Angelo B. A. Laranjeira^1*, Tim Kong, MSc¹, Steven Craig Snyder, PhD^1*, Mary C. Fulbright^1*, Daniel A.C. Fisher, PhD^1*, Daniel T. Starczynowski, PhD² and Stephen T. Oh, MD, PhD³

¹Division of Hematology, Department of Medicine, Washington University School of Medicine, St Louis, MO
²Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
³Department of Medicine, Washington University School of Medicine, Saint Louis, MO

Joseph Kim^1,2, Audrey-Ann Supreme, BS^2,3*, Bailey West, BS^2,4*, Mariah C. Antopia, BS^2,5*, Karen Reddy, PhD^6*, Leslie Cope, PhD^7*, Jung-Hyun Kim, PhD^8*, Raajit K. Rampal, MD, PhD⁹, Richard Koche, PhD^9*, Jerry L. Spivak, MD^2,7, Alison R. Moliterno, MD² and Linda Resar, MD^1,2,4,7,10

¹Cellular and Molecular Medicine Graduate Program, Johns Hopkins University School of Medicine, Baltimore, MD
²Department of Medicine, Division of Hematology, Johns Hopkins University School of Medicine, Baltimore, MD
³Doctoral Diversity Program, Johns Hopkins University School of Medicine, Baltimore, MD
⁴Pathobiology Graduate Program, Johns Hopkins University School of Medicine, Baltimore, MD
⁵The Institute for Basic Biomedical Sciences, Johns Hopkins University School of Medicine, Baltimore, MD
⁶The Johns Hopkins University School of Medicine, Baltimore, MD
⁷Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD
⁸National Cancer Center Korea, Goyang, Korea, Republic of (South)
⁹Human Oncology and Pathogenesis Program, Leukemia Service, Department of Medicine, Center for Epigenetics, Memorial Sloan Kettering Cancer Center, New York, NY
¹⁰Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD

Charlotte K Brierley, bmbch^1,2, Bon Ham Yip^3*, Giulia Orlando^1*, Harsh Goyal^4,5*, Sean Wen, BSc, MSc, PhD^6*, Jeremy Wen³, Max F. Levine^7*, Alba Rodriguez-Meira^1,8,9*, Assunta Adamo^1*, Matthew Bashton^10*, Angela Hamblin, MD, PhD^11*, Sally-Ann Clark, BSc, PhD^6*, Jennifer O Sullivan^1,12*, Lauren Murphy^1*, Aude-Anais Olijnik^1*, Anitria Cotton, MBA, BS^13*, Shilpa Narina^3*, Shondra Pruett-Miller^3*, Amir Enshaei^14*, Claire N Harrison¹⁵, Mark W. Drummond^16*, Steve Knapper^17*, Ayalew Tefferi, MD¹⁸, Ileana antony-Debre^19,20,21*, Supat Thongjuea^1*, Stefan N Constantinescu^4,5, Elli Papaemmanuil^2,7, Bethan Psaila, MD, PhD²², John D. Crispino, PhD, MBA³ and Adam J Mead, MRCP, FRCPath, PhD^6,23

¹Medical Research Council (MRC) Weatherall Institute of Molecular Medicine (WIMM) and NIHR Biomedical Research Centre, University of Oxford, Oxford, United Kingdom
²Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York City
³Division of Experimental Haematology, St Jude Children's Research Hospital, Memphis, TN
⁴Ludwig Institute For Cancer Research, Brussels, Belgium
⁵Nuffield Department of Medicine, University of Oxford, Ludwig Institute for Cancer Research, Oxford, United Kingdom
⁶Medical Research Council (MRC) Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, National Institute for Health Research Biomedical Research Centre, University of Oxford, Oxford, United Kingdom
⁷Isabl Inc., New York, NY
⁸Broad Institute of MIT and Harvard, Cambridge, MA
⁹Department of Cancer Biology, Dana Farber Cancer Institute, Boston, MA
¹⁰The Hub for Biotechnology in the Built Environment, Department of Applied Sciences, Northumbria University, Newcastle-upon-Tyne, United Kingdom
¹¹Cancer and Haematology Centre, The Churchill Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom
¹²Dept of Haematology, Guys and St Thomas’ NHS Foundation Trust, London, United Kingdom
¹³Division of Experimental Hematology, St Jude Children's Research Hospital, Memphis, TN
¹⁴Wolfson Childhood Cancer Research Centre, Newcastle University, Newcastle, United Kingdom
¹⁵Guy’s and St. Thomas’ NHS Foundation Trust, London, ENG, United Kingdom
¹⁶Dept of Haematology, Beatson West of Scotland Cancer Centre, Glasgow, United Kingdom
¹⁷Division of Cancer & Genetics, School of Medicine, Cardiff University, Cardiff, United Kingdom
¹⁸Division of Hematology, Mayo Clinic, Rochester, MN
¹⁹Université Paris-Saclay, Gif-sur-Yvette, France
²⁰INSERM UMR1287, Gustave Roussy, Villejuif, France
²¹Gustave Roussy, Villejuif, France
²²Medical Research Council (MRC) Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, National Institute for Health Research Biomedical Research Centre, University of Oxford, Oxford, ENG, United Kingdom
²³Co-senior author, ., United Kingdom

Nicole D. Vincelette, PhD¹, Xiaoqing Yu, PhD^2*, Andrew T. Kuykendall, MD³, Jungwon Moon^1*, Siyuan Su^4*, Chia-Ho Cheng, PhD^5*, Rinzine Sammut, MD^1*, Hai Vu Nguyen, PhD^6*, Erika Adriana Eksioglu, PhD, MS⁷, Onyee Chan, MD⁸, Najla H Al Ali, MS^8*, Parth C. Patel, DO, MS¹, Dae Hyun Lee^9*, Shima Nakanishi, PhD^10*, Renan Ferreira^11*, Qianxing Mo, PhD^3*, Suzanne Cory^12*, Harshani Lawrence, PhD^11*, Ling Zhang, MD¹³, Daniel Murphy, PhD^14*, Rami S. Komrokji, MD⁸, Daesung Lee, PhD^4*, Scott H. Kaufmann, MD, PhD¹⁵, John L. Cleveland, PhD¹⁶ and Seongseok Yun, MD, PhD⁸

¹Malignant Hematology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL
²Department of Biostatistics and Bioinformatics, Moffitt Cancer Center, Tampa, FL
³Moffitt Cancer Center, Tampa, FL
⁴Chemistry, University of Illinois Chicago, Chicago, IL
⁵Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL
⁶Walter and Eliza Hall Institute, Parkville, Australia
⁷Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL
⁸Department of Malignant Hematology, Moffitt Cancer Center, Tampa, FL
⁹University of South Florida, Tampa, FL
¹⁰Tumor Biology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL
¹¹H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL
¹²Walter and Eliza Hall Institute, Pariville, Australia
¹³Department of Pathology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL
¹⁴University of Glasgow, Glasgow, United Kingdom
¹⁵Mayo Clinic, Rochester, MN
¹⁶Department of Tumor Biology, Moffitt Cancer Center, Tampa, FL

Molly Brakhane, MSc¹, Vittorio Abbonante, PhD^2*, Angelo B. A. Laranjeira^3*, Christian Di Buduo, PhD^2*, Brooke Sadler, PhD⁴, Katrina Ashworth^5*, Tim Kong, MSc³, Fan He, PhD³, Mary C. Fulbright^3*, Dong Chen, MD, PhD⁶, Regina Clemens, MD^7*, Elena Pegoraro^8*, Michele P. Lambert, MD, MTR⁹, Kandace Gollomp, MD⁹, Jorge Di Paola, MD⁵, Alessandra Balduini, MD² and Stephen T. Oh, MD, PhD¹⁰

¹Division of Hematology, Washington University at St. Louis, Saint Louis, MO
²University of Pavia, Pavia, ITA
³Division of Hematology, Department of Medicine, Washington University School of Medicine, St Louis, MO
⁴Pediatrics, Washington University School of Medicine, Saint Louis, MO
⁵Department of Pediatrics, Washington University School of Medicine, St Louis, MO
⁶Division of Hematopathology, Mayo Clinic, Rochester, MN
⁷Departmnet of Pediatrics, Washington University at St Louis, St Louis, MO
⁸University of Padova, Padova, ITA
⁹Division of Hematology, Children's Hospital of Philadelphia, Philadelphia, PA
¹⁰Department of Medicine, Washington University School of Medicine, Saint Louis, MO

Billy Truong¹, Monika Toma, PhD^2*, Yong Zhang, MD, PhD^3*, Susan Shinton^4*, Muheng Li^4*, Xiang Hua, MS^5*, Dietmar Kappes, PhD^5*, Paul Shapiro, PhD^6*, Tomasz Skorski, MD, PhD² and David L. Wiest, PhD⁷

¹Fox Chase Cancer Center, Fox Chase Cancer Center, Philadelphia, PA
²Fels Cancer Institute for Personalized Medicine, Temple University School of Medicine, Philadelphia, PA
³Penn State Health Milton S. Hershey Medical Center, Hershey
⁴Nuclear Dynamics and Cancer Program, Fox Chase Cancer Center, Philadelphia, PA
⁵Transgenic Animal Facility, Fox Chase Cancer Center, Philadelphia, PA
⁶School of Pharmacy, University of Maryland, Baltimore, MD
⁷Fox Chase Cancer Center, Temple Health, Philadelphia, PA