Nicole Prutsch, PhD^1,2, Amélie Vromman, PhD^2,3*, Brittaney Leeper, BS^4*, Mengyu Chen, BS^3*, Shuning He, PhD^1*, Siyang Ren, MS^5*, Christopher J. Walker, PhD^6*, Mark W. Zimmerman, PhD^1*, Mariana Janini Gomes, PhD^3*, Eduardo J. Folco^3*, Philipp J. Rauch, MD^7,8, Prafulla C. Gokhale, PhD^4*, Brian J. Abraham, PhD^9*, Donna S. Neuberg, ScD⁵, Benjamin L. Ebert, MD, PhD^7,8,10, Peter Libby, MD^2,3* and A. Thomas Look, MD^1,2

¹Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA
²equal contribution, Boston
³Department of Medicine, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA
⁴Experimental Therapeutics Core and Belfer Center for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, MA
⁵Department of Data Science, Dana-Farber Cancer Institute, Boston, MA
⁶Karyopharm Therapeutics Inc., Newton, MA
⁷Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
⁸Broad Institute of MIT and Harvard University, Cambridge, MA
⁹Department of Computational Biology, St. Jude Children’s Research Hospital, Memphis, TN
¹⁰Howard Hughes Medical Institute, Boston, MA

Candice Quin, PhD^1*, Erica DeJong, MSc^1*, Amy J. M. McNaughton, PhD^2*, Marco M. Buttigieg, BSc^3*, Salman Basrai^4*, Sagi Abelson^5,6*, Margaret Larche, MBChB, PhD^1*, Michael J. Rauh, MD, PhD² and Dawn ME Bowdish, PhD^7*

¹McMaster University, Hamilton, ON, Canada
²Department of Pathology and Molecular Medicine, Queen's University, Kingston, ON, Canada
³Queen's University, Kingston, ON, Canada
⁴Ontario Institute for Cancer Research, Mississauga, ON, Canada
⁵Ontario Institute for Cancer Research, Toronto, Canada
⁶University Health Network, Princess Margaret Cancer Centre, Toronto, Canada
⁷McMaster University, Hamilton, ON, CAN

Adriana Chiaramida^1*, Sandra G. Obwar^1*, Gabriel K. Griffin, MD^1*, Anja E.H. Nordstrom^2*, Maria Ericsson, PhD^2*, Dilshad H. Khan, PhD^1* and Roger Belizaire, MD, PhD³

¹Department of Pathology, Dana-Farber Cancer Institute, Boston, MA
²Department of Cell Biology, Harvard Medical School, Boston, MA
³Department of Pathology, Dana-Farber Cancer Institute, Inc., Boston, MA

J. Scott Beeler, MD, PhD^1*, Duc Tran^2*, Jie Liu, MBBS, MPH², Zilan Xin^2*, Brian Wiley^2*, Irenaeus C.C. Chan, MSc^2*, Michael H. Kramer, MD, PhD³, Armel L. Batchi-Bouyou, MD^2*, Xiaoyu Zong, MPH^4*, Matthew J. Walter, MD², Sarantis Chlamydas, PhD^5*, Francesca Ferraro², Stephen T. Oh, MD, PhD⁶, Ben Busby, PhD^7*, Daniel C. Link, MD², Yin Cao, ScD, MPH^4* and Kelly L. Bolton, MD²

¹Department of Medicine, Washington University School of Medicine, St. Louis, MO
²Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO
³Division of Oncology, Department of Medicine, Washington University School of Medicine, St Louis, MO
⁴Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine, St. Louis
⁵Olink Proteomics, Uppsala, Sweden
⁶Department of Medicine, Washington University School of Medicine, Saint Louis, MO
⁷DNAnexus, Mountain View, CA

Yifan Zhou, BS, MS^1,2,3*, Diana M Abraham, BA^4*, Taha Bartu Hayal, PhD^5*, Ashley Laurel Gin^5*, Xing Fan, MD, PhD^4*, Byung-Chul Lee, BS, PhD^6,7,8*, Taehoon Shin, PhD^6,9*, Rohan V Hosuru, BS^4*, Elizabeth Lake Potter, PhD^10*, So Gun Hong, DVM, PhD⁵, Mario Roederer, PhD^10*, George Vassiliou, FRCPath, MRCP, PhD, MBBS^1,11,12, Cynthia E. Dunbar, MD⁵ and Chuanfeng Wu, MD, Ph.D^5*

¹Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom
²Translational Stem Cell Biology Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda
³Haematological Cancer Genetics, Wellcome Trust Sanger Institute, Cambridge, United Kingdom
⁴Translational Stem Cell Biology Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD
⁵Translational Stem Cell Biology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD
⁶Translational Stem Cell Biology Branch, National Heart, Lung and Blood Institute, National Institutes of Health, BETHESDA, MD
⁷Department of Biological Sciences, Sookmyung Women’s University, Seoul, Korea, Republic of (South)
⁸Research Institute of Women’s Health, Sookmyung Women’s University, Seoul, Korea, Republic of (South)
⁹Department of Laboratory Animal Medicine, College of Veterinary Medicine, Jeju National University, Jeju, Korea, Republic of (South)
¹⁰Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD
¹¹Department of Haematology, University of Cambridge, Cambridge, United Kingdom
¹²Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, United Kingdom

Johannes Schetelig, MD, MSc^1,2, Frederik Damm, MD^3*, Ulf - Peter Günther, Dr.^4*, Henning Baldauf^2*, Carina Rave^5*, Linda Koster^6*, Gerhard Schöfl, Dr.^4*, Anja Klussmeier, Dr.^4*, Kamal Menghrajani, MD⁷, Kelly L. Bolton, MD⁸, Elke Rücker-Braun, PhD^2,9*, Falk Heidenreich, PhD^9,10*, Marie Münn^4*, Markus Fuhrmann^4*, Ilaria Visco^4*, Mareike Frick, MD^11*, Raphael Hablesreiter^12*, Christopher Maximilian Arends^12*, Liesbeth C. de Wreede, PhD^13*, Olena Nesterenko, MD^14*, Matthias Stelljes, MD¹⁵, Gesine Bug, MD^16*, Thomas Schröder, MD^17*, Ivan Sergeevich Moiseev, MD^18*, Helene Schoemans^19*, Christian Koenecke, MD²⁰, Raphael Teipel, MD^21*, Malte von Bonin, MD^22*, Lars Bullinger²³, Martin Bornhäuser, MD^24*, Marcel R.M. van den Brink²⁵, Alexander H. Schmidt, Dr.^2*, Vinzenz Lange, Dr.^26*, Zinaida Peric, MD PhD^27* and Olaf Penack, MD^28*

¹TU Dresden, Dresden, Saxony, Germany
²DKMS Group gGmbH, Dresden, Germany
³Department of Hematology, Oncology and Tumor Immunology, Campus Virchow, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany
⁴DKMS Life Science Lab, Dresden, Germany
⁵Clinical Trials Unit, DKMS Group gGmbH, Dresden, Germany
⁶EBMT Leiden Study Unit, Leiden, Netherlands
⁷MSKCC Memorial Sloan Kettering Cancer Center, New York, NY
⁸Department of Medicine, Division of Oncology, Section of Stem Cell Biology, Washington University School of Medicine, Saint Louis, MO, Washington University In St Louis, St Louis, MO
⁹University Hospital Dresden, Dresden, Germany
¹⁰DKMS Ggmbh, Clinical Trials Unit, Dresden, Germany
¹¹Department of Hematology, Oncology, and Cancer Immunology, Charité-Universitätsmedizin Berlin, Campus Virchow Klinikum, Berlin, Germany
¹²Department of Hematology, Oncology and Cancer Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany
¹³Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, Netherlands
¹⁴Department of Clinical Transfusiology of Blood Service Center, National specialized children's hospital «Ohmatdyt», Kyiv, Ukraine
¹⁵University of Muenster, Muenster, Germany
¹⁶Klinik fuer Innere Medzin III, Ulm, Germany
¹⁷Department of Hematology and Stem Cell Transplantation, West German Cancer Center, University Hospital Essen, Essen, Germany
¹⁸St Petersburg University, St Petersburg, Russian Federation
¹⁹University Hospitals Leuven and KU Leuven, Leuven, Belgium
²⁰Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany
²¹Department of Internal Medicine I, University Hospital Dresden, Dresden, Germany
²²Department of Internal Medicine I, University Hospital, TU Dresden, Dresden, Germany
²³Department of Hematology, Oncology, and Cancer Immunology, Charité-Universitätsmedizin Berlin, Berlin, Germany
²⁴Department of Internal Medicine 1, University Hospital Carl Gustav Carus, Technical University Dresden, Dresden, Germany
²⁵Adult Bone Marrow Transplantation Service, Memorial Sloan Kettering Cancer Center, New York, NY
²⁶DKMS Life Science Lab Dresden, Dresden, Germany
²⁷University of Zagreb, Zagreb, Croatia
²⁸Department of Hematology, Oncology, and Cancer Immunology, Charité Universitätsmedizin Berlin, Campus Virchow Klinik, Berlin, Germany