Camille Vaganay^1*, Frank Ling^1*, Lois M. Kelly^2*, Duong Ho Nhat^2*, Antoine Forget, Ph.D.^3*, Paul-Arthur Meslin^1*, Hélène Pasquer, M.D.^4*, Rathana Kim, Pharm.D.^5*, Marie Passet, Pharm.D. / Ph.D.^6*, Sofiane Fodil, M.D.^7*, Tony Huynh, MD^8*, Angela H Su^9*, Christopher F Bassil, Ph.D.^10*, Matthieu Duchmann, M.D. / Ph.D.^11*, Gabriela Alexe, PhD^12*, Gael Fortin^13*, Carine Legrand, Ph.D.^2*, Khansa Saadallah^14*, Christopher Delaney^15*, Kim Pacchiardi^16*, Anja Kocijancic^2*, Lisa Aziez^17*, Nina Fenouille, Ph.D.^1*, Marie Sebert, MD, PhD^18*, Lionel Ades, MD, PhD¹⁹, Emmanuel Raffoux, M.D.^20*, Emmanuelle Clappier, Pharm.D., Ph.D.^21*, Lina Benajiba, MD, PhD¹⁶, Kimberly Stegmaier, MD⁹, Kris C. Wood, Ph.D.^22*, Raphael Itzykson, M.D. / Ph.D.²³, Camille Lobry, Ph.D.^16* and Alexandre Puissant, Ph.D.²⁴

¹St Louis Hospital, INSERM U944, Paris, FRA
²St Louis Hospital, INSERM U944, PARIS, France
³Department of Cellular and Molecular Pharmacology (UCSF), Nevan Krogan's lab, San Francisco, CA
⁴St Louis Hospital, INSERM U944, PARIS, FRA
⁵Assistance Publique Des Hopitaux De Paris (AP-HP) - Universite Paris Descartes -, Paris, Ile-de-France, FRA
⁶APHP, Paris, FRA
⁷St Louis Hospital, AP-HP, PARIS, France
⁸Université De Paris, Institut Cochin, CNRS UMR8104, INSERM U1016, Paris,, Paris, FRA
⁹Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA
¹⁰Department of Pharmacology and Cancer Biology, Kris Wood's lab, Durham, NC
¹¹Institut de Recherche Saint-Louis (IRSL), Institut National de la Santé et de la Recherche Médicale (INSERM), Centre National de la Recherche Scientifique (CNRS), Université Paris Cité, Paris, France
¹²Pediatric Oncology, Dana-Farber Cancer Institute, Boston
¹³INSERM U944, Paris, FRA
¹⁴Cytomorpholab, PARIS, France
¹⁵Duke University School of Medicine, Durham, NC
¹⁶St Louis Hospital, INSERM U944, Paris, France
¹⁷Cochin Institute, PARIS, France
¹⁸Hematology department, Saint-Louis Hospital, Paris, France
¹⁹Institut de Recherche Saint-Louis, INSERM UMR 944, Paris, France
²⁰Service d’Hématologie Clinique, Hôpital Saint-Louis, Paris, FRA
²¹Laboratoire d'Hématologie, Université Paris Cité, Assistance Publique des Hôpitaux de Paris Nord, Hôpital Saint-Louis, Paris, France
²²Department of Pharmacology and Cancer Biology, Duke University, Durham, NC
²³UMR7212/U944, Institut National de la Santé et de la Recherche Médicale, Saint-Louis Institute, University Paris 7, Paris, France
²⁴INSERM U944, Saint-Louis Research Institute, Paris, France

Li Du, PhD^1,2,3, Jiamin Guo, MSc^2,4, Zhenhua Chen, PhD^5*, Jianjun Chen, PhD⁵, Guido Marcucci, MD⁶ and Steven T. Rosen, MD^7,8

¹Judy and Bernard Briskin Center for Multiple Myeloma Research, Beckman Research Institute City of Hope, Duarte, CA
²Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA
³Toni Stephenson Lymphoma Center, Beckman Research Institute City of Hope, Duarte, CA
⁴Irell & Manella Graduate School of Biological Sciences, Beckman Research Institute, City of Hope, Duarte, CA
⁵Department of Systems Biology, Beckman Research Institute, City of Hope, Monrovia, CA
⁶Department of Hematologic Malignancies Translational Science, Gehr Family Center for Leukemia Research, City of Hope National Medical Center and Beckman Research Institute, Duarte, CA
⁷Department of Hematology and HCT, City of Hope Comprehensive Cancer Center, Duarte, CA
⁸Department of Hematology and Hematopoietic Cell Transplantation, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA

Priyanka Sharma, PhD¹, Lauren B. Ostermann, BSc^1*, Sujan Piya, PhD^1*, Baozhen Ke, BS^1*, Natalia Baran, MD, PhD, MSc², Anudishi Tyagi, PhD^3*, Muharrem Muftuoglu, MD¹, Mahesh Basyal, BSc^4*, Qi Zhang, PhD^3*, Joanne Munck, PhD^5*, Kim-Hien Dao, DO, PhD^6*, Martin Sims, PhD^5*, Bing Z. Carter, PhD¹, Venkata Lokesh Battula, PhD⁷, Michael Andreeff, MD PhD³ and Gautam Borthakur, MD³

¹Section of Molecular Hematology and Therapy, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
²The University of Texas MD Anderson Cancer Center, Houston, TX
³Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
⁴Department of Leukemia, Section of Molecular Hematology and Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX
⁵Astex Pharmaceuticals, Cambridge, United Kingdom
⁶Astex Pharmaceuticals, Inc., Pleasanton, CA
⁷Department of Leukemia, UT MD Anderson Cancer Center, Houston, TX

Kedwin Ventura, MS^1*, Josh Prokopec^2*, Biswas Neupane, PhD^1*, Zhenxia Gao^1*, Wei Du, MD^1*, Yinan Gong, PhD^2* and Sawa Ito, MD¹

¹Hematology and Oncology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA
²Hillman Cancer Center/Department of Immunology, University of Pittsburgh, Pittsburgh, PA

Satoshi Kaito, MD, PhD^1*, Kazumasa Aoyama, PhD^1*, Motohiko Oshima, PhD^1*, Karl Agger, PhD^2*, Kristian Helin, PhD^2*, Yasuhito Nannya, MD, PhD³, Seishi Ogawa⁴, Atsuya Nishiyama, PhD^5*, Makoto Nakanishi, MD, PhD^5* and Atsushi Iwama, MD, PhD¹

¹Division of Stem Cell and Molecular Medicine, Center for Stem Cell Biology and Regenerative Medicine, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan
²BRIC, University of Copenhagen, Copenhagen, Denmark
³Division of Hematopoietic Disease Control, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan
⁴Department of Pathology and Tumor Biology, Kyoto University Graduate School of Medicine, Sakyoku, KYO, Japan
⁵Division of Cancer Cell Biology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan

Zhixiang Chen, MD^1,2*, Yuanhua Cai, MD, PhD^1,2*, Xiaolin Lai, MD, PhD^2*, Xuechun Wang, PhD^3*, Xiongbin Yan, MD^1,2*, Yaping Wang, MD, PhD^1,2*, Fuquan Tu, MD, PhD^2,4*, Wanting Wu, MD^1,2*, Yang Li, MD, PhD^1,2*, Lili Pan, MD, PhD^2*, Yi Zheng, MD^2*, Jinggang Li, MD, PhD^2*, Xiaofan Li, MD, PhD^1,2 and Shaoyuan Wang, MD^1,2*

¹Union Clinical Medical Colleges, Fujian Medical University, Fuzhou, China
²Department of Hematology, Fujian Institute of Hematology, Fujian Provincial Key Laboratory on Hematology, Fujian Medical University Union Hospital, Fuzhou, China
³Department of Hematology, Fujian Institute of Hematology, Fujian Provincial Key Laboratory on Hematology, Fujian Medical University Union Hospital, Fuzhou, NJ, China
⁴Emergency Intensive Care Unit, Fujian Medical University Union Hospital, Fuzhou, China