Tingting Hong^1*, Shengli Li, PHD^2*, Shaohai Fang, MS^3*, Anna Guzman^4*, Wei Han, MS^3*, Yubin Zhou, PhD^5*, Leng Han, PhD^6*, Margaret Goodell, PhD⁷ and Yun Huang, PhD^8,9

¹Institute of Biosciences and Technology, Texas A&M health science center, HOUSTON, TX
²Department of Biochemistry and Molecular Biology, McGovern Medical School at UTHealth, The University of Texas Health Science Center at Houston, Houston, TX
³Center for Epigenetics and Disease Prevention, Texas A&M University, Institute of Biosciences and Technology, Houston, TX
⁴Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX
⁵Center for Translational Cancer Research, Institute of Biosciences and Technology, Texas A&M University, Houston, TX
⁶Department of Biochemistry and Molecular Biology, University of Texas Health Science Center at Houston, Houston, TX
⁷Molecular and Cellular Biology Department, Baylor College of Medicine, Houston, TX
⁸Institute of Biosciences and Technology, Texas A&M University, College of Medicine, Houston
⁹Center for Epigenetics & Disease Prevention, Institute of Biosciences and Technology, Texas A&M University, Houston, TX

Luise Hartmann^1,2,3,4*, Judith Hecker, MD^5*, Jennifer Beauvarlet^5*, Mark Van Der Garde, MSc, PhD^2,4,5*, Michele Kyncl, MSc^5*, Maja Rothenberg-Thurley, PhD^3*, Luise Fischer, PhD^6,7*, Susann Winter, PhD^6,7*, Bianka Ksienzyk^3*, Frank Ziemann, MD^1,2,4*, Martina Rauner, PhD^8*, Elena Tsourdi, MD^8*, Jörg Lützner, MD^9*, Andreas Roth, MD^10*, Karsten Spiekermann, MD^1,2,3,4, Lorenz C Hofbauer, MD^6,8*, Uwe Platzbecker, MD^2,6,11, Katharina S. Götze^2,4,5 and Klaus H. Metzeler, MD^1,2,3,4

¹Experimental Leukemia and Lymphoma Research (ELLF), University Hospital, LMU Munich, Munich, Germany
²German Cancer Research Center (DKFZ), Heidelberg, Germany
³Laboratory for Leukemia Diagnostics, Department of Hematology and Oncology, University Hospital, LMU Munich, Munich, Germany
⁴CHOICE consortium, German Cancer Consortium (DKTK), Munich, Germany
⁵Department of Medicine III, Technical University of Munich, Munich, Germany
⁶CHOICE consortium, German Cancer Consortium (DKTK), Dresden, Germany
⁷Medical Clinic I, Technical University of Dresden, Dresden, Germany
⁸Center for Healthy Aging, Technical University of Dresden, Dresden, Germany
⁹Department of Orthopedic Surgery, Technical University of Dresden, Dresden, Germany
¹⁰Department of Orthopedic Surgery, University Hospital Leipzig, Leipzig, Germany
¹¹Hematology and Cellular Therapy, University Hospital Leipzig, Leipzig, Germany

Kimberly Skead^1,2*, Armande Ang Houle^1,2*, Sagi Abelson, PhD^1,2*, Marie-Julie Fave, PhD^2*, Boxi Lin^3*, David Soave, PhD^2,4*, Stephen Wright, PhD^5*, John E. Dick, PhD, FRS^1,2,6, Quaid Morris, PhD^1,2,7* and Phillip Awadalla, PhD^1,2*

¹Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada
²Ontario Institute for Cancer Research, Toronto, ON, Canada
³Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada
⁴Department of Mathematics, Wilfrid Laurier Univesity, Waterloo, ON, Canada
⁵Department of Ecology and Evolutionary Biology, University of Toronto, Toronto, ON, Canada
⁶Princess Margaret Cancer Centre, University Health Network (UHN), Toronto, ON, Canada
⁷Computational & Systems Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY

Kelly L. Bolton, MD, PhD¹, Michael Foote, MD^2*, Justin Jee^3*, Anton Safonov, MD⁴, Ryan Ptashkin, MS^5*, Sean Devlin, PhD^6*, Erika Gedvilaite^5*, Teng Gao^7*, Elli Papaemmanuil, PhD^8,9, Melissa S. Pessin, MD, PhD^10*, Mini Kamboj^3*, Joseph Vijai, PhD⁴, Kenneth Offit, MD^11*, Phillip Awadalla, PhD^12*, Pradeep Nataranjan^13*, Michael F. Berger, PhD^5,14*, Larry Norton, MD^15*, Ross L. Levine, MD³ and Ahmet Zehir, PhD^5*

¹Department of Medicine, Leukemia Service, Memorial Sloan Kettering Cancer Center, FAIRFEILD, CT
²Memorial Sloan Kettering Cancer Center, New York
³Memorial Sloan Kettering Cancer Center, New York, NY
⁴Memorial Sloan Kettering, New York, NY
⁵Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY
⁶Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY
⁷Center for Computational Oncology, Memorial Sloan Kettering Cancer Center, New York, NY
⁸Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, NY
⁹5Computational Oncology Service, Department of Epidemiology & Biostatistics, Center for Computational Oncology, Memorial Sloan Kettering Cancer Center, New York, NY
¹⁰Department of Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY
¹¹Memorial Sloan-Kettering Cancer Ctr., New York, NY
¹²Ontario Institute for Cancer Research, Ontario, Canada
¹³Harvard Medical School, Cambridge, MA
¹⁴Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY
¹⁵Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY