FL
²Department of Malignant Hematology, Moffitt Cancer Center, Tampa, FL
³H. Lee Moffitt Cancer Center, Tampa, FL

Gopila Gupta^1*, May Chiu², Eshrak Al-Shaibani^3*, Maria Agustina Perusini, MD⁴, Josephine Lucero⁵, Daniela Zackova, MD^6*, Ivana Jeziskova^7*, Anezka Kvetkova^7*, Tomas Jurcek^7*, Jaeyoon John Kim^8*, Danielle Pyne^9*, Anthea Travas^10*, Amirthagowri Ambalavanan^10*, Jiri Mayer, Prof, MD^11,12, Jessie Medeiros¹⁰, Sagi Abelson^1,13* and Dennis Dong Hwan Kim, MD, PhD^{14,15,16,17,18}

¹University Health Network, Princess Margaret Cancer Centre, Toronto, Canada
²PRINCESS MARGARET CANCER CENTRE- UNIVERSITY HEALTH CENTRE, Christchurch, New Zealand
³Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada
⁴Princess Margaret Cancer Centre / University Health Network, Toronto, ON, Canada
⁵Princess Margaret Cancer Centre, University Health Network, Toronto, Canada
⁶University Hospital Brno and Masaryk University, Brno, CZE
⁷Dpt. of Internal Medicine Hematology and Oncology, University Hospital Brno and Masaryk University, Brno, Czech Republic
⁸Department of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada
⁹University Health Network, Toronto, ON, Canada
¹⁰University Health Network, Toronto, Canada
¹¹Masaryk University and University Hospital Brno, Brno, Czech Republic
¹²Clinic of Internal Medicine - Hematology and Oncology, University Hospital Brno, Brno, Czech Republic
¹³Ontario Institute for Cancer Research, Toronto, Canada
¹⁴Hans Messner Allogenic Transplant Program, Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada
¹⁵Faculty of Medicine, Department of Medicine, University of Toronto, Toronto, ON, Canada
¹⁶Hans Messner Allogenic Transplant Program, Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University Health Network, Toronto, Canada
¹⁷Hans Messner Allogeneic Transplant Program, Division of Medical Oncology and Haematology, Princess Margaret Cancer Centre, University Health Network, University of Toronto, Toronto, Canada
¹⁸Leukemia program, Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University Health Network, University of Toronto, Toronto, Canada

Hamza Celik^*, Maryanne Covington^*, Katherine Drake^*, Kamna Katiyar^*, Alex Margulis^*, Amanda Smith^*, Gaurang Trivedi^*, Brittney Wass^*, Guofeng Zhang, Nina Zolotarjova^*, Sunkyu Kim^* and Ricardo Macarrón

Incyte Research Institute, Wilmington, DE

Valentina Boldrini, MD^1,2*, Paola Guglielmelli, MD, PhD^2,3, Giada Rotunno^2,3*, Chiara Maccari^2,3*, Giacomo Coltro, MD^2,3*, Giuseppe Gaetano Loscocco, MD^2,3*, Francesco Mannelli, MD^2,3*, Naseema Gangat, MBBS⁴, Ayalew Tefferi, MD⁴ and Alessandro M. Vannucchi^2,3

¹University of Florence, Florence, Italy
²CRIMM, Center for Research and Innovation of Myeloproliferative Neoplasms, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy
³Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy
⁴Division of Hematology, Mayo Clinic, Rochester, MN