65th ASH Annual Meeting & Exposition: 301. Vasculature, Endothelium, Thrombosis and Platelets: Basic and Translational: The Multimodal Platelet; Discovery of Novel Platelet Functions and Applications From Cancers to Thrombocytopenias

Symposia: Vasculature, Endothelium, Thrombosis and Platelets: Basic and Translational Oral and Poster Abstracts
Oral

Research, Fundamental Science, Bleeding and Clotting, autoimmune disorders, Biological therapies, Translational Research, Non-Biological therapies, platelet disorders, Chimeric Antigen Receptor (CAR)-T Cell Therapies, genomics, bioinformatics, drug development, Diseases, thrombocytopenias, Immune Disorders, Therapies, Biological Processes, molecular biology, Technology and Procedures, profiling

Room 33 (San Diego Convention Center)

Moderators:

Kellie R. Machlus, PhD, Boston Children's Hospital and Harvard Medical School and Karl Desch, MD, University of Michigan

Disclosures:

No relevant conflicts of interest to declare.

The purpose of Oral Session 301 is to present new discoveries in platelet function and new platelet targets for the treatment of platelet related disorders. The theme includes new platelet functions including their sequestration of circulating tumour DNA and a protective role in lung cancer metastasis. The theme also includes new platelet protein function (actinin) and platelet transcripts. It also includes 2 potential therapeutic targets for immune thrombocytopenia (targeting autoreactive B cells and mitophagy).

4:00 PM

277

Platelets Sequester Extracellular DNA, Capturing Tumour-Derived and Free Fetal DNA

Lauren Murphy, BSc¹^*, Jeanne Inchauspe²^*, Nikolaos Sousos³^*, Natalie Jooss⁴^*, Hayley L Belnoue-Davis⁵^*, Pamela Holland⁶^*, Rong Li, PhD⁷^*, Giampiero Valenzano⁸^*, Fenella Roseman⁹^*, Sujata Biswas⁷^*, Sally-Ann Clark, BSc, PhD¹^*, Jennifer O'Sullivan¹⁰^*, Michael Rimmer¹¹^*, Abdullah O Khan¹²^*, Christina Simoglou Karali¹^*, Eric ONeill⁸^*, Nadia Nasreddin¹³^*, Ian Hitchcock¹⁴, Milka Koupenova¹⁵^*, Manu Vatish¹⁶^*, Paul Rees¹⁷^*, Simon Leedham¹³^*, Adam J Mead, MRCP, FRCPath, PhD¹, Benjamin Schuster-Boeckler¹⁸^*, Christopher Gregory¹⁹^* and Bethan Psaila, MD, PhD²⁰

¹Medical Research Council (MRC) Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, National Institute for Health Research Biomedical Research Centre, University of Oxford, Oxford, United Kingdom
²University of Oxford, MRC WIMM, Oxford, United Kingdom
³Haematopoietic Stem Cell Biology Laboratory, Medical Research Council Molecular Haematology Unit, Medical Research Council Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom
⁴University of Oxford, WIMM, Oxford, United Kingdom
⁵Wellcome Centre for Human Genetics, University of Oxford,, Oxford, United Kingdom
⁶University of Edinburgh, Centre for Inflammation Research, Institute for Regeneration and Repair, Edinburgh, United Kingdom
⁷University of Oxford, Oxford, United Kingdom
⁸Department of Oncology, University of Oxford, Oxford, United Kingdom
⁹Nuffield Department of Women's and Reproductive Health, University of Oxford, Oxford, United Kingdom
¹⁰Department of Clinical Haematology, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom
¹¹Centre for Inflammation Research, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, United Kingdom
¹²MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom
¹³Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
¹⁴York Biomedical Research Institute (YBRI), Department of Biology, University of York, York, United Kingdom
¹⁵University of Massachusetts Medical School, Worcester, MA
¹⁶Oxford University Hospitals Foundation Trust, Oxford, GBR
¹⁷Department of Physics, Swansea University, Swansea, United Kingdom
¹⁸Ludwig Institute for Cancer Research, University of Oxford, Oxford, United Kingdom
¹⁹University of Edinburgh, Edinburgh, GBR
²⁰Medical Research Council (MRC) Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, National Institute for Health Research Biomedical Research Centre, University of Oxford, Oxford, ENG, United Kingdom

4:15 PM

278

Gpibα Caar-T Cells Induce Autoreactive B Cells Elimination to Treat Immune Thrombocytopenia

Jie Zhou¹^*, Heng Mei¹^*, Yanyan Xu²^*, Jinhui Shu¹^*, Linlin Huang¹^*, Min Xu¹^*, Haojie Jiang²^*, Junling Liu²^* and Yu Hu, MD³^*

¹Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
²Department of Biochemistry and Molecular Cell Biology, Shanghai Jiao Tong University School of Medicine, Shanghai, China
³Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

4:30 PM

279

Iguratimod Regulates CD4+ T-Cell Homeostasis and Function By Restoring PINK1/Parkin-Mediated Mitophagy in Immune Thrombocytopenia

Yuxiu Chen¹^*, Kai-Yan Liu, MD, PhD^1,2,3, Haixia Fu, MD^1,4^* and Xiaohui Zhang, MD^{1,3,5,6,7,8,9}^*

¹Peking University People's Hospital, Peking University Institute of Hematology, Beijing, China
²Peking University People’s Hospital, Beijing, China, Beijing, CHN
³Peking University People's Hospital, Beijing, China
⁴Peking University People’s Hospital, Peking University Institute of Hematology, Beijing, Beijing, China
⁵Peking University People’s Hospital, Peking University Institute of Hematology, Beijing, China., Beijing, China
⁶Peking University people hospital, Beijing, China
⁷Collaborative Innovation Center of Hematology, Peking University, Beijing, China
⁸National Clinical Research Center for Hematologic Disease, Beijing, China
⁹Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, China

4:45 PM

280

Single Cell RNA Sequencing of Human Platelets Reveals a Stochastic Nature of the Platelet Transcriptome

Walter Wolfsberger Wolfsberger, PhD¹^*, Taras Oleksyk, PhD¹^* and Anthony Washington, PhD²

¹Oakland University, Rochester, MI
²Department of Biology, Oakland University, Rochester, MI

5:00 PM

281

Notch1 Regulates Hepatic Thrombopoietin Production

Yueyue Sun^1,2^*, Huan Tong^1,2^*, Lingyu Zeng^1,2^*, Kailin Xu^1,2^* and Jianlin Qiao, PhD^1,3

¹Blood Diseases Institute, Xuzhou Medical University, Xuzhou, China
²Department of Hematology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China
³Department of Hematology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou City, Jiangsu Province, China

5:15 PM

282

Platelet Angiopoietin-1 Protects Against Experimental Lung Metastasis By Limiting Tumor Cell Extravasation

Harvey G. Roweth, PhD, BSc^1,2, Isabelle C. Becker, PhD^2,3, Michael Malloy¹^*, Sophie Munn¹^*, Pryia Kumar²^*, Alec A Schmaier, MD, PhD^2,4 and Elisabeth Battinelli, MD, PhD^1,2

¹Brigham and Women's Hospital, Boston, MA
²Harvard Medical School, Boston, MA
³Boston Children's Hospital, Boston, MA
⁴Beth Israel Deaconess Medical Center, Boston, MA

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^*signifies non-member of ASH

301.O1.6 301. Vasculature, Endothelium, Thrombosis and Platelets: Basic and Translational: The Multimodal Platelet; Discovery of Novel Platelet Functions and Applications From Cancers to Thrombocytopenias