-Author name in bold denotes the presenting author
-Asterisk * with author name denotes a Non-ASH member
Clinically Relevant Abstract denotes an abstract that is clinically relevant.

PhD Trainee denotes that this is a recommended PHD Trainee Session.

Ticketed Session denotes that this is a ticketed session.

622.O2.6 622. Lymphomas: Translational – Non-Genetic: Elucidating Biomarkers and Mechanisms of Therapy in Lymphoma

Symposia: Lymphomas: Translational–Non-Genetic Program: Oral and Poster Abstracts
Type: Oral
Hematology Disease Topics & Pathways:
Research, Fundamental Science, Biological therapies, Antibody Therapy, Translational Research, Lymphomas, non-Hodgkin lymphoma, Bispecific Antibody Therapy, B Cell lymphoma, Chimeric Antigen Receptor (CAR)-T Cell Therapies, Checkpoint Inhibitor, Diseases, indolent lymphoma, immune mechanism, aggressive lymphoma, Therapies, Immunotherapy, immunology, Lymphoid Malignancies, Monoclonal Antibody Therapy, Biological Processes, molecular biology
Sunday, December 10, 2023: 9:30 AM-11:00 AM
Grand Hall C (Manchester Grand Hyatt San Diego)
Moderators:
Jean L. Koff, MD, MSc, Emory University School of Medicine and Amy Duffield, MD, PhD, Icahn School of Medicine at Mount Sinai Hospital
Disclosures:
Koff: Viracta Therapeutics: Research Funding; BeiGene: Consultancy.
This Session Will Describe Molecular and Cellular Biomarkers of Potential Prognostic Significance, as well as Identify Genetic and Molecular Mechanisms of Response to Immune and Cellular Therapies for Lymphoid Malignancies.
9:30 AM

Jon E. Arnason, MD1, Jurriaan Brouwer-Visser2*, Stefano Luminari, MD3, David Tucker4*, Tae Min Kim, MD, PhD5*, Won Seog Kim, MD6*, Laura Magnano, MD, PhD7*, Dylan Sun2*, Jessica Cai2*, Kamil Cygan2*, Srikanth Ambati2*, Hesham Mohamed2, Aafia Chaudhry2 and Vladimir Jankovic2*

1Beth Israel Deaconess Medical Center, Boston, MA
2Regeneron Pharmaceuticals, Inc., Tarrytown, NY
3Azienda Unità Sanitaria Locale-IRCCS, Reggio Emilia, Italy
4Royal Cornwall Hospital, Cornwall, United Kingdom
5Seoul National University Hospital, Seoul, Korea, Republic of (South)
6Samsung Medical Center, Center for Hematologic Malignancy, Seoul, Korea, Republic of (South)
7Department of Hematology, Hospital Clínic, Barcelona, Barcelona, Spain

9:45 AM

Dylan J. Tatterton, MSc1*, Benjamin Sale, MSc1*, Joel Allen, PhD2*, Maddy L. Newby, BSc (Hons)2*, Giorgia Chiodin, PhD1*, Patrick J. Duriez, PhD1*, John Butler2*, Katy J. McCann, PhD1*, David W. Scott, MBChB, PhD3, Ryan Morin, PhD4, Andrew S. Davies, BSc (Hons) BM (Hons) PhD FRCP5*, Dean J. Bryant, PhD1*, Freda K. Stevenson, DPhil1, Max Crispin, DPhil, FRSB, FRSC, FHEA2* and Francesco Forconi, MD, PhD, DM, FRCPath1,6*

1School of Cancer Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom
2Biological Sciences, University of Southampton, Southampton, United Kingdom
3Centre for Lymphoid Cancer, British Columbia Cancer Agency, Vancouver, BC, Canada
4Genome Sciences Center, BC Cancer Research Institute, Vancouver, BC, Canada
5Southampton Experimental Cancer Medicine Centre, University of Southampton, Southampton, United Kingdom
6Department of Haematology, Southampton University Hospital Trust, Southampton, United Kingdom

10:00 AM

Zijun Y. Xu-Monette, PhD1*, Yong Li, PhD2, Thomas Snyder3*, Tiantian Yu, PhD4*, Tingxun LU4*, Alexandar Tzankov5*, Carlo Visco, MD6*, Govind Bhagat, MD7, Wenbin Qian8*, Karen Dybkaer, PhD, MSC9*, April Chiu, MD10*, Wayne Tam, MD11, Youli Zu, MD, PhD12*, Eric D. Hsi, MD13, Frederick Hagemeister14*, Heounjeong Go15*, Maurilio Ponzoni, MD16, Andrés José María Ferreri, MD17, Michael Møller18*, Benjamin M. Parsons, DO19, Joannes H.J.M. Van Krieken, PhD, MD20*, Yingjun Wang, MD21*, Miguel Angel Piris, PhD, MD22*, Jane Winter23, Qingyan Au24*, Ilan Kirsch25*, Mingzhi Zhang, MD26*, John D Shaughnessy, Jr, PhD27*, Bing Xu28* and Ken H. Young, MD, PhD29

1Department of Pathology, Duke University Medical Center, Durham, NC
2Medicine, Baylor College of Medcine, Houston, TX
3Adaptive Biotechnologies, Seattle, WA
4Duke University, Durham, NC
5Medical University Basel, Basel, Switzerland
6University of Verona, Verona, ITA
7Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York
8The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
9Aalborg University Hospital, Aalborg, Denmark
10Mayo Clinic, Rochester, MN
11Well Cornell Medical College, New York, NY
12Houston Methodist Hospital, Houston, TX
13Wake Forest Baptist Medical Center, Winston Salem, NC
14Department of Lymphoma/Myeloma, The University of Texas MD Anderson Cancer Cente, Houston, TX
15Asan Medical Center Children's Hospital, Seoul, KOR
16Pathology Unit, San Raffaele H. Scientific Institute, Milano, Italy
17Unit of Lymphoid Malignancies, Department of Onco-Haematology, IRCCS San Raffaele Scientific Institute, Milano, Italy
18Odense University Hospital, Odense, Denmark
19Gundersen Lutheran Health System, La Crosse, WI
20University Hospital Nijmegen, Nijmegen, NLD
21The first affiliated hospital of Zhengzhou University, Zhengzhou, CHN
22Hospital Universitario Marques Valdecilla, Santander, Cantabria, ESP
23Robert H. Lurie Comp. Cancer Center, Chicago, IL
24NeoGenomics Laboratories, Aliso Viejo, CA
25Adaptive Biotechnologies, Seattle
26the First Affiliated Hospital of Zhengzhou University, Zhengzhou, CHN
27University of Arkansas For Medical Sciences, Little Rock, AR
28The First Affiliated Hospital of Xiamen University and Institute of Hematology, Xiamen, China
29Duke Cancer Institute, Duke University Medical Center, Durham, NC

10:15 AM

Yoshiaki Abe, MD, PhD1*, Junko Zenkoh2*, Daisuke Ikeda3*, Sawa Aya4*, Daisuke Kaji, MD, PhD5*, Rikako Tabata6*, Ryota Matsuoka, MD, PhD7*, Manabu Fujisawa8*, Kenichi Makishima, MD, PhD9*, Sakurako Suma, MD, PhD9*, Keiichiro Hattori10*, Yasuhito Suehara, MD, PhD11*, Tatsuhiro Sakamoto12*, Chikashi Yoshida13*, Hiroko Bando14*, Ayako Suzuki2*, Yasunori Ota, MD, PhD15*, Yoshihito Otsuka16*, Kosei Matsue6, Shigeru Chiba12*, Yutaka Suzuki, PhD17* and Mamiko Sakata-Yanagimoto12

1Department of Hematology, Institute of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan
2The University of Tokyo, Tokyo, Japan
3Division of Hematology/Oncology, Kameda Medical Center, Kamogawa-Shi, CHI, Japan
4Department of Breast-Thyroid-Endocrine Surgery, University of Tsukuba Hospital, Tsukuba, Japan
5Department of Hematology, Toranomon Hospital, Tokyo, Japan
6Division of Hematology/Oncology, Kameda Medical Center, Chiba, Japan
7Department of Pathology, Institute of Medicine, University of Tsukuba, Tsukuba, Japan
8Centre for Lymphoid Cancer, British Columbia Cancer, Vancouver, Canada
9Department of Hematology, University of Tsukuba Hospital, Tsukuba, Ibaraki, Japan
10Department of Hematology, University of Tsukuba Hospital, Washington, DC
11University of Tsukuba Hospital, Tsukuba, Japan
12Department of Hematology, Institute of Medicine, University of Tsukuba, Tsukuba, Japan
13National Hospital Organization Mito Medical Center, Mito, Japan
14Department of Breast and Endocrine Surgery, University of Tsukuba, Tsukuba, Japan
15Department of Pathology, The Institute of Medical Science Research Hospital, The University of Tokyo, Tokyo, Japan
16Department of Clinical Laboratory, Kameda Medical Center, Kamogawa, Japan
17Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Japan

10:30 AM

Jon Celay, PhD1*, Miriam Recalde, PhD2*, María Victoria Revuelta, PhD3*, Marta Larrayoz, PhD2*, Sara Rodriguez, PhD2*, Maria J Garcia-Barchino, PhD2*, Jennifer R. Chapman-Fredricks, MD4*, Teresa Lozano, PhD5*, Juan J Lasarte, PhD5*, Ming Q. Du, MD6*, Izidore S. Lossos, MD7, Sergio Roa, PhD8*, Aldo Roccaro, MD, PhD9, Miguel Canales10*, Felipe Prosper, MD, PhD11, Bruno Paiva11*, Leandro Cerchietti, MD12 and Jose A. Martinez-Climent, MD/PhD2

1Hematology and Oncology Program, Centre for Applied Medical Research (CIMA), Instituto de Investigaciones Sanitarias de Navarra (IdiSNA), Cancer Center Clinica Universidad de Navarra (CCUN), Pamplona, Navarra, Spain
2Center for Applied Medical Research, Clinica University of Navarra Cancer Center, University of Navarra, Pamplona, Spain
3Weill Cornell Medicine, New York, NY
4Department of Pathology and Laboratory Medicine, University of Miami, Miami, FL
5Immunology and Immunotherapy Program. Cima Universidad de Navarra. IdiSNA., Pamplona, Spain
6Division of Cellular and Molecular Pathology, Department of Pathology, University of Cambridge, Cambridge, United Kingdom
7Sylvester Comprehensive Cancer Center, Division of Hematology, University of Miami School of Medicine, Miami, FL
8Department of Biochemistry and Genetics, University of Navarra, Pamplona, Spain
9Clinical Trial Center, Translational Research and Phase I Unit, ASST Spedali Civili di Brescia, Brescia, BS, Italy
10Department of Hematology, Clínica Universidad de Navarra; Hematology and Oncology Program, Center for Applied Medical Research (CIMA); Instituto de Investigaciones Sanitarias de Navarra (IdiSNA), Pamplona, Spain
11Cancer Center Clinica Universidad de Navarra, Centro de Investigación Médica Aplicada (CIMA), IDISNA, CIBER-ONC number CB16/12/00369 and CB16/12/00489, Pamplona, Spain
12Department of Medicine, Division of Hematology & Medical Oncology, Weill Cornell Medical College, New York, NY

10:45 AM

Yusuke Isshiki, MD, PhD1, Patrizia Porazzi, PhD2*, Xi Chen, PhD3*, Matthew Teater, PhD1*, Ioannis Karagiannidis, PhD3*, Henna S. Nam, BS1*, Ari M Melnick, MD1, Marco Ruella, MD4 and Wendy Beguelin, PhD5*

1Department of Medicine, Division of Hematology and Medical Oncology, Weill Cornell Medicine, New York, NY
2Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA
3Department of Medicine, Weill Cornell Medicine, New York, NY
4Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA
5Department of Medicine, Weill Cornell Medical College, New York, NY

*signifies non-member of ASH