65th ASH Annual Meeting & Exposition: 113. Sickle Cell Disease, Sickle Cell Trait and Other Hemoglobinopathies, Excluding Thalassemias: Basic and Translational: Poster II

Symposia: Sickle Cell Disease, Sickle Cell Trait and Other Hemoglobinopathies, Excluding Thalassemias: Basic and Translational Oral and Poster Abstracts
Poster

Halls G-H (San Diego Convention Center)

2481

Elevated Heme Drives Evoked and Ongoing Pain Behaviors in WT Mice By Sensitization of Dorsal Root Ganglia Neurons

Samuel J Zorn¹^*, Vanessa L Ehlers, PhD¹^*, Amanda M. Brandow, DO, MS² and Cheryl L Stucky, PhD¹^*

¹Department of Cellular Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, WI
²Department of Pediatrics, Section of Hematology/Oncology/Bone Marrow Transplantation, Medical College of Wisconsin, Milwaukee, WI

2482

8-Oxoguanine DNA Glycosylase 1 Inhibition Suppresses Inflammatory Responses in Sickle Cell Disease

Kang Le¹^*, Zenaide Quezado², Sayuri Kamimura²^*, Meghann L. Smith²^*, Yuki Tahara³^*, Yujeong Lee³^*, Laxminath Tumburu, PhD¹^*, Anna Conrey¹^*, Eric T Kool³^* and Swee Lay Thein, MBBS, DSc, FRCP, FRCPath, MRCP, MRCPath¹

¹Sickle Cell Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD
²Clinical Center, National Institutes of Health, Bethesda, MD
³Department of Chemistry, Stanford University, Stanford, CA

2483

Steady-State Von Willebrand Factor Antigen Levels Predict Low Platelet Counts and Risk for Complications in Hospitalizations for Painful Sickle Cell Vaso-Occlusive Episodes

Xu Zhang, PhD¹^*, Binal Shah, PhD¹^*, Jin Han, PharmD²^*, Jose A. Lopez, M.D³, Dominic W. Chung, Ph.D³^*, Junmei Chen, PhD³, Victor R. Gordeuk, MD⁴ and Santosh L. Saraf, MD⁵

¹Department of Medicine, University of Illinois At Chicago, Chicago, IL
²College of Pharmacy, University of Illinois Chicago, Chicago, IL
³University of Washington, Bloodworks Research Institute, Seattle, WA
⁴Department of Medicine, University of Illinois Chicago, Chicago, IL
⁵Department of Medicine, University of Illinois College of Medicine, Willowbrook, IL

2484

Deciphering Metabolomic Signatures Associated with Sickle Cell Disease Using Mouse Models

Claudia Montllor-Albalate^*, Alka A Potdar, PhD^*, Yu-Wei Chen^*, Francis DeGuzman^* and G. Karen Yu, PhD^*

Pfizer Inc, South San Francisco, CA

2485

Functional and Multi-Omics Signatures of Mitapivat Efficacy upon Activation of Pyruvate Kinase in Red Blood Cells from Patients with Sickle Cell Disease

Angelo D'Alessandro, PhD¹, Kang Le²^*, Maureen Lundt²^*, Quan Li³^*, Emily Dunkelberger⁴^*, Troy Cellmer⁴^*, Andrew J Worth, PhD⁵^*, Spurthi Patil⁶^*, Chris Huston⁶^*, Abby Grier⁷^*, Monika monikA.dzieciatkow⁷^*, Daniel Stephenson, PhD⁷^*, William A Eaton³^* and Swee Lay Thein, MBBS, DSc, FRCP, FRCPath, MRCP, MRCPath⁸

¹Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, CO
²Sickle Cell Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD
³Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD
⁴Laboratory of Chemical Physics, NIDDK NIH, Bethesda, MD
⁵Agios Pharmaceuticals, Inc, Cambridge, MA
⁶Agios Pharmaceuticals, Inc., Cambridge, MA
⁷Department of Biochemistry and Molecular Genetics, University of Colorado Denver, Aurora, CO
⁸Sickle Cell Branch, National Heart, Lung & Blood Institute, Bethesda, MD

2486

The Role of P-Selectin in Microvascular Hemodynamics and Cerebral Brain Volumes in Aging Sickle Cell Mice

Jahnavi Gollamudi, MD¹, Rowan Goldin²^*, Paul Territo, MS, PHD³^* and Hyacinth Idu Hyacinth, MD, PhD, MPH¹

¹University of Cincinnati, Cincinnati, OH
²Kenyon College, Gambier, OH
³Indiana University School of Medicine, Indianapolis, IN

2487

Neutralization of IL-1β and P-Selectin Inhibition Attenuate Organ Injury in Mice with Sickle Cell Disease

Erica M.F. Gotardo¹^*, Lucas F.S. Gushiken, PhD¹^*, Pamela L Brito, MSc¹^*, Flavia C. Leonardo¹^*, Lidiane S. Torres, PhD²^*, Sergei Agoulnik, PhD³^*, Jiri Kovarik, PhD⁴^*, Andreas Bruederle, MD⁵^*, John Millholland, PhD⁶^*, Fernando Ferreira Costa, MD, PhD¹ and Nicola Conran, PhD⁷

¹Hematology and Transfusion Center, University of Campinas - UNICAMP, Campinas, Sao Paulo, Brazil
²Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine, New York, NY
³Novartis Precision Medicine (former affiliation), Cambridge, MA
⁴Novartis Institutes for Biomedical Research, Basel, Switzerland
⁵Novartis Pharma AG, Basel, Switzerland
⁶Novartis Precision Medicine, Cambridge, MA
⁷Hematology and Transfusion Center, University of Campinas - UNICAMP, Campinas, Sp, Brazil

2488

Localization of Silent Cerebral Infarcts in Children with Sickle Cell Disease Impacts Structural Disconnection

Amy Mirro, MEng¹^*, Michael M. Binkley, PhD¹^*, Landon C. Power¹^*, Kristin P. Guilliams, MD, MSCI¹^*, Slim Fellah, PhD¹^*, Michael R. DeBaun, MD, MPH², Andria L. Ford, MD, MSCI¹^*, Jin-Moo Lee, MD, PhD¹^* and Melanie E. Fields, MD¹

¹Washington University, St. Louis, MO
²Vanderbilt University School of Medicine, Nashville, TN

2489

Palmitoylethanolamide Modulates Gait By Targeting Purkinje Cells in the Brain of Sickle Mice

Kristen Peterson¹^*, Kendall O'Daniel¹^*, Donovan Alexander Argueta, PhD¹, Mya Angela Arellano, BS²^*, Raghda T Fouda, MD/PhD¹^*, Graham J Velasco³^*, Natalie Garcia¹^* and Kalpna Gupta, PhD^1,4

¹Hematology/Oncology Division, Department of Medicine, University of California, Irvine, CA
²Hematology/Oncology Division, Department of Medicine, University of California, Victorville, CA
³Pathology Department, VA Long Beach Healthcare System, Long Beach, Long Beach, CA
⁴Department of Medicine, Division of Hematology, Oncology and Transplantation, University of Minnesota, Minneapolis, MN

2490

Mechanism-Based Targeting of Sickle Cell Pathobiology and Pain with Novel Transdermal Curcumin

Yugal Goel, PhD¹^*, Mya Angela Arellano, BS²^*, Raghda T Fouda, MD/PhD¹^*, Daniel Kerr, PhD³^*, Sirsendu Jana, PhD⁴^*, Reina Alexis Lomeli¹^*, Graham J Velasco⁵^*, Probal Banerjee, PhD³^*, Donovan Alexander Argueta, PhD¹, Mihir Gupta⁶^*, Richard Prince, PhD⁷^*, Abdu Alayash, PhD⁴^*, Joel Friedman, PhD^7,8^* and Kalpna Gupta, PhD^1,9

¹Hematology/Oncology Division, Department of Medicine, University of California, Irvine, CA
²Hematology/Oncology Division, Department of Medicine, University of California, Victorville, CA
³Department of Chemistry and Center for Developmental Neuroscience, The College of Staten Island (CUNY), Staten Island, NY
⁴Laboratory of Biochemistry and Vascular Biology, Center for Biologics Evaluation and Research Food and Drug Administration (FDA), Silver Spring, MD
⁵Pathology Department, VA Long Beach Healthcare System, Long Beach, Long Beach, CA
⁶Department of Neurosurgery, Johns Hopkins University, Baltimore, MD
⁷Vascarta Inc., NJ
⁸Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY
⁹Department of Medicine, Division of Hematology, Oncology and Transplantation, University of Minnesota, Minneapolis, MN

2491

The Effect of Tucaresol on Translational MRI Estimates of Cerebral Physiology in Townes SCD Mice

James A. Goodman, PhD¹^*, Yi-Fen Yen, PhD²^*, Yinching Iris Chen, PhD²^*, Suk-Tak Chan, PhD²^*, Jonah P. Weigand Wittier, BS³^*, Jay M. Janz, PhD¹^*, Steven Arkin, MD⁴, Denis Rybin, PhD¹^*, Kelly Marie Knee, PhD¹, Debra D Pittman, MS⁵ and Joseph B. Mandeville, PhD²^*

¹Pfizer, Inc, Cambridge, MA
²Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital & Harvard Medical School, Charlestown, MA
³Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA
⁴Rare Hematology Clinical Research, Pfizer Inc, Cambridge, MA
⁵Pfizer, Inc, Windham, NH

2492

Longitudinal Characterization of Hemodynamic Changes with Multimodal Optical Techniques in Patients with Sickle Cell Disease Treated with Mitapivat

Timothy Quang, PhD¹^*, Ingrid Frey, RN²^*, Julia Xu, MD, MS², Golnar Mostashari³^*, Anna Conrey⁴^*, Dina S. Parekh, MD¹^*, Ruth Pierre Charles, DSc, PA-C⁵^*, Brian Hill³^*, Swee Lay Thein, MBBS, DSc, FRCP, FRCPath, MRCP, MRCPath⁶ and Bruce J Tromberg³^*

¹National Institutes of Health, Bethesda, MD
²Sickle Cell Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD
³National Institutes of Health, Bethesda
⁴NATIONAL INSTITUTES OF HEALTH, BETHESDA, MD
⁵National Heart, Lung, and Blood Institute, NIH, Bethesda
⁶Sickle Cell Branch, National Heart, Lung & Blood Institute, Bethesda, MD

2493

Hydroxyurea’s Impact on Erythropoiesis, Cell Death and HbF Expression in the Hudep-2 Model

Lea Kuznicki, MSc¹^*, Sandrine Laurance, PhD²^*, Laetitia Claer, MSc³^* and Caroline Le Van Kim, PhD³^*

¹Université Paris Cité and Université des Antilles, INSERM, Biologie intégrée du globule rouge, F-75015 Paris, France, Paris, AL, France
²Integrated Biology of the Red Cell, Université Paris Cité and Université des Antilles, INSERM, Biologie intégrée du globule rouge, F-75015 Paris, France, Paris, France
³Université Paris Cité and Université des Antilles, INSERM, Biologie intégrée du globule rouge, F-75015 Paris, France, Paris, France

2494

Quantitative Model-Based Assessment of Multiple Sickle Cell Disease Therapeutic Approaches Alone and in Combination

Amy Moody^*, Tristan Maurer^* and Jatin Narula^*

Pfizer Inc, Cambridge, MA

2495

Β-Lactam Antibiotic Ceftriaxone As a Potential Therapeutic Intervention for Chronic Pain in Sickle Cell Disease

Ying He, PhD¹^*, Xiao Guo¹^*, Robert Molokie, MD^2,3 and Zaijie Jim Wang, PhD¹^*

¹University of Illinois at Chicago, Chicago, IL
²Jesse Brown VA Medical Center, Chicago, IL
³Division of Hematology/Oncology, University of Illinois Chicago, Chicago, IL

2496

17R-Resolvin D1 Improves Inflammatory Cardiomyopathy in a Mouse Model of Sickle Cell Disease

Enrica Federti¹^*, Domenico Mattoscio²^*, Antonio Recchiuti²^*, Alessandro Mattè, BSc, PhD³^*, Maria Monti⁴^*, Flora Cozzolino⁴^*, Martina Ceci⁵^*, Manuela Iezzi⁶^*, Angela Siciliano⁷^*, Veronica Riccardi⁸^*, Alice Passarini⁹^*, Carlo Brugnara, MD¹⁰ and Lucia De Franceschi, MD¹¹

¹University of Verona, Verona, Italy
²Department of Medical, Oral, ad Biotechnology Science, G. d’Annunzio University of Chieti - Pescara, Chieti, ITA
³Department of Medicine, University of Verona and AOUI Verona, Verona, Italy
⁴Dipartimento Scienze Chimiche, Università degli studi di Napoli "Federico II", Naples, Naples, ITA
⁵Dipartimento di Neuroscienze, Imaging e Scienze Cliniche (DNISC), G. d’Annunzio University of Chieti – Pescara, Chieti, Italy
⁶Dipartimento di Neuroscienze, Imaging e Scienze Cliniche (DNISC), G. d’Annunzio University of Chieti – Pescara, Chieti, CH, ITA
⁷Department of Medicine, University of Verona & AOUI Verona, Verona, ITA
⁸University of Verona & AOUI Verona, Verona, Italy, Verona, ITA
⁹Department of Medicine, University of Verona & AOUI Verona, Verona, Italy
¹⁰Lab of Medicine and Pathology, Children’s Hospital, Harvard Medical School, Boston, Boston, MA
¹¹Dept of Medicine, Policlinico GB Rossi, Policlinico GB Rossi, Univ. of Vero, Verona, Italy

2497

Roxyscan: A Novel Method to Assess Red Blood Cell Resilience to Oxidative Stress in Sickle Cell Disease

Carolina A. Hernandez¹^*, Marissa J.M. Traets¹^*, Myrthe J. van Dijk^1,2^*, Wouter W. van Solinge¹^*, Frans A. Kuypers, PhD³^*, Minke A.E. Rab^1,4^*, Eduard J. Van Beers, MD, PhD⁵^* and Richard van Wijk¹

¹Central Diagnostic Laboratory - Research, University Medical Center Utrecht, Utrecht, Netherlands
²Center for Benign Hematology, Thrombosis and Hemostasis - Van Creveldkliniek, University Medical Center Utrecht, Utrecht, Netherlands
³Children's Hospital Oakland - Research Inst., Oakland, CA
⁴Department of Hematology, Erasmus MC, Rotterdam, Netherlands
⁵Center for Benign Hematology, Thrombosis and Hemostasis - Van Creveldkliniek, University Medical Centre Utrecht, Utrecht, Netherlands

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^*signifies non-member of ASH