-Author name in bold denotes the presenting author
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102.O1.6 102. Iron Homeostasis and Biology: Exploring Molecular Mechanisms and Therapeutic Options in Iron Homeostasis

Symposia: Iron Homeostasis and Biology Program: Oral and Poster Abstracts
Type: Oral
Hematology Disease Topics & Pathways:
Research, clinical trials, Translational Research, Clinical Research, Diseases, Therapies, Maternal Health
Monday, December 11, 2023: 4:30 PM-6:00 PM
Room 25 (San Diego Convention Center)
Immacolata Andolfo, immacolata.andolfo@unina.it, and Sarah Ducamp, PhD, Boston Children's Hospital and Harvard Medical School
No relevant conflicts of interest to declare.
In this session, we will delve into both new molecular mechanisms and therapeutic options in iron homeostasis. Our exploration will span a diverse array of topics. This includes uncovering the novel role of PCBP1 in the regulation of iron efflux through intestinal ferroportin. Moreover, we will investigate the iron regulation orchestrated by Irf5 in macrophages within erythromyeloblastic islands.

Additionally, we will extensively examine emerging therapeutic opportunities designed to uphold iron homeostasis. This comprehensive evaluation will encompass analysis of clinical trials that specifically target rare conditions, such as congenital hypotransferrinemia and erythropoietic protoporphyria.

Conducting innovative structure-function analysis, we will unlock insights into the structural predictions that will facilitate the pharmacological targeting of human erythroferrone in the future.

As a crucial facet, we recognize that iron plays an indispensable role in maternal and fetal health throughout pregnancy. In light of this, we will dissect the synergistically adverse effects resulting from the interaction between maternal iron deficiency and inflammation on the embryo during pregnancy.

4:30 PM

Yubo Wang1*, Olga Protchenko1*, Kari Huber1*, Minoo Shakoury-Elizeh1* and Caroline Philpott, MD2

1NIDDK, Bethesda, MD
2National Institutes of Health, Bethesda, MD

4:45 PM

Rachel Josselsohn1,2, Anshul Vagrecha, MD, MBBS3, Margaret LaPan3*, Julien Papoin, MS3*, Jonah Kamen3*, Young Min Cho3*, Riaz Rao3*, Laurel Romano, PhD4*, Nathan Salomonis, PhD5*, Theodosia A. Kalfa, MD, PhD6, Lionel Blanc, PhD2,3 and Betsy J. Barnes, DPhil3

1Feinstein Institutes for Medical Research, Feinstein Institute For Medical Research, Manhasset, NY
2Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY
3Feinstein Institutes for Medical Research, Northwell, Manhasset, NY
4Hematology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
5Division of Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
6Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH

5:00 PM

Daniel Srole1*, Chun-Ling Jung1*, Alan J Waring2*, Elizabeta Nemeth, PhD1 and Tomas Ganz1

1Center for Iron Disorders, David Geffen School of Medicine at UCLA, Los Angeles, CA
2Lundquist Institute, David Geffen School of Medicine at UCLA, Los Angeles, CA

5:15 PM

Ilona Kleine Budde, PhD1*, Cristina Díaz De Heredia, MD2*, Raffaella Mariani, MD, PhD3*, Alberto Piperno, MD, PhD4,5*, Katja Moser, MD6*, Mayka Sanchez, PhD7,8*, Thomas Bodewes, MD, PhD1* and Maya Isaila, MD, PhD1*

1Medical and Clinical Affairs, Prothya Biosolutions, Amsterdam, Netherlands
2Hospital Universitari Vall d’Hebron, Vall d’Hebron Institut de Recerca, Barcelona, Spain
3Centre for Rare Diseases, European Reference Network, EuroBloodNet, Fondazione IRCCS San Gerardo dei Tintori, Monza, ITA
4Genetic, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy
5Tettamanti Research Centre, Monza, Italy
6Klinik für Kinder- und Jugendmedizin, Klinikum Aschaffenburg-Alzenau, Aschaffenburg, Germany
7Department of Basic Sciences, Iron Metabolism: Regulation and Diseases Group, Universitat Internacional De Catalunya, Sant Cugat Del Vallès-Barcelona, Spain
8Diagnostics in Inherited Blood Diseases, BloodGenetics S.L., Esplugues de Llobregat, Spain

5:30 PM

Gayle Ross, MD1*, Peter Stewart, MD2*, George Mensing, MPH3*, Melanie Chin, PhD3*, Haley Howell, BS3*, Heidi Mangus3* and William Savage, MD, PhD3

1Royal Melbourne Hospital, Melbourne, Australia
2Royal Prince Alfred Hosptial, Sydney, Australia
3Disc Medicine, Watertown, MA

5:45 PM

Veena Sangkhae, PhD1, Allison L Fisher, PhD2*, Vida Zhang, PhD1*, Tomas Ganz, MD, PhD1 and Elizabeta Nemeth, PhD1

1Center for Iron Disorders, David Geffen School of Medicine at UCLA, Los Angeles, CA
2Division of Nephrology, Program in Membrane Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA

*signifies non-member of ASH