-Author name in bold denotes the presenting author
-Asterisk * with author name denotes a Non-ASH member
Clinically Relevant Abstract denotes an abstract that is clinically relevant.

PhD Trainee denotes that this is a recommended PHD Trainee Session.

Ticketed Session denotes that this is a ticketed session.

701.O1.6 701. Experimental Transplantation: Basic and Translational: GVHD, Intestinal Immunity, and the Gut Microbiome

Symposia: Experimental Transplantation: Basic and Translational Program: Oral and Poster Abstracts
Type: Oral
Hematology Disease Topics & Pathways:
Research, Fundamental Science, Translational Research
Saturday, December 9, 2023: 4:00 PM-5:30 PM
Room 7 (San Diego Convention Center)
Moderators:
Jarrod A Dudakov, PhD, Fred Hutchinson Cancer Research Center and Antiopi Varelias, PhD, ARRAY(0x101f1fb0)
Disclosures:
No relevant conflicts of interest to declare.
4:00 PM
343
Intestinal Epithelial-Derived IL-34 Regulates Macrophage Polarization in an Apolipoprotein E Dependent Manner and Mitigates the Severity of Graft Versus Host Disease

Aditiya Rayasam, PhD1*, Alison Moe, PhD1*, Ravi Shah, PhD1*, Cheng-Yin Yuan, PhD1*, Marco Colonna, PhD2*, James Miller, MD1*, Anthony Zamora, PhD1* and William Drobyski, MD1

1Medical College of Wisconsin, Milwaukee, WI
2Washington University School of Medicine, Saint Louis, MO
4:15 PM
344
Enterococcus Induces MHC-II Expression in the Colonic Epithelium to Aggravate Graft-Versus-Host Disease

Chi L Nguyen, BA1*, Marina Burgos da Silva, PhD2*, Romina Ghale, BA3*, Kristen Victor, BA3*, Anqi Dai, MS3*, Melissa Docampo, PhD3*, Kate A. Markey, MBBS, PhD, FRACP, MPH4,5, Jonathan U. Peled, MD, PhD6 and Marcel R.M. van den Brink6,7,8

1Gerstner Sloan Kettering Graduate School of Biomedical Sciences, New York, NY
2Department of Immunology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York
3Memorial Sloan Kettering Cancer Center, New York, NY
4Division of Medicine, University of Washington, Seattle, WA
5Fred Hutchinson Cancer Center, Seattle, WA
6Adult Bone Marrow Transplantation Service, Memorial Sloan Kettering Cancer Center, New York, NY
7Department of Medicine, Adult Bone Marrow Transplantation Service, Memorial Sloan Kettering Cancer Center, New York, NY
8Weill Cornell Medical College, New York, NY
4:30 PM
345
Microbiota-Specific T Cells Contribute to Graft-Versus-Host Disease after Allogeneic Stem Cell Transplantation

Albert C Yeh, MD1, Motoko Koyama, MD, PhD1, Olivia Waltner2*, Simone A Minnie, PhD1, Julie Boiko, MD, MS3, Tamer B Shabaneh, PhD2*, Shuichiro Takahashi, PhD1*, Ping Zhang, MD2*, Kathleen Ensbey2*, Christine Schmidt, BA2*, Samuel Legg2*, Tomoko Sekiguchi2*, Ethan Nelson2*, Shruti Bhise2*, Andrew Stevens2*, Tracy A Goodpaster2*, Saranya R. Chakka2*, Scott N. Furlan, MD2*, Kate A. Markey, MBBS, PhD, FRACP, MPH4, Marie Bleakley, PhD, MBBS, MMSc5, Charles O Elson III, PhD6* and Geoffrey R Hill, MD4

1Translational Sciences and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA
2Fred Hutchinson Cancer Center, Seattle, WA
3University of Washington, Seattle, WA
4Translational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA
5Translational Science and Therapeutics, Fred Hutchinson Cancer Center, Seattle, WA
6University of Alabama, Birmingham, AL
4:45 PM
346
IL-33 Induces Paneth Cell Production of EGF and Soluble ST2, Regulating Epithelial Regeneration after Intestinal Injury

Marco Calafiore, PhD1*, YA-Yuan Fu2*, Paola Vinci3*, Viktor Arnhold, MD4*, Winston Chang3*, Suze Jansen5*, Anastasiya Egorova3*, Shuichiro Takashima, MD, PhD1*, Jason Kuttiyara3*, Takahiro Ito, MD3*, Jonathan Serody, MD6, Susumu Nakae7*, Heth Turnquist8*, Johan van Es9*, Hans Clevers9,10,11*, Caroline A. Lindemans, MD PhD12, Bruce R Blazar, MD13 and Alan M. Hanash, MD14

1Memorial Sloan Kettering Cancer Center, New York, NY
2MEMORIAL SLOAN KETTERING CANCER CENTER, New York, NY
3MSKCC, NY
4MSKCC, New York, NY
5UMC Utrecht, Utrecht, NLD
6Univ. of North Carolina School of Medicine, Chapel Hill, NC
7Hiroshima University, Hiroshima, Japan
8Pitt, Pittsburgh
9Hubrecht Institute, Utrecht, Netherlands
10Princess Maxima Center, Utrecht, Netherlands
11Roche Pharma Research and Early Development, Basel, Switzerland
12Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, Netherlands
13Division of Pediatric Blood and Marrow Transplantation, University of Minnesota, Minneapolis, MN
14Adult Bone Marrow Transplantation Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY
5:00 PM
347
Inflammatory Memory Restrains Intestinal Stem Cell (ISC) Regeneration after Allogeneic Stem Cell Transplantation (SCT)

Dongchang Zhao, PhD1*, Visweswaran Ravikumar2*, Emma Lauder2*, Lu Li1*, Yaping Sun, MD, PhD, MS1*, Katherine Oravecz-Wilson, MS, BS3*, Michael Brooks3*, Evan Keller, PhD, DVM2*, Fengju Chen1*, Laure Maneix, PhD1*, Ana Santibanez1*, Chad Creighton1*, Arvind Rao, PhD3* and Pavan Reddy, MD4

1Baylor College of Medicine, Houston, TX
2University of Michigan, Ann Arbor
3University of Michigan, Ann Arbor, MI
4Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston
5:15 PM
348
Platelet Subpopulations and Distinct Platelet Function Defects after Hematopoietic Stem Cell Transplantation in Mice and Humans

Kristina Mott1*, Lukas Johannes Weiss, MD2,3*, Margret Droste3*, Maria Drayss, MD2,3*, Sabrina Kraus, MD4*, Torsten Steinbrunn, MD, PhD4,5* and Harald Schulze, PhD3

1Institute of Experimental Biomedicine, University Hospital Würzburg, WüRzburg, Germany
2Department of Internal Medicine I, University Hospital Würzburg, Würzburg, Germany
3Institute of Experimental Biomedicine, University Hospital Würzburg, Würzburg, Germany
4Department of Internal Medicine II, University Hospital Würzburg, Würzburg, Germany
5Dana-Farber Cancer Institute, Department of Medical Oncology, Harvard Medical School, Boston, MA
See more of: Oral and Poster Abstracts
<< Previous Session | Next Session >>
*signifies non-member of ASH