-Author name in bold denotes the presenting author
-Asterisk * with author name denotes a Non-ASH member
Clinically Relevant Abstract denotes an abstract that is clinically relevant.

PhD Trainee denotes that this is a recommended PHD Trainee Session.

Ticketed Session denotes that this is a ticketed session.

642.O3.6 642. Chronic Lymphocytic Leukemia: Clinical and Epidemiological: New Inhibitors and Cellular Therapies for Treatment of Relapsed CLL

Symposia: Chronic Lymphocytic Leukemia: Clinical and Epidemiological Program: Oral and Poster Abstracts
Type: Oral
Hematology Disease Topics & Pathways:
Biological therapies, Clinical Practice (Health Services and Quality), Bispecific Antibody Therapy, Chimeric Antigen Receptor (CAR)-T Cell Therapies, Combination therapy, Therapies
Saturday, December 9, 2023: 4:00 PM-5:30 PM
Grand Hall D (Manchester Grand Hyatt San Diego)
Moderators:
Paul M. Barr, MD, University of Rochester and Barbara F. Eichhorst, MD, University of Cologne
Disclosures:
Barr: AstraZeneca: Consultancy, Research Funding; AbbVie: Consultancy; Bristol Myers Squibb: Consultancy; Pharmacyclics LLC, an AbbVie Company: Consultancy; Janssen: Consultancy; TG therapeutics: Consultancy, Research Funding; Celgene: Consultancy; Genentech: Consultancy; Morphosys: Consultancy; Seattle Genetics: Consultancy; MEI Pharma: Consultancy; Gilead: Consultancy.
Data on new non-covalent binding BTK inhibitors as well as on new Bcl2 inhibitors in relapsed CLL will be shown. In addition to that data on bispecific antibodies and CART cell therapy will be demonstrated.
4:00 PM

Jennifer A. Woyach, MD1*, Jennifer R. Brown, MD, PhD2, Paolo Ghia, MD, PhD3, Lindsey E. Roeker, MD4, Krish Patel, MD5, Toby A. Eyre6*, Talha Munir, MBBS, MRCP, FRCPath, PhD7*, Ewa Lech-Maranda, MD, PhD8*, Nicole Lamanna, MD9, Constantine S. Tam, MD, MBBS10*, John F. Seymour, MBBS, PhD, FRACP11, Benoit Tessoulin12*, Nirav N. Shah, MD13, Chaitra S Ujjani, MD14, Bita Fakhri, MD, MPH15, Catherine C. Coombs, MD16, Ian W. Flinn, MD, PhD17, Manish Patel, MD18*, Sunita D. Nasta, MD19, Jonathon B. Cohen, MD, MS20, Alvaro J. Alencar, MD21, Chan Y. Cheah, MD, DMSc22, Shuo Ma, MD, PhD23, Joanna M. Rhodes, MD, MSCE24*, Deepa Jagadeesh, MD25, Pier Luigi Zinzani, MD, PhD26, Anders Osterborg, MD, PhD27*, Koji Izutsu, MD, PhD28, Donald E. Tsai, MD, PhD29*, Paolo Abada, MD29, Minna Balbas, PhD29*, Jian Li, MS29*, Amy S. Ruppert, PhD30*, Wojciech Jurczak, MD, PhD31 and William G. Wierda, MD, PhD32

1The Ohio State University Comprehensive Cancer Center, Columbus, OH
2Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA
3Università Vita-Salute San Raffaele and IRCCS Ospedale San Raffaele, Milano, Italy
4Memorial Sloan Kettering Cancer Center, New York, NY
5Swedish Cancer Institute, Seattle, WA
6Oxford University Hospitals NHS Foundation Trust, Churchill Cancer Center, Oxford, United Kingdom
7Department of Haematology, St. James's University Hospital, Leeds, United Kingdom
8Institute of Hematology and Transfusion Medicine, Warsaw, Poland
9Herbert Irving Comprehensive Cancer Center, Columbia University, New York
10Alfred Health and Monash University, Melbourne, VIC, Australia
11Peter MacCallum Cancer Center, Royal Melbourne Hospital and University of Melbourne, Melbourne, VIC, Australia
12Hematology Department, University Hospital, Nantes, France
13Medical College of Wisconsin, Milwaukee, WI
14Fred Hutchinson Cancer Research Center, Seattle, WA
15Stanford University School of Medicine, Stanford, CA
16University of California Irvine, Irvine, CA
17Sarah Cannon Research Institute, Nashville, TN
18Florida Cancer Specialists, Sarah Cannon Research Institute, Sarasota, FL
19Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA
20Winship Cancer Institute, Emory University, Atlanta, GA
21Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL
22Linear Clinical Research and Sir Charles Gairdner Hospital, Perth, Western Australia, Australia
23Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, IL
24Rutgers Cancer Institute of New Jersey, New Brunswick, NJ
25Department of Hematology and Medical Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH
26Institute of Hematology "Seràgnoli" University of Bologna, Bologna, Italy
27Karolinska Institute and Karolinska University Hospital, Stockholm, Sweden
28National Cancer Center Hospital, Tokyo, Japan
29Loxo@Lilly, Indianapolis, IN
30Eli Lilly and Company, Indianapolis, IN
31Maria Sklodowska-Curie National Research Institute of Oncology, Krakow, Poland
32MD Anderson Cancer Center, Houston, TX

4:15 PM

Jennifer R. Brown, MD, PhD1, Sai Prasad Desikan, MD2*, Bastien Nguyen, PhD3*, Helen Won, PhD3*, Shady I. Tantawy, MD4, Samuel McNeely, PhD5*, Narasimha Marella, Ph.D.3*, Kevin Ebata, PhD3*, Jennifer A. Woyach, MD2, Krish Patel, MD6, Constantine S. Tam, MD, MBBS7, Toby A. Eyre8*, Chan Y. Cheah, MBBS, FRACP, FRCPA, DMSc9, Nirav N. Shah, MD10, Paolo Ghia, MD, PhD11, Wojciech Jurczak, MD, PhD12, Minna Balbas, PhD3*, Binoj Nair, PhD3*, Paolo Abada, MD3, Chunxiao Wang, Ph.D.5*, Ying (Denise) Wang, PhD3*, Lindsey E. Roeker, MD13, Varsha Gandhi, PhD14 and William G. Wierda, MD, PhD4

1Chronic Lymphocytic Leukemia Center, Division of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA
2The Ohio State University Comprehensive Cancer Center, Columbus, OH
3Loxo@Lilly, Indianapolis, IN
4MD Anderson Cancer Center, Houston, TX
5Eli Lilly and Company, Indianapolis, IN
6Swedish Cancer Institute, Seattle, WA
7Alfred Health and Monash University, East Melbourne, Australia
8Oxford University Hospitals NHS Foundation Trust, Churchill Cancer Center, Oxford, United Kingdom
9Linear Clinical Research and Sir Charles Gairdner Hospital, Perth, Western Australia, Australia
10Medical College of Wisconsin, Milwaukee, WI
11Università Vita-Salute San Raffaele and IRCCS Ospedale San Raffaele, Milan, Italy
12Maria Skłodowska – Curie National Research Institute of Oncology, Kraków, Poland
13Memorial Sloan Kettering Cancer Center, New York, NY
14Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX

4:30 PM

Constantine S. Tam, MD, MBBS1,2*, Mary Ann Anderson3,4*, Masa Lasica5*, Emma Verner6,7*, Stephen S. Opat, MBBS, FRACP, FRCPA8,9, Shuo Ma, MD, PhD10, Robert Weinkove, MBBS, PhD, FRACP, FRCPA11,12*, Raul Cordoba, MD, PhD13, Jacob Soumerai, MD14, Paolo Ghia, MD, PhD15, Sophie Leitch16*, James Hilger17*, Yiqian Fang18*, David Simpson19*, Haiyi Guo20* and Chan Yoon Cheah, MD21,22,23

1Alfred Hospital, Melbourne, VIC, Australia
2Monash University, Clayton, VIC, Australia
3Division of Blood Cells and Blood Cancer, The Walter and Eliza Hall Institute, Parkville, VIC, Australia
4Peter Mac Callum Cancer Centre, Melbourne, VIC, Australia
5Department of Haematology, St Vincent’s Hospital Melbourne, Victoria, Australia, Fitzroy, VIC, Australia
6Concord Repatriation General Hospital, Concord, NSW, Australia
7University of Sydney, Sydney, NSW, Australia
8School of Clinical Sciences, Monash University, Melbourne, VIC, Australia
9Monash Health, Clayton, VIC, Australia
10Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, IL
11Cancer Immunotherapy Programme, Malaghan Institute of Medical Research, Wellington, New Zealand
12Te Rerenga Ora Wellington Blood & Cancer Centre, Te Whatu Ora Health New Zealand Capital, Coast & Hutt Valley, Wellington, New Zealand
13Hospital Universitario Fundacion Jimenez Diaz, Madrid, Spain
14Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, MA
15Universita' Vita-Salute San Raffaele C.F. 97187560152, Milano, MI, Italy
16Waitematā District Health Board, Auckland, New Zealand
17BeiGene USA, Inc., San Mateo
18BeiGene (Shanghai) Co., Ltd., Shanghai, China
19BeiGene USA, Inc, San Mateo, CA
20BeiGene (Shanghai) Co., Ltd, Shanghai, China
21Linear Clinical Research and Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia
22Department of Haematology, Sir Charles Gairdner Hospital and Pathwest Laboratory Medicine, Nedlands, Western Australia, Australia
23Medical School, University of Western Australia, Crawley, Western Australia, Australia

4:45 PM

Jennifer A. Woyach, MD1, Deborah M. Stephens, DO2, Danielle M Brander, MD3, Adam S Kittai, MD4, Boyu Hu, MD2, Andrea Sitlinger, MD3*, Emily K Curran, MD5, Fenlai Tan, MD, PhD6, Yi Chen, PhD7*, Stephen P. Anthony, DO7, Yu Chen, MD, PhD7 and John C. Byrd, MD8

1The Ohio State University Comprehensive Cancer Center, Columbus, OH
2Huntsman Cancer Institute, University of Utah, Salt Lake City, UT
3Duke Cancer Center, Durham, NC
4Division of Hematology, The Ohio State University, Columbus, OH
5Hematology/Oncology, University of Cincinnati, Cincinnati, OH
6Guangzhou Lupeng Pharmaceutical Co. Ltd, Guangzhou, China
7Newave Pharmaceutical Inc., Pleasanton, CA
8Department of Internal Medicine, University of Cincinnati, Cincinnati, OH

5:00 PM

William Townsend, MD, FRCPath, MRCP1*, Sarah Leong, MBBS1*, Mittal Shah, PhD2*, Toby Batten, BSc(HONS), MSc3*, David Tucker4*, Bryson Pottinger5*, Shankaranarayana Paneesha, MD6, Dima El-Sharkawi, MBBS, FRCPath, PhD7*, Toby A. Eyre8*, Ho Pui Jeff Lam1*, Jiexin Zheng9*, Sarah Cook10*, David Granger, PhD10*, David Ahern, PhD11*, Kieran O'Donovan, PhD10*, Amit C. Nathwani, MD, PhD9,10 and Parag Jasani, FRCPath, MBBS, MRCP9*

1NIHR Clinical Research Facility, University College London Hospitals NHS Foundation Trust, London, United Kingdom
2NovalGen Ltd, London, ENG, United Kingdom
3Veramed, London, Twickenham, United Kingdom
4Royal Cornwall Hospital, Cornwall, United Kingdom
5Department of Haematology, Royal Cornwall, Hospital, Truro, United Kingdom
6Birmingham Heartlands Hospital, Birmingham, United Kingdom
7The Royal Marsden NHS Foundation Trust, Sutton, United Kingdom
8Oxford University Hospitals NHS Foundation Trust, Churchill Cancer Center, Oxford, United Kingdom
9Royal Free London - NHS Foundation Trust, London, United Kingdom
10NovalGen Ltd, London, United Kingdom
11Kennedy Institute of Rheumatology, University of Oxford, Oxford, United Kingdom

5:15 PM

Tanya Siddiqi, MD1*, David G Maloney, MD, PhD2, Saad S. Kenderian, MD3, Danielle M Brander, MD4, Kathleen Dorritie, MD5, Jacob Soumerai, MD6, Peter A Riedell, MD7, Nirav N. Shah, MD8, Rajneesh Nath9*, Bita Fakhri, MD, MPH10, Deborah M. Stephens, DO11, Shuo Ma, MD, PhD12, Tatyana Feldman, MD13*, Scott R. Solomon, MD14, Stephen J. Schuster15*, Serena K. Perna16*, Sherilyn A. Tuazon17*, San-San Ou17*, Neha Rane16* and William G. Wierda, MD, PhD18

1City of Hope National Medical Center, Duarte, CA
2Fred Hutchinson Cancer Center, Seattle, WA
3Mayo Clinic, Rochester, MN
4Duke University Health System, Durham, NC
5UPMC Hillman Cancer Center, Pittsburgh, PA
6Center for Lymphoma, Massachusetts General Hospital Cancer Center, Boston, MA
7David and Etta Jonas Center for Cellular Therapy, University of Chicago, Chicago, IL
8Medical College of Wisconsin, Milwaukee, WI
9Banner MD Anderson Cancer Center, Gilbert, AZ
10University of California San Francisco, San Francisco, CA
11Huntsman Cancer Institute, University of Utah, Salt Lake City, UT
12Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, IL
13John Theurer Cancer Center at Hackensack Meridian Health, HMH School of Medicine, Hackensack, NJ
14Northside Hospital Cancer Institute, Atlanta, GA
15Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA
16Bristol Myers Squibb, Princeton, NJ
17Bristol Myers Squibb, Seattle, WA
18The University of Texas MD Anderson Cancer Center, Houston, TX

*signifies non-member of ASH