65th ASH Annual Meeting & Exposition: 201. Granulocytes, Monocytes, and Macrophages: Poster III

Symposia: Granulocytes, Monocytes, and Macrophages Oral and Poster Abstracts
Poster

Halls G-H (San Diego Convention Center)

Single-Cell RNA Sequencing Reveals Contradictory Immune Microenvironment in Hemophagocytic Syndrome

Guo Qiu¹^*, Xi Xu²^* and Qifa Liu, MD¹

¹Nanfang Hospital, Southern Medical University, Guangzhou, China
²Nanfang Hospital, Southern Medical University, Guangzhou, CHN

3907

High-Throughput Screening to Develop a Biologically Relevant Netosis Induction Model

Kieran Zukas¹^*, Justin Cayford²^*, Andrew Retter, MBBS³, Mark Eccleston²^* and Terry Kelly²^*

¹Volition America, Carlsbad
²Volition America, Carlsbad, CA
³Guy's & St. Thomas' NHS Trust, London, GBR

3908

Targeted Deletion of Pparβ/δ in Myeloid Cells Enhances Their Tumor-Promoting Function

Anthos Christofides, MD^1,2^*, Rinku Pal, BS¹^*, Nikolaos Patsoukis, PhD^1,3^* and Vassiliki A Boussiotis, MD, PhD¹

¹Hematology-Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA
²Medicine, Yale University, New Heaven, MA
³Simcere of America, Cambridge, MA

3909

Real-World Treatment Patterns and Outcomes Among Patients with Secondary Hemophagocytic Lymphohistiocytosis Treated with Emapalumab in the United States: The Real-HLH Study

Carl E Allen, MD¹, Shanmuganathan Chandrakasan, MD², Michael B. Jordan, MD³, Jennifer W Leiding, MD⁴^*, Abiola Oladapo, PhD⁵^*, Priti Pednekar, PhD⁶^*, Kelly Walkovich, MD⁷ and John Yee, MD⁵^*

¹Baylor College of Medicine, Houston, TX
²Aflac Cancer and Blood Disorders Center of Children’s Healthcare of Atlanta, Emory University, Atlanta, GA
³Divisions of Immunobiology, and Bone Marrow Transplantation and Immune Deficiency, Department of Pediatrics, Cincinnati Children’s Hospital, Cincinnati, OH
⁴Division of Allergy and Immunology, Department of Pediatrics, Johns Hopkins University, Baltimore, MD
⁵Sobi, Inc., Waltham, MA
⁶PRECISIONheor, Bethesda, MD
⁷C.S. Mott Children’s Hospital, University of Michigan, Ann Arbor, MI

3910

Tissue-Resident Macrophages in the Bone Marrow Comprise a Diverse Cellular Population Derived from Hematopoietic Stem Cells

Paul D. Kingsley, PhD¹^*, Eli T. Rust¹^*, Alec J. Kingsley¹^*, Jonathan J. Pinney, PhD²^*, Fátima Rivera-Escalera, PhD²^*, Conner P. Bennett¹^*, Leah A. Vit¹^*, Alison C. Livada, MS¹, Craig Morrell, DVM, PhD¹, Michael R. Elliott, PhD², Kathleen E. McGrath, PhD¹ and James Palis, MD¹

¹University of Rochester, Rochester, NY
²University of Virginia, Charlottesville, VA

3911

Platelet Factor 4 Modulates the Bactericidal Ability of Neutrophil Extracellular Traps

Abigail E Skidmore¹^*, Nate Levine²^*, Veronica Bochenek, BA²^*, Manuela Roggiani, PhD³^*, Mark Goulian, PhD³^*, Kandace Gollomp, MD^2,4 and Anh T.P. Ngo, PhD²

¹Division of Hematology, Children's Hospital of Philadelphia, Mount Laurel, NJ
²Division of Hematology, Children's Hospital of Philadelphia, Philadelphia, PA
³Department of Biology, University of Pennsylvania School of Arts & Sciences, Philadelphia, PA
⁴Department of Pediatrics, University of Pennsylvania PSOM, Philadelphia, PA

3912

KLF2 Regulates NLRP3 Inflammasome Priming and Activation in Murine Myeloid Cells

Devashis Mukherjee, MD, MS¹^*, Sriram Satyavolu, BS²^*, Asha Thomas, PhD²^*, Yuexin Li, BS²^* and Lalitha Nayak, MD^3,4

¹Pediatrics, Case Western Reserve University/Rainbow Babies and Children's Hospital, Cleveland, OH
²Case Western Reserve University, Cleveland, OH
³Department of Medicine, Division of Hematology and Oncology, Case Western Reserve University and University Hospitals Cleveland Medical Center, Cleveland, OH
⁴University Hospitals Cleveland Medical Center, Cleveland

3913

Characterization of TREM-1 Signaling in Human Neutrophils By Kinome Array and RNA-Seq

Frederic Ries, MD¹^*, Matthias Klein, PhD²^*, Nora Sophia Lindhauer¹^*, Sophie Többen³^*, Florian Heidel⁴ and Markus P. Radsak¹^*

¹Department of Hematology and Medical Oncology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany
²Institute for Immunology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany
³Department of Hematology and Medical Oncology, University Medical Center of the Johannes Gutenberg University, Mainz, Germany
⁴Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School (MHH), Hannover, Germany

3914

Recombinant Human Diamine Oxidase Against Histamine Induced Shock - Implications for Mast Cell Activation Syndrome

Matthias Weiss-Tessbach, MD, PhD¹^*, Birgit Reiter, PhD²^*, Felix Kosta, MSc²^*, Martin Murauer, MD²^*, Elisabeth Gludovacz, PhD³^*, Thomas Böhm, MD²^*, Bernd Jilma, MD² and Marlene Rager-Resch, DVM²^*

¹Internal Medcine I, Medical University of Vienna, Vienna, Austria
²Medical University of Vienna, Vienna, Austria
³Biotechnology, University of Natural Resources and Life Sciences, Vienna, Austria

3915

CD10^-CD14^-hla-DR^-CD45⁺SSC⁺⁺ Neutrophils with G-MDSC-like Feature Relate to Progress and Poor Prognosis in Non-Hodgkins Lymphoma Patients

Ji Zhou¹^*, Yingwei Li²^*, Xue Liang, PhD³^* and Zhimin Zhai, MD⁴

¹Department of Epidemiology and Health Statistics, Anhui Medical University, Hefei, China
²Hematologic Department of the Second Affiliated Hospital of Anhui Medical University, Hefei, China
³Hematologic Department, the Second Affiliated Hospital of Anhui Medical University, Hefei, China
⁴The Second Affiliated Hospital of Anhui Medical University, Hefei, China

3916

HT-6184 Inhibits the Formation of the NLRP3 Inflammasome in Human Monocytic THP-1 Cells

Benjamin Bearss, MS^*, Devan Bursey, MS^*, Taylor Avei^*, Alexis Mollard, PhD^*, Jared Bearss, MBA^*, Margit Maria Janat-Amsbury, MD, PhD and David J. Bearss, PhD

Halia Therapeutics, Lehi, UT

3917

Safety and Efficacy of Anakinra in Haemophagocytic Lymphohistiocytosis Associated with Acute Leukaemia

Hannah Al-Yousuf, MBBS¹^*, Elspeth Payne, MD, PhD, FRCPath²^*, Satyen Gohil³^* and Jessica Manson⁴^*

¹University College London Hospital, London, ENG, United Kingdom
²UCL Cancer Institute, University College London, London, United Kingdom
³University College London Hospital, London, GBR
⁴University College London Hospital, London, United Kingdom

3918

Beneficial Role of Erythrocyte Sphingosine 1-Phosphate in Preventing Renal Macrophage Polarization and Fibrosis through Combating HIF-1α-Dependent Creatine Phosphate Shuttle

Tingting Xie¹^*, Changhan Chen¹^*, Yiyan Wang¹^*, Zhenjiang Li¹^*, Benjamin C. Brown²^*, Rodney E. Kellems³^*, Weiru Zhang¹^*, Angelo D'Alessandro, PhD⁴ and Yang Xia, MD, PhD¹^*

¹Xiangya Hospital, Central South University, Changsha, China
²Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Denver
³The University of Texas McGovern Medical School at Houston, Houston
⁴Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, CO

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