Lydian A. de Ligt^1,2,3*, Aafke E. Gaartman^2,4*, Kadère Konté^2,4*, Taco W. Kuijpers^2,5*, Karin Fijnvandraat^2,6*, Bart J. Biemond⁷, Robin van Bruggen^2* and Erfan Nur, MD, PhD^2,4

¹Department of Pediatric Hematology, Emma Children's Hospital, Amsterdam University Medical Centers, Amsterdam, Netherlands
²Department of Blood Cell Research, Sanquin Research and Landsteiner Laboratory, Amsterdam, Netherlands
³Department of Hematology, Amsterdam University Medical Centers, Amsterdam, AL, Netherlands
⁴Department of Hematology, Amsterdam University Medical Centers, Amsterdam, Netherlands
⁵Pediatric Immunology, Emma Children's Hospital, Amsterdam University Medical Centers, Amsterdam, Netherlands
⁶University of Amsterdam, Amsterdam, Netherlands
⁷Department of Hematology, Amsterdam University Medical Centers, location University of Amsterdam, Amsterdam, Netherlands

Vinzon Ibanez^1*, Kestis Vaitkus^1*, Robert Molokie, MD², Yogenthiran Saunthararajah, MD³ and Donald Lavelle¹

¹University of Illinois Chicago, Jesse Brown VA Medical Center, Chicago, IL
²Division of Hematology/Oncology, University of Illinois Chicago, Chicago, IL
³Cleveland Clinic Case Western Reserve Univ., Cleveland, OH

Mya Angela Arellano, BS^1*, Donovan Alexander Argueta, PhD², Yugal Goel, PhD^2,3*, Natalie Garcia^2* and Kalpna Gupta, PhD^2,4

¹Hematology/Oncology Division, Department of Medicine, University of California, Victorville, CA
²Hematology/Oncology Division, Department of Medicine, University of California, Irvine, CA
³Hematology/Oncology Division, Department of Medicine, University of California, Irvine, Orange, CA
⁴Department of Medicine, Division of Hematology, Oncology and Transplantation, University of Minnesota, Minneapolis, MN

Marion Serra^1*, Patricia Hermand, PhD^2*, Romain Duval, PhD^3*, Carine Lefevre, PhD^2*, Jade Merrer^4*, Fallou Leye^5*, Mohammad Salma, PhD^6*, Marine Aglave, PhD^7*, William Vainchenker, MD, PhD^8*, Caroline Le Van Kim, PhD^9*, Slim Azouzi, PhD^10,11,12* and Berengere Koehl, MD, PhD^13,14*

¹Inserm S1134, Paris, FRA
²Integrated Red Blood Cell Biology, Inserm U1134, Paris, FRA
³Centre National de Référence pour les Groupes Sanguins, Établissement Français du Sang (EFS) Ile-de-France, Université de Paris Cité, UMR_S1134, BIGR, Inserm, Paris, France
⁴Unité d'Epidémiologie Clinique, INSERM CIC 1426, AP-HP, Hôpital Robert Debré,, Paris, France
⁵Unité d'Epidémiologie Clinique, INSERM CIC 1426, AP-HP, Hôpital Robert Debré, Paris, France
⁶Institut De GénéTique MoléCulaire, Montpellier, FRA
⁷Gustave Roussy Cancer Campus, Villejuif, France
⁸INSERM UMR1287, Gustave Roussy, Paris-Saclay University, Villejuif, France
⁹Université Paris Cité and Université des Antilles, INSERM, Biologie intégrée du globule rouge, F-75015 Paris, France, Paris, France
¹⁰CNRGS, EFS, Paris, France
¹¹Laboratoire d'Excellence GR-Ex, Paris, France
¹²Inserm U1134, Integrated Biology of Red Blood Cells, Université Paris Cité, Inserm, Paris, France
¹³Hematology Unit, Sickle Cell disease Center, Hôpital Robert Debré, APHP, Université Paris Cité, Paris, France
¹⁴Integrated Red Blood Cell Biology, Inserm U1134, Laboratory of Excellence GrEx, Paris, France

Katie Lien, PhD^1*, Joanna Gemel, PhD^2*, Eric C. Beyer, MD, PhD^3* and Gabrielle Lapping-Carr, MD⁴

¹The University of Chicago Pritzker School of Medicine, Chicago, IL
²University of Chicago, Chicago, IL
³Comer Children's Hospital, University of Chicago, Chicago, IL
⁴Section of Pediatric Hematology/Oncology, Department of Pediatrics, University of Chicago, Chicago, IL

Patrick Ellsworth, MD^1,2, Izabela Pawlinski^1*, Rachel Sielaty, BS^1*, Anton Ilich, MD^1*, Chatphatai Moonla, MD^1*, Yuriy Prokopenko, MD^1*, Dougald M. Monroe, PhD¹, Rafal Pawlinski, PhD³ and Nigel S. Key, MD^1,2

¹UNC Blood Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC
²Division of Hematology, University of North Carolina at Chapel Hill, Chapel Hill, NC
³UNC Blood Research Center, University of North Carolina, Chapel Hill, NC

Zoe Sekyonda, BS^1*, Calvin Abonga, MS^2*, Christopher A. Delianides, MS^2*, Solomon Oshabaheebwa, MS^1*, Jane A. Little, MD³, Michael A. Suster, PhD^1*, Pedram Mohseni, PhD^1,4* and Umut A. Gurkan, PhD^1,5

¹Case Western Reserve University, Cleveland, OH
²Department of Electrical, Computer, and Systems Engineering, Case Western Reserve University, Cleveland, OH
³Division of Hematology and UNC Blood Research Center, University of North Carolina, Chapel Hill, NC
⁴Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH
⁵Department of Mechanical and Aerospace Engineering, Case Western Reserve University, Shaker Heights, OH

Marissa J.M. Traets^1*, Brigitte A. van Oirschot^1*, Titine J.J. Ruiter^1,2*, Charles Levine^3*, Anita W. Rijneveld, M.D.⁴, Judith J.M. Jans^2*, Minke A.E. Rab^1,4*, Yu-Wei Chen^5* and Richard van Wijk¹

¹Central Diagnostic Laboratory - Research, University Medical Center Utrecht, Utrecht, Netherlands
²Section Metabolic Diagnostics, Department of Genetics, University Medical Center Utrecht, Utrecht, Netherlands
³Pfizer Inc., San Francisco
⁴Department of Hematology, Erasmus University Medical Center, Rotterdam, Netherlands
⁵Pfizer Inc, South San Francisco, CA

Varsha Bhat^1*, Alka A Potdar, PhD^2*, Ashwin P Patel, MD, PhD, MPH³, Gregory Gibson^1*, G. Karen Yu, PhD^2* and Vivien A Sheehan, PhD³

¹Center for Integrative Genomics, School of Biological Sciences, Georgia Institute of Technology, Atlanta, GA
²Pfizer Inc, South San Francisco, CA
³Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Emory University School of Medicine, Atlanta, GA

Roopa Taranath, PhD^*, Li Zhao, MD, PhD^*, Gregory Bourne, PhD^*, Ramesh R Bhatt, PhD^*, Scott Plevy, MD^*, David Y Liu, PhD and Ashok Bhandari, PhD^*

Protagonist Therapeutics, Inc., Newark, CA

Aliya U. Zaidi, PhD^1*, Xiufeng Gao, MD, MSc^1*, Robert Goodrich, BSc^1*, Marta Ferranti, MSc^1*, Rasa Borhan, BSc^1*, Ke Liu, PhD^1*, Nnamdi Okeke, PharmD^1*, Michael Tarasev, PhD, MBA^1*, Mariama Kabore^2*, Courtney D. Fitzhugh, MD³, Priya Sethu Chockalingam, PhD^4* and Patrick C. Hines, MD, PhD^1,5

¹Functional Fluidics Inc., Detroit, MI
²National Institutes of Health, Bethesda, MD
³Cellular and Molecular Therapeutics Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD
⁴Beam Therapeutics, Cambridge, MA
⁵Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI

Ziming Li^1*, Omika Katoch, Ph.D^2*, Ramakrishna Ungalara^1* and Tirthadipa Pradhan-Sundd, PhD³

¹University of Pittsburgh, Pittsburgh, PA
²Pittsburgh Heart, Lung and Blood Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA
³Versiti Blood Research Institute, Milwaukee, WI

Cristiane Maria de Souza, PhD^1*, Sami Yokoo^2*, Ana Carolina Lima Camargo, PhD^3*, Romenia Ramos Domingues^2*, Carolina Lanaro, BSc, PhD^1*, Marina Dorigatti Borges, PhD^1*, Renata Sesti-Costa, PhD^1*, Sara Teresinha Olalla Saad, MD¹, Adriana Franco Paes Leme, PhD^2* and Fernando Ferreira Costa, MD, PhD⁴

¹Hematology and Hemotherapy Center, University of Campinas - UNICAMP, Campinas, Brazil
²National Center for Research in Energy and Materials (CNPEM), Campinas, Brazil
³University of Campinas - UNICAMP, Campinas, Brazil
⁴Hematology and Transfusion Center, University of Campinas - UNICAMP, Campinas, Sao Paulo, Brazil

Rikesh K Dubey, PhD^1,2, Omika Katoch, Ph.D^2,3*, Enrico M Novelli, MD² and Prithu Sundd, PhD^1,2,4,5

¹Versiti blood research Institute, Milwaukee, WI
²Pittsburgh Heart, Lung and Blood Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA
³Versiti Blood Research Centre, Milwaukee, WI
⁴Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA
⁵Medical College of Wisconsin, Division of Hematology and Oncology, Milwaukee, WI

John Paderi, PhD^1*, Rikesh K Dubey, PhD², Gabriel Njikang, PhD^1* and Prithu Sundd, PhD²

¹IHP Therapeutics, San Carlos, CA
²Pittsburgh Heart, Lung and Blood Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA

Grace Bechtel, BSc^1*, Gabriella Sugerman^1*, Alicia Chang, MD², Manuel Rausch, PhD^3* and Adam Bush, PhD¹

¹Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX
²Pediatric Hematology/Oncology, Dell Children’s Medical Center, Austin, TX
³Department of Aerospace Engineering and Engineering Mechanics, The University of Texas at Austin, Austin, TX