65th ASH Annual Meeting & Exposition: 301. Vasculature, Endothelium, Thrombosis and Platelets: Basic and Translational: Insights Into the Role of Endothelium in Cardiovascular Disease and Thrombosis

Symposia: Vasculature, Endothelium, Thrombosis and Platelets: Basic and Translational Oral and Poster Abstracts
Oral

Research, Fundamental Science, Bleeding and Clotting, bleeding disorders, Iron Deficiency, Translational Research, thromboembolism, Diseases, thrombotic disorders, VWD, metabolism, Biological Processes, Metabolic Disorders, molecular biology, pathogenesis

Room 28 A-D (San Diego Convention Center)

Moderators:

Sol Schulman, MD, PhD, Beth Israel Deaconess Medical Center and Harvard Medical School and Audrey C Cleuren, PhD, Oklahoma Medical Research Foundation

Disclosures:

Schulman: Quercis: Research Funding; Novo Nordisk: Other: Research Materials; Genentech: Other: Research Materials; Penumbra: Other: Unpaid role on a study advisory board.

The purpose of this Oral session 301_3 is to present discoveries on endothelial cell pathways and interactions leading to cardiovascular thrombosis and thromboinflammation. The theme includes insights into the role of the JAK2 mutation and endothelial MPL receptor in the development of cardiovascular disease in patients carrying this mutation. It will also present how LDL promotes the development of cardiovascular disease by promoting the self-association of von Willebrand factor. The theme will present novel integrin-dependent interactions of the endothelium with neutrophils in cancer associated thrombosis, how endothelial cells release von Willebrand factor, how endothelial cells regulate NO in response to iron and the role of the endothelial Piezo 1 calcium channel in preventing thromboinflammation.

12:00 PM

499

Unlocking the Role of Endothelial MPL Receptor and JAK2V617F Mutation: Insights into Cardiovascular Dysfunction in MPNs and Chip

Huichun Zhan, MD^1,2, Haotian Zhang³, Nicholas Kafeiti⁴^*, Sandy Lee^5,6, Kyla Masarik⁴^* and Haoyi Zheng⁷^*

¹Department of Medicine, Stony Brook School of Medicine, Stony Brook
²Northport VA Medical Center, Northport
³Stony Brook University, Stony Brook, NY
⁴Stony Brook School of Medicine, Stony Brook, NY
⁵Graduate Program in Molecular & Cellular Pharmacology, Stoney Brook University, Stony Brook, NY
⁶Graduate Program in Molecular & Cellular Pharmacology, Stoney Brook University, Setauket, NY
⁷Saint Francis Hospital, Roslyn, NY

12:15 PM

500

Interactions between Integrin α9β1 and VCAM-1 Promote Neutrophil Hyperactivation and Deep Vein Thrombosis in a Murine Model of Lung Cancer

Nilesh Pandey, PhD¹^*, Harpreet Kaur, PhD²^*, Shiva Jashwanth Gaddam, MD³, Tarek Magdy Mohamed, PhD¹^*, Karen Stokes, PhD⁴^*, Kavitha Beedupalli, MBBS³^* and Nirav Dhanesha, PhD⁵

¹Department of Pathology and Translational Pathobiology, Louisiana State University Health Sciences Center at Shreveport, Shreveport, LA
²Department of Pathology and Translational Pathobiology,, Louisiana State University Health Sciences Center at Shreveport, Shreveport, LA
³Department of Hematology and Oncology and Feist Weiller Cancer Center, Louisiana State University Health Sciences Center-Shreveport, Shreveport, LA
⁴Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center at Shreveport, Shreveport, LA
⁵Department of Pathology, LSUHS-Shreveport, Shreveport, LA

12:30 PM

501

Ralb and Exocyst Regulate Endothelial Cell Von Willebrand Factor Release

Moua Yang, PhD¹, Lourdes Mendez, MD²^* and Anish V Sharda, MBBS³

¹Harvard Medical School, Boston
²Section of Hematology, Department of Internal Medicine, Yale School of Medicine - Yale Cancer Center, New Haven, CT
³Yale Comprehensive Cancer Center, Yale University School of Medicine, New Haven, CT

12:45 PM

502

Endothelial Hemoglobin Alpha Mediates Iron Regulation of Endothelial Nitric Oxide

Luke S Dunaway, PhD¹^*, Shruthi Nyshadham, BS¹^*, Melissa A Luse, MS^1,2^*, Skylar A Loeb, BS^1,2^*, Adam Goldfarb, MD³ and Brant Isakson, PhD^1,2^*

¹Cardiovascular Research Center, University of Virginia, Charlottesville, VA
²Department of Molecular Physiology and Biophysics, University of Virginia, Charlottesville, VA
³University of Virginia Health Sciences Center, Charlottesville, VA

1:00 PM

503

Piezo1 Ca²⁺channel Activation Prevents Inflammation-Induced Endothelial Prothrombotic Transformation By Stimulating an Antithrombotic Pathway

Kelsey D Sack, MD, PhD^1,2,3, Wandi Zhu, PhD⁴^*, Calum MacRae, MD, PhD⁴^* and Robert Flaumenhaft, MD, PhD⁵

¹Division of Hemostasis and Thrombosis, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Belmont, MA
²Division of Pulmonary and Critical Care, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA
³Division of Pulmonary and Critical Care, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA
⁴Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA
⁵Division of Hemostasis and Thrombosis, Beth Israel Deaconess Medical Center, Boston, MA

1:15 PM

504

Self-Association of Von Willebrand Factor (VWF) into Prothrombotic Fibers Is Most Potently Enhanced By the Highly Atherogenic Small, Dense Fraction of Low-Density Lipoprotein (sd-LDL)

Junmei Chen, PhD¹, Forrest Nussdorfer, MS¹^*, Raymond Adili, MD¹, Kimsey Platten, BS²^*, Nicole Rhoads¹^*, Richard Maldonado¹^*, Franklin Reed¹^*, Yi Wang¹^*, Minhua Ling, PhD¹^*, Sergio Fazio³^*, Xiaoyun Fu, PhD¹, Nathalie Pamir⁴^*, Jose A. Lopez, M.D⁵ and Dominic W. Chung, Ph.D⁵^*

¹Bloodworks Research Institute, Seattle, WA
²Washington University In St. Louis, St Louis, MO
³Regeneron, New York, NY
⁴OHSU, Portland, OR
⁵University of Washington, Bloodworks Research Institute, Seattle, WA

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^*signifies non-member of ASH

301.O3.6 301. Vasculature, Endothelium, Thrombosis and Platelets: Basic and Translational: Insights Into the Role of Endothelium in Cardiovascular Disease and Thrombosis