65th ASH Annual Meeting & Exposition: 401. Blood Transfusion: Advances in Transfusion Medicine

Symposia: Blood Transfusion Oral and Poster Abstracts
Oral

Room 33 (San Diego Convention Center)

Moderators:

Avital Mendelson, PhD, New York Blood Center and David R Gibb, MD, PhD, Cedars-Sinai Medical Center

Disclosures:

No relevant conflicts of interest to declare.

10:30 AM

Genetic Polymorphisms in the Ferrireductase STEAP3 Regulate a Ferroptosis-like Process of Lipid Peroxidation-Induced Hemolysis in Murine and Human Red Blood Cells

Angelo D'Alessandro, PhD¹, Gregory R Keele, PhD²^*, Ariel M Hay³^*, Travis Nemkov, PhD⁴^*, Daniel Stephenson, PhD⁵^*, Xutao Deng⁶^*, Mars Stone⁶^*, Steven Kleinman, MD⁷^*, Steven Spitalnik, MD⁸, Philip J Norris⁹^*, Michael Paul Busch, MD, PhD⁶^*, Gary A Churchill, PhD¹⁰^* and James C Zimring, MD, PhD¹¹^*

¹Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, CO
²RTI International, Research Triangle Park, NC
³University of Virginia, Charlottesville, VA
⁴University of Colorado Anschutz Medical Campus, Aurora, CO
⁵Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, CO
⁶Vitalant Research Institute, San Francisco, CA
⁷Kleinman Biomedical Research, Victoria, BC, CAN
⁸Columbia University, New York, NY
⁹University of California San Francisco, San Francisco, CA
¹⁰Jackson Laboratory, Chapel Hill, NC
¹¹University of Virginia School of Medicine, Charlottesville, VA

10:45 AM

698

The Cs^a and Cs^b Red Cell Antigens of the Cost Blood Group Collection Correspond to the HNA-3a and HNA-3b Neutrophil Antigens: Unexpected Twins with Implications for Sickle Cell Anemia

Jonathan De Oliveira Rios¹^*, Alisa Soudry²^*, Romain Duval, PhD³^*, Alexandre Raneri⁴^*, Thomas Poyot⁵^*, Jérome Babinet⁶^*, Mariane De Montalembert, MD, PhD⁷, Claudia Regina Bonini Domingos⁸^*, Caroline Le Van Kim, PhD⁹^*, Marc Romana, PhD¹⁰^*, Thierry Peyrard, PhD¹¹^* and Slim Azouzi, PhD^12,13^*

¹Laboratory of Hemoglobins and Genetics of Hematologic Diseases, Sao Paulo State University, Université de Paris Cité, UMR_S1134, BIGR, Inserm, Paris, France
²Université de Paris Cité, UMR_S1134, BIGR, Inserm, Paris, France
³Centre National de Référence pour les Groupes Sanguins, Établissement Français du Sang (EFS) Ile-de-France, Université de Paris Cité, UMR_S1134, BIGR, Inserm, Paris, France
⁴Université de Paris Cité, UMR_S1134, BIGR, Inserm, Paris, FRA
⁵Centre National de Référence pour les Groupes Sanguins, Établissement Français du Sang (EFS), Paris, France
⁶Centre National de Référence pour les Groupes Sanguins, Établissement Français du Sang (EFS) Ile-de-France, Paris, France
⁷Department of General Pediatrics and Pediatric Infectious Diseases, Necker-Enfants Malades Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France
⁸Laboratory of Hemoglobins and Genetics of Hematologic Diseases, Sao Paulo State University, Sao Paulo, Brazil
⁹Université Paris Cité and Université des Antilles, INSERM, Biologie intégrée du globule rouge, F-75015 Paris, France, Paris, France
¹⁰Université des Antilles, UMR_S1134, BIGR, Inserm, Pointe-a -Pitre, GLP
¹¹Centre National de Référence pour les Groupes Sanguins, Établissement Français du Sang (EFS), Université de Paris Cité, UMR_S1134, BIGR, Inserm, Paris, France
¹²CNRGS, EFS, Paris, France
¹³Inserm U1134, Integrated Biology of Red Blood Cells, Université Paris Cité, Inserm, Paris, France

11:00 AM

699

Developmental Differences between Neonatal and Adult Platelets in Regard to Immune Protein Content and Regulation of Monocyte Inflammatory Responses

Patricia Ellen Davenport, MD¹^*, Christopher S. Thom, MD, PhD², Erin L Soule-Albridge, MS¹^*, Emily Nolton, BS¹^*, Zhi-Jian Liu, MD, PhD, BSc¹^*, Henry A Feldman, PhD³^* and Martha Sola-Visner, MD¹

¹Division of Newborn Medicine, Boston Children's Hospital, Boston, MA
²Division of Neonatology, Children's Hospital of Philadelphia, Philadelphia, PA
³Institutional Centers for Clinical and Translational Research, Boston Children's Hospital, Boston, MA

11:15 AM

700

Bioengineered Glycoprotein-Deficient iPSC-Derived Megakaryocytes for the Sensitive Detection and Characterization of Patient Antibodies in Autoimmune Thrombocytopenia

Nanyan Zhang, MD, PhD¹, Brian R. Curtis, PhD² and Peter J. Newman, PhD¹

¹Blood Research Institute, Versiti, Milwaukee, WI
²Platelet and Neutrophil Immunology Laboratory, Versiti, Milwaukee, WI

11:30 AM

701

Donor-Specific Antibody Mean Fluorescence Intensity Threshold Predicts Platelet Transfusion Response in HLA-Alloimmunized Patients

Matthew Tanner, MD, PhD¹, Aaron Boothby, MD², Danny Youngs, BS, CHS(ACHI)³^*, Idoia Gimferrer, MD/PhD, D(ACHI)³^*, Josefine Bribiesca Rodriguez⁴^*, Jenna Tan⁴^*, Rida Hasan, MD⁵, Lauge Sokol-Hessner, MD⁶^*, Hamilton Tsang, MD⁷^* and Sandhya R Panch, MD⁸

¹Internal Medicine Residency Program, University of Washington, Seattle, WA
²Hematology-Oncology Fellowship Program, University of Washington, Saint Paul, MN
³Blood Works NW, Seattle, WA
⁴University of Washington School of Medicine, Seattle, WA
⁵Transfusion Medicine Division, University of Washington, Seattle, WA
⁶Division of General Internal Medicine, University of Washington, Seattle, WA
⁷Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA
⁸Hematology /Transfusion, Fred Hutchinson Cancer Center, Seattle, WA

11:45 AM

702

Tranexamic Acid to Prevent Bleeding in Patients with Hematologic Malignancies and Severe Thrombocytopenia (TREATT trial). a Randomized Placebo-Controlled Trial

Lise J Estcourt, DPhil, MBBChir^1,2, Zoe K McQuilten, MBBS, PhD, FRACP, FRCPA^3,4^*, Peter Bardy, FRCP, FRCPath⁵^*, Merrole Cole-Sinclair, MBBS⁶, Graham P. Collins, MBBS, DPhil⁷, Philip J Crispin, MBBS, FRACP, FRCPA^8,9^*, Jennifer Curnow, MBBS, FRACP, FRCPA, PhD¹⁰^*, Amber Degelia, BS¹¹^*, Claire Dyer, MSc¹²^*, Vanessa Fox, BSc¹³^*, Adam Friebe, FRCPA, FRACP, MBBS¹⁴^*, Lajos Floro, MD¹⁵^*, Effie Grand, MBChB, PhD¹⁶^*, Cara Hudson, MSc¹⁷^*, Gail Jones, MD¹⁸^*, Joanne Joseph, MBBS¹⁹, Charlotte Kallmeyer, MD²⁰^*, Marina Karakantza, MBBS²¹^*, Paul Kerr, MBChB, PhD²²^*, Sara Last²³^*, Maria Lobo-Clarke, BSc²³^*, Matthew Lumley, MD²⁴^*, Mary Frances McMullin, MD, FRCPath, FRCP²⁵, Patrick G. Medd, MBBS, PhD²⁶^*, Suzy M Morton, MBBCh^27,28^*, Andrew David Mumford, PhD²⁹^*, Maria Mushkbar, MBBS, FRCPath³⁰^*, Joe Parsons, BSc¹⁷^*, Gillian Powter, BA³¹^*, Mallika Sekhar, MBBS³²^*, Richard Soutar, MD³³^*, William S. Stevenson, MBBS, PhD³⁴, Elango Subramoniapillai³⁵^*, Robyn Sutherland, BN, BSc¹³^*, Jeff Szer, MBBS, FRACP³⁶, Neil A Waters, BSc³⁷^*, Andrew H. Wei, MBBS, PhD³⁸, David Alan Westerman, MBBS, FRCPA, FRACP³⁹, Sarah A Wexler, FRCP, FRCPath⁴⁰^*, Erica M. Wood, MD⁴¹ and Simon J Stanworth, MD, DPhil^1,42,43^*

¹NHS Blood and Transplant, Oxford, United Kingdom
²Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom
³Transfusion Research Unit, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia
⁴Department of Haematology, Monash Health, Melbourne, Australia
⁵Royal Adelaide Hospital, Adelaide, SA, AUS
⁶St. Vincent's Hospital, Fitzroy, VIC, AUS
⁷Haematology, Oxford Cancer and Haematology Centre, Oxford, ENG, United Kingdom
⁸Canberra Hospital, Canberra, ACT, AUS
⁹Australian National University, CANBERRA, ACT, AUS
¹⁰Westmead Hospital, Sydney, AUS
¹¹Monash University, Melbourne, VIC, AUS
¹²NHS Blood and Transplant Clinical Trials Unit, NHS Blood and Transplant, Oxford, United Kingdom
¹³Monash University, Melbourne, Australia
¹⁴Andrew Love Cancer Center, Barwon Health, Geelong, Geelong, Australia
¹⁵Kings College Hospital, London, ENG, GBR
¹⁶Salisbury NHS Foundation Trust, Salisbury, United Kingdom
¹⁷NHS Blood and Transplant Clinical Trials Unit, NHS Blood and Transplant, Bristol, United Kingdom
¹⁸Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom
¹⁹St. Vincent's Hospital, Sydney, NSW, AUS
²⁰United Lincolnshire Hospitals, Lincoln, United Kingdom
²¹NHS Blood and Transplant, Leeds, United Kingdom
²²Royal Devon University Healthcare, Exeter, United Kingdom
²³NHS Blood and Transplant Clinical Trials Unit, NHS Blood and Transplant, Cambridge, United Kingdom
²⁴Department of Haematology, Birmingham Heartlands Hospital, Birmingham
²⁵Haematology, Belfast City Hospital, Queen's University Belfast, Belfast, United Kingdom
²⁶University Hospitals Plymouth NHS Trust, Plymouth, United Kingdom
²⁷University Hospitals Birmingham, Birmingham, United Kingdom
²⁸NHS Blood and Transplant, Birmingham, United Kingdom
²⁹School of Cellular and Molecular Medicine, University of Bristol, Bristol, United Kingdom
³⁰Department of Haematology, University Hospital Coventry and Warwickshire, Coventry, United Kingdom
³¹NHSBT Clinical Trials Unit, NHS Blood and Transplant, Oxford, United Kingdom
³²Royal Free Hospital, London, United Kingdom
³³Glasgow Royal Infirmary, Glasgow, United Kingdom
³⁴Department of Haematology, Royal North Shore Hospital, Sydney, NSW, AUS
³⁵Royal Brisbane Hospital, Brisbane, Australia
³⁶Department of Clinical Haematology, Peter MacCallum Cancer Centre and the Royal Melbourne Hospital, Melbourne, VIC, Australia, Melbourne, VIC, Australia
³⁷Transfusion Research Unit, School of Public Health and Preventive Medicine, Monash University, Melbourne, AUS
³⁸Peter MacCallum Cancer Centre and Royal Melbourne Hospital, Melbourne, Australia
³⁹Peter MacCallum Cancer Inst., Melbourne, VIC, AUS
⁴⁰Royal United Hospitals Foundation Trust, Royal United Hospitals Foundation Trust, Bath, United Kingdom
⁴¹Transfusion Research Unit, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia
⁴²NIHR Blood and Transplant Research Unit in data driven transfusion practice, Oxford, United Kingdom
⁴³Oxford University Hospitals NHS Trust, Oxford, United Kingdom

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^*signifies non-member of ASH

401.O1.6 401. Blood Transfusion: Advances in Transfusion Medicine