Michael D. Tarantino, MD¹, Scott Kolodny, MD^2*, Jessica Zhang, MS^2*, Brian Jamieson, MD² and Michael Vredenburg, PhD^2*

¹Bleeding and Clotting Disorders Institute, Peoria, IL
²Sobi, Inc., Durham, NC

Masataka Kuwana^1*, Tomoki Ito, MD, PhD², Shugo Kowata, MD^3*, Yoshihiro Hatta, MD⁴, Katsumichi Fujimaki, MD^5*, Kensuke Naito, MD, PhD^6*, Shingo Kurahashi, MD, PhD^7*, Toshiya Kagoo^8*, Kazuki Tanimoto, MD, PhD^9*, Natsuko Shichiri^10*, So Saotome^10*, Esteban Masuda, PhD¹¹ and Yoshiaki Tomiyama, MD, PhD¹²

¹Department of Allergy and Rheumatology,, Nippon Medical School, Tokyo, JPN
²1st. Department of Internal medicine, Kansai Medical University, Hirakata, Japan
³Iwate Medical University School of Medicine, Morioka, JPN
⁴Department of Medicine Division of Hematology and Rheumatology, Nihon University School of Medicine, Tokyo, Japan
⁵Fujisawa City Hospital, Fujisawa City, KAN, JPN
⁶Department of Hematology, Hamamatsu Medical Center, Shizuoka, Japan
⁷Department of Hematology and Oncology, Toyohashi Municipal Hospital, Aichi, JPN
⁸Division of Hematology, Department of Internal Medicine, National Hospital Organization Tokyo Medical Center, Tokyo, Japan
⁹Division of Hematology and Oncology, Japanese Red Cross Fukuoka Hospital, Fukuoka, FKO, JPN
¹⁰Kissei Pharmaceutical Co., Ltd., Tokyo, Japan
¹¹Rigel Pharmaceuticals, Inc., South San Francisco, CA
¹²Department of Hematology and Oncology, Osaka University Graduate School of Medicine, Suita, Japan

Lamya Garabet^1,2*, Anbjørg Rangberg^1*, Raul Teruel-Montoya, PhD^3*, Maria Luisa Lozano, MD, PhD^3*, Christine Monceyron Jonassen^1,4* and Waleed Ghanima, MD, PhD⁵

¹Center of Laboratory Medicine, Østfold Hospital, Grålum, Norway
²Department of Multidisciplinary Laboratory Medicine and Medical Biochemistry, Akershus University Hospital, Lørenskog, Norway
³Servicio de Hematología, Hospital General Universitario Morales Messeguer, Centro Regional de Hemodonación, IMIB-Pascual Parrilla, CIBERER-ISCIII, Universidad de Murcia, Murcia, Spain
⁴Department of Virology, Norwegian Institute of Public Health, Oslo, Norway
⁵Østfold Hospital, Gralum, Norway

Zhuo-Yu An^1*, Haixia Fu, MD^1*, Yun He^1*, Xiaolu Zhu, MD^2*, Jin Wu^3*, Qiu-Sha Huang^4*, Kaiyan Liu⁵ and Xiaohui Zhang, MD^6*

¹Peking University People's Hospital, Peking University Institute of Hematology, Beijing, China
²Peking University Institute of Hematology, Peking University People’s Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, China
³Peking University People’s Hospital, Beijing, MD, China
⁴Peking University People's Hospital, Peking University Institute of Hematology, Beijing, CHN
⁵Peking University People’s Hospital, Beijing, China, Beijing, CHN
⁶Peking University People’s Hospital, Peking University Institute of Hematology, Beijing, China., Beijing, China

Alessandro Bosi^1*, Marta Canzi^2*, Marco Capecchi, MD^3*, Juri Alessandro Giannotta, MD^4*, Andrea Artoni^5*, Wilma Barcellini, MD^6* and Bruno Fattizzo⁷

¹Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy, Milan, Italy
²Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy, Milan, ITA
³Clinica Moncucco, Division of Hematology, Lugano, Switzerland
⁴Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milano, ITA
⁵Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, ITA
⁶UOC Ematologia, UOS Fisiopatologia delle Anemie, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico di Milano, Milan, Italy
⁷Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico, Milano, ITA

Zhuo-Yu An^1*, Yun He^1*, Xiaolu Zhu, MD^2*, Qiu-Sha Huang^3*, Jin Wu^4*, Haixia Fu, MD^1*, Yuan-Yuan Zhang^5*, Ying-jun Chang, PhD^6*, Xiangyu Zhao, M.D, Ph.D¹, Kaiyan Liu⁷ and Xiaohui Zhang, MD^8*

¹Peking University People's Hospital, Peking University Institute of Hematology, Beijing, China
²Peking University Institute of Hematology, Peking University People’s Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, China
³Peking University People's Hospital, Peking University Institute of Hematology, Beijing, CHN
⁴Peking University People’s Hospital, Beijing, MD, China
⁵Peking University Institute of Hematology, Peking University People's Hospital, Beijing, China
⁶Peking University People’s Hospital, Peking University Institute of Hematology, Beijing, China
⁷Peking University People’s Hospital, Beijing, China, Beijing, CHN
⁸Peking University People's Hospital, Beijing, China

Roy Khalife, MD, MHPE^1,2, Bonnie T Niu, BSc³, Iris Perelman, MSc^1*, Darine El-Chaar, MD^1,4*, Dean Fergusson, PhD^2,5*, Alan Karovitch, MD, MEd^2,4*, Johnathan P. Mack, MD, MSc^1,2, Melanie Tokessy^6*, Kathryn Elizabeth Webert, MD, MSc^7,8* and Alan T. Tinmouth, MD, MSc^1,2,9*

¹Ottawa Hospital Research Institute, Ottawa, ON, Canada
²Department of Medicine, University of Ottawa, Ottawa, ON, Canada
³Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada
⁴Department of Obstetrics and Gynecology, University of Ottawa, Ottawa, ON, Canada
⁵Ottowa Hospital Research Institute, Ottawa, ON, Canada
⁶Eastern Ontario Regional Laboratory Association, Ottawa, ON, Canada
⁷Canadian Blood Services, Ancaster, ON, Canada
⁸Department of Medicine and the Department of Molecular Medicine and Pathology, McMaster University, Hamilton, ON, Canada
⁹Canadian Blood Services, Ottawa, ON, Canada

Einar Ljungström Elmfors, MD^1*, Andreas Ørslev Rasmussen, Computational biologist M. Sc.^2*, Nadine G. Andersson, MD, PhD^3,4*, Annika Martensson, MD, PhD^3,5*, Eva Birgitte Leinoe, MD Phd^6*, Maria Rossing, MD Phd^2* and Eva Zetterberg, MD, PhD¹

¹Skane University Hospital, Malmö, Sweden
²Genomic Medicine, Rigshospitalet, Copenhagen, Denmark
³Department of Clinical Sciences and Pediatrics, Lund University, Lund, Sweden
⁴Department for Pediatric Hematology and Oncology and Center for Thrombosis and Hemostasis, Skane University Hospital, Malmö, Sweden
⁵Department of Pediatric Hematology and Oncology, Skane University Hospital, Lund, SWE
⁶Dept. of Hematology, Rigshospitalet, Copenhagen, Denmark

Li-Ping Yang^1*, Hai-Xia Fu^1*, Peng Zhao^2*, Jin Wu, MD^3*, Qiu-Sha Huang^2*, Yuan-Yuan Zhang^4*, Jun Kong, MD^5*, Zhi-Dong Wang^6*, Jing Liu^7*, Kaiyan Liu⁸, Xiao Jun Huang, MD⁹ and Xiaohui Zhang^5*

¹Peking University People's Hospital, Peking University Institute of Hematology;N, Beijing, CHN
²Peking University People's Hospital, Peking University Institute of Hematology, Beijing, CHN
³Peking University People's Hospital, Beijing, CHN
⁴Peking University Institute of Hematology， Peking University People's Hospital，, Beijing, China
⁵Peking University People's Hospital, Peking University Institute of Hematology, Beijing, China
⁶Peking University Institute of Hematology， Peking University People's Hospital，, Beijing, CHN
⁷Peking University Institute of Hematology, BEIJING, CHN
⁸Peking University People’s Hospital, Beijing, China, Beijing, CHN
⁹Peking University People’s Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, China

Qi Feng^*, Anli Liu^*, Nan Jiang^* and Jun Peng^*

Qilu Hospital of Shandong University, Jinan, China

Alfredo Pinedo-Rodríguez^1*, Alicia K Pérez-Rojas^2*, Sergio Rodriguez-Rodriguez, MD, MSc², Alfonso Orozco^3* and Roberta Demichelis, MD²

¹Internal Medicine Department, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico
²Hematology and Oncology Department, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico
³Hematology and Oncology Department, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico, Mexico

Ye-Jun Wu^1*, Qingyuan Qu^1*, Yuxiu Chen^2*, Menglin Li^2*, Mengyu Xiao^2*, Jianying Zhou^2*, Gaochao Zhang^3*, Haixia Fu, MD^4*, Xiao Jun Huang, MD^2,5,6,7 and Xiaohui Zhang, MD^2,8,9,10*

¹Peking University Institute of Hematology, Peking University People’s Hospital, Beijing, China
²Peking University People's Hospital, Peking University Institute of Hematology, Beijing, China
³Peking University People’s Hospital, Beijing, CHN
⁴Peking University People’s Hospital, Peking University Institute of Hematology, Beijing, China., Beijing, China
⁵Research Unit of Key Technique for Diagnosis and Treatments of Hematologic Malignancies, Chinese Academy of Medical Sciences, Beijing, China
⁶Peking University People’s Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, China
⁷Peking-Tsinghua Center for Life Sciences, Beijing, China
⁸Collaborative Innovation Center of Hematology, Peking University, Beijing, China
⁹National Clinical Research Center for Hematologic Disease, Beijing, China
¹⁰Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, China

Xiaolu Zhu, MD^1*, Hui Liu^2*, Zhao Wang, MD, PhD³, Zhongxing Jiang, MD^4*, Liangming Ma^5*, Min Wang, MD^6*, Jiamin Zhang, PhD^7*, Zhuoyu An^8*, Yejun Wu^8*, Yun He^8*, Haixia Fu, MD^9*, Yingjun Chang, PhD^8*, Lanping Xu, MD^10*, Kaiyan Liu, MD, PhD^11*, Xiao Jun Huang, MD⁸ and Xiaohui Zhang, MD, PhD^8*

¹Peking University Institute of Hematology, Peking University People’s Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, China
²Beijing Hospital, Beijing, China
³Beijing Friendship Hospital,Capital Medical University, Beijing, China, Beijing, China
⁴Department of Hematology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
⁵Department of Hematology, Shanxi Bethune Hospital, Taiyuan, China
⁶Department of Hematology, China-Japan Friendship Hospital, Beijing, China
⁷Department of Hematology, First Affiliated Hospital of Chongqing Medical University, Chongqing, China
⁸Peking University People's Hospital, Peking University Institute of Hematology, Beijing, China
⁹Peking University People’s Hospital, Peking University Institute of Hematology, Beijing, China
¹⁰Peking University People's Hospital, Beijing, China
¹¹Peking University Institute of Hematology, Peking University People's Hospital, Beijing, China

Zhifa Wang^1*, Nan Wang^2*, Juntao Ouyang^3*, Jingyao Ma, MMSc^4*, Man-Chiu Poon⁵, Zhenping Chen, PhD, MD^6*, Xiaoling Cheng^2* and Runhui Wu, MD^7*

¹Beijing Children’s Hospital, Capital Medical University, Beijing, AL, China
²Department of Pharmacy, Beijing Children's Hospital, Capital Medical University, beijing, China
³Beijing Pediatric Research Institute, Beijing Children’s Hospital, Capital Medical University, beijing, China
⁴Hematology Center, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, China
⁵University of Calgary, Calgary, AB, Canada
⁶Beijing Children's Hospital, Beijing, Beijing, CHN
⁷Hematology Department, Beijing Children's Hospital, Affiliated to Capital Medical University, Beijing, China

Tomas Jose Gonzalez-Lopez, MD¹, Gloria Perez Segura^2*, Abel Domingo^3*, Elsa Lopez Ansoar, MD^4*, Francisco Javier Diaz Galvez^5*, Reyes Jimenez Barcenas^6*, Daniel Martinez Carballeira, MD^7*, Dunia De Miguel Llorente^8*, Alvaro Perona Blazquez^9*, Gerardo Aguilar-Monserrate^10*, Julio Dávila-Valls^11*, Isabel Gonzalez Gascon^12*, Amalia Cuesta^13*, María Luisa Bengochea Casado^14*, Gerardo Julio Hermida Fernandez^15*, Jose Maria Alonso Alonso^16*, Miguel Angel Pozas Mañas^17*, Ana Torres-Tienza^18*, Carlos Aguilar, MD^19*, Dolores Fernandez-Jimenez^20*, Inmaculada Soto^21* and Silvia Bernat^22*

¹Hospital Universitario de Burgos, Burgos, Spain
²Hospital Universitario 12 de Octubre, Madrid, Spain
³Fundació Privada Hospital Asil de Granollers, Granollers, ESP
⁴Hospital Universitario Álvaro Cunqueiro, Vigo, Spain
⁵Hospital Universitario de Burgos, BURGOS, ESP
⁶Hospital de la Serranía de Ronda , Ronda, Málaga, Spain, Ronda, Spain
⁷Hospital Universitario Central de Asturias, Oviedo, Asturias, Spain, Oviedo, Spain
⁸Hospital Universitario de Guadalajara, Guadalajara, Spain, Guadalajara, ESP
⁹Complejo Hospitalario Universitario de Albacete, Albacete, Spain, Albacete, ESP
¹⁰Hospital Clínico Universitario de Valladolid, Valladolid, Spain, Valladolid, Spain
¹¹Hospital Universitario Nuestra Senora de Sonsoles, Avila, ESP
¹²Hospital Universitario Infanta Leonor, Madrid, Spain, Madrid, ESP
¹³Hospital Sierrallana, Torrelavega, Cantabria, Spain, Torrelavega, Spain
¹⁴Hospital Universitario Severo Ochoa, Madrid, ESP
¹⁵Hospital Universitario de Burgos, Burgos, ESP
¹⁶Hospital Rio Carrión, Palencia, Palencia, ESP
¹⁷Hospital Universitario Río Hortega, Valladolid, Spain, Valladolid, ESP
¹⁸Hospital General de Segovia, Segovia, Spain, Segovia, Spain
¹⁹Hospital Santa Bárbara, Soria, Spain, Soria, Spain
²⁰Hospital Universitario San Cecilio, Granada, Spain, Granada, Spain
²¹Hospital Universitario Central de Asturias, Oviedo, Asturias, Spain, Oviedo, ESP
²²Hospital Universitario de La Plana, Villareal, Castellón, Spain, Villareal, Spain

Jennifer MacWhirter - DiRaimo^1*, Kevin Won^1*, Caroline Kruse^1* and Terry B Gernsheimer, MD²

¹Platelet Disorder Support Association, Cleveland, OH
²University of Washington and Fred Hutchinson Cancer Center, Seattle, WA

Taylor Olmsted Kim, MD^1,2, Jennifer M. Geris, PhD, MPH^3,4*, Amanda B. Grimes, MD^4,5, Rachael F. Grace, MD^6,7, Michele P. Lambert, MD, MTR^8,9, Melissa J. Rose, DO^10,11, Kristin A. Shimano, MD¹², Omar Niss, MD^13,14, Cindy Neunert, MD, MScs^15,16, Taizo A. Nakano, MD¹⁷, Derek Macmath, MD^18*, Bogdan Dinu^4,5*, Susan E. Kirk, PA-C^3,19*, Jenny M. Despotovic, DO, MS²⁰, Jonathan M. Flanagan, PhD^5,21 and Michael E. Scheurer, PhD^3,4

¹Children's Hospital Los Angeles, Los Angeles, CA
²University of Southern California, Keck School of Medicine, Los Angeles, CA
³Department of Pediatrics, Baylor College of Medicine, Houston, TX
⁴Baylor College of Medicine, Houston, TX
⁵Texas Children’s Cancer and Hematology Center, Houston, TX
⁶Dana-Farber/Boston Children’s Cancer and Blood Disorders Center, Harvard Medical School, Boston, MA
⁷Boston Children's Hospital, Boston, MA
⁸Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA
⁹Children's Hospital of Philadelphia, Philadelphia, PA
¹⁰The Ohio State University College of Medicine, Columbus, OH
¹¹Nationwide Children’s Hospital, Columbus, OH
¹²Pediatric Allergy, Immunology, and Bone Marrow Transplant Division, University of California San Francisco Benioff Children's Hospital, San Francisco, CA
¹³University of Cincinnati College of Medicine, Cincinnati, OH
¹⁴Hematology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
¹⁵Columbia University Medical Center, New York, NY
¹⁶Morgan Stanley Children’s Hospital, New York, NY
¹⁷Pediatric Hematology Oncology Division, Children's Hospital Colorado, Aurora, CO
¹⁸National Institutes of Health, National Institute of Allergy and Infectious Diseases, Bethesda, MD
¹⁹Cancer and Hematology Center, Texas Children's Hospital, Houston, TX
²⁰Agios Pharmaceuticals, Cambridge, MA
²¹Texas Children's Cancer & Hematology Center, Baylor College of Medicine, Houston, TX

Hong Tian^1*, Yun Li^1*, Xin Lv^1*, Lu Zhou^2*, Depei Wu, M.D.³, Ziqiang Yu^4* and Jie Yin, MD^5*

¹The First Affiliated Hospital of Soochow University, Suzhou, China
²Affiliated Hospital of Nantong University, Nantong, China
³The First Affiliated Hospital of Soochow University, SUZHOU, China
⁴National Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, First Affiliated Hospital of Soochow University, Suzhou, China
⁵First Affiliated Hospital of Soochow University, Suzhou, China

Husam El Sharu, MD^1*, Maria Jamil, MD^2*, Sukhvir Singh^3*, Sara Cowles^3*, Darla K. Liles, MD⁴ and Joshua Zweigle, MD⁵

¹Internal Medicine, East Carolina University/ Brody School of Medicine, Greenville, NC
²Henry Ford Health, Detroit, MI
³East Carolina University/ Brody School of Medicine, Greenville, NC
⁴Division of Hematology–Oncology, Department of Internal Medicine, East Carolina University Brody School of Medicine, Greenville, NC
⁵Internal Medicine, East Carolina University/ Brody school of Medicine, Greenville, NC

Maria Eva Mingot Castellano, MD, PhD^1*, Begoña Pedrote Amador, MD^1*, Riccardo Tomasello, MD^2* and Waleed Ghanima, MD, PhD³

¹Instituto de Biomedicina de Sevilla, IBIS, Servicio de Hematología, Hospital Universitario Virgen del Rocio, Sevilla, Spain
²2. Departments of Research and Haemato-oncology, Østfold Hospital and Institute of Clinical Medicine, University of Oslo, Oslo, Norway
³Østfold Hospital and Institute of Clinical Medicine, University of Oslo, Oslo, Norway

Yadan Wang, PhD, MD^1*, Abdul Rehman Arif^2*, Yajie Ding^3*, Wenlan Chen^3*, Li Cai^3*, Mei Xue^3*, Jun Deng, MD, PhD^3* and Heng Mei^3*

¹Union Hospital, Wuhan, Hubei, China
²Zhongnan Hospital of Wuhan University, Wuhan, China
³Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China