Vimal K. Derebail, MD¹, Laura Y. Zhou, PhD^2*, Yihan Tang, MS^3*, Laila Elsherif, PhD⁴, Kammie L. Patillo, RN^5*, David Wichlan^6*, Kristina Landes, MPH^7*, Paula McCune, RN^8*, Laura R. Loehr, MD, PhD, MS^9*, Payal Desai, MD¹⁰, Robert Cronin, MD, MS¹¹, Jianwen Cai, PhD^3* and Kenneth I. Ataga, MD^12,13

¹UNC Kidney Center, Division of Nephrology and Hypertension, University of North Carolina, Chapel Hill, NC
²Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC
³Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC
⁴Center for Sickle Cell Disease, University of Tennessee Health Sciences, Memphis, Memphis, TN
⁵Clinical Trials Unit, Office of Research, University of Tennessee Health Science Center, Memphis, TN
⁶University of North Carolina At Chapel Hill, Chapel Hill, NC
⁷The Ohio State University, Columbus, OH
⁸Clinical Trials Unit, University of Tennessee Health Science Center, Memphis, TN
⁹Division of General Internal Medicine, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC
¹⁰Levine Cancer Institute, Department of Hematology, Atrium Health, Charlotte, NC
¹¹Department of Internal Medicine, The Ohio State University, Columbus, OH
¹²Center for Sickle Cell Disease, University of Tennessee Health Sciences Center, Memphis, TN
¹³Methodist Comprehensive Sickle Cell Center, Memphis, TN

Yan Zheng, MD, PhD^1*, Pei-Lin Chen, MPH^2*, Jeffery Gossett^3*, Guolian Kang, PhD, MS⁴ and Clifford M Takemoto, MD⁵

¹Pathology, St. Jude Children’s Research Hospital, Memphis, TN
²St. Jude Children’s Research Hospital, Memphis, TN
³Department of Biostatistics, St. Jude Children’s Research Hospital, Memphis
⁴Department of Biostatistics, St. Jude Children’s Research Hospital, Memphis, TN
⁵Department of Hematology, St. Jude Children’s Research Hospital, Memphis, TN

Susanna Curtis, MD, PhD¹, Elizabeth Stidham, MPH^1*, Robyn T. Cohen, MD, MPH^2*, Angela Liu, MD¹, Marc Probst, MD^3*, Tiffany Mitchell, MD^1*, George Loo, DrPH^1*, Jordan Bellis, BS^1*, Chiemika Ihiasota, BA^1* and Jeffrey A. Glassberg, MD⁴

¹Icahn School of Medicine at Mount Sinai, New York, NY
²Department of Pediatrics, Boston Medical Center, Boston, MA
³Columbia University, New York
⁴Department of Emergency Medicine, Icahn School of Medicine at Mount Sinai, New York, NY

Katherine Zhuo^1*, Thomas D Coates^1,2,3,4,5, John C. Wood, MD, PhD^6* and Jon A Detterich, MD^4*

¹USC Keck School of Medicine, Los Angeles, CA
²Pediatrics and Pathology, University of Southern California Keck School of Medicine, Los Angeles, CA
³Hematology/Oncology, Children's Hospital of LA, Los Angeles, CA
⁴Children's Hospital Los Angeles, Los Angeles, CA
⁵Hematology/Oncology, Children's Hospital Los Angeles, Los Angeles, CA
⁶Division of Cardiology, Children's Hospital Los Angeles, Los Angeles, CA

Iheanyi Okpala, FRCPath¹, Emmanuel Modebe^2*, Charles Nonyelu, MBBS^3*, Augustine Duru, BSc, MBBS, FMCPath^4*, Osita Ezenwosu, MBBS, MSc, FMSPaed^5*, Barth Chukwu^2*, Anazoeze Jude Madu, MBBS, MD^2*, Chinedu Anthony Ezekekwu, MBBS⁶, John Chinawaeze Aneke, MBBS^7*, Mildred Izuka^8*, Chisom Nri-Ezedi^7*, Oluomachi Charity Nnachi^9*, Alozie Uchenna Eze, MD^10*, Ifeoma Ajuba, MBBS, FMCPath^11*, Emeka Paul Okwummuo, MBBS^7*, Jane Chilaka^12*, Chinenye Onodugo^2*, Uwaoma Fidelis-Ewa^2*, Obineche Agwu^8*, Ebele Muoghalu, MBBS^4*, Ikechukwu Anigbogu, MBBS^3*, Helen Chioma Okoye, MBBS^4*, Chilota Chibuife Efobi, MBBS^7*, Obiora Ejiofor^13*, Ngozi Ugwu, MBBS, MPH, MSc, FWACP, FMCPath^14*, Collins Maduka, MBBS^3*, Nneka Iloanusi^2*, Angela Ugwu, MBBS, BSc, FMCPath^15*, Emmanuel Chide Okocha, MBBS, MD^7* and Thomas Ulasi^12*

¹College of Medicine, University of Nigeria, Enugu, Nigeria
²University of Nigeria Teaching Hospital, Enugu, Nigeria
³University of Nigeria Teaching Hospital, Enugu, AL, NGA
⁴University of Nigeria Teaching Hospital, Enugu, NGA
⁵Department of Paediatrics, Faculty of Medical Sciences, College of Medicine, University of Nigeria Teaching Hospital, Enugu, Nigeria
⁶University of Nigeria Teaching Hospital, Enugu, Enugu, NGA
⁷Nnamdi Azikiwe University Teaching Hospital, Nnewi, NGA
⁸Federal Medical Centre, Umuahia, Nigeria
⁹Federal Teaching Hospital, Abakaliki Ebonyi State, Abakaliki, NGA
¹⁰Federal Medical Centre, Umuahia, NGA
¹¹Nnamdi Azikiwe University Teaching Hospital, Awka, AL, NGA
¹²Nnamdi Azikiwe University Teaching Hospital, Nnewi, Nigeria
¹³Chukwuemeka Odumegwu Ojukwu University Teaching Hospital, Awka, Nigeria
¹⁴Alex Ekwueme Federal University Teaching Hospital, Abakaliki, Nigeria
¹⁵Department of Haematology and Immunology, University of Nigeria Teaching Hospital, Enugu, Nigeria

Aleksandra S Dain, MD¹, Yimei Li, PhD^2,3*, Sahal Master, MPH^4*, Shri Karthikeyan^1*, Leslie Raffini, MD^1,5, Kelly D. Getz, PhD^3,5* and Janet L. Kwiatkowski, MD, MSCE^1,5

¹Division of Hematology, Children's Hospital of Philadelphia, Philadelphia, PA
²Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, PA
³Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA
⁴Children's Hospital of Philadelphia, Philadelphia, PA
⁵Department of Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA

Marilyn J. Telen, MD¹, Milena Batchvarova, MS^2* and Martha Delahunty, PhD^2*

¹Duke University Medical Center, Duke Comprehensive Sickle Cell Center, Durham, NC
²Duke Comprehensive Sickle Cell Center, Duke Univ. School of Medicine, Durham, NC

Caroline Vuong, MD^1*, Paul Brinkman^2*, Harriët Heijboer^1*, Erfan Nur, MD, PhD³, Cornelia De Groot - Eckhardt¹, Suzanne W.J. Terheggen-Lagro^4*, Bart J. Biemond³, Anke-Hilse Maitland-van der Zee^5* and Karin Fijnvandraat^6*

¹Department of Pediatric Hematology, Amsterdam University Medical Centers, Amsterdam, Netherlands
²Department of Pulmonary Medicine, Amsterdam University Medical Centers, Amsterdam, Netherlands
³Department of Hematology, Amsterdam University Medical Centers, Amsterdam, Netherlands
⁴Department of Pediatric Pulmonology, Amsterdam University Medical Centers, Amsterdam, Netherlands
⁵Department of Respiratory Medicine, Amsterdam University Medical Centers, Amsterdam, Netherlands
⁶University of Amsterdam, Amsterdam, Netherlands

Pratiksha Shankarlal Nathani, MBBS^1*, Maithri Vallabhaneni, MBBS^2*, Kanishka Uttam Chandani, MD^3*, Kalaivani Babu^4*, Ummul Asfeen, DO^5*, Beenish Najam, MBBS^6*, Srinishant Rajarajan, MBBS^4*, Sai Gautham Kanagala, MBBS^7*, Zainab Muslehuddin, MD^8*, Shubham Adroja, MBBS⁹, Akhil Jain, MD^10* and Rupak Desai, MBBS^11*

¹Vilasrao Deshmukh Government Medical College, Latur, India
²Baton Rouge General Medical Center, Baton Rouge
³New York Medical College, Landmark Medical Center, Cumberland, RI
⁴Sri Ramachandra Medical College and Research Institute, Chennai, India
⁵New York Medical College, Saint Michael's Medical Center, Newark
⁶Karachi Medical and Dental College, Karachi, Pakistan
⁷Internal Medicine, Metropolitan Hospital Center, New York, NY
⁸Sinai Grace Hospital, Wayne State University, Detroit Medical Center, West Bloomfield, MI
⁹Houston Methodist Hospital, Houston, TX
¹⁰Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
¹¹Independent Researcher, Outcomes Research, Atlanta, GA

Kirby A Fibben^1*, Elliot Chaikof^2*, Bibek Dhakal^3*, Simon Park^3* and Diane Park^3*

¹Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA
²Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA
³Beth Israel Deaconess Medical Center, Boston, MA

Naomi Gunawardena, MD¹, Julia Mewha, BS^1*, Jade Neverson, BS^2* and Stella T. Chou, MD^3,4

¹Division of Hematology, Children's Hospital of Philadelphia, Philadelphia, PA
²Philadelphia College of Osteopathic Medicine, Philadelphia, PA
³Division of Hematology, The Children's Hospital of Philadelphia, Philadelphia, PA
⁴Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA

Husam El Sharu, MD^1*, Joshua Zweigle, MD², Maria Jamil, MD^3*, Sukhvir Singh^4*, Sara Cowles^4* and Darla K. Liles, MD⁵

¹Internal Medicine, East Carolina University/ Brody School of Medicine, Greenville, NC
²Internal Medicine, East Carolina University/ Brody school of Medicine, Greenville, NC
³Henry Ford Health, Detroit, MI
⁴East Carolina University/ Brody School of Medicine, Greenville, NC
⁵Division of Hematology–Oncology, Department of Internal Medicine, East Carolina University Brody School of Medicine, Greenville, NC

Dennis Kalibala^1*, Catherine Nabaggala, BS^2*, Lynnth Turyagyenda, MS^3*, Vincent Mboizi^1*, Shubaya Kasule Naggayi, MSc^1*, Maxencia Kabatabaazi, MMed^1*, Caterina Rosano, MD, MPH^4*, Deogratias Munube, MD^5*, Phillip Kasirye, MD^5*, John Ssenkusu, PhD^6*, Robert Opoka, MBChB, PhD^5*, Paul Bangirana, PhD^7*, Nancy S. Green, MD⁸, Richard Idro, PhD^5* and Ezekiel Mupere, MD, PhD^5*

¹Global Health Uganda, Kampala, Uganda
²Department of Paediatrics and Child Health, Makerere University College of Health Sciences, Kampala, Uganda
³2Uganda-CWRU Research Collaboration, Kampala, Uganda
⁴Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA
⁵Department of Pediatrics and Child Health, Makerere University College of Health Sciences, Kampala, Uganda
⁶Department of Epidemiology and Biostatistics, Makerere University College of Health Sciences, Kampala, Uganda
⁷Department of Psychiatry, Makerere University College of Health Sciences, Kampala, Uganda
⁸Department of Pediatrics, Division of Pediatric Hematology, Oncology and Stem Cell Tranplantation, Columbia University Irving Medical Center, New York, NY

Olufunke Y. Martin, MD¹, Rasa Borhan, BSc^2*, Aliya U. Zaidi, PhD^2*, Deepika S. Darbari, MBBS, MS³, Patrick C. Hines, MD, PhD^2,4 and Andrew D. Campbell, MD⁵

¹Center for Cancer and Blood Disorders, Children's National Hospital, Woodbury, MN
²Functional Fluidics Inc., Detroit, MI
³Division of Hematology, Center for Cancer and Blood Disorders, Children's National Hospital, Washington, DC
⁴Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI
⁵Center for Cancer and Blood Disorders, Children's National Medical Center, Washington, DC

Olivia Perez De Acha, MD^1*, Terrell Coring, MD, PharmD², Shuchi Pandey, MBBS^3*, Krishna Shah, MD^4*, Nikita Chintapally, MBBS^5*, Jhanvi T Dave, MBBS^3* and Hedy Smith, MD⁶

¹Internal Medicine, MedStar Georgetown/Washington Hospital Center, Hyattsville, MD
²MedStar Georgetown/Washington Hospital Center, Washington, MD
³MedStar Georgetown/Washington Hospital Center, Washington, DC
⁴MedStar/Georgetown-Washington Hospital Center, Washington, DC
⁵Department of Internal Medicine, Medstar/Georgetown-Washington Hospital Center, Washington, DC
⁶Medstar Washington Hospital Center, Washington, DC

Abdullah Kutlar, MD¹, Vikas Joshi^2*, Andreas Brueckner^3*, Julie Kanter, MD⁴, Darla K. Liles, MD⁵, Jeremie Lincy^3*, Rahul Manjare, MBBS, MD^2*, Yvonne Dei Adomakoh, MBBS, MD⁶, Matthew M. Heeney, MD⁷, Mariane de Montalembert, MD, PhD⁸, Deborah Keefe, MD, MPH^9*, Kwaku Marfo, MBA, PharmD, MPH^3* and Kenneth I. Ataga, MD¹⁰

¹Medical College of Georgia, Augusta, GA
²Novartis Healthcare Private Limited, Hyderabad, India
³Novartis Pharma AG, Basel, Switzerland
⁴University of Alabama Birmingham, Birmingham, AL
⁵Brody school of Medicine at East Carolina University, Greenville, NC
⁶University of Ghana Medical School/Korle Bu Teaching Hospital, Accra, Greater Accra, Ghana
⁷Boston Children's Hospital, 300 Longwood Ave, Boston, MA
⁸Necker-Enfants Malades Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), University of Paris-Cité, Paris, France
⁹Novartis Pharmaceuticals Corporation, East Hanover, NJ
¹⁰University of Tennessee Health Sciences Center, Memphis, Nashville, TN

Pablo Bartolucci, MD, PhD^1*, Saliou Diop, MD, MSc², Aurélien Yapi, MD^3*, Giovanna Cannas, MD^4*, Gonzalo De Luna, MD^5*, Maryse Etienne-Julan, MD^6*, Jean-Benoit Arlet, MD, PhD^7*, Stephanie Ngo, MD^8*, Emmanuelle Bernit, MD^9*, Justine Gellen-Dautremer, MD^10*, Gylna Loko, MD^11*, Stanislas Nimubona, MD^12*, Maximilien Grall^13*, Pierre Cougoul^14*, Aldiouma Guindo, PharmD, PhD^15* and Vincent Audard, MD, PhD^16*

¹Sickle Cell Referral Center, Henri-Mondor University Hospital- UPEC, AP-HP, Creteil, France
²Centre National de Transfusion sanguine, Université Cheikh Anta Diop, Dakar, Senegal
³Centre Hospitalier et Universitaire (CHU) de Bouaké, Bouaké, Côte d'Ivoire
⁴Hopital Edouard Herriot, Lyon, France
⁵Centre de la Drépanocytose, Hôpital Henri Mondor, Paris, France
⁶CHU De Pointe-à-Pitre, Pointe-à-Pitre, Guadeloupe
⁷Hopital Europeen Georges Pompidou, Paris, France
⁸Centre Hospitalier Delafontaine, Saint-Denis, France
⁹CHU Pointe-à-Pitre, Pointe à Pitre, Guadeloupe
¹⁰CHU de Poitiers Site de la Milétrie, Poitiers, France
¹¹CHU Martinique, Le Lamentin, Martinique
¹²Hopital Pontchaillou, Rennes, France
¹³Department of Internal Medicine, Rouen Teaching Hospital, Rouen, France
¹⁴Toulouse University Hospital, Toulouse, France
¹⁵Sickle Cell Research and Control Centre (CRLD), University of Bamako, Bamako, Mali
¹⁶Henri Mondor Hospital, Creteil, France

Rima Zahr, DO^1*, Guolian Kang, PhD, MS², Sara Rashkin, PhD^3*, Yutaka Yasui^4*, Csaba Kovesdy^1*, Clifford M Takemoto, MD⁵, Jeffrey D. Lebensburger, DO, MSPH⁶, Mitchell Weiss, MD, PhD⁷, Santosh L. Saraf, MD⁸ and Kenneth I. Ataga, MD⁹

¹University of Tennessee Health Science Center, Memphis, TN
²Department of Biostatistics, St. Jude Children’s Research Hospital, Memphis, TN
³St. Jude Children's Research Hospital, MEMPHIS, TN
⁴St. Jude Children's Research Hospital, Department of Epidemiology and Cancer Control, Memphis, TN
⁵Department of Hematology, St. Jude Children’s Research Hospital, Memphis, TN
⁶University of Alabama at Birmingham, Birmingham, AL
⁷St. Jude Children's Research Hospital, Memphis, TN
⁸Department of Medicine, University of Illinois College of Medicine, Willowbrook, IL
⁹University of Tennessee Health Sciences Center, Memphis, Nashville, TN

Vivian Phan, MS^1*, Ju Ae Park, MD^2*, Robin Yates Dulman, MD¹, Angela Lewis, NP^1*, Noravy Briere, NP^1*, Bailey Notarangelo, RN^1* and Elizabeth Yang, MD, PhD^1,3

¹Center for Cancer and Blood Disorders, Pediatric Specialists of Virginia, Fairfax, VA
²Inova Fairfax Hospital, Falls Church, VA
³George Washington University School of Medicine, Washington, DC

Stephanie Ibemere, PhD, MSN, RN^1,2,3, Tonia Onyeka, MBBS, DA WA, MSc, FWACS^3,4*, Osita Ezenwosu, MBBS, MSc, FMSPaed^3,5*, Helen Chioma Okoye, MBBS, MSc, MD, FMCPath, FWACP^6*, Ngozi Ugwu, MBBS, MPH, MSc, FWACP, FMCPath^7*, Paula Jean Tanabe, PhD, RN, FAEN, FAAN⁸, Nirmish Shah, MD⁹ and Echezona Ezeanolue, MD^3,10*

¹Duke University School of Nursing, Durham, NC
²Global Health Institute, Duke University, Durham
³Center for Translation and Implementation Research, University of Nigeria Nsukka, Enugu, Nigeria
⁴Dept. of Anaesthesia/Pain & Palliative Care Unit, College of Medicine, University of Nigeria Nsukka, Enugu, Nigeria
⁵Department of Paediatrics, Faculty of Medical Sciences, College of Medicine, University of Nigeria Teaching Hospital, Enugu, Nigeria
⁶Department of Haematology and Immunology, University of Nigeria College of Medicine Ituku-Ozala, Enugu, Nigeria
⁷Department of Haematology & Immunology, Faculty of Basic Clinical Sciences, Ebonyi State University, Abakaliki, Nigeria
⁸Duke University, Durham, NC
⁹Duke University School of Medicine, Duke Medical Ctr, NC
¹⁰HealthySunrise Foundation, Las Vegas

Christina M Abrams, MD¹, Natalia Davila^2*, Cathy Melvin, PhD, MPH^3*, Sherif M. Badawy, MD, MBA, MS⁴, Michael B Potter, MD^5*, Robert Gibson, PhD, MS^6*, Allison A King, MD, MPH, PhD^7,8, Victor R. Gordeuk, MD⁹, Chinonyelum Nwosu, MPH^10*, Jerlym S. Porter, PhD, MPH¹¹, Sophie Li^12*, Jeffrey A. Glassberg, MD¹³, Richard Lottenberg, MD¹⁴, Lisa Klesges, PhD, MS^15*, Nirmish Shah, MD¹⁶ and Jane S Hankins, MD, MS^17,18

¹Department of Pediatrics, Division of Hematology/Oncology, Medical University of South Carolina, Charleston, SC
²College of Nursing, Medical University of South Carolina, Charleston
³Department of Public Health Sciences, Division of Health Behavior and Health Promotion, Medical University of South Carolina, Charleston, SC
⁴Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University, Chicago, IL
⁵University of California San Francisco School of Medicine, San Francisco, CA
⁶Department of Emergency Medicine, Medical College of Georgia-Augusta University, Augusta, GA
⁷Department of Pediatrics, Washington University in St. Louis, Saint Louis, MO
⁸Division of Public Health Services, Department of Surgery, Washington University School of Medicine in St. Louis, Saint Louis, MO
⁹Sickle Cell Center, University of Illinois at Chicago, Chicago, IL
¹⁰Department of Hematology, St. Jude Children's Research Hospital, Memphis, TN
¹¹Department of Psychology and Biobehavioral Sciences, St. Jude Children's Research Hospital, Memphis, TN
¹²RTI International, Research Triangle Park, NC
¹³Department of Emergency Medicine, Icahn School of Medicine at Mount Sinai, New York, NY
¹⁴Department of Medicine, University of Florida, Gainesville, FL
¹⁵Department of Public Health Sciences, Department of Surgery, Washington University School of Medicine in St. Louis, St Louis, MO
¹⁶Division of Hematology–Duke Sickle Cell Comprehensive Care Unit, Duke University Medical Center, Durham, NC
¹⁷Departments of Hematology and Global Pediatric Medicine, St. Jude Children’s Research Hospital, Memphis, TN
¹⁸Center for Sickle Cell Disease, University of Tennessee Health Science Center, Memphis, TN

Alina Sadaf, MBBS¹, Min Dong, PhD^2*, Jennifer Korpik^1*, Amanda Pfeiffer^1*, Theodosia A. Kalfa, MD, PhD³, Teresa S. Latham, MA^1*, Alexander A. Vinks, PharmD, PhD, FCP^4*, Russell E. Ware, MD, PhD¹ and Charles T. Quinn, MD, MS⁵

¹Division of Hematology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
²Division of Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
³Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
⁴Division of Clinical Pharmacology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH
⁵Division of Hematology, Cincinnati Children's Hospital Med. Ctr., Cincinnati, OH

Aliyah Allick, BS^1*, Emily Rao, MD, MA, MS^2*, James F. Casella, MD², Keith Slifer, PhD^1*, Alicia Cannon, PhD^3*, Hangyi Jiang, PhD^4,5*, Eric Chin, MD^6,7,8* and Eboni Lance, MD, PhD^7,9

¹Kennedy Krieger Institute, Baltimore, MD
²Division of Hematology, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD
³Neuropsychology, Kennedy Krieger Institute, Baltimore, MD
⁴Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD
⁵F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD
⁶Department of Neurodevelopmental Medicine, Phelps Center for Cerebral Palsy and Neurodevelopmental Medicine, Kennedy Krieger Institute, Baltimore, MD
⁷Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD
⁸Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD
⁹Department of Neurology and Developmental Medicine, Kennedy Krieger Institute, Baltimore, MD

Zean Liao^1*, Kok Hoe Chan, MD² and Modupe Idowu, MD³

¹McGovern Medical School at UTHealth Houston, Houston, TX
²Division of Hematology/Oncology, Department of Internal Medicine, McGovern Medical School at the University of Texas Health Science Center at Houston (UTHealth Houston), Houston, TX
³Department of Hematology and Oncology, The University of Texas Health Science Center McGovern Medical School, Houston, TX

Kevin H.M. Kuo, MD, FRCPC, MSc^1,2,3, Sylvia Titi Singer, MD⁴, Gershwin Theophilus Blyden, MD, PhD^5*, Lanetta Bronté-Hall, MD, MPH, MSPH⁶, Aidan Faller, BS^7*, Abdullah Kutlar, MD⁸, Frans A. Kuypers, PhD^9*, Aliya U. Zaidi, PhD^10*, Patrick C. Hines, MD, PhD¹⁰, Niren Patel, MBBS^11*, Sandra Larkin, MS^12*, Hanny Al-Samkari, MD¹³, Sujit Sheth, MD¹⁴, Seyed Mehdi Nouraie, MD^15* and Susan Perrine, MD¹⁶

¹Division of Medical Oncology and Hematology, Department of Medicine, University Health Network, Toronto, ON, Canada
²Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada
³Division of Hematology, Department of Medicine, University of Toronto, Toronto, ON, Canada
⁴UCSF Benioff Childrens Hospital Oakland, Oakland, CA
⁵Foundation for Sickle Cell Disease Research, Miami, FL
⁶The Foundation for Sickle Cell Disease Research, Hollywood, FL
⁷Phoenicia Biosciences, Boston, MA
⁸Medical College of Georgia, Augusta, GA
⁹Children's Hospital Oakland Research Institute, Oakland, CA
¹⁰Functional Fluidics Inc., Detroit, MI
¹¹Department of Medicine, Augusta University, Augusta, GA
¹²University of California San Francisco, Oakland, CA
¹³Division of Hematology, Massachusetts General Hospital, Harvard Medical School, Boston, MA
¹⁴Division of Hematology and Oncology, Department of Pediatrics, Weill Cornell Medicine, New York, NY
¹⁵Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA
¹⁶Phoenicia Biosciences, Inc., Boston, MA

Kim Abbegail Tan Aldecoa, MD^1,2, Camelia Arsene, MD, PhD, MHS^1,2*, Tiffany Chng, BS^1,3*, Garett Cherry, BS^1,3*, Nabila Chowdhury, MS4^1,3*, Ryan Clark, BS^1,3*, Dana Deeb, BS^1,3*, Lisa Deptula, MMS^1,3*, Grey Dietz, MS^1,3*, Ewomamobuho Eto, BA^1,3*, Victoria Golston, MS^1,3*, Landon Lawson, MS^1,3*, Chef Stan Lucena Macaraeg, MD^4*, Chioma Mbionwu, BS^1,3*, Obiefuna Okponyia, MD, MBA^1,5*, Jennifer Orejuela, MS^1,3*, Thomaida Qipo^1,3*, Sumit Raut, MD^1,2*, Geetha Krishnamoorthy, MD^1,2* and Judie Goodman, DO⁶

¹Trinity Health Oakland, Pontiac, MI
²Wayne State University, Detroit, MI
³Ross University School of Medicine, Bridgetown, Barbados
⁴University of Connecticut, Hartford, CT
⁵Detroit Wayne County Authority Health, Detroit, MI
⁶Department of Hematology and Oncology, Trinity Health Oakland, Pontiac, MI

Maria Lysandrou, BA¹, Nives Quaye^2* and Robert Cronin, MD, MS³

¹The Ohio State University College of Medicine, Columbus, OH
²The Ohio State University, Columbus, OH
³Department of Internal Medicine, The Ohio State University, Columbus, OH

Katherine Stafford, MBBS, MPH^1,2*, Soravis Osataphan, MD^3*, Gemlyn George, MD² and Rushad Patell, MBBS³

¹Hospital Medicine, Denver Health and Hospital Authority, Denver, CO
²University of Colorado, Aurora, CO
³Division of Medical Oncology and Hematology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA

Gladys Kelly Keza^1*, Dapa Aly Diallo, MD^2*, Ibrahima Diagne, MD^3*, Mariane de Montalembert, MD, PhD⁴, Anne Corbasson^5*, Françoise Bernaudin^6*, Brigitte Ranque^7*, Binta Coulibaly^8*, Galacteros Frederic^9*, Saliou Diop^10*, Constant Vodouhé^11*, Olivier Hermine, MD, PhD^12*, Agnès Lainé^13*, Eléonor Kafando^14*, Ahoefa Vovor, MD^15*, Sébastien Jan^16*, Leon Tshilolo^17*, Robert Hue^18* and Jean-Benoit Arlet, MD, PhD^19*

¹Université Senghor Alexandrie, Egypte, Alexandrie, Egypt
²Centre De Recherche Et De Lutte Contre La Grepanocytose, Bamako, MLI
³Université Gaston Berger, Saint Louis, Senegal
⁴Necker-Enfants Malades Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), University of Paris-Cité, Paris, France
⁵Hôpital Européen Georges Pompidou, Assistance Publique -hopitaux De Paris, Paris, FRA
⁶Hôpital Intercommunal de Créteil, Créteil, France
⁷internal medicine department, hôpital européen Georges Pompidou, assistance publique des hôpitaux de Paris, Paris, France
⁸Fresenius Kabi compagny, Francfort-sur-le-Main, Germany
⁹Sickle Cell Referral Center, Henri-Mondor University Hospital- UPEC, AP-HP, Creteil, France
¹⁰Centre de transfusion sanguine de Dakar, centre de la drépanocytose, Dakar, Senegal
¹¹Association DORYS, Strasbourg, France
¹²Imagine institute, Université Paris Cité, PARIS, FRA
¹³Institut des mondes Africains, Paris, France
¹⁴Department of biology, UFR des sciences de la santé de l’Université Joseph Ki Zerbo, Ouagadougou, Burkina Faso
¹⁵Faculty of health sciences, Lomé, Togo
¹⁶Dréparique NGO, Paris, France
¹⁷Centre Hospitalier Monkole, Kinshasa, Congo (The Democratic Republic of the)
¹⁸Drepafrique NGO, Paris, France
¹⁹Department of internal medicine, French sickle cell disease referral center, Hôpital européen Georges Pompidou, AP-HP, Paris, France

Liza Afzali-Hashemi^1*, Melanie Franse^2*, Koen P.A. Baas^3*, Anouk Schrantee^3*, John C. Wood, MD, PhD^4*, Aart J Nederveen^3*, Bart J. Biemond⁵ and Sharon O'Neil, PhD^6*

¹Department of Hematology and Radiology & Nuclear Medicine, Amsterdam University Medical Centers, location University of Amsterdam, Amsterdam, Netherlands
²Nederlands Instituut voor Forensische Psychiatrie en Psychologie, Utrecht, Netherlands
³Department of Radiology & Nuclear Medicine, Amsterdam University Medical Centers, location University of Amsterdam, Amsterdam, Netherlands
⁴Division of Cardiology, Children's Hospital Los Angeles, Los Angeles, CA
⁵Department of Hematology, Amsterdam University Medical Centers, location University of Amsterdam, Amsterdam, Netherlands
⁶Division of Neurology and The Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, CA

Lana Mucalo, MD^1*, Shuang Jia^1*, Ashima Singh, PhD², Mark Roethle^1*, Janelle Highland, MA^1*, Dawn Retherford^1*, Jessica J. Rico^1*, Nicole Steiner^1*, Martin Hessner, PhD^1* and Amanda M. Brandow, DO, MS³

¹Medical College of Wisconsin, Milwaukee, WI
²Department of Pediatrics, Division of Hematology and Oncology, Medical College of Wisconsin, Pewaukee, WI
³Department of Pediatrics, Section of Hematology/Oncology/Bone Marrow Transplantation, Medical College of Wisconsin, Milwaukee, WI

Mira Patel Pochron^1*, Adeseye Michael Akinsete, MBBS^2*, Shehu Umar Abdullahi, MD^3*, Foluke A Fasola^4*, Modupe Idowu, MD⁵, Sharon Pennington, MD⁶, William B Ershler, MD⁷, Marshall Patrick Stagg^8*, Earl Fields^9*, Morgan Sterling^9*, Satheesh Chonat, MD⁹, Yuvika Paliwal^10*, Karena Kong^10*, David R Archer, PhD⁹, Adeyemi Adenola^10* and Eleanor A Lisbon, MD¹⁰

¹Pfizer Inc, South San Francisco, CA
²College of Medicine, University of Lagos, Idi-Araba, Lagos, Nigeria
³Department of Pediatrics, Bayero University/Aminu Kano Teaching Hospital, Kano, Nigeria
⁴University of Ibadan/University College Hospital, Idi-Araba, Ibadan, Nigeria
⁵Department of Hematology and Oncology, The University of Texas Health Science Center McGovern Medical School, Houston, TX
⁶Mississippi Center For Advanced Medicine, Madison, MS
⁷Inova Schar Cancer Institute, Fairfax, VA
⁸Baton Rouge General Medical Center, Baton Rouge, LA
⁹Aflac Cancer and Blood Disorders Center, Children’s Healthcare of Atlanta, Emory University Department of Pediatrics, Atlanta, GA
¹⁰Pfizer Inc, New York, NY

Alexandra Power-Hays, MD^1,2, Ruth Namazzi, MD^3,4*, Charles Kato^4*, Andrea Conroy, PhD^5*, Heather Ann Hume, MD, FRCPC⁶, Chandy C. John, MD, MS^5*, Susan E. Stuber, MA^1*, Adam C. Lane, PhD^1*, Teresa S. Latham, MA^1*, Robert Opoka, MBChB, PhD^7,8* and Russell E. Ware, MD, PhD^1,2

¹Division of Hematology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
²Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH
³Department of Paediatrics, Makerere University, Kampala, Uganda
⁴Global Health Uganda, Kampala, Uganda
⁵Indiana University School of Medicine, Indianapolis, IN
⁶Department of Pediatrics, Centre Hospitalier Universitaire Sainte Justine, Montreal, QC, CAN
⁷Department of Paediatrics and Child Health, College of Health Sciences, Makerere University, Kampala, Uganda
⁸Aga Khan Medical College, Nairobi, Kenya

Saliou Diop, MD, MSc¹, Aldiouma Guindo, PharmD, PhD^2*, Gonzalo De Luna, MD^3*, Aurélien Yapi, MD^4*, Giovanna Cannas, MD^5*, Maryse Etienne-Julan, MD^6*, Jean-Benoit Arlet, MD, PhD^7*, Stephanie Ngo, MD^8*, Emmanuelle Bernit, MD^9*, Justine Gellen-Dautremer, MD^10*, Gylna Loko, MD^11*, Stanislas Nimubona, MD^12*, Anoosha Habibi, MD¹³, Vincent Audard, MD, PhD^14* and Pablo Bartolucci, MD, PhD^15*

¹Centre National de Transfusion sanguine, Université Cheikh Anta Diop, Dakar, Senegal
²Sickle Cell Research and Control Centre (CRLD), University of Bamako, Bamako, Mali
³Sickle Cell Referral Center, Henri-Mondor University Hospital- UPEC, AP-HP, Creteil, France
⁴Centre Hospitalier et Universitaire (CHU) de Bouaké, Bouaké, Côte d'Ivoire
⁵Hopital Edouard Herriot, Lyon, France
⁶CHU De Pointe-à-Pitre, Pointe-à-Pitre, Guadeloupe
⁷Hopital Europeen Georges Pompidou, Paris, France
⁸Centre Hospitalier Delafontaine, Saint-Denis, France
⁹CHU Pointe-à-Pitre, Pointe à Pitre, Guadeloupe
¹⁰CHU de Poitiers Site de la Milétrie, Poitiers, France
¹¹CHU Martinique, Le Lamentin, Martinique
¹²Hopital Pontchaillou, Rennes, France
¹³Sick, Hopital Henri Mondor, Creteil Cedex, France
¹⁴Henri Mondor Hospital, Creteil, France
¹⁵Service de Médecine Interne, CHU Henri Mondor, Créteil, France

Marco Aurelio Salvino, PhD¹, Bulent Antmen^2*, Frederick Chite Asirwa^3*, Satheesh Chonat, MD⁴, Lucia De Franceschi, MD⁵, Perla Eleftheriou, FRCPath, MRCP^6*, Adlette Inati, MD^7,8, Johnny Mahlangu, MBBCh, MMed^9,10, Erfan Nur, MD, PhD¹¹, Salvador Payán-Pernía^12*, Asad Charania, MBBS^13*, Diana Gradinaru^14*, Allison Hsia, PhD^15*, Yves Luder^14*, Thomas Perretti^14*, Sasha Srekovic^16* and Pablo Bartolucci, MD, PhD^17*

¹Hospital São Rafael – IDOR / PPGMS-UFBa, Salvador, Brazil, Salvador, Brazil
²Department of Pediatric Hematology, Adana Acibadem Hospital, Adana, Turkey, Adana, Turkey
³International Cancer Institute (ICI), Eldoret, Kenya
⁴Department of Pediatrics, Emory University School of Medicine and Aflac Cancer and Blood Disorders Center, Children’s Healthcare of Atlanta, Atlanta, GA
⁵Dept of Medicine, Policlinico GB Rossi, Policlinico GB Rossi, Univ. of Vero, Verona, Italy
⁶University College London Hospital, London, GBR
⁷Gilbert and Rose-Marie Chagoury School of Medicine, Lebanese American University, Byblos, Lebanon
⁸NINI Hospital, Tripoli, Lebanon
⁹University of the Witwatersrand and National Health Laboratory Service, Johannesburg, South Africa
¹⁰Haemophilia Comprehensive Care Center, Charlotte Maxeke Johannesburg Hospital, Johannesburg, South Africa
¹¹Department of Hematology, Amsterdam UMC, location AMC, Amsterdam, Netherlands
¹²Servicio de Hematologia, Hospital Universitario Virgen del RocÍo, Instituto de Biomedicina de Sevilla (IBiS), Sevilla, Spain
¹³F. Hoffmann-La Roche Ltd, London, United Kingdom
¹⁴F. Hoffmann-La Roche Ltd, Basel, Switzerland
¹⁵Genentech, Inc, San Fransisco, CA
¹⁶Genentech, Inc., San Fransisco, CA
¹⁷Service de Médecine Interne, CHU Henri Mondor, Créteil, France

Biree Andemariam, MD¹, Vivien A. Sheehan, MD, PhD², Moayed Hamza, MBBCh^3*, Kirsty Kelly, MSc^3* and John Climax, PhD, DSc^3*

¹University of Connecticut Health, Farmington, CT
²Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Emory University School of Medicine, Atlanta, GA
³Afimmune, Dublin, Ireland