Modupe Idowu, MD¹, Lucas Otieno, MD, MPH^2*, Bogdan Dumitriu, MD³, Clarisse LC Lobo, MD, PhD^4*, Swee Lay Thein, MD, DSc^5*, Biree Andemariam, MD⁶, Obiageli E Nnodu, MD⁷, Adlette Inati, MD⁸, Alexander K Glaros, MD^9*, Sara Teresinha Olalla Saad, MD¹⁰, Pablo Bartolucci, MD, PhD^11*, Raffaella Colombatti, MD¹², Ali T Taher, MD, PhD, FRCP¹³, Miguel R Abboud, MD¹⁴, Abdulafeez Oluyadi, PharmD^15*, Varsha Iyer, PhD^15*, Ophelia Yin, PhD^16,17*, Susan Morris, PhD^15*, Amber M Yates, MD^15*, Hui Shao, PhD^15*, Spurthi Patil^15*, Rolandas Urbstonaitis, PharmD, MBS^15*, Ahmar U Zaidi, MD^15* and Wally R Smith, MD¹⁸

¹McGovern Medical School, UTHealth, Houston, TX
²Victoria Biomedical Research Institute, Kisumu, Kenya
³Mid-Atlantic Permanente Medical Group, Largo, MD
⁴Research Division, HEMORIO, Rio de Janeiro, Brazil
⁵Sickle Cell Branch, The National Heart, Lung, and Blood Institute, Bethesda, MD
⁶New England Sickle Cell Institute, University of Connecticut Health, Farmington, CT
⁷Centre of Excellence for Sickle Cell Disease Research and Training, Department of Haematology and Blood Transfusion, College of Health Sciences, University of Abuja, Abuja, Nigeria
⁸Lebanese American University Gilbert and Rose-Marie Chagoury School of Medicine, Byblos and NINI Hospital, Tripoli, Lebanon
⁹Division of Hematology/Oncology, Children’s Hospital of Michigan, Detroit, MI
¹⁰Hematology and Transfusion Medicine Center - University of Campinas/Hemocentro-UNICAMP, Campinas, São Paulo, Brazil, University of Campinas (Unicamp), Campinas, Brazil
¹¹Reference Center of Sickle Cell Disease, Mondor University Hospital, Créteil, France
¹²Pediatric Hematology Oncology Unit, University of Padova, Padova, Italy
¹³American University of Beirut Medical Center, Beirut, Lebanon
¹⁴Department of Pediatrics and Adolescent Medicine, American University of Beirut Medical Center, Beirut, Lebanon
¹⁵Agios Pharmaceuticals, Inc., Cambridge, MA
¹⁶iTeos Therapeutics, Watertown, MA
¹⁷At time of research, Agios Pharmaceuticals, Inc., Cambridge, MA
¹⁸Virginia Commonwealth University, Richmond, VA

Miguel R Abboud, MD¹, Rodolfo D Cançado, MD, PhD^2*, Mariane De Montalembert, MD, PhD³, Wally R Smith, MD⁴, Hala Rimawi, FRCP^5*, Ersi Voskaridou, MD^6*, Birol Guvenc, MD^7*, Deborah Keefe, MD, MPH^8*, Kai Grosch^9*, Michele L Nassin, MD⁸, Jimmy Watson, MD^10*, Justin Yssel, PhD^10*, Evgeniya Reshetnyak, PhD^8* and Yvonne Dei Adomakoh, MBBS, MD¹¹

¹Department of Pediatrics and Adolescent Medicine, American University of Beirut Medical Center, Beirut, Lebanon
²Department of Hematology/Oncology, Hospital Samaritano – São Paulo, São Paulo, Brazil
³Department of General Pediatrics and Pediatric Infectious Diseases, Necker-Enfants Malades Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France
⁴Division of General Internal Medicine, Department of Medicine, Virginia Commonwealth University, Richmond, VA
⁵Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan
⁶Thalassaemia Centre, Laikon General Hospital, Athens, Greece
⁷Department of Hematology, Medical Faculty, Cukurova University, Adana, Balcali, TUR
⁸Novartis Pharmaceuticals Corporation, East Hanover, NJ
⁹Novartis Pharma AG, Basel, Switzerland
¹⁰Global Health DU, Novartis Ireland Limited, Dublin, Ireland
¹¹University of Ghana Medical School/Korle Bu Teaching Hospital, Accra, Greater Accra, Ghana

Anna Conrey, NP^1*, Ingrid Frey, RN^1*, Nancy Asomaning, MS^1*, Ruth Pierre Charles, DSc, PA-C^2*, Dina Parekh, MD^3*, Julia Xu, MD, MS¹, Kang Le^1*, Britney Kruah^1*, Quan Li^4*, Emily Dunkelberger^5*, Troy Cellmer^5*, Amber M Yates, MD^6*, Megan Wind-Rotolo^6*, Neal Jeffries, PhD^7*, William A Eaton^4* and Swee Lay Thein, MBBS, DSc, FRCP, FRCPath, MRCP, MRCPath⁸

¹Sickle Cell Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD
²Sickle cell Branch, National Heart, Lung and Blood Institutes / National Institutes of Health, Bethesda, MD
³Sickle Cell Branch, National Heart, Lung and Blood Institutes / NIH, Bethesda, MD
⁴Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD
⁵Laboratory of Chemical Physics, NIDDK NIH, Bethesda, MD
⁶Agios Pharmaceuticals, Inc., Cambridge, MA
⁷Office of Biostatistics Research, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD
⁸Sickle Cell Branch, National Heart, Lung & Blood Institute, Bethesda, MD

Santosh L. Saraf, MD¹, Shehu Umar Abdullahi, MD^2*, Adeseye Michael Akinsete, MBBS^3*, Foluke A Fasola^4*, Modupe Idowu, MD⁵, Sharon Pennington, MD⁶, William B Ershler, MD⁷, Marshall Patrick Stagg^8*, Wai Chin^9*, Eric Zimmerman^9*, Adeyemi Adenola^10*, Mira Patel Pochron^9* and Eleanor A Lisbon, MD¹⁰

¹Division of Hematology/Oncology, University of Illinois Chicago, Chicago, IL
²Department of Pediatrics, Bayero University/Aminu Kano Teaching Hospital, Kano, Nigeria
³College of Medicine, University of Lagos, Idi-Araba, Lagos, Nigeria
⁴University of Ibadan/University College Hospital, Idi-Araba, Ibadan, Nigeria
⁵Department of Hematology and Oncology, The University of Texas Health Science Center McGovern Medical School, Houston, TX
⁶Mississippi Center For Advanced Medicine, Madison, MS
⁷Inova Schar Cancer Institute, Fairfax, VA
⁸Baton Rouge General Medical Center, Baton Rouge, LA
⁹Pfizer Inc, South San Francisco, CA
¹⁰Pfizer Inc, New York, NY

Shubaya Kasule Naggayi, MSc^1,2*, Dennis Kalibala^2*, Robert Opoka, MBChB, PhD^3,4*, Caterina Rosano, MD, MPH^5*, Deogratias Munube, MD^4*, Phillip Kasirye, MD^4*, Ezekiel Mupere, MD, PhD^4*, Vincent Mboizi^2*, John Ssenkusu, PhD^6*, Nancy S. Green, MD⁷, Richard Idro, PhD^4* and Paul Bangirana, PhD^8*

¹Makerere University College of Health Sciences, Kampala, Uganda
²Global Health Uganda, Kampala, Uganda
³Department of Paediatrics and Child Health, College of Health Sciences, Makerere University, Kampala, Uganda
⁴Department of Pediatrics and Child Health, Makerere University College of Health Sciences, Kampala, Uganda
⁵Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA
⁶Department of Epidemiology and Biostatistics, Makerere University College of Health Sciences, Kampala, Uganda
⁷Department of Pediatrics, Division of Hematology, Oncology and Stem Cell Transplantation, Columbia University Irving Medical Center, New York, NY
⁸Department of Psychiatry, Makerere University College of Health Sciences, Kampala, Uganda

Nirmish Shah, MD¹, Girindra Raval, MBBS², Abdullah Kutlar, MD³, Niren Patel, MBBS^4*, Mayuko Takezaki^4*, Biaoru Li, MD, PhD^4*, Manickam Alagar, PhD^4*, Hongyan Xu, PhD^5*, Kelly Blackburn^6*, Santhosh Vadivelu, PhD⁷, Robert Schaub, PhD⁷, David Santos^7* and Betty Pace⁸

¹Department of Medicine, Division of Hematology - Duke Sickle Cell Comprehensive Care Unit, Duke University Medical Center, Durham, NC
²Department of Medicine, Medical College of Georgia, Augusta, GA
³Medical College of Georgia, Augusta, GA
⁴Department of Medicine, Augusta University, Augusta, GA
⁵Department of Population Health Sciences, Augusta University, Augusta, GA
⁶AkiraBio, Wellesley, MA
⁷Akirabio, Wellesley, MA
⁸Augusta University, Augusta, GA