Xin He, MD^1*, Lei Zhang, MD^2*, Yang Li^3*, Haojie Dong, PhD^4*, Lianjun Zhang, PhD^5*, Daisuke Nakada, PhD⁶, Guido Marcucci, MD^5,7,8, Yun Luo^9* and Ling Li, PhD⁴

¹City of Hope National Medical Center, Monrovia, CA
²City of Hope National Medical Center, Monrovia
³city of hope, monrovia, CA
⁴Department of Hematological Malignancies Translational Science, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA
⁵Department of Hematologic Malignancies Translational Science, Gehr Family Center for Leukemia Research, City of Hope National Medical Center and Beckman Research Institute, Duarte, CA
⁶Department of Molecular & Human Genetics, Baylor College of Medicine, Houston, TX
⁷Hematology/HCT, City of Hope National Medical Center, Duarte, CA
⁸Department of Hematological Malignancies Translational Science, Gehr Family Center for Leukemia Research, Hematologic Malignancies and Stem Cell Transplantation Institute, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA
⁹College of Pharmacy, Western University of Health Sciences, Pomona

Qingyu Luo, PhD¹, Evangeline G. Raulston^1*, Miguel A. Prado, PhD^2,3*, Xiaowei Wu, PhD^4,5*, Kira Gritsman, MD, PhD^6,7, Kezhi Yan, PhD^1*, Christopher A. G. Booth, PhD^1*, Ran Xu, PhD^1*, Peter van Galen, PhD⁸, John G. Doench, PhD^9*, Shai Shimony, MD^1,10*, Henry W. Long, PhD^11*, Donna S. Neuberg, ScD¹², Joao A. Paulo, PhD^3* and Andrew A. Lane, MD, PhD¹

¹Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA
²Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Spain
³Department of Cell Biology, Harvard Medical School, Boston, MA
⁴Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA
⁵Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA
⁶Department of Medical Oncology, Montefiore Medical Center, Bronx, NY
⁷Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY
⁸Division of Hematology, Brigham and Women's Hospital, Boston, MA
⁹Genetic Perturbation Platform, Broad Institute of MIT and Harvard, Cambridge, MA
¹⁰Department of Hematology, Rabin Medical Center, Tel Aviv Faculty of Medicine, Tel Aviv, Israel
¹¹Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA
¹²Department of Data Science, Dana-Farber Cancer Institute, Boston, MA

Thomas Koehnke, MD^1,2, Daiki Karigane, MD, PhD^1,2*, Eleanor Hilgart^3*, Kensuke Kayamori, MD, PhD^1,2*, Amy C Fan, PhD^1,4*, Cailin T Collins^1,2, Fabian P Suchy, PhD^1,2*, Athreya S Rangavajhula^1,4*, Yang Feng, PhD^1,2, Yusuke Nakauchi, MD, PhD^1,2*, Eduardo Martinez-Montes^3*, Michael Koldobskiy, MD, PhD^3*, Andy Feinberg, MD, MPH^3* and Ravi Majeti, MD^2,5

¹Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA
²Cancer Institute, Stanford University School of Medicine, Stanford, CA
³Center for Epigenetics, Johns Hopkins University School of Medicine, Baltimore, MD
⁴Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA
⁵Stanford Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, CA

Bac Viet Le, PhD^1*, Umeshkumar Vekariya, PhD^1*, Monika Toma, PhD^1*, Margaret Nieborowska-Skorska, MD, PhD^1*, Marie-Christine Caron, PhD^2*, George Vassiliou, FRCPath, MRCP, PhD, MBBS³, Malgorzata Gozdecka, PhD^4*, Zayd Haydar^1*, Gurushankar Chandramouly, PhD^5*, Emir Hadzijusufovic, DVM^6,7*, Wolfgang R. Sperr, MD^6,7*, Richard Pomerantz, PhD^5*, Peter Valent, MD^6,8, Jean-Yves Masson, PhD^2*, Gaorav Gupta, MD, PhD^9*, Grant A Challen, PhD¹⁰ and Tomasz Skorski, MD, PhD¹

¹Fels Cancer Institute for Personalized Medicine, Temple University School of Medicine, Philadelphia, PA
²Laval University Cancer Research Center, Quebec City, Canada
³Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, United Kingdom
⁴Wellcome Trust Sanger Institute, Cambridge, ENG, GBR
⁵Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA
⁶Department of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, Vienna, Austria
⁷Ludwig Boltzmann Institute for Hematology and Oncology, Medical University of Vienna, Vienna, Austria
⁸Ludwig Boltzmann Institute for Hematology and Oncology, Vienna, Austria
⁹UNC-Chapel Hill, Chapel Hill
¹⁰Washington University School of Medicine In St. Louis, Saint Louis, MO

Leisi Zhang, MD^1*, Mingli Li, PhD^1*, Anthony KN Chan, PhD^1,2*, Qiao Liu, MD, PhD^1*, Hyunjun Kang, PhD^3*, Sheela Pangeni Pokharel^1*, Nicole Mattson^1*, Priyanka Singh, PhD^1*, Lu Yang, PhD^1,2* and Chun-Wei David Chen, PhD^1,2

¹Department of Systems Biology, City of Hope National Medical Center, Duarte, CA
²Division of Epigenetics and Transcriptional Engineering, City of Hope National Medical Center, Duarte, CA
³Department of Hematologic Malignancies Translational Science, City of Hope National Medical Center, Duarte, CA

Xiangguo Shi, PhD¹, Minhua Li^1*, Lin Tan^2*, Zian Liu^3*, Yudan Zhu^4*, Tiessen Jonathan^1*, Jing Zhou^1*, Mengdie Feng^1*, Yuki Kageyama, MD, PhD^1*, Hassan Samee^1*, Kristen Andreozzi^1*, Philip Lorenzi^2*, Koichi Takahashi, MD, PhD⁵, Michalis Agathocleous, PhD⁶ and Daisuke Nakada, PhD¹

¹Department of Molecular & Human Genetics, Baylor College of Medicine, Houston, TX
²Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX
³Department of Integrative Physiology, Baylor College of Medicine, Houston, TX
⁴Department of Molecular & Human Genetics, Baylor College of Medicine, Houston
⁵Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
⁶Children’s Medical Center Research Institute, University of Texas Southwestern Medical Center, Houston, TX