Ada Antypiuk^1*, Alberto Martinez, PhD², Ute Schaeper, PhD^3*, Uwe Platzbecker, MD⁴ and Francesca Vinchi, PhD¹

¹Iron Research Laboratory, New York Blood Center, New York, NY
²Silence Therapeutics, London, GBR
³Silence Therapeutics GmbH, Berlin, Germany
⁴Medical Clinic and Policlinic 1, Hematology and Cellular Therapy, University Hospital Leipzig, Leipzig, Germany

Michela Asperti, PhD^1*, Magdalena Gryzik, PhD^2*, Manuela Cominelli^3*, Francesca Pagani, PhD^4*, Pietro Luigi Poliani^5*, Domenico Girelli, MD, PhD⁶, Göran Westerberg, PhD^7*, John Öhd, PhD^7* and Maura Poli^2*

¹Department of Molecular and Translational Medicine, University of Brescia, Brescia, ITA
²Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy
³Unit of Pathology, University of Brescia, Brescia, BS, ITA
⁴Unit of Pathology, University of Brescia, Brescia, Italy
⁵Unit of Pathology, University of Brescia, Brescia, ITA
⁶Department of Medicine, University of Verona, Verona, Italy
⁷Modus Therapeutics AB, Stockholm, Sweden

Nina S Mathew, Joe S. Al-Ramahi^* and Tahani Atieh, D.O.

University of Kansas Medical Center, Westwood, KS

Silvie Suriany^1*, Clio Gonzalez-Zacarias, MS^2*, Chau Vu, PhD^3*, Sharon O'Neil, PhD^4*, Gagan Mathur, MD^5*, Dawn Ward, MD^6*, Alyssa Ziman, MD^6*, Ellen B. Klapper, MD^7*, Lefan Zhuang, MD^8*, Christopher C Denton, MD⁹ and John C. Wood, MD, PhD^10*

¹Childrens Hospital Los Angeles, Los Angeles, CA
²Neurosciences Program, University of Southern California, Los Angeles, CA
³Bioengineering, University of Southern California, Los Angeles, CA
⁴Division of Neurology and The Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, CA
⁵Transfusion Medicine, Children's Hospital of Los Angeles, Los Angeles, CA
⁶Wing-Kwai and Alice Lee-Tsing Chung Transfusion Service, Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA
⁷Transfusion Medicine, Cedars Sinai Medical Center, Los Angeles, CA
⁸Transfusion Medicine, City of Hope, Duarte, CA
⁹Hematology, Children's Hospital Los Angeles, Los Angeles, CA
¹⁰Heart Institute, Chilren's Hospital Los Angeles, Los Angeles, CA

Chia-Yu Wang, PhD^*, Emiliano Melgar-Bermudez, BSc^*, Diana Welch, BSc^*, Samuel Cadena, PhD^*, Lorena Lerner, PhD^*, Jasbir Seehra, PhD^* and Jenn Lachey, PhD

Keros Therapeutics, Lexington, MA

Adlette Inati, MD^1,2, Nada Sbeiti, MD^3*, Evelyne Khoriaty, MD^4*, Suzan Koussa, MD^5*, Ali T Taher, MD, PhD, FRCP^6,7, Therese Abi Nasr, MD^5* and Tim St Pierre, PhD, BSc^8*

¹Gilbert and Rose-Marie Chagoury School of Medicine, Lebanese American University, Byblos, Lebanon
²NINI Hospital, Tripoli, Lebanon
³Rafic Hariri University Hospital, Beirut, Lebanon
⁴Clemenceau Medical Center, Dubai, United Arab Emirates
⁵Chronic Care Center, Baabda, Lebanon
⁶American University of Beirut Medical Center, Beirut, Lebanon
⁷Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon
⁸The University of Western Australia, Perth, Australia

Pimpisid Koonyosying, Ph.D.^1*, Maciej Garbowski, MD, PhD^2*, Ute Schaeper, PhD^3*, Alberto Martinez, PhD⁴ and John B. Porter, MD^5*

¹Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
²University College London, London, United Kingdom
³Silence Therapeutics GmbH, Berlin, Germany
⁴Silence Therapeutics, London, GBR
⁵University College London, University College London Hospitals, London, United Kingdom

Yvette Y. Yien, PhD¹, Samantha Gillis^2*, Mark Perfetto^3* and Hector Bergonia^4*

¹University of Pittsburgh School of Medicine, Pittsburgh, PA
²University of Delaware, Newark, DE
³University of Pittsburgh, Pittsburgh
⁴University of Utah, Salt Lake City, UT

Silvia Sighinolfi^1,2*, Annamaria Aprile, PhD^1,2, Stefano Beretta, PhD^2*, Mariangela Storto^2*, Ivan Merelli, PhD^2,3* and Giuliana Ferrari, PhD^1,2

¹Vita-Salute San Raffaele University, Milan, Italy
²San Raffaele-Telethon Institute for Gene Therapy (SR-Tiget), IRCCS San Raffaele Scientific Institute, Milan, Italy
³Institute for Biomedical Technologies, National Research Council, Segrate, Italy

Katherine Fielding, FRACP FRCPA MBBS¹, Ricardo Ataide, PhD^2*, Cavan Bennett, PhD^2*, Anne Pettikiriarachchi, PhD^2*, Danielle Clucas, MBBS^2*, Ute Schaeper, PhD^3* and Sant-Rayn Pasricha, MD, PhD^4,5,6

¹The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia
²The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
³Silence Therapeutics GmbH, Berlin, Germany
⁴Population Health and Immunity, Walter and Eliza Hall Institute of Medical Research, Fitzroy North, VIC, Australia
⁵Diagnostic Haematology, Royal Melbourne Hospital, Parkville, VIC, Australia
⁶Clinical Haematology, Royal Melbourne Hospital & Peter MacCallum Cancer Centre, Parkville, Australia