65th ASH Annual Meeting & Exposition: 101. Red Cells and Erythropoiesis, Excluding Iron: Red Cells: Erythropoiesis in Stress and Disease

Symposia: Red Cells and Erythropoiesis, Excluding Iron Oral and Poster Abstracts
Oral

Research, Fundamental Science, Translational Research, hematopoiesis, Biological Processes, molecular biology

Room 33 (San Diego Convention Center)

Moderators:

Robert Paulson, PhD, Pennsylvania State University and Sharon A Singh, MD, Cohen Children's Medical Center of New York

Disclosures:

No relevant conflicts of interest to declare.

This symposium will discuss red blood cell development, differentiation, and function in abnormal contexts. The purpose of this session is to present unpublished data on how erythropoietic mechanisms change during stress, disease, and/or rare genetics.

2:00 PM

139

Mitochondrial tRNA Pseudouridylation Regulates Erythropoiesis Via the mTOR Signaling Pathway: Implications for Mlasa and Treatment Strategies

Yajing Chu, PhD¹^*, Bichen Wang¹^*, Deyang Shi¹^*, Yu Lian¹^*, Shuang Yang¹^*, Mutian Cao¹^*, Tao Cheng², Lihong Shi, PhD¹^*, Weiping Yuan, MD, PhD¹ and Jun Shi³^*

¹State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & PUMC, Tianjin, China
²State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences&Peking Union Medical College, Tianjin, China
³Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China

2:15 PM

140

Spatial Mapping Reveals Distinct Erythroid Niches in Mice and Humans during Development and Stress

Xu Han, PhD¹^*, Kehan Ren^1,2, Pan Wang, Ph.D.¹^*, Honghao Bi, PhD¹, Inci Aydemir³^*, Ermin Li, Ph.D.¹^* and Peng Ji, MD, PhD¹

¹Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL
²Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL
³Northwestern University, Chicago, IL

2:30 PM

141

Urea Transporter B Is Produced in the Jk Null Blood Group Yet Fails to Integrate into the Red Cell Membrane Impacting Erythropoiesis and Erythrocytes

Fenny Chong¹^*, Pauline Dizon^1,2^*, Genghis H Lopez, PhD¹^*, Glenda M Millard³^*, Tanya Powley³^*, Catherine A Hyland, PhD¹^*, Daniel Kolarich, PhD²^* and Rebecca E Griffiths, PhD¹

¹Research and Development, Australian Red Cross Lifeblood, Brisbane, QLD, Australia
²Institute for Glycomics, Griffith University, Southport, QLD, Australia
³Red Cell Reference Laboratory, Australian Red Cross Lifeblood, Brisbane, QLD, Australia

2:45 PM

142

The ATF4-RPS19BP1 Axis Modulates Ribosome Biogenesis to Promote Erythropoiesis

Zhaofeng Zheng¹^*, Shangda Yang²^*, Fanglin Gou²^*, Chao Tang²^*, Zhaoru Zhang³^*, Penglei Jiang³, Pengxu Qian, PhD³^*, Ping Zhu²^*, Hui Cheng²^* and Tao Cheng^4,5

¹State Key Laboratory of Experimental Hematology, Institute of Hematology & Blood Diseases Hospital, Tianjin, China
²State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences &Peking Union Medical College, Tianjin, China
³Institute of Hematology, Zhejiang University, Hangzhou, China
⁴State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical Colleg, Tianjin, China
⁵Tianjin Institutes of Health Science, Tianjin, China

3:00 PM

143

m6A Mediated Ribostasis of RNA Stress Granule Assembly Governs Blood Development and Regeneration

Rajesh D. Gunage^1,2^* and Leonard I. Zon, MD^2,3,4

¹Stem Cell Program and Division of Hematology/Oncology, Boston Children's Hospital and Dana Farber Cancer Institute, Boston, MA
²Harvard Medical School, Boston, MA
³Harvard Stem Cell Institute, Cambridge, MA
⁴Howard Hughes Medical Institute, Boston, MA

3:15 PM

144

Rps19 and Rpl5 Play Distinct Roles in hematopoietic Stem Cell maintenance and Erythroid Differentiation

Yuefeng Tang, PhD¹, Te Ling, PhD², Mushran Khan³^*, Riaz Rao⁴^*, Vincent P Schulz, PhD⁵^*, Julien Papoin, MS⁴^*, Anupama Narla, MD⁶, Jeffrey Michael Lipton, MD, PhD⁷, James Palis, MD⁸, Laurie A. Steiner, MD⁹, Patrick G Gallagher, MD¹⁰, Mohandas Narla, DSc¹¹, John D. Crispino, PhD, MBA¹² and Lionel Blanc, PhD⁴

¹The Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY
²St. Jude Children's Research Hospital, Memphis, TN
³The Feinstein Institute For Medical Research, Manhasset, NY
⁴Feinstein Institutes for Medical Research, Northwell, Manhasset, NY
⁵Yale School of Medicine, New Haven, CT
⁶Stanford University, Stanford, CA
⁷Cohen Children's Medical Center of NY, New Hyde Park, NY
⁸University of Rochester, Rochester, NY
⁹Department of Pediatrics, University of Rochester, Rochester, NY
¹⁰Yale University School of Medicine, New Haven, CT
¹¹LFKRI, New York Blood Center Enterprises, New York, NY
¹²Division of Experimental Hematology, St Jude Children's Research Hospital, Memphis, TN

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^*signifies non-member of ASH

101.O1.6 101. Red Cells and Erythropoiesis, Excluding Iron: Red Cells: Erythropoiesis in Stress and Disease