Nayeli Esparza^1*, Eva Bresson^2*, Safia Safa-Tahar-Henni^3*, Joan Defrene^2*, Élodie Roques^3*, Florence Bonnet-Magnaval^3*, Vincent-Philippe Lavallée^4*, Brian T. Wilhelm, PhD, BSc^5* and Frederic Barabe, MD⁶

¹Laval University, Québec, QC, Canada
²Laval University, Québec, Canada
³University of Montreal, Montreal, QC, CAN
⁴Centre Hospitalier Universitaire Sainte-Justine Research Center, Montreal, QC, CAN
⁵Institute for Research in Immunology and Cancer of the University of Montreal, Montreal, QC, Canada
⁶Hôpital de l'Enfant-Jésus, Division of Hematology and Medical Oncology, CHU de Québec - Université Laval, Québec, QC, Canada

Adnan K. Mookhtiar, MSc¹, Hidehiro Itonaga, MD, PhD^1,2, Sarah Greenblatt, PhD^1*, Concepcion Martinez, MS^1*, Jun Sun, PhD^1*, Krystal Lisa Hossack, MS^1*, Ramin Shiekhattar, PhD^1*, Daniel Bilbao, PhD³, Maria Ken E. Figueroa, MD¹, Simone Sidoli, PhD^4* and Stephen D. Nimer, MD¹

¹University of Miami, Sylvester Comprehensive Cancer Center, Miami, FL
²Transfusion and Cell Therapy Unit, Nagasaki University Hospital, Nagasaki city, NSK, Japan
³Cancer Modeling Shared Resource, Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL
⁴Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY

Jelena Milosevic, PhD^1*, Johannes Elferich, PhD^2*, Kashish Chetal^3*, Mary Ayres^4*, Varsha Gandhi, PhD⁵, Ruslan Sadreyev, PhD^3*, Nikolaus Grigorieff, PhD^2*, Shobha Vasudevan, PhD^6* and David Sykes, MD, PhD⁷

¹Center for Regenerative Medicine, MGH, Boston, MA
²Howard Hughes Medical Institute, University of Massachusetts Chan Medical School, Worcester, MA
³Department of Molecular Biology, Massachusetts General Hospital, Boston, MA
⁴Department of Experimental Therapeutics, MD Anderson Cancer Center, Houston, TX
⁵Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX
⁶MGH, HMS, BOSTON, MA
⁷The Massachusetts General Hospital, Boston, MA

Takayuki Hoshii, PhD^1*, Sota Kikuchi^1*, Seito Shibata^1*, Makoto Matsumoto^1*, Bahityar Rahmutulla^2*, Masaki Fukuyo^3*, Scott A Armstrong, MD, PhD⁴ and Atsushi Kaneda^2*

¹Chiba University, Chiba, Japan
²Department of Molecular Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan
³Chiba University, Chiba, JA, Japan
⁴Pediatric Oncology, Dana-Farber Cancer Institute, Boston

Zhe Chen^1*, Feng Wu^2*, Lei Li^3* and Yu Hou, PhD⁴

¹Institute of Life Sciences, Chongqing Medical University, Chongqing, China
²Institute of Life Sciences, Chongqing Medical University, chongqing, China
³Institute of Life Sciences, Chongqing Medical Univerity, Chongqing, China
⁴Institute of Life Sciences, Chongqing Medical University, CHONGQING, Chongqing, China

Miranda Fernandez-Serrano, MSc^1,2*, Alba Mesa, MD^3*, Ignacio Campillo-Marcos, PhD^4,5*, Marta Casado-Pelaez^4*, Shubhra Bhattacharya^6*, Laura Palomo, PhD^7*, Wencke Walter, PhD^8*, Pau Marin-Escudero, MSc^1*, Mar Mallo^9*, Julia Montoro^10*, Francesc Sole, PhD¹¹, Elisabetta Mereu, PhD^12*, Caterina Mata^13*, David Corujo, PhD^6*, Torsten Haferlach, MD, PhD⁸, Marcus Buschbeck, PhD^14*, Manel Esteller, MD^15,16,17,18, David Valcarcel, MD, PhD¹⁰, Silvia Saumell, MD, PhD^19,20* and Gael Roue, PhD²¹

¹Lymphoma Tranlastional group, Josep Carreras Leukaemia Research Institute, Badalona, Spain
²Department of Biochemistry and Molecular Biology, Autonomous University of Barcelona (UAB), Barcelona, Spain
³Hematology Department, ICO-Hospital Universitari Germans Trias i Pujol, Badalona, Spain
⁴Cancer Epigenetics group, Josep Carreras Leukaemia Research Institute, Badalona, Spain
⁵Centro de Investigación Biomédica en Red Cáncer (CIBERONC), Madrid, Spain
⁶Chromatin, Metabolism and Cell Fate group, Josep Carreras Leukaemia Research Institute, Badalona, Spain
⁷Experimental Hematology, Vall d’Hebron Institute of Oncology (VHIO), Vall d’Hebron Barcelona Hospital Campus, Barcelona, Spain
⁸MLL Munich Leukemia Laboratory, Munich, Germany
⁹Myelodysplastic Syndromes Research Group, Josep Carreras Leukaemia Research Institute, ICO-Hospital Germans Trias i Pujol, Universitat Autònoma de Barcelona, Badalona, Barcelona, Spain
¹⁰Service of Hematology, Hospital Universitari Vall d’Hebron, Barcelona; Vall d’Hebron Instituto de Oncología (VHIO), Barcelona, Spain
¹¹MDS Group, Josep Carreras Leukaemia Research Institut, ICO-Hospital Germans Trias i Pujol, Universitat Autònoma de Barcelona, Barcelona, Spain
¹²Cellular Systems Genomics group, Josep Carreras Leukaemia Research Institute, Badalona, Spain
¹³Single Cell Unit, Josep Carreras Leukaemia Research Institute, Badalona, Spain
¹⁴Chromatin, Metabolism and Cell Fate group, Josep Carreras Leukaemia Research Institute (IJC), Badalona, ESP
¹⁵Josep Carreras Leukaemia Research Institute, Badalona, Spain
¹⁶School of Medicine, Physiological Sciences Department, University of Barcelona, Badalona, Spain
¹⁷Centro de Investigacion Biomedica en Red Cancer, Madrid, Spain
¹⁸Institució Catalana de Recerca i Estudis Avançats, Barcelona, Spain
¹⁹Vall d'Hebron Institute of Oncology, Vall d'Hebron University Hospital, Barcelona, Spain
²⁰Department of Hematology, University Hospital Vall d’Hebron, University Autònoma of Barcelona (UAB). Experimental Hematology Unit, Vall d’Hebron Institute of Oncology (VHIO), Barcelona, ESP
²¹Lymphoma translational group, Josep Carreras Leukemia Research Institute, Badalona, Spain

Xiaotu Ma, PhD¹, Rhonda E Ries, MA^2*, Quang Tran, PhD^1*, Yanling Liu^1*, Pandurang Kolekar, PhD^1*, Ramzi Alsallaq^1*, Zhikai Liang^1*, Timothy Shaw^3*, Meghana Devineni^4*, Anne Deslattes Mays^5*, Ching Lau^5*, Johann K. Hitzler, MD⁶ and Soheil Meshinchi, MD, PhD⁷

¹St. Jude Children's Research Hospital, Memphis, TN
²Translational Science and Therapeutics, Fred Hutchinson Cancer Research Center, Seattle, WA
³Moffitt Cancer Center, Tampa, FL
⁴Rhodes College, Memphis, TN
⁵The Jackson Laboratory for Genomic Medicine, farmington, CT
⁶Division Hematology/Oncology, The Hospital for Sick Children, Toronto, ON, CAN
⁷Translational Sciences and Therapeutics, Fred Hutchinson Cancer Research Center, Seattle, WA

Brian Chernak, MD¹, Marta Galan-Diez, PhD^2,3*, Abdullah Mahmood Ali, PhD^4,5,6, Alvaro Cuesta-Dominguez, PhD^2*, Ziwei Chen, PhD^7*, Thomas Koehnke, MD⁸, Ravi Majeti, MD⁹, Martin Carroll, MD¹⁰, Azra Raza, MD^4,6 and Stavroula Kousteni, PhD^2,6

¹Division of Hematology/Oncology, Columbia University Irving Medical Center, New York City, NY
²Department of Physiology and Cellular Biophysics, Columbia University Irving Medical Center, New York, NY
³Regeneron Pharmaceuticals, Tarrytown, NY
⁴Department of Medicine, Columbia University Irving Medical Center, New York, NY
⁵Division of Hematology/Oncology, Columbia University Irving Medical Center, New York, NY
⁶Edward P. Evans Myelodysplastic Syndromes Center, Columbia University Irving Medical Center, New York, NY
⁷Department of Systems Biology, Columbia University Irving Medical Center, New York, NY
⁸Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, CA
⁹Stanford University School of Medicine, Stanford, CA
¹⁰Division of Hematology/Oncology, Department of Medicine, The Perelman School of Medicine at The University of Pennsylvania, Philadelphia, PA

Sean M. Post, PhD¹, Kerstin Rhan, PhD^1*, Shelley Herbrich, MS^2*, Oscar Benitez^3*, Ashley G Rodriguez, MS^3*, Xiaorui Zhang, MS^1*, Michael R Meier^4*, Jared Brottem^3*, Martina Crysandt, MD^5*, Prerna Malaney, PhD⁶ and Isabel naarmann-Devries, PHD^7*

¹MD Anderson, Houston, TX
²UT MD Anderson, Houston, TX
³MD Anderson, Houston
⁴UT Health McWilliams School of Biomedical Informatics, Houston, TX
⁵Department of Hematology and Oncology, University Hospital RWTH Aachen and Center for Integrated Oncology Aachen-Bonn-Cologne-Düsseldorf (CIOABCD), Aachen, Germany
⁶MD Anderson Cancer Centre, Houston, TX
⁷RWTH Aachen University, Aachen Germany, Aachen, Germany

Eirini Sofia Fasouli^1*, Konstantina Giavi^1*, Charikleia Makri^1*, Leonid Bystrykh^2*, Anthi Bouchla^3*, Emmanouil Athanasiadis^1*, Giannis Vatsellas^1*, Vasiliki Pappa^4* and Eleni Katsantoni^5*

¹Basic Research Center, Biomedical Research Foundation, Academy of Athens, Athens, Greece
²UMCG / University of Groningen, Groningen, Netherlands
³Hematology Unit, 2nd Department of Internal Medicine - Propaedeutic and Research Unit, School of Medicine, National and Kapodistrian University of Athens, Attikon University Hospital, Athens, Greece
⁴Second Department of Internal Medicine and Research Institute, Hematology Unit, National and Kapodistrian University of Athens, Medical School, University General Hospital "Attikon", Athens, Greece
⁵Biomedical Research Foundation, Academy of Athens, Athens, Greece

Yoko Nishinaka-Arai, PhD, MT^1,2*, Yohko Kitagawa, PhD^3*, Yasuhiro Kazuki, PhD^4*, Yasuyuki Arai, MD, PhD⁵, Tatsutoshi Nakahata, PhD, MD^6*, Akira Niwa, MD, PhD^3* and Megumu K Saito, MD, PhD^3*

¹Center for iPS cell research and application, Kyoto University, Kyoto, Japan
²Department of Human Health Sciences, Kyoto University, Kyoto, Japan
³Center for iPS Cell Research and Application, Kyoto University, Kyoto, Japan
⁴Division of Genome and Cellular Functions, Department of Molecular and Cellular Biology, School of Life Science, Faculty of Medicine, Tottori University, Tottori, Japan
⁵Department of Hematology, Kyoto University Hospital, Kyoto, Japan
⁶Central institute for experimental animals, Kawasaki, Japan

Xiuhua Su^*, Tao Sun^*, Yuan Xia^*, Mingying Li^*, Dongmei Wang^*, Fei Lu, MD^*, Jingjing Ye^* and Chunyan Ji, md, phd

Department of Hematology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China

Yuqing Dan^*, Ruibao Ren, MD, PhD, Donghe Li, PhD^* and Ping Liu, MD, PhD^*

Shanghai Institute of Hematology, State Key Laboratory for Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China

Yang Li^1*, Haley Abel, PhD^2*, Michelle Cai, MD^3*, Taylor Lavalle^4*, Tiankai Yin, BA⁵, Nichole Helton^6*, Amanda Smith^2*, Christopher A Miller, PhD^6* and Timothy J Ley⁶

¹Division of Oncology, Department of Internal Medicine, Washington University in St. Louis School of Medicine, Saint Louis, MO
²Washington University in St. Louis, St. Louis, MO
³Division of Oncology, Department of Internal Medicine, Washington University in St. Louis, St. Louis, MO
⁴University of Missouri School of Medicine, Columbia, MO
⁵Washington University in St. Louis, Saint Louis, MO
⁶Division of Oncology, Department of Internal Medicine, Washington University in St. Louis School of Medicine, St. Louis, MO

Yanan Li, PhD^1*, Wei Yang, PhD^2*, Riddhi M. Patel^1*, Emily B. Casey^1*, Elisabeth Denby^1* and Jeffrey Magee, MD, PhD^3,4

¹Department of Pediatrics, Division of Hematology and Oncology, Washington University School of Medicine, St. Louis, MO
²Department of Genetics, Washington University School of Medicine, St. Louis, MO
³Department of Pediatrics, Washington University School of Medicine, Saint Louis, MO
⁴Washington University School of Medicine, Saint Louis, MO

Daelynn Buelow, PhD^1*, Xining Yang, Ph.D^2*, Deedra Nicolet³, Krzysztof Mrózek, MD, PhD⁴, Kathrin Krowiorz, PhD^5*, Raj Bhayadia^6*, Jack Stromatt^7*, Anna Denny^8*, Christoph Wiegel, Ph.D^9*, Colin Corbett^8*, Salma Abdelbaky^9*, Yonger Xue^8*, Yizhou Dong, PhD^8*, Jeremy Hui^2*, Arshia Shad^2*, Sharon Gao^2*, Si Wei Wu^10*, Marion van den Bosch, PhD^11*, Liam MacPhee^2*, Leo Escano, BS^12*, James S. Blachly¹³, Jonathan E Kolitz, MD¹⁴, William Blum, MD¹⁵, Maria R. Baer, MD¹⁶, Jan-Henning Klusmann, MD¹⁷, Ann-Kathrin Eisfeld, MD*³, Arefeh Rouhi, PhD^2*, Sharyn D. Baker, PharmD¹⁸, Florian Kuchenbauer, MD, PhD, FRCPC¹⁹ and Christopher C. Oakes, PhD²⁰

¹Division of Pharmaceutics & Pharmacology, The Ohio State Univeristy, Lewis Center, OH
²Terry Fox Laboratory, British Columbia Cancer Research Institute, Vancouver, BC, Canada
³Clara D. Bloomfield Center for Leukemia Outcomes Research, The Ohio State University, Columbus, OH
⁴Clara D. Bloomfield Center for Leukemia Outcomes Research, The Ohio State University Comprehensive Cancer Center, Columbus, OH
⁵Division of Hematology and Oncology, University Hospital Ulm, Ulm, Germany
⁶Department of Pediatrics, Goethe University Frankfurt, Frankfurt (main), DEU
⁷Division of Pharmaceutics and Pharmacology, The Ohio State University, Columbus, OH
⁸Division of Pharmaceutics & Pharmacology, The Ohio State University, Columbus, OH
⁹Division of Hematology, The Ohio State University, Columbus, OH
¹⁰Terry Fox Laboratory, British Columbia Cancer Research Institute, Vancouver, BC, CAN
¹¹InteRNA Technologies BV, Utrecht, Netherlands
¹²Terry Fox Laboratory, British Columbia Cancer Research Institute, Vancouver, Canada
¹³Department of Hematology, The Ohio State University Comprehensive Cancer Center, Columbus, OH
¹⁴Zucker School of Medicine at Hofstra/Northwell, Zuckerberg Cancer Center, Lake Success, NY
¹⁵Winship Cancer Institute of Emory University, Atlanta, GA
¹⁶Department of Medicine, University of Maryland School of Medicine, Baltimore, MD
¹⁷Goethe University Frankfurt, Frankfurt, Hessen, Germany
¹⁸Ohio State University, Columbus, OH
¹⁹BC Cancer Research Centre, Vancouver, BC, Canada
²⁰Division of Hematology, Department of Internal Medicine, Comprehensive Cancer Center, The Ohio State University, Columbus, OH

Arjun Dhir, MSc¹, Kevin Tur-Rodriguez^1*, Samantha Swenson^1*, Kasidy Weber^1*, Abu Rafay^2*, Vikas Kumar^1*, Shannon M. Buckley, PhD³ and Kate Hyde, PhD⁴

¹University of Nebraska Medical Center, Omaha, NE
²Northeastern University, Boston, MA
³University of Utah, SLC, UT
⁴Department of Biochemistry and Molecular Biology, and Fred and Pamela Buffet Cancer Center, University of Nebraska Medical Center, Omaha, NE

Rhea H. Desai^1*, Peter J. Browett², Purvi M. Kakadia^1* and Stefan K. Bohlander^1*

¹Leukaemia and Blood Cancer Research Unit, Department of Molecular Medicine and Pathology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand
²University of Auckland School of Medicine, Auckland, NZL

Junli Mou^1*, Yu Liu^1*, Xiaoyu Liu^1*, Runxia Gu, MD^1*, Yingxi Xu, PhD^1*, Kejing Tang^1*, Zheng Tian^1*, Haiyan Xing^1*, Qing Rao, MS^1*, Min Wang^2*, Shaowei Qiu, MD^3* and Jianxiang Wang, MD²

¹State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China
²State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences &Peking Union Medical College, Tianjin, China
³National Clinical Research Center for Blood Diseases, State Key Laboratory of Experimental Hematology, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences &Peking Union Medical College, Tianjin, China

Mengli Zhang^1*, Shaela Wright^2*, Xiaowen Chen^3*, Ye Xin^1*, Yingcai Jin^1*, Jianxiang Zhang^1*, Xue Yang^1*, Xinfeng Chen^1*, Judith Hyle^2*, Wojciech Rosikiewicz^4*, Beisi Xu, PhD^2*, Liusheng He^5*, Feiqiu Wen^3*, Chunliang Li, PhD⁴ and Peng Xu, PhD⁶

¹Soochow University, Suzhou, China
²St. Jude Children's Research Hospital, Memphis
³Shenzhen Children's Hospital, shenzhen, China
⁴St. Jude Children's Research Hospital, Memphis, TN
⁵Core Facility of Flow Cytometry, St. Jude Children's Research Hospital, Memphis
⁶Hematology Center, Cyrus Tang Medical Institute, Soochow University, Suzhou, Jiang Su, China

Jiexian Ma^1*, Shunrong Sun^1*, Min Wu^2*, Xinyu Zuo^1*, Mixue Xie^3*, Xiaoqin Wang, MD^4*, Xiu-Jin Ye^5*, Shuhong Shen, MD, PhD⁶ and Yanhui Xie^1*

¹Department of Hematology, Huadong Hospital Affiliated with Fudan University, Shanghai, China
²Huadong Hospital Affiliated To Fudan University, Shanghai, CHN
³Department of Hematology, The First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China
⁴Affiliated Huashan Hospital of Fudan University, Shanghai, China
⁵The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China
⁶Key Laboratory of Pediatric Hematology & Oncology of the Ministry of Health of China, Department of Hematology & Oncology, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China

Jing Zhou^1*, Xing Chen^2*, Yang Cao^3*, Liang Huang⁴ and Gaoxiang Wang^5*

¹Department of Hematology, Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China, Wuhan, China
²tongji hospital, wuhan, China
³Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China, Wuhan, China
⁴Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, wuhan, China
⁵Department of Hematology, Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China, wuhan, China

Sean Wen, BSc, MSc, PhD^1,2*, Jennifer O Sullivan^3,4*, Joanna Baxter^5*, Nikolaos Sousos^3,4*, Adam J Mead, MRCP, FRCPath, PhD^3,6 and Alba Rodriguez-Meira^3,7,8,9*

¹Haematopoietic Stem Cell Biology Laboratory, Medical Research Council Molecular Haematology Unit, Medical Research Council Weatherall Institute of Molecular Medicine, University of Oxford, Cambridge, ENG, United Kingdom
²Medical Research Council Centre for Computational Biology, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom
³NIHR Biomedical Research Centre, University of Oxford, Oxford, United Kingdom
⁴Haematopoietic Stem Cell Biology Laboratory, Medical Research Council Molecular Haematology Unit, Medical Research Council Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom
⁵Department of Haematology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom
⁶Medical Research Council (MRC) Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, National Institute for Health Research Biomedical Research Centre, University of Oxford, Oxford, United Kingdom
⁷Medical Research Council (MRC) Weatherall Institute of Molecular Medicine (WIMM) and NIHR Biomedical Research Centre, University of Oxford, Oxford, United Kingdom
⁸Broad Institute of MIT and Harvard, Cambridge, MA
⁹Department of Cancer Biology, Dana Farber Cancer Institute, Boston, MA

Fu Ziyu, PhD^1*, Yun Tan, PhD^1*, Xiaoguang Xu, PhD^1*, Jie Xu² and Sai-Juan Chen, MD, PhD^1*

¹Shanghai Institute of Hematology, National Research Center for Translational Medicine, State Key Laboratory of Medical Genomics, Ruijin Hospital Affiliated to Shanghai Jiao Tong University (SJTU) School of Medicine, Shanghai, China
²Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

Ilaria Crespiatico^1*, Mattia Zaghi, PhD^2*, Cristina Mastini, PhD^3*, Deborah D'Aliberti, PhD^4*, Mario Mauri, PhD^3*, Carl Mirko Mercado, MSc^3*, Diletta Fontana, PhD^5*, Silvia Spinelli, MSc^4*, Valentina Crippa, MSc^3*, Elena Inzoli, MD^6*, Beatrice Manghisi, MD^4,6*, Ivan Civettini, MD^7,8*, Daniele Ramazzotti, PhD^4*, Valentina Fabiola Ilenia Lavoro, MD^4,9*, Michele Gengotti, MD^10*, Virginia Brambilla, MD^11*, Andrea Aroldi, MD^12*, Federica Banfi, MSc^13*, Cristiana Barone, PhD^14*, Roberto Orsenigo, MSc^15*, Ludovica Riera, BSc, PhD^16*, Mara Riminucci, MD^17*, Alessandro Corsi, MD^17*, Massimo Breccia^18*, Alessandro Morotti, MD, PhD¹⁹, Daniela Cilloni, MD^19*, Aldo Roccaro, MD, PhD²⁰, Antonio Sacco, MSc^21*, Fabio Stagno, MD, PhD²², Marta Serafini, PhD^23*, Federica Mottadelli, MSc^24*, Giovanni Cazzaniga, PhD^25,26, Fabio Pagni, MD^27*, Roberto Chiarle, MD^16,28, Emanuele Azzoni, PhD^14*, Alessandro Sessa^2*, Carlo Gambacorti-Passerini, MD^7,8, Elena Maria Elli, MD^29*, Luca Mologni, PhD^7* and Rocco Piazza, MD, PhD^4,12*

¹Department of Medicine and Surgery, University of Milano Bicocca, Monza, Italy
²Stem Cell and Neurogenesis Unit, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milano, ITA
³Department of Medicine and Surgery, University of Milano-Bicocca, Monza, ITA
⁴Department of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy
⁵Department of Medicine and Surgery, Università degli Studi Milano-Bicocca, Monza, ITA
⁶Hematology Division and Bone Marrow Unit, Fondazione IRCCS San Gerardo dei Tintori, Monza, ITA
⁷Department of Medicine and Surgery, University Milano-Bicocca, Monza, Italy
⁸Hematology Department, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy
⁹Hematology Division and Bone Marrow Unit, Fondazione IRCCS San Gerardo dei Tintori, Monza, MB, Italy
¹⁰Department of Medicine and Surgery, University of Milano - Bicocca, Monza, ITA
¹¹Department of Pathology, University Milan Bicocca, Monza, ITA
¹²Hematology Division and Bone Marrow Unit, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy
¹³IRCCS San Raffaele Scientific Institute, Milano, ITA
¹⁴Department of Medicine and Surgery, University of Milano Bicocca, Monza, ITA
¹⁵Biomedical Research in Melanoma-Animal Models and Cancer Laboratory, Vall D'Hebron Research Institute (VHIR), Vall D'Hebron Hospital Barcelona-Uab, Barcelona, ESP
¹⁶Department of Pathology, A.O.U Città della Salute e della Scienza, Torino, Italy
¹⁷Department of Molecular Medicine, Az. Policlinico Umberto I, Sapienza University of Rome, ROME, ITA
¹⁸Department of Translational and Precision Medicine, Hematology-Sapienza University, Rome, Italy
¹⁹Department of Clinical and Biological Sciences, University of Turin, Orbassano, ITA
²⁰Clinical Trial Center, Translational Research and Phase I Unit, ASST Spedali Civili di Brescia, Brescia, BS, Italy
²¹Clinical Trial Center, Translational Research and Phase I Unit, ASST Spedali Civili di Brescia, Brescia, Italy
²²Division of Hematology and Bone Marrow Transplant, AOU Policlinico “Rodolico – San Marco”, Catania, Italy
²³Centro Tettamanti, IRCCS San Gerardo dei Tintori, MONZA, ITA
²⁴Centro Tettamanti, IRCCS San Gerardo dei Tintori, Monza, ITA
²⁵Centro Tettamanti, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy
²⁶School of Medicine and Surgery, University of Milan-Bicocca, Monza, Italy
²⁷Department of Pathology, University of Milano-Bicocca, Monza, Italy
²⁸Children's Hospital Boston, Boston, MA
²⁹Hematology Division and Bone Marrow Unit, IRCCS Foundation San Gerardo dei Tintori, Monza, Italy., Monza, Italy

Lucca L.M. Derks, MSc^1,2*, Inge Van Der Werf^1,2*, Laurianne Trabut, MSc^1,2*, Eline Bertrums, MD^1,2,3*, Jurrian De Kanter, MSc^1,2*, Axel Rosendahl Huber, PhD^1,2* and Ruben Van Boxtel, PhD^1,2*

¹Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands
²Oncode Institute, Utrecht, Netherlands
³Department of Pediatric Oncology/Hematology, Erasmus Medical Center, Rotterdam, Netherlands

Yuanyuan Ji, Ph.D.^*, Jebrail Dempsey, B.S.^*, Toby Thomas, B.S.^*, Jacob Lark, B.S.^*, Albert Son, B.S.^* and Stephen Chung, M.D.

Division of Hematology/Oncology, Department of Internal Medicine, Children's Research Institute, University of Texas Southwestern, Dallas, TX