Vignesh Shanmugam, MD^1,2, Neriman Tokcan, PhD^3,4*, Daniel Chafamo^5*, Sean Sullivan^4*, Haley Martin^6*, Gail A Newton, PhD^6*, Mehdi Borji, MS^4*, Naeem Nadaf^4*, Irving Barrera^4*, Dylan Cable, PhD^4,7*, Jackson Weir^4,8*, Orr Ashenberg, PhD^5*, Caroline Uhler, PhD^4,9,10*, Geraldine Pinkus, MD^1*, Scott Rodig, MD, PhD¹, Margaret A. Shipp, MD¹¹, Evan Macosko, MD, PhD^4,12*, Abner Louissaint, MD, PhD^13*, Fei Chen, PhD^4,14* and Todd R. Golub, MD^4,15,16*

¹Department of Pathology, Brigham and Women's Hospital, Boston, MA
²Cancer Program, Broad Institute of MIT and Harvard, Cambridge, MA
³Department of Mathematics, University of Massachusetts Boston, Boston, MA
⁴Broad Institute of MIT and Harvard, Cambridge, MA
⁵Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA
⁶Department of Pathology, Massachusetts General Hospital, Boston, MA
⁷Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA
⁸Biological and Biomedical Sciences Program, Harvard University, Cambridge, MA
⁹Laboratory for Information & Decision Systems, Massachusetts Institute of Technology, Cambridge, MA
¹⁰Institute for Data, Systems, and Society, Massachusetts Institute of Technology, Cambridge, MA
¹¹Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
¹²Department of Psychiatry, Massachusetts General Hospital, Boston, MA
¹³Massachusetts General Hospital, Boston, MA
¹⁴Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA
¹⁵Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA
¹⁶Division of Pediatric Hematology/Oncology, Boston Children's Hospital, Boston, MA

Ilja Kalashnikov, MD^1*, Veronica Russell^2*, Panu Kovanen, MD, PhD^3*, Johannes Dunkel, MD, PhD^3*, Marja-Liisa Karjalainen-Lindsberg, MD, PhD^3*, Annika Pasanen, MD, PhD^4*, Rachel Kositsky, PhD^5*, Sarah L. Ondrejka, DO⁶, Tanu Goyal, MD^7*, Eric D. Hsi, MD⁸, Mette Ølgod Pedersen, MD^9*, Anne Ortved Gang, MD^10*, Magdalena Czader, MD, PhD^11*, Jiehao Zhou^12*, Mina Xu, MD^13*, Nathan Paulson^13*, Jean L. Koff, MD, MSc¹⁴, Andrew G Evans, MD, PhD^15*, Yasodha Natkunam, MD, PhD¹⁶, Ridas Juskevicius, MD¹⁷, Abner Louissaint, MD, PhD^18*, Elizabeth Thacker^19*, Tushar Dave^2*, Cassandra L. Love², Chad M McCall, MD, PhD^20*, Choon Kiat Ong, PhD, BSc^21*, Michael Churnetski, BS^22*, Haley Martin^23*, Jennifer R. Chapman-Fredricks, MD^24*, Javeed Iqbal, PhD, MSc^25*, Amy Chadburn, MD²⁶, Payal Sojitra^27*, Amir Behdad, MD^28*, William Choi, MBBS, MRCP²⁹, Jie Xu, MD PhD^30*, Emily F. Ferguson Mason, MD, PhD^17*, Kikkeri N Naresh³¹, Yuri D. Fedoriw, MD^32*, Dina Sameh Soliman, MD, MBBS, MSc³³, Sandeep Dave, M.D.^34* and Sirpa Leppä, Professor^1,4

¹University of Helsinki, Helsinki, Finland
²Duke University, Durham, NC
³Department of Pathology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
⁴Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland
⁵AstraZeneca, Waltham, MA
⁶Department of Laboratory Medicine, Cleveland Clinic, Cleveland, OH
⁷Cleveland Clinic, Cleveland, OH
⁸Department of Pathology, Wake Forest Baptist Medical Center, Winston Salem, NC
⁹Herlev hospital, Herlev, DNK
¹⁰Copenhagen University Hospital, Herlev, Denmark
¹¹Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN
¹²Indiana University, Indianapolis, IN
¹³Yale University, New Haven, CT
¹⁴Winship Cancer Institute, Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA
¹⁵Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY
¹⁶Stanford Univ. Med. Ctr., Stanford, CA
¹⁷Vanderbilt University Medical Center, Nashville, TN
¹⁸Massachusetts General Hospital, Boston, MA
¹⁹Data Driven Bioscience, Durham, NC
²⁰Carolinas Pathology Group, Charlotte, NC
²¹National Cancer Centre Singapore, Singapore, Singapore, SGP
²²Emory University, Atlanta, GA
²³Department of Pathology, Massachusetts General Hospital, Boston, MA
²⁴University of Miami Miller School of Medicine, Miami, FL
²⁵Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE
²⁶Department of Pathology and Laboratory Medicine, Weill Cornell Medicine/New York Presbyterian Hospital, New York, NY
²⁷Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ
²⁸Regents of The University of Michigan, Ann Arbor, MI
²⁹Tuen Mun Hospital, Happy Valley, NA, HKG
³⁰Department of Hematopathology, The University of Texas M.D. Anderson Cancer Center, Houston, TX
³¹Fred Hutchinson Cancer Center, Seattle, WA
³²University of North Carolina, Chapel Hill, NC
³³HMC-Qatar, Doha, QAT
³⁴Duke University Medical Center, Durham, NC

Stefan K. Alig, MD¹, Mohammad Shahrokh Esfahani, PhD^1*, Andrea Garofalo¹, Michael Yu Li, BS^2*, Cédric Rossi, MD, PhD^3,4, Timothy Flerlage, MD^5*, Jamie E. Flerlage, MD, MS⁶, Ragini Adams^7*, Michael S. Binkley, MD, MS^8*, Navika Shukla, MD¹, Michael Jin, BS^1*, Mari Olsen^1*, Adele Telenius, MPhil, BSc^2*, Jurik A Mutter, PhD^1*, Joseph G Schroers-Martin, MD¹, Brian J. Sworder, MD, PhD⁹, Shinya Rai, MD, PhD^2*, Daniel King, MD^1*, Andre Schultz, PhD^1*, Jan Lukas Bögeholz, MD^1*, Shengqin Su^10*, Karan R Kathuria^1*, Chih Long Liu^1*, Xiaoman Kang^1*, Deanna M. Langfitt, PhD^11*, Kristine Faye Pobre-Piza^12*, Feng Tian^1*, Maya J. Strohband^1*, Valeria Spina^13*, Thomas Tousseyn^14*, Lieselot Buedts^15*, Luc-Matthieu Fornecker, MD, PhD^16*, Sharon M. Castellino, MD, MSc¹⁷, Ranjana H. Advani, MD¹, Davide Rossi¹³, Ryan C Lynch, MD¹⁸, Herve Ghesquieres, MD, PhD^19*, Olivier Casasnovas, MD^20*, David M. Kurtz, MD, PhD¹, Lianna J. Marks, MD²¹, Michael P. Link, MD²¹, Marc Andre, MD^22*, Peter Vandenberghe, MD, PhD²³, Christian Steidl, MD, PhD², Maximilian Diehn, MD, PhD^24* and Ash A. Alizadeh, MD, PhD¹

¹Department of Medicine, Divisions of Oncology and Hematology, Stanford University, Stanford, CA
²Centre for Lymphoid Cancer, BC Cancer, Vancouver, BC, Canada
³Stanford University, Stanford, CA
⁴CHU Dijon, Dijon, France
⁵Department of Oncology, St Jude Children's Research Hospital, Memphis, TN
⁶Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN
⁷Department of Pediatrics, Division of Pediatric Hematology and Oncology, Stanford University, Stanford, CA
⁸Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA
⁹Division of Oncology, Department of Medicine, Stanford University, Irvine, CA
¹⁰Department of Radiation Oncology, Stanford University School of Medicine, Palo Alto, CA
¹¹Department of Bone Marrow Transplant and Cellular Therapy, St. Jude Children's Research Hospital, Memphis, TN
¹²Department of Infectious Diseases, St Jude Children's Research Hospital, Memphis, TN
¹³Oncology Institute of Southern Switzerland, Bellinzona, Switzerland
¹⁴Department of Imaging & Pathology, KU Leuven, Leuven, Belgium
¹⁵Department of Human Genetics, KU Leuven, Leuven, Belgium
¹⁶Hematology Department, Institut De Cancérologie Strasbourg Europe, Strasbourg, France
¹⁷Department of Pediatrics, Emory University School of Medicine, Atlanta, GA
¹⁸Division of Hematology and Oncology, University of Washington, Seattle, WA
¹⁹Centre Hospitalier Lyon Sud, Lyon, France
²⁰Department of Hematology, Centre Hospitalier Universitaire Dijon, Dijon, France
²¹Department of Pediatrics, Division of Pediatric Hematology and Oncology, Stanford University, Palo Alto, CA
²²Department of Hematology, Clinique de Mont-Godinne, Yvoir, Belgium
²³Department of Hematology, Department of Human Genetics, University Hospitals Leuven, KU Leuven, Leuven, Belgium
²⁴Department of Radiation Oncology, Stanford University, Stanford, CA

Matias Autio^1,2*, Suvi-Katri Leivonen, PhD^1,2, Marja-Liisa Karjalainen-Lindsberg, MD, PhD^3*, Teijo Pellinen, PhD^4* and Sirpa Leppä, Professor^1,2

¹University of Helsinki, Helsinki, Finland
²Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland
³Department of Pathology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
⁴Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland

Kanutte Huse, PhD^1,2*, Yngvild Blaker, MD PhD^1*, Jillian Frances Wise, PhD^1*, Ankush Sharma, PhD^1*, Leo Meriranta, MD^3*, Kathrine Thuestad Isaksen, MD^1,2*, Ivana Spasevska, PhD^1,2*, Sigve Nakken, PhD^4*, Vera Hilden^1,2*, Mette Førsund^5*, Sirpa Leppä, Professor³, Erlend B. Smeland^5*, Harald Holte, MD, PhD⁶ and June Helen Myklebust, PhD^1,2

¹Institute for Cancer Research, Oslo University Hospital, Oslo, Norway
²Precision Immunotherapy Alliance, University of Oslo, Oslo, Norway
³Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland
⁴University of Oslo, Oslo, Norway
⁵Oslo University Hospital, Oslo, Norway
⁶Department of Oncology, Oslo University Hospital, Oslo, NOR

Tobias Wertheimer^1,2*, Hosna Baniadam, MSc^3*, Stefanie Reisenauer^4*, Marcel Pohly^5,6*, Lukas Rindlisbacher^7*, Minqi Lin^7*, Stefanie Kreutmair^7*, Susanne Unger^8*, Jarno Kivioja, PhD^9*, Andreas Moor^6*, Burkhard Becher^10*, Wolfgang Huber^11* and Thorsten Zenz¹²

¹Institute for Experimental Immunology, University of Zurich, Zurich, NY, Switzerland
²Department for Medical Oncology and Hematology, University Hospital Zurich, Zurich, Switzerland
³European Molecular Biology Laboratory, Heidelberg, Germany
⁴University Hospital Zurich, Zurich, Switzerland
⁵University Hospital Zurich, Switzerland, Zurich, CHE
⁶Dep. of Biosystems Science and Eng., ETH Zurich, Zurich, Switzerland
⁷University of Zurich, Zurich, Switzerland
⁸University of Zurich, Zurich, AL, CHE
⁹University Hospital Zurich, Zürich, ZH, CHE
¹⁰University of Zurich, Zurich, CHE
¹¹Genome Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany
¹²Department of Medical Oncology and Hematology, University Hospital Zurich, Zurich, Switzerland